tripartite motif containing 44 (TRIM44) - coding DNA reference sequence

(used for variant description)

(last modified August 28, 2015)

This file was created to facilitate the description of sequence variants on transcript NM_017583.4 in the TRIM44 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering TRIM44 transcript NM_017583.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.5007
                                                      ggaggct       c.-301

 .         .         .         .         .         .                g.5067
 gagcgggcggcgcgacgcgggggccgacgggggcgccgggtggccgcgccggaagtgcct       c.-241

 .         .         .         .         .         .                g.5127
 tgcgcggcagaggaagcgcagggacagagcggagcaggccgagccggcggaaagggtctt       c.-181

 .         .         .         .         .         .                g.5187
 tgctgctgcgcccgggcaggggctgccgcggccccaggtcccgcttcgagacgcggcgcg       c.-121

 .         .         .         .         .         .                g.5247
 gtccaggcgggaggcgactccctaggaagggacccggggcgggaggaggaagtgaggccg       c.-61

 .         .         .         .         .         .                g.5307
 cgcggaaggaaggcggcgagccccggggccccgaggccttggccgcgtcacagcacccac       c.-1

          .         .         .         .         .         .       g.5367
 ATGGCCTCTGGAGTGGGCGCGGCCTTCGAGGAACTGCCTCACGACGGCACGTGTGACGAG       c.60
 M  A  S  G  V  G  A  A  F  E  E  L  P  H  D  G  T  C  D  E         p.20

          .         .         .         .         .         .       g.5427
 TGCGAGCCCGACGAGGCTCCGGGGGCCGAGGAAGTGTGCCGAGAATGCGGCTTCTGCTAC       c.120
 C  E  P  D  E  A  P  G  A  E  E  V  C  R  E  C  G  F  C  Y         p.40

          .         .         .         .         .         .       g.5487
 TGCCGCCGCCATGCCGAGGCGCACAGGCAGAAGTTCCTCAGTCACCATCTGGCCGAATAC       c.180
 C  R  R  H  A  E  A  H  R  Q  K  F  L  S  H  H  L  A  E  Y         p.60

          .         .         .         .         .         .       g.5547
 GTCCACGGCTCCCAGGCCTGGACCCCGCCAGCTGACGGAGAGGGGGCGGGGAAGGAAGAA       c.240
 V  H  G  S  Q  A  W  T  P  P  A  D  G  E  G  A  G  K  E  E         p.80

          .         .         .         .         .         .       g.5607
 GCGGAGGTCAAGGTGGAGCAGGAGAGGGAGATAGAAAGCGAGGCAGGGGAAGAGAGTGAG       c.300
 A  E  V  K  V  E  Q  E  R  E  I  E  S  E  A  G  E  E  S  E         p.100

          .         .         .         .         .         .       g.5667
 TCGGAGGAAGAGAGCGAGTCAGAGGAAGAGAGCGAGACAGAGGAAGAGAGTGAGGATGAG       c.360
 S  E  E  E  S  E  S  E  E  E  S  E  T  E  E  E  S  E  D  E         p.120

          .         .         .         .         .         .       g.5727
 AGCGATGAGGAGAGTGAAGAAGACAGCGAGGAAGAAATGGAGGATGAGCAAGAAAGCGAG       c.420
 S  D  E  E  S  E  E  D  S  E  E  E  M  E  D  E  Q  E  S  E         p.140

          .         .         .         .         .         .       g.5787
 GCCGAAGAAGACAACCAAGAAGAAGGGGAATCCGAGGCGGAGGGAGAAACTGAGGCAGAA       c.480
 A  E  E  D  N  Q  E  E  G  E  S  E  A  E  G  E  T  E  A  E         p.160

          .         .         .         .         .         .       g.5847
 AGTGAATTTGACCCAGAAATAGAAATGGAAGCAGAGAGAGTGGCCAAGAGGAAGTGTCCG       c.540
 S  E  F  D  P  E  I  E  M  E  A  E  R  V  A  K  R  K  C  P         p.180

          .         .         .         .         .         .       g.5907
 GACCATGGGCTTGATTTGAGTACCTATTGCCAGGAAGATAGGCAGCTCATCTGTGTCCTG       c.600
 D  H  G  L  D  L  S  T  Y  C  Q  E  D  R  Q  L  I  C  V  L         p.200

          .         .         .         .         .         .       g.5967
 TGTCCAGTCATTGGGGCTCACCAGGGCCACCAACTCTCCACCCTAGACGAAGCCTTTGAA       c.660
 C  P  V  I  G  A  H  Q  G  H  Q  L  S  T  L  D  E  A  F  E         p.220

           | 02        .         .         .         .         .    g.27505
 GAATTAAGA | AGCAAAGACTCAGGTGGACTGAAGGCCGCTATGATCGAATTGGTGGAAAGG    c.720
 E  L  R   | S  K  D  S  G  G  L  K  A  A  M  I  E  L  V  E  R      p.240

          .         .        | 03.         .         .         .    g.68152
 TTGAAGTTCAAGAGCTCAGACCCTAAA | GTAACTCGGGACCAAATGAAGATGTTTATACAG    c.780
 L  K  F  K  S  S  D  P  K   | V  T  R  D  Q  M  K  M  F  I  Q      p.260

          .         .         .         .         .         .       g.68212
 CAGGAATTTAAGAAAGTTCAGAAAGTGATTGCTGATGAGGAGCAGAAGGCCCTTCATCTA       c.840
 Q  E  F  K  K  V  Q  K  V  I  A  D  E  E  Q  K  A  L  H  L         p.280

          .         .         .         .         .         .       g.68272
 GTGGACATCCAAGAGGCAATGGCCACAGCTCATGTGACTGAGATACTGGCAGACATCCAA       c.900
 V  D  I  Q  E  A  M  A  T  A  H  V  T  E  I  L  A  D  I  Q         p.300

          .         .         .         .         .         .       g.68332
 TCCCACATGGATAGGTTGATGACTCAGATGGCCCAAGCCAAGGAACAACTTGATACCTCT       c.960
 S  H  M  D  R  L  M  T  Q  M  A  Q  A  K  E  Q  L  D  T  S         p.320

          .         .        | 04.         .        | 05.         . g.148568
 AATGAATCAGCTGAGCCAAAGGCAGAG | GGCGATGAGGAAGGACCCAG | TGGTGCCAGTGAA c.1020
 N  E  S  A  E  P  K  A  E   | G  D  E  E  G  P  S  |  G  A  S  E   p.340

          .                                                         g.148583
 GAAGAGGACACATGA                                                    c.1035
 E  E  D  T  X                                                      p.344

          .         .         .         .         .         .       g.148643
 aggcttgctacccccagtggaaaatcatcccctccccttgtgtgtatgtgacagcgtgta       c.*60

          .         .         .         .         .         .       g.148703
 tgtaacggcttctgatttctgtgaaagctgctcagcaacaaacgtacttccaccagatgt       c.*120

          .         .         .         .         .         .       g.148763
 gtccccagatccacagcaggcacatatctctccaagggatgaccagttttatgcttactg       c.*180

          .         .         .         .         .         .       g.148823
 tgtgcttctcatcccctggttgtggtaggtcaaggaaaagagcccctttgatccaccagg       c.*240

          .         .         .         .         .         .       g.148883
 agcaattaagaaaggtccttcaggtaatccctcaatggctgctttgaacttactcaggaa       c.*300

          .         .         .         .         .         .       g.148943
 agccagcccccataatattgtattaccaaacagtatcgctttgttaggaaggatctggaa       c.*360

          .         .         .         .         .         .       g.149003
 taatcttgaagggaagtcagagttttctccctgcctattaacaaaaacccaattttgttc       c.*420

          .         .         .         .         .         .       g.149063
 atattgaagcatgaaataaatgagagcaaggtagggccaaattaactcttgtggacagtc       c.*480

          .         .         .         .         .         .       g.149123
 cctaaaagtccagttctacatttgtgaaaattgtggtgccatgaattaagatggatgact       c.*540

          .         .         .         .         .         .       g.149183
 ggaaaaaggtgttggagaaagagttaaagatgaggaagagatatttttagtatatgaagt       c.*600

          .         .         .         .         .         .       g.149243
 tatccaggacttgatattcataattcagtgctgtggaaatgaaaaaaatgattgaagagg       c.*660

          .         .         .         .         .         .       g.149303
 tggaacggaaatgaccttagggggaaaaaaaaggaccaaagaagtctgattaaaagttga       c.*720

          .         .         .         .         .         .       g.149363
 aatcagtatttctgaattcaaattgcttgaatttccaaaatagtcagtaaaggatctaat       c.*780

          .         .         .         .         .         .       g.149423
 agaaccagaattatttgggtgaattctgcaggttttatgggcttgtcacaacgtgaaggg       c.*840

          .         .         .         .         .         .       g.149483
 ctggaatgtatattaccaaatgggaatttccattgtaggtttttgctagtcccaccccca       c.*900

          .         .         .         .         .         .       g.149543
 ttttagcctaatttggcttaaacgcagtatggggagaattgttcccattccatgtgttct       c.*960

          .         .         .         .         .         .       g.149603
 gaattcagctcatctcccagcatatagatatatcctcctttaactccgaccagaaccctt       c.*1020

          .         .         .         .         .         .       g.149663
 cttcctgtggcactccccacccatagaccttcagatcatctcccacaccctggatctcac       c.*1080

          .         .         .         .         .         .       g.149723
 tctcctcttagtaacagagacactcctgaggttggacttccttgcttttctctacttcca       c.*1140

          .         .         .         .         .         .       g.149783
 aatcacaatttcttacaaccaagctttgtgctcccgagtaagcagggatgtactagggga       c.*1200

          .         .         .         .         .         .       g.149843
 atgtaaaactgcaaacttaaaaacctgcatcttcttgaagcatcagttttacttaccaaa       c.*1260

          .         .         .         .         .         .       g.149903
 tggtttagagtcataagatgacctatttttatataaaagttatattatagaataaaatgt       c.*1320

          .         .         .         .         .         .       g.149963
 tcatacgcatagactgttaagataaaaaaataggaatcttgcaaggtaattcttatttgc       c.*1380

          .         .         .         .         .         .       g.150023
 aagtgggttatgtgttcactctcctctacctttatggtattttggtgttcacttacgaag       c.*1440

          .         .         .         .         .         .       g.150083
 catacaactagaaccatatccaagcagactctgggttgctgttaacccagggcctagact       c.*1500

          .         .         .         .         .         .       g.150143
 tctagtgcctctgaggcagaaccaaaggagcctgcactgggggaaatcccttttcctgcc       c.*1560

          .         .         .         .         .         .       g.150203
 tgcctgtctgcctgtgacctgtgtacgtattacaggctttaggaccagctgattgttatg       c.*1620

          .         .         .         .         .         .       g.150263
 cttgcaggatggttttgaaacagaaacaatacttgtttactgtaggaatcctatttatat       c.*1680

          .         .         .         .         .         .       g.150323
 tatttttcagtcctgtgaatgctgtgaaaagatttattcctttgaggccaggaagctccc       c.*1740

          .         .         .         .         .         .       g.150383
 aggcatatatgcttctaggttaggattgtcctgactcactaaagatgccaggatattggg       c.*1800

          .         .         .         .         .         .       g.150443
 gctgaggggagtttgaggtgttaaaaaaaaaaaaaaaaaagcatttttctctcaaactga       c.*1860

          .         .         .         .         .         .       g.150503
 tggccaagaaatggctaggacaattttggtgctttacctatctctgcaaagactggagaa       c.*1920

          .         .         .         .         .         .       g.150563
 tttggcataccattaattacaaccaccaatcatatccaacaaaagtaccctaaaagaagg       c.*1980

          .         .         .         .         .         .       g.150623
 accagtggccactctcgaaaaaatttaagtatcagaagattaaaaagattttaggatttg       c.*2040

          .         .         .         .         .         .       g.150683
 gaagcttgtattgtctttccccaataatcattgtttgatctccaaatagtagccttatat       c.*2100

          .         .         .         .         .         .       g.150743
 tagcaatagacagatcattggttctccatatctgatcatatgttactactttgaatcagt       c.*2160

          .         .         .         .         .         .       g.150803
 atttgggaaattcaagcatttatgcagtggatataaatggaaatataaaaatatttgcca       c.*2220

          .         .         .         .         .         .       g.150863
 acctgtctcagtaacttatcatatctctgtgatcctcaaggaaagcacttttgcttttac       c.*2280

          .         .         .         .         .         .       g.150923
 ttagaaagcgtttcagatttgctttatagactcctgctgtcttcagtacctgataaaact       c.*2340

          .         .         .         .         .         .       g.150983
 ttaaccagggaagcattaaacacagtgcagcagcttttgcccaggcttctaagttcctgc       c.*2400

          .         .         .         .         .         .       g.151043
 cggcagcatttatcaatgtaagaactaggatgcttcctgcagtggcactaccttccccta       c.*2460

          .         .         .         .         .         .       g.151103
 gagctggagcatgctgcttggccttaagccccagcatgatgaggcttccctcctgccagg       c.*2520

          .         .         .         .         .         .       g.151163
 tcagtaaaagttagagagctcagaattgggtcttgcctgggtgcaggtggcagggtttgc       c.*2580

          .         .         .         .         .         .       g.151223
 tgaaacccctaaagagaagtcaccaagggaggcaggtaatgaatgtttccagaatcagtc       c.*2640

          .         .         .         .         .         .       g.151283
 ggatactcatagcaatttctggctatctttcaaatgttgaatttctggatgctgagaggg       c.*2700

          .         .         .         .         .         .       g.151343
 actttgatttgatatcattaaatccaggacagtcccaagaagtgcttggagtctcggctc       c.*2760

          .         .         .         .         .         .       g.151403
 tgacagcccaagaagggaaataacttgtattaaggaacaactatgagccaggccctgagc       c.*2820

          .         .         .         .         .         .       g.151463
 tgtctcttagataataaaacagatggggagtggaagagtcatttgcttcaagttatacag       c.*2880

          .         .         .         .         .         .       g.151523
 ctaggaaatactcaagccaaatcttgaacgcagctccccctaattctgtggacaggcact       c.*2940

          .         .         .         .         .                 g.151578
 ttgtaccacacaccatggtccacctaaaaacagaaggataaaaagacttcaggtt            c.*2995

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Tripartite motif containing 44 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.