tripartite motif containing 63, E3 ubiquitin protein ligase (TRIM63) - coding DNA reference sequence

(used for variant description)

(last modified February 6, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_032588.3 in the TRIM63 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033268.1, covering TRIM63 transcript NM_032588.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         agacagaattcgggcaccag       c.-121

 .         .         .         .         .         .                g.5080
 gagaaggaagccaacaggatccgacccggtgttttgtgacaaaggcaagacccccaggtc       c.-61

 .         .         .         .         .         .                g.5140
 tacttagagcaaagttagtagaggaggcagctaggcgtggctctcattccttcccacaga       c.-1

          .         .         .         .         .         .       g.5200
 ATGGATTATAAGTCGAGCCTGATCCAGGATGGGAATCCCATGGAGAACTTGGAGAAGCAG       c.60
 M  D  Y  K  S  S  L  I  Q  D  G  N  P  M  E  N  L  E  K  Q         p.20

          .         .         .         .         .         .       g.5260
 CTGATCTGCCCTATCTGCCTGGAGATGTTTACCAAGCCAGTGGTCATCTTGCCGTGCCAG       c.120
 L  I  C  P  I  C  L  E  M  F  T  K  P  V  V  I  L  P  C  Q         p.40

          .         .         .          | 02        .         .    g.6215
 CACAACCTGTGCCGGAAGTGTGCCAATGACATCTTCCAG | GCTGCAAATCCCTACTGGACC    c.180
 H  N  L  C  R  K  C  A  N  D  I  F  Q   | A  A  N  P  Y  W  T      p.60

          .         .         .         .         .         .       g.6275
 AGCCGGGGCAGCTCAGTGTCCATGTCTGGAGGCCGTTTCCGCTGCCCCACCTGCCGCCAC       c.240
 S  R  G  S  S  V  S  M  S  G  G  R  F  R  C  P  T  C  R  H         p.80

          .         .         .         .         .         .       g.6335
 GAGGTGATCATGGATCGTCACGGAGTGTACGGCCTGCAGAGGAACCTGCTGGTGGAGAAC       c.300
 E  V  I  M  D  R  H  G  V  Y  G  L  Q  R  N  L  L  V  E  N         p.100

          .         .         .   | 03     .         .         .    g.11328
 ATCATCGACATCTACAAACAGGAGTGCTCCAG | TCGGCCGCTGCAGAAGGGCAGTCACCCC    c.360
 I  I  D  I  Y  K  Q  E  C  S  S  |  R  P  L  Q  K  G  S  H  P      p.120

          .         .         .         .         .         .       g.11388
 ATGTGCAAGGAGCACGAAGATGAGAAAATCAACATCTACTGTCTCACGTGTGAGGTGCCC       c.420
 M  C  K  E  H  E  D  E  K  I  N  I  Y  C  L  T  C  E  V  P         p.140

          .         .         .         .         .         .       g.11448
 ACCTGCTCCATGTGCAAGGTGTTTGGGATCCACAAGGCCTGCGAGGTGGCCCCATTGCAG       c.480
 T  C  S  M  C  K  V  F  G  I  H  K  A  C  E  V  A  P  L  Q         p.160

          .         .  | 04      .         .         .         .    g.12312
 AGTGTCTTCCAGGGACAAAAG | ACTGAACTGAATAACTGTATCTCCATGCTGGTGGCGGGG    c.540
 S  V  F  Q  G  Q  K   | T  E  L  N  N  C  I  S  M  L  V  A  G      p.180

          .         .         .         .         .        | 05.    g.14014
 AATGACCGTGTGCAGACCATCATCACTCAGCTGGAGGATTCCCGTCGAGTGACCAAG | GAG    c.600
 N  D  R  V  Q  T  I  I  T  Q  L  E  D  S  R  R  V  T  K   | E      p.200

          .         .         .         .         .         .       g.14074
 AACAGTCACCAGGTAAAGGAAGAGCTGAGCCAGAAGTTTGACACGTTGTATGCCATCCTG       c.660
 N  S  H  Q  V  K  E  E  L  S  Q  K  F  D  T  L  Y  A  I  L         p.220

          .         .         .         .         .         .       g.14134
 GATGAGAAGAAAAGTGAGTTGCTGCAGCGGATCACGCAGGAGCAGGAGAAAAAGCTTAGC       c.720
 D  E  K  K  S  E  L  L  Q  R  I  T  Q  E  Q  E  K  K  L  S         p.240

          .         .         .         .         .         .       g.14194
 TTCATCGAGGCCCTCATCCAGCAGTACCAGGAGCAGCTGGACAAGTCCACAAAGCTGGTG       c.780
 F  I  E  A  L  I  Q  Q  Y  Q  E  Q  L  D  K  S  T  K  L  V         p.260

          .         .         .         .         .  | 06      .    g.14993
 GAAACTGCCATCCAGTCCCTGGACGAGCCTGGGGGAGCCACCTTCCTCTTG | ACTGCCAAG    c.840
 E  T  A  I  Q  S  L  D  E  P  G  G  A  T  F  L  L   | T  A  K      p.280

          .     | 07   .         .         .         .         .    g.15353
 CAACTCATCAAAAG | CATTGTGGAAGCTTCCAAGGGCTGCCAGCTGGGGAAGACAGAGCAG    c.900
 Q  L  I  K  S  |  I  V  E  A  S  K  G  C  Q  L  G  K  T  E  Q      p.300

          .         .         .         .         .         .       g.15413
 GGCTTTGAGAACATGGACTTCTTTACTTTGGATTTAGAGCACATAGCAGACGCCCTGAGA       c.960
 G  F  E  N  M  D  F  F  T  L  D  L  E  H  I  A  D  A  L  R         p.320

          .          | 08        .         .         .         .    g.18711
 GCCATTGACTTTGGGACAG | ATGAGGAAGAGGAAGAATTCATTGAAGAAGAAGATCAGGAA    c.1020
 A  I  D  F  G  T  D |   E  E  E  E  E  F  I  E  E  E  D  Q  E      p.340

          .         .         .  | 09      .                        g.20780
 GAGGAAGAGTCCACAGAAGGGAAGGAAGAAG | GACACCAGTAA                      c.1062
 E  E  E  S  T  E  G  K  E  E  G |   H  Q  X                        p.353

          .         .         .         .         .         .       g.20840
 ggagctggatgaatgagaggcccccagatgcagagagactggagagggtggggaggggcc       c.*60

          .         .         .         .         .         .       g.20900
 cagcggccttggtgacaggcccagggtgggaggggtcggggcccctggaggggcaatggg       c.*120

          .         .         .         .         .         .       g.20960
 gaggtgatgtcttctctctgctcagagagcagggactagggtaggaccctcaccgctgcg       c.*180

          .         .         .         .         .         .       g.21020
 tccagcagacactgaaccagaattggaaacgtgcttgaaacaatcacacaggacactttt       c.*240

          .         .         .         .         .         .       g.21080
 ctacattggtgcaaaatggaatattttgtacatttttaaaatgtgatttttgtatatact       c.*300

          .         .         .         .         .         .       g.21140
 tgtatatgtatgccaatttggtgctttttgtaaaggaacttttgtataataatgcctggt       c.*360

          .         .         .         .         .         .       g.21200
 cgttgggtgacctgcgattgtcagaaagaggggaaggaagccaggttgatacagctgccc       c.*420

          .         .         .         .         .         .       g.21260
 acttcctttcctgagcaggaggatggggtagcactcacagggacgatgtgctgtatttca       c.*480

          .         .         .         .         .         .       g.21320
 gtgcctatcccagacatacggggtggtaactgagtttgtgttatatgttgttttaataaa       c.*540

          .         .                                               g.21349
 tgcacaatgctctcttcctgttcttcaaa                                      c.*569

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tripartite motif containing 63, E3 ubiquitin protein ligase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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