thyroid hormone receptor interactor 4 (TRIP4) - coding DNA reference sequence

(used for variant description)

(last modified July 9, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_016213.4 in the TRIP4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_046848.1, covering TRIP4 transcript NM_016213.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 ggaactagtccggtgcaggacgtggggcttttgcagctcagctggttccggctggggaag       c.-1

          .         .         .         .         .         .       g.5120
 ATGGCGGTGGCTGGGGCGGTGTCCGGGGAGCCGCTGGTGCACTGGTGCACCCAGCAGTTG       c.60
 M  A  V  A  G  A  V  S  G  E  P  L  V  H  W  C  T  Q  Q  L         p.20

          .         .         .         .  | 02      .         .    g.11161
 CGGAAGACTTTCGGCCTGGATGTCAGCGAGGAGATCATTCA | GTACGTTTTGTCAATTGAG    c.120
 R  K  T  F  G  L  D  V  S  E  E  I  I  Q  |  Y  V  L  S  I  E      p.40

          .         .         .         .         .         .       g.11221
 AGTGCTGAAGAGATACGAGAATATGTTACTGATCTCCTCCAGGGAAATGAAGGCAAAAAA       c.180
 S  A  E  E  I  R  E  Y  V  T  D  L  L  Q  G  N  E  G  K  K         p.60

          .         .         .         .         .         .       g.11281
 GGTCAATTCATAGAAGAACTTATAACCAAATGGCAAAAGAATGATCAGGAGTTGATTTCG       c.240
 G  Q  F  I  E  E  L  I  T  K  W  Q  K  N  D  Q  E  L  I  S         p.80

          .         .         .  | 03      .         .         .    g.12623
 GATCCTTTGCAGCAGTGCTTCAAAAAAGATG | AAATTTTAGATGGGCAGAAATCAGGCGAC    c.300
 D  P  L  Q  Q  C  F  K  K  D  E |   I  L  D  G  Q  K  S  G  D      p.100

          .         .         .         .         .         .       g.12683
 CATCTAAAGCGGGGTAGGAAGAAAGGGAGAAACAGACAGGAAGTTCCTGCATTTACTGAA       c.360
 H  L  K  R  G  R  K  K  G  R  N  R  Q  E  V  P  A  F  T  E         p.120

          .         .         .         .      | 04  .         .    g.14817
 CCTGACACGACTGCAGAGGTTAAAACACCTTTTGATTTGGCCAAG | GCACAAGAGAACAGC    c.420
 P  D  T  T  A  E  V  K  T  P  F  D  L  A  K   | A  Q  E  N  S      p.140

          .         .         .         .         .         .       g.14877
 AACTCCGTAAAGAAGAAGACAAAGTTTGTCAATTTATACACAAGAGAGGGACAGGACAGG       c.480
 N  S  V  K  K  K  T  K  F  V  N  L  Y  T  R  E  G  Q  D  R         p.160

          .         .         .         .         .         .       g.14937
 CTTGCAGTCCTGCTCCCTGGTCGTCACCCTTGTGATTGCCTGGGCCAGAAGCACAAGCTC       c.540
 L  A  V  L  L  P  G  R  H  P  C  D  C  L  G  Q  K  H  K  L         p.180

          .         .         .         .         .         .       g.14997
 ATCAATAACTGTCTGATCTGTGGGCGCATTGTCTGTGAACAAGAAGGCTCAGGCCCTTGC       c.600
 I  N  N  C  L  I  C  G  R  I  V  C  E  Q  E  G  S  G  P  C         p.200

          .         | 05         .         .         .         .    g.17981
 TTATTCTGTGGCACTCTG | GTGTGTACTCATGAGGAACAAGATATTTTACAGCGTGACTCA    c.660
 L  F  C  G  T  L   | V  C  T  H  E  E  Q  D  I  L  Q  R  D  S      p.220

          .         .         .        | 06.         .         .    g.23549
 AACAAGAGCCAGAAACTGCTAAAGAAACTCATGTCAG | GAGTGGAGAATTCTGGAAAGGTG    c.720
 N  K  S  Q  K  L  L  K  K  L  M  S  G |   V  E  N  S  G  K  V      p.240

          .         .         .         .         .         .       g.23609
 GACATCTCTACCAAGGACCTTCTTCCTCATCAAGAATTGCGAATTAAGTCTGGTCTGGAG       c.780
 D  I  S  T  K  D  L  L  P  H  Q  E  L  R  I  K  S  G  L  E         p.260

          .         .         .         .        | 07.         .    g.26822
 AAGGCTATCAAGCATAAAGACAAACTGTTAGAGTTTGACAGAACTAG | TATTCGAAGGACC    c.840
 K  A  I  K  H  K  D  K  L  L  E  F  D  R  T  S  |  I  R  R  T      p.280

          .         .         .         .         .         .       g.26882
 CAAGTCATTGATGATGAGTCAGATTACTTTGCCAGTGATTCTAACCAATGGTTGTCCAAA       c.900
 Q  V  I  D  D  E  S  D  Y  F  A  S  D  S  N  Q  W  L  S  K         p.300

          .         .         .         .         .         .       g.26942
 CTTGAGCGGGAAACCTTGCAGAAGCGAGAGGAGGAGCTGAGAGAACTTCGACACGCCTCT       c.960
 L  E  R  E  T  L  Q  K  R  E  E  E  L  R  E  L  R  H  A  S         p.320

          .         .         .         .         .         .       g.27002
 CGACTTTCTAAGAAGGTCACCATTGACTTTGCAGGAAGGAAGATCCTGGAAGAAGAAAAT       c.1020
 R  L  S  K  K  V  T  I  D  F  A  G  R  K  I  L  E  E  E  N         p.340

          .         .    | 08    .         .         .         .    g.31318
 TCACTAGCAGAGTATCATAGCAG | ACTAGATGAGACAATACAGGCCATTGCCAATGGAACC    c.1080
 S  L  A  E  Y  H  S  R  |  L  D  E  T  I  Q  A  I  A  N  G  T      p.360

          .         .         .         .         .         .       g.31378
 TTGAACCAGCCACTGACCAAATTGGATAGATCTTCTGAAGAGCCTTTGGGAGTTCTGGTA       c.1140
 L  N  Q  P  L  T  K  L  D  R  S  S  E  E  P  L  G  V  L  V         p.380

          .         .         . | 09       .         .         .    g.35767
 AATCCCAACATGTACCAGTCCCCTCCCCAG | TGGGTTGACCACACAGGTGCAGCCTCACAG    c.1200
 N  P  N  M  Y  Q  S  P  P  Q   | W  V  D  H  T  G  A  A  S  Q      p.400

          .         .         .         .         .         .       g.35827
 AAGAAGGCTTTCCGTTCTTCAGGATTTGGACTAGAGTTCAACTCATTTCAGCACCAGTTG       c.1260
 K  K  A  F  R  S  S  G  F  G  L  E  F  N  S  F  Q  H  Q  L         p.420

          .         .         .         .         .         .       g.35887
 CGAATCCAGGATCAAGAATTTCAGGAAGGCTTTGATGGTGGCTGGTGCCTCTCTGTACAT       c.1320
 R  I  Q  D  Q  E  F  Q  E  G  F  D  G  G  W  C  L  S  V  H         p.440

          .         .         .         | 10         .         .    g.41249
 CAGCCCTGGGCTTCTCTGCTTGTCAGAGGGATTAAAAG | GGTGGAGGGCAGATCCTGGTAC    c.1380
 Q  P  W  A  S  L  L  V  R  G  I  K  R  |  V  E  G  R  S  W  Y      p.460

          .         .         .         .         .         .       g.41309
 ACCCCCCACAGAGGACGACTTTGGATAGCAGCCACAGCTAAAAAACCCTCCCCTCAAGAA       c.1440
 T  P  H  R  G  R  L  W  I  A  A  T  A  K  K  P  S  P  Q  E         p.480

          .         .         .         .    | 11    .         .    g.42753
 GTCTCAGAACTCCAGGCTACATATCGTCTTCTTCGTGGGAAAG | ATGTGGAATTTCCTAAT    c.1500
 V  S  E  L  Q  A  T  Y  R  L  L  R  G  K  D |   V  E  F  P  N      p.500

          .         .         .         .         .         .       g.42813
 GACTATCCGTCAGGTTGTCTTCTGGGCTGTGTGGACCTAATTGACTGCTTGTCCCAGAAG       c.1560
 D  Y  P  S  G  C  L  L  G  C  V  D  L  I  D  C  L  S  Q  K         p.520

          .      | 12  .         .         .         .         .    g.62247
 CAATTTAAGGAGCAG | TTTCCAGACATCAGTCAAGAGTCTGATTCTCCATTTGTTTTCATC    c.1620
 Q  F  K  E  Q   | F  P  D  I  S  Q  E  S  D  S  P  F  V  F  I      p.540

          .         .         .         .         .         | 13    g.72195
 TGCAAAAATCCTCAGGAAATGGTTGTGAAGTTTCCTATTAAAGGAAATCCAAAAATCT | GG    c.1680
 C  K  N  P  Q  E  M  V  V  K  F  P  I  K  G  N  P  K  I  W |       p.560

          .         .         .         .         .         .       g.72255
 AAATTGGATTCCAAGATCCATCAAGGAGCAAAGAAGGGGTTAATGAAGCAGAATAAAGCT       c.1740
 K  L  D  S  K  I  H  Q  G  A  K  K  G  L  M  K  Q  N  K  A         p.580

                                                                    g.72261
 GTCTGA                                                             c.1746
 V  X                                                               p.581

          .         .         .         .         .         .       g.72321
 cccaggagaaaaggaactatacagcatagtggagttttgtgtactaaaattgctatctac       c.*60

          .         .         .         .         .         .       g.72381
 tggtcctttggaattgaagtagtagaaacctaaaggcttggcgtcaggcttgaatatctc       c.*120

          .         .         .         .         .         .       g.72441
 agaacttaaactcttaccaaaatctgtatatttttcttaaggagtgggattcctacttta       c.*180

          .         .         .         .         .                 g.72500
 tgtaatggggtcgaaatctttgaacacattatttataaaaacctgtttaaaaattctaa        c.*239

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Thyroid hormone receptor interactor 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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