tRNA methyltransferase 1 homolog (S. cerevisiae) (TRMT1) - coding DNA reference sequence

(used for variant description)

(last modified February 11, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_001136035.2 in the TRMT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering TRMT1 transcript NM_001136035.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5009
                                                    gattcgccc       c.-121

 .         .         .         .         .         .                g.5069
 acccactgtgccaacatggcggcgcccaggtcctaattcgggaaacgtgcaccttgacta       c.-61

 .         .         .        | 02.         .         .             g.5350
 attcggttttctgtggctacgagagcag | gcttggcgggcggaggcgccagcggatgtctc    c.-1

          .         .         .         .         .         .       g.5410
 ATGCAAGGATCGTCTCTGTGGCTAAGCCTCACTTTCCGCTCCGCCCGGGTGCTCTCTAGA       c.60
 M  Q  G  S  S  L  W  L  S  L  T  F  R  S  A  R  V  L  S  R         p.20

          .         .         .         .         .         .       g.5470
 GCCCGGTTTTTCGAGTGGCAGTCTCCAGGGCTGCCGAATACAGCAGCGATGGAGAACGGC       c.120
 A  R  F  F  E  W  Q  S  P  G  L  P  N  T  A  A  M  E  N  G         p.40

          .         .         .         .         .         .       g.5530
 ACCGGGCCCTACGGAGAAGAACGTCCACGTGAAGTCCAGGAGACGACAGTCACCGAGGGG       c.180
 T  G  P  Y  G  E  E  R  P  R  E  V  Q  E  T  T  V  T  E  G         p.60

          .         .         .         .         .         .       g.5590
 GCTGCCAAAATCGCCTTTCCCAGTGCCAACGAGGTCTTTTATAACCCGGTGCAGGAATTC       c.240
 A  A  K  I  A  F  P  S  A  N  E  V  F  Y  N  P  V  Q  E  F         p.80

          .     | 03   .         .         .         .         .    g.5743
 AATCGGGACCTGAC | ATGTGCTGTGATCACCGAGTTTGCTCGCATTCAGCTTGGGGCCAAA    c.300
 N  R  D  L  T  |  C  A  V  I  T  E  F  A  R  I  Q  L  G  A  K      p.100

          . | 04       .         .         .         .         .    g.6031
 GGAATCCAGA | TCAAGGTTCCAGGAGAGAAGGACACGCAAAAAGTGGTCGTGGACTTGTCA    c.360
 G  I  Q  I |   K  V  P  G  E  K  D  T  Q  K  V  V  V  D  L  S      p.120

          .         .         .         .         .         .       g.6091
 GAGCAAGAGGAGGAAAAGGTTGAACTGAAAGAGAGTGAAAACCTGGCCTCAGGAGACCAA       c.420
 E  Q  E  E  E  K  V  E  L  K  E  S  E  N  L  A  S  G  D  Q         p.140

          .         .         .    | 05    .         .         .    g.6310
 CCTCGCACAGCGGCCGTGGGGGAGATCTGTGAG | GAAGGCCTGCATGTGCTGGAAGGCCTG    c.480
 P  R  T  A  A  V  G  E  I  C  E   | E  G  L  H  V  L  E  G  L      p.160

          .         .         .         .         .         .       g.6370
 GCAGCTTCAGGCCTACGTTCCATTCGATTTGCCCTAGAGGTGCCTGGGCTCAGATCTGTG       c.540
 A  A  S  G  L  R  S  I  R  F  A  L  E  V  P  G  L  R  S  V         p.180

          .         .         .         .         .         .       g.6430
 GTTGCAAACGATGCCTCCACCCGGGCTGTGGATCTCATACGCCGGAATGTCCAGCTCAAT       c.600
 V  A  N  D  A  S  T  R  A  V  D  L  I  R  R  N  V  Q  L  N         p.200

          .         .         .         .  | 06      .         .    g.8757
 GACGTGGCCCACCTGGTACAGCCGAGCCAAGCAGATGCCCG | GATGCTGATGTACCAGCAC    c.660
 D  V  A  H  L  V  Q  P  S  Q  A  D  A  R  |  M  L  M  Y  Q  H      p.220

          .         .         .         .         .         .       g.8817
 CAGAGGGTGTCGGAGAGGTTTGACGTCATCGATCTGGACCCCTATGGCAGCCCAGCCACC       c.720
 Q  R  V  S  E  R  F  D  V  I  D  L  D  P  Y  G  S  P  A  T         p.240

          .         .         .        | 07.         .         .    g.8955
 TTCCTGGATGCAGCTGTGCAGGCTGTGAGTGAAGGAG | GGTTGCTGTGTGTGACCTGCACA    c.780
 F  L  D  A  A  V  Q  A  V  S  E  G  G |   L  L  C  V  T  C  T      p.260

          .         .         .         .         .         .       g.9015
 GACATGGCGGTGTTGGCGGGGAACAGCGGGGAGACGTGCTACAGCAAGTACGGGGCCATG       c.840
 D  M  A  V  L  A  G  N  S  G  E  T  C  Y  S  K  Y  G  A  M         p.280

          .         .         . | 08       .         .         .    g.11473
 GCCCTCAAGAGCCGGGCCTGCCACGAGATG | GCCCTGAGAATCGTCCTGCACAGCCTGGAC    c.900
 A  L  K  S  R  A  C  H  E  M   | A  L  R  I  V  L  H  S  L  D      p.300

          .         .         .         .         .         .       g.11533
 CTCCGCGCCAACTGCTACCAGCGCTTCGTGGTGCCGCTGCTCAGCATCAGCGCTGACTTC       c.960
 L  R  A  N  C  Y  Q  R  F  V  V  P  L  L  S  I  S  A  D  F         p.320

          .         .         .         .         .          | 09    g.11749
 TACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAGGCCAAGGTCAAGGCCTCAGCCAG | C    c.1020
 Y  V  R  V  F  V  R  V  F  T  G  Q  A  K  V  K  A  S  A  S  |      p.340

          .         .         .         .         .         .       g.11809
 AAGCAGGCGCTGGTGTTCCAGTGTGTGGGCTGCGGGGCCTTCCACCTTCAGCGTCTCGGC       c.1080
 K  Q  A  L  V  F  Q  C  V  G  C  G  A  F  H  L  Q  R  L  G         p.360

          .         .       | 10 .         .         .         .    g.11945
 AAAGCGTCAGGAGTCCCCAGCGGCCG | GGCCAAGTTCTCTGCAGCCTGTGGTCCCCCTGTG    c.1140
 K  A  S  G  V  P  S  G  R  |  A  K  F  S  A  A  C  G  P  P  V      p.380

          .         .         .       | 11 .         .         .    g.12089
 ACCCCCGAGTGTGAACACTGTGGGCAACGACACCAG | CTTGGTGGCCCCATGTGGGCAGAG    c.1200
 T  P  E  C  E  H  C  G  Q  R  H  Q   | L  G  G  P  M  W  A  E      p.400

          .         .         .         .         .         .       g.12149
 CCCATCCATGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGC       c.1260
 P  I  H  D  L  D  F  V  G  R  V  L  E  A  V  S  A  N  P  G         p.420

          .         .         .         .         .  | 12      .    g.12292
 CGCTTCCACACCTCGGAGCGGATCCGAGGGGTCCTGAGCGTCATCACTGAG | GAGCTCCCG    c.1320
 R  F  H  T  S  E  R  I  R  G  V  L  S  V  I  T  E   | E  L  P      p.440

          .         .         .         .         .         .       g.12352
 GACGTGCCTCTGTACTACACCCTGGACCAGCTGAGCAGCACCATCCACTGCAACACACCA       c.1380
 D  V  P  L  Y  Y  T  L  D  Q  L  S  S  T  I  H  C  N  T  P         p.460

          .        | 13.         .         .         .         .    g.13933
 AGCCTCCTGCAGTTGCG | GTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCAC    c.1440
 S  L  L  Q  L  R  |  S  A  L  L  H  A  D  F  R  V  S  L  S  H      p.480

          .         .         .         .         .         .       g.13993
 GCCTGTAAGAACGCTGTGAAGACGGATGCCCCTGCCTCTGCCCTCTGGGACATCATGCGT       c.1500
 A  C  K  N  A  V  K  T  D  A  P  A  S  A  L  W  D  I  M  R         p.500

        | 14 .         .         .         .         .         .    g.14153
 TGCTGG | GAGAAGGAATGTCCGGTGAAACGGGAGCGACTATCAGAGACTAGCCCAGCGTTC    c.1560
 C  W   | E  K  E  C  P  V  K  R  E  R  L  S  E  T  S  P  A  F      p.520

          .         .    | 15    .         .         .         .    g.16180
 CGCATTCTCAGTGTGGAGCCCAG | GCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAAC    c.1620
 R  I  L  S  V  E  P  R  |  L  Q  A  N  F  T  I  R  E  D  A  N      p.540

          .         .         .         .         .         .       g.16240
 CCCAGCTCCCGACAGCGAGGACTCAAGCGCTTCCAGGCTAACCCGGAGGCCAACTGGGGT       c.1680
 P  S  S  R  Q  R  G  L  K  R  F  Q  A  N  P  E  A  N  W  G         p.560

          .         .    | 16    .         .         .         .    g.16390
 CCCCGGCCTCGTGCCCGGCCAGG | GGGCAAGGCGGCCGACGAAGCTATGGAGGAGAGACGC    c.1740
 P  R  P  R  A  R  P  G  |  G  K  A  A  D  E  A  M  E  E  R  R      p.580

          .         .         .         .         .         .       g.16450
 AGGCTGCTTCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGG       c.1800
 R  L  L  Q  N  K  R  K  E  P  P  E  D  V  A  Q  R  A  A  R         p.600

          .         .         .    | 17    .         .         .    g.16695
 CTCAAGACATTTCCTTGCAAGAGGTTTAAGGAG | GGCACCTGTCAACGCGGGGACCAGTGC    c.1860
 L  K  T  F  P  C  K  R  F  K  E   | G  T  C  Q  R  G  D  Q  C      p.620

          .         .         .         .         .         .       g.16755
 TGCTACTCCCACAGCCCCCCGACACCCAGGGTTTCTGCTGATGCTGCCCCTGACTGTCCA       c.1920
 C  Y  S  H  S  P  P  T  P  R  V  S  A  D  A  A  P  D  C  P         p.640

          .         .         .         .         .         .       g.16815
 GAGACCTCCAACCAGACCCCCCCTGGACCTGGGGCTGCCGCTGGGCCAGGCATAGACTGA       c.1980
 E  T  S  N  Q  T  P  P  G  P  G  A  A  A  G  P  G  I  D  X         p.659

          .         .         .                                     g.16850
 accaataaagagatgtcacgtcaccttctcccgat                                c.*35

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The TRNA methyltransferase 1 homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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