transient receptor potential cation channel, subfamily C, member 3 (TRPC3) - coding DNA reference sequence

(used for variant description)

(last modified May 8, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_001130698.1 in the TRPC3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering TRPC3 transcript NM_001130698.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               gggaagactgcact       c.-61

 .         .         .         .         .         .                g.5074
 gccgcgaaggcggaggaggccggcagccggcacccccacactcggaccgcagccggcgcg       c.-1

          .         .         .         .         .         .       g.5134
 ATGTCCACCAAGGTCAGGAAGTGCAAAGAACAAGCAAGGGTGACCTTCCCGGCGCCGGAG       c.60
 M  S  T  K  V  R  K  C  K  E  Q  A  R  V  T  F  P  A  P  E         p.20

          .         .         .         .         .         .       g.5194
 GAGGAGGAAGACGAGGGCGAGGACGAGGGCGCGGAGCCGCAGCGCCGCCGCCGGGGCTGG       c.120
 E  E  E  D  E  G  E  D  E  G  A  E  P  Q  R  R  R  R  G  W         p.40

          .         .         .         .         .         .       g.5254
 AGGGGCGTCAACGGGGGGCTGGAGCCGCGCTCGGCGCCCTCGCAGCGGGAGCCGCACGGC       c.180
 R  G  V  N  G  G  L  E  P  R  S  A  P  S  Q  R  E  P  H  G         p.60

          .         .         .      | 02  .         .         .    g.23737
 TACTGCCCGCCGCCCTTCTCCCACGGGCCGGACCT | GTCCATGGAGGGAAGCCCATCCCTG    c.240
 Y  C  P  P  P  F  S  H  G  P  D  L  |  S  M  E  G  S  P  S  L      p.80

          .         .         .         .         .         .       g.23797
 AGACGCATGACAGTGATGCGGGAGAAGGGCCGGCGCCAGGCTGTCAGGGGCCCGGCCTTC       c.300
 R  R  M  T  V  M  R  E  K  G  R  R  Q  A  V  R  G  P  A  F         p.100

          .         .         .         .         .         .       g.23857
 ATGTTCAATGACCGCGGCACCAGCCTCACCGCCGAGGAGGAGCGCTTCCTCGACGCCGCC       c.360
 M  F  N  D  R  G  T  S  L  T  A  E  E  E  R  F  L  D  A  A         p.120

          .         .         .         .         .         .       g.23917
 GAGTACGGCAACATCCCAGTGGTGCGCAAGATGCTGGAGGAGTCCAAGACGCTGAACGTC       c.420
 E  Y  G  N  I  P  V  V  R  K  M  L  E  E  S  K  T  L  N  V         p.140

          .         .         .         .         .         .       g.23977
 AACTGCGTGGACTACATGGGCCAGAACGCGCTGCAGCTGGCTGTGGGCAACGAGCACCTG       c.480
 N  C  V  D  Y  M  G  Q  N  A  L  Q  L  A  V  G  N  E  H  L         p.160

          .         .         .         .         .         .       g.24037
 GAGGTGACCGAGCTGCTGCTCAAGAAGGAGAACCTGGCGCGCATTGGCGACGCCCTGCTG       c.540
 E  V  T  E  L  L  L  K  K  E  N  L  A  R  I  G  D  A  L  L         p.180

          .         .         .         .         .         .       g.24097
 CTCGCCATCAGCAAGGGCTACGTGCGCATCGTAGAGGCCATCCTCAACCACCCTGGCTTC       c.600
 L  A  I  S  K  G  Y  V  R  I  V  E  A  I  L  N  H  P  G  F         p.200

          .         .         .         .         .         .       g.24157
 GCGGCCAGCAAGCGTCTCACTCTGAGCCCCTGTGAGCAGGAGCTGCAGGACGACGACTTC       c.660
 A  A  S  K  R  L  T  L  S  P  C  E  Q  E  L  Q  D  D  D  F         p.220

          .         .         .         .         .         .       g.24217
 TACGCTTACGACGAGGACGGCACGCGCTTCTCGCCGGACATCACCCCCATCATCCTGGCG       c.720
 Y  A  Y  D  E  D  G  T  R  F  S  P  D  I  T  P  I  I  L  A         p.240

          .         .         .         .         .         .       g.24277
 GCGCACTGCCAGAAATACGAAGTGGTGCACATGCTGCTGATGAAGGGTGCCAGGATCGAG       c.780
 A  H  C  Q  K  Y  E  V  V  H  M  L  L  M  K  G  A  R  I  E         p.260

          .         .         .         .         .         .       g.24337
 CGGCCGCACGACTATTTCTGCAAGTGCGGGGACTGCATGGAGAAGCAGAGGCACGACTCC       c.840
 R  P  H  D  Y  F  C  K  C  G  D  C  M  E  K  Q  R  H  D  S         p.280

          .         .         .         .         .         .       g.24397
 TTCAGCCACTCACGCTCGAGGATCAATGCCTACAAGGGGCTGGCCAGCCCGGCTTACCTC       c.900
 F  S  H  S  R  S  R  I  N  A  Y  K  G  L  A  S  P  A  Y  L         p.300

          .         .         .         .         .         .       g.24457
 TCATTGTCCAGCGAGGACCCGGTGCTTACGGCCCTAGAGCTCAGCAACGAGCTGGCCAAG       c.960
 S  L  S  S  E  D  P  V  L  T  A  L  E  L  S  N  E  L  A  K         p.320

          .         .        | 03.         .         .         .    g.31581
 CTGGCCAACATAGAGAAGGAGTTCAAG | AATGACTATCGGAAGCTCTCCATGCAATGCAAA    c.1020
 L  A  N  I  E  K  E  F  K   | N  D  Y  R  K  L  S  M  Q  C  K      p.340

          .         .         .         .         .         .       g.31641
 GACTTTGTAGTGGGTGTGCTGGATCTCTGCCGAGACTCAGAAGAGGTAGAAGCCATTCTG       c.1080
 D  F  V  V  G  V  L  D  L  C  R  D  S  E  E  V  E  A  I  L         p.360

          .         .         .         .         .         .       g.31701
 AATGGAGATCTGGAATCAGCAGAGCCTCTGGAGGTACACAGGCACAAAGCTTCATTAAGT       c.1140
 N  G  D  L  E  S  A  E  P  L  E  V  H  R  H  K  A  S  L  S         p.380

          .         .         .       | 04 .         .         .    g.41834
 CGTGTCAAACTTGCCATTAAGTATGAAGTCAAAAAG | TTTGTGGCTCATCCCAACTGCCAG    c.1200
 R  V  K  L  A  I  K  Y  E  V  K  K   | F  V  A  H  P  N  C  Q      p.400

          .         .         .         .         .         .       g.41894
 CAGCAGCTCTTGACGATCTGGTATGAGAACCTCTCAGGCCTAAGGGAGCAGACCATAGCT       c.1260
 Q  Q  L  L  T  I  W  Y  E  N  L  S  G  L  R  E  Q  T  I  A         p.420

          .         .         .         .         .         .       g.41954
 ATCAAGTGTCTCGTTGTGCTGGTCGTGGCCCTGGGCCTTCCATTCCTGGCCATTGGCTAC       c.1320
 I  K  C  L  V  V  L  V  V  A  L  G  L  P  F  L  A  I  G  Y         p.440

          .         .  | 05      .         .         .         .    g.44700
 TGGATCGCACCTTGCAGCAGG | CTGGGGAAAATTCTGCGAAGCCCTTTTATGAAGTTTGTA    c.1380
 W  I  A  P  C  S  R   | L  G  K  I  L  R  S  P  F  M  K  F  V      p.460

          .         .         .         .         .         .       g.44760
 GCACATGCAGCTTCTTTCATCATCTTCCTGGGTCTGCTTGTGTTCAATGCCTCAGACAGG       c.1440
 A  H  A  A  S  F  I  I  F  L  G  L  L  V  F  N  A  S  D  R         p.480

          .         .         .         .         .         .       g.44820
 TTCGAAGGCATCACCACGCTGCCCAATATCACAGTTACTGACTATCCCAAACAGATCTTC       c.1500
 F  E  G  I  T  T  L  P  N  I  T  V  T  D  Y  P  K  Q  I  F         p.500

          .         .         .         .         .         | 06    g.46369
 AGGGTGAAAACCACCCAGTTTACATGGACTGAAATGCTAATTATGGTCTGGGTTCTTG | GA    c.1560
 R  V  K  T  T  Q  F  T  W  T  E  M  L  I  M  V  W  V  L  G |       p.520

          .         .         .         .         .         .       g.46429
 ATGATGTGGTCTGAATGTAAAGAGCTCTGGCTGGAAGGACCTAGGGAATACATTTTGCAG       c.1620
 M  M  W  S  E  C  K  E  L  W  L  E  G  P  R  E  Y  I  L  Q         p.540

          .         .         .         .         .         .       g.46489
 TTGTGGAATGTGCTTGACTTTGGGATGCTGTCCATCTTCATTGCTGCTTTCACAGCCAGA       c.1680
 L  W  N  V  L  D  F  G  M  L  S  I  F  I  A  A  F  T  A  R         p.560

          .         .         .         .         .         .       g.46549
 TTCCTAGCTTTCCTTCAGGCAACGAAGGCACAACAGTATGTGGACAGTTACGTCCAAGAG       c.1740
 F  L  A  F  L  Q  A  T  K  A  Q  Q  Y  V  D  S  Y  V  Q  E         p.580

          .         .         .         .         .   | 07     .    g.49195
 AGTGACCTCAGTGAAGTGACACTCCCACCAGAGATACAGTATTTCACTTATG | CTAGAGAT    c.1800
 S  D  L  S  E  V  T  L  P  P  E  I  Q  Y  F  T  Y  A |   R  D      p.600

          .         .         .         .         .         .       g.49255
 AAATGGCTCCCTTCTGACCCTCAGATTATATCTGAAGGCCTTTATGCCATAGCTGTTGTG       c.1860
 K  W  L  P  S  D  P  Q  I  I  S  E  G  L  Y  A  I  A  V  V         p.620

          .         .         .         .         .         .       g.49315
 CTCAGCTTCTCTCGGATTGCGTACATCCTCCCTGCAAATGAGAGCTTTGGCCCCCTGCAG       c.1920
 L  S  F  S  R  I  A  Y  I  L  P  A  N  E  S  F  G  P  L  Q         p.640

          .         .         .         .         .         .       g.49375
 ATCTCTCTTGGAAGGACTGTAAAGGACATATTCAAGTTCATGGTCCTCTTTATTATGGTG       c.1980
 I  S  L  G  R  T  V  K  D  I  F  K  F  M  V  L  F  I  M  V         p.660

          .         .         .         .         .         .       g.49435
 TTTTTTGCCTTTATGATTGGCATGTTCATACTTTATTCTTACTACCTTGGGGCTAAAGTT       c.2040
 F  F  A  F  M  I  G  M  F  I  L  Y  S  Y  Y  L  G  A  K  V         p.680

          .        | 08.         .         .         .         .    g.52280
 AATGCTGCTTTTACCAC | TGTAGAAGAAAGTTTCAAGACTTTATTTTGGTCAATATTTGGG    c.2100
 N  A  A  F  T  T  |  V  E  E  S  F  K  T  L  F  W  S  I  F  G      p.700

          .         .         .         .         .         .       g.52340
 TTGTCTGAAGTGACTTCCGTTGTGCTCAAATATGATCACAAATTCATAGAAAATATTGGA       c.2160
 L  S  E  V  T  S  V  V  L  K  Y  D  H  K  F  I  E  N  I  G         p.720

          .         .         .         .         .         .       g.52400
 TACGTTCTTTATGGAATATACAATGTAACTATGGTGGTCGTTTTACTCAACATGCTAATT       c.2220
 Y  V  L  Y  G  I  Y  N  V  T  M  V  V  V  L  L  N  M  L  I         p.740

          .         .         .    | 09    .         .         .    g.53720
 GCTATGATTAATAGCTCATATCAAGAAATTGAG | GATGACAGTGATGTAGAATGGAAGTTT    c.2280
 A  M  I  N  S  S  Y  Q  E  I  E   | D  D  S  D  V  E  W  K  F      p.760

          .         .         .         .         .         .       g.53780
 GCTCGTTCAAAACTTTGGTTATCCTATTTTGATGATGGAAAAACATTACCTCCACCTTTC       c.2340
 A  R  S  K  L  W  L  S  Y  F  D  D  G  K  T  L  P  P  P  F         p.780

          .         .         .         .         .         .       g.53840
 AGTCTAGTTCCTAGTCCAAAATCATTTGTTTATTTCATCATGCGAATTGTTAACTTTCCC       c.2400
 S  L  V  P  S  P  K  S  F  V  Y  F  I  M  R  I  V  N  F  P         p.800

          .         .         .         .         .         .       g.53900
 AAATGCAGAAGGAGAAGGCTTCAGAAGGATATAGAAATGGGAATGGGTAACTCAAAGTCC       c.2460
 K  C  R  R  R  R  L  Q  K  D  I  E  M  G  M  G  N  S  K  S         p.820

     | 10    .         .         .         .         .         .    g.57116
 AGG | TTAAACCTCTTCACTCAGTCTAACTCAAGAGTTTTTGAATCACACAGTTTTAACAGC    c.2520
 R   | L  N  L  F  T  Q  S  N  S  R  V  F  E  S  H  S  F  N  S      p.840

          .         .        | 11.         .         .         .    g.74358
 ATTCTCAATCAGCCAACACGTTATCAG | CAGATAATGAAAAGACTTATAAAGCGGTATGTT    c.2580
 I  L  N  Q  P  T  R  Y  Q   | Q  I  M  K  R  L  I  K  R  Y  V      p.860

          .         .         .         .    | 12    .         .    g.76893
 TTGAAAGCACAAGTAGACAAAGAAAATGATGAAGTTAATGAAG | GTGAATTAAAAGAAATC    c.2640
 L  K  A  Q  V  D  K  E  N  D  E  V  N  E  G |   E  L  K  E  I      p.880

          .         .         .         .         .         .       g.76953
 AAGCAAGATATCTCCAGCCTTCGTTATGAACTTTTGGAAGACAAGAGCCAAGCAACTGAG       c.2700
 K  Q  D  I  S  S  L  R  Y  E  L  L  E  D  K  S  Q  A  T  E         p.900

          .         .         .         .         .         .       g.77013
 GAATTAGCCATTCTAATTCATAAACTTAGTGAGAAACTGAATCCCAGCATGCTGAGATGT       c.2760
 E  L  A  I  L  I  H  K  L  S  E  K  L  N  P  S  M  L  R  C         p.920

                                                                    g.77019
 GAATGA                                                             c.2766
 E  X                                                               p.921

          .         .         .         .         .         .       g.77079
 tgcagcaacctggatttggctttgactatagcacaaatgtgggcaataatatttctaagt       c.*60

          .         .         .         .         .         .       g.77139
 atgaaatacttgaaaaactatgatgtaaatttttagtattaactacctttatcatgtgaa       c.*120

          .         .         .         .         .         .       g.77199
 cctttaaaagttagctcttaatggttttattgttttatcacatgaaaatgcattttattt       c.*180

          .         .         .         .         .         .       g.77259
 gtctgctttgacattacagtggcataccattgtgttgaaaagcccaatattactatatta       c.*240

          .         .         .         .         .         .       g.77319
 ttgaaacttttattcattttagagtaaactccacatctttgcactacctgtttgcctcca       c.*300

          .         .         .         .         .         .       g.77379
 agagactatcagttccttggggacagggaccatgtcttattcatctttgtgtctccagca       c.*360

          .         .         .         .         .         .       g.77439
 tctagtacagtgcctggtatatagtaggtgctcaataaatgttgaaaccaactgaactgc       c.*420

          .         .         .         .         .         .       g.77499
 caacaaaataaaaataaaaagtcttcactatgtagcataccttcccttgtccaagttctg       c.*480

          .         .         .         .         .         .       g.77559
 aagaggttttttttttttttttttaatagaaactgaagacattttacaaccagctatgac       c.*540

          .         .         .         .         .         .       g.77619
 ttggtaagacattcttagaattttaggtgtcactgataatcctagaaccactgagcccca       c.*600

          .         .         .         .         .         .       g.77679
 agtgaagaatttaacaacaaaatgggttaatgaaaaatataattacattgtatatttaag       c.*660

          .         .         .         .                           g.77727
 tttcatagaattatttaaaacaacacattaaagatttttctaaaatat                   c.*708

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transient receptor potential cation channel, subfamily C, member 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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