transient receptor potential cation channel, subfamily C, member 6 (TRPC6) - coding DNA reference sequence

(used for variant description)

(last modified July 18, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_004621.5 in the TRPC6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011476.1, covering TRPC6 transcript NM_004621.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        gggat       c.-421

 .         .         .         .         .         .                g.5065
 cttgacggagagtgcgggggatgaaggcgggagctgagggctggagagtctctgttgaca       c.-361

 .         .         .         .         .         .                g.5125
 tagtaactcttcagctccgtctcccttgctctccgctcttacgcttcgctaccaccagcg       c.-301

 .         .         .         .         .         .                g.5185
 gccccgcctgtgccctctctgcccgggcgccccagacgcatcctcgcggggtctcctcgg       c.-241

 .         .         .         .         .         .                g.5245
 cctgacctgctcaggtcaagatcctctttgcacccccttaagtggtgacttttccccggg       c.-181

 .         .         .         .         .         .                g.5305
 ccagtgggcgagccacttgcggcgggcgtctgcaccccctgcttcaccgtcgtcccctgg       c.-121

 .         .         .         .         .         .                g.5365
 gcaccggtctgcccaggtccagttcggccgctgacgcgaaccctccgcaccgggtccccg       c.-61

 .         .         .         .         .         .                g.5425
 ctggaactgcccactcggctcccccgggagcggggcccaggccagtcgggcgttcccgcc       c.-1

          .         .         .         .         .         .       g.5485
 ATGAGCCAGAGCCCGGCGTTCGGGCCCCGGAGGGGCAGTTCTCCCCGGGGCGCTGCCGGA       c.60
 M  S  Q  S  P  A  F  G  P  R  R  G  S  S  P  R  G  A  A  G         p.20

          .         .         .         .         .         .       g.5545
 GCCGCTGCGCGGCGCAACGAGAGCCAGGACTATCTGCTCATGGACTCGGAGCTGGGAGAA       c.120
 A  A  A  R  R  N  E  S  Q  D  Y  L  L  M  D  S  E  L  G  E         p.40

          .         .         .         .         . | 02       .    g.84140
 GACGGCTGCCCGCAAGCCCCGCTGCCTTGCTACGGCTACTACCCCTGCTT | CCGGGGATCT    c.180
 D  G  C  P  Q  A  P  L  P  C  Y  G  Y  Y  P  C  F  |  R  G  S      p.60

          .         .         .         .         .         .       g.84200
 GACAACAGACTGGCTCACCGGCGGCAGACAGTTCTCCGTGAGAAGGGGAGAAGGTTAGCT       c.240
 D  N  R  L  A  H  R  R  Q  T  V  L  R  E  K  G  R  R  L  A         p.80

          .         .         .         .         .         .       g.84260
 AATCGAGGACCAGCATACATGTTTAGTGATCGCTCCACAAGCCTATCTATAGAGGAGGAA       c.300
 N  R  G  P  A  Y  M  F  S  D  R  S  T  S  L  S  I  E  E  E         p.100

          .         .         .         .         .         .       g.84320
 CGCTTTTTGGATGCAGCTGAATATGGTAACATCCCAGTGGTGCGGAAGATGTTAGAAGAA       c.360
 R  F  L  D  A  A  E  Y  G  N  I  P  V  V  R  K  M  L  E  E         p.120

          .         .         .         .         .         .       g.84380
 TGCCACTCACTCAACGTTAACTGTGTGGATTACATGGGCCAGAATGCCCTACAGTTGGCA       c.420
 C  H  S  L  N  V  N  C  V  D  Y  M  G  Q  N  A  L  Q  L  A         p.140

          .         .         .         .         .         .       g.84440
 GTGGCCAATGAGCATCTGGAAATTACAGAACTTCTTCTCAAGAAAGAAAACCTCTCTCGA       c.480
 V  A  N  E  H  L  E  I  T  E  L  L  L  K  K  E  N  L  S  R         p.160

          .         .         .         .         .         .       g.84500
 GTTGGGGATGCTTTGCTTCTAGCTATTAGTAAAGGTTATGTTCGGATTGTGGAAGCAATT       c.540
 V  G  D  A  L  L  L  A  I  S  K  G  Y  V  R  I  V  E  A  I         p.180

          .         .         .         .         .         .       g.84560
 CTCAGTCATCCGGCTTTTGCTGAAGGCAAGAGGTTAGCAACCAGCCCTAGCCAGTCTGAA       c.600
 L  S  H  P  A  F  A  E  G  K  R  L  A  T  S  P  S  Q  S  E         p.200

          .         .         .         .         .         .       g.84620
 CTCCAGCAAGATGATTTTTATGCCTATGATGAAGATGGGACACGGTTCTCCCATGATGTG       c.660
 L  Q  Q  D  D  F  Y  A  Y  D  E  D  G  T  R  F  S  H  D  V         p.220

          .         .         .         .         .         .       g.84680
 ACTCCAATCATTCTGGCTGCCCACTGCCAGGAATATGAAATTGTGCATACCCTCCTGCGG       c.720
 T  P  I  I  L  A  A  H  C  Q  E  Y  E  I  V  H  T  L  L  R         p.240

          .         .         .         .         .         .       g.84740
 AAGGGTGCTAGGATTGAACGGCCTCATGATTATTTCTGCAAGTGCAATGACTGCAACCAG       c.780
 K  G  A  R  I  E  R  P  H  D  Y  F  C  K  C  N  D  C  N  Q         p.260

          .         .         .         .         .         .       g.84800
 AAACAGAAGCATGACTCGTTTAGCCACTCCAGATCTAGGATTAATGCCTATAAAGGCCTG       c.840
 K  Q  K  H  D  S  F  S  H  S  R  S  R  I  N  A  Y  K  G  L         p.280

          .         .         .         .         .         .       g.84860
 GCAAGTCCGGCTTACCTGTCATTGTCTAGTGAAGATCCAGTCATGACGGCTTTAGAACTT       c.900
 A  S  P  A  Y  L  S  L  S  S  E  D  P  V  M  T  A  L  E  L         p.300

          .         .         .         .      | 03  .         .    g.97205
 AGCAATGAACTGGCAGTTCTGGCCAATATTGAGAAAGAGTTCAAG | AATGACTACAAAAAA    c.960
 S  N  E  L  A  V  L  A  N  I  E  K  E  F  K   | N  D  Y  K  K      p.320

          .         .         .         .         .         .       g.97265
 CTGTCAATGCAGTGCAAAGACTTTGTTGTTGGACTCCTTGATCTGTGCAGAAACACTGAA       c.1020
 L  S  M  Q  C  K  D  F  V  V  G  L  L  D  L  C  R  N  T  E         p.340

          .         .         .         .         .         .       g.97325
 GAAGTCGAGGCCATTCTGAATGGGGATGTTGAAACGCTCCAGAGTGGTGATCACGGTCGC       c.1080
 E  V  E  A  I  L  N  G  D  V  E  T  L  Q  S  G  D  H  G  R         p.360

          .         .         .         .         | 04         .    g.99839
 CCAAATCTCAGCCGTTTAAAACTTGCCATTAAATATGAAGTAAAAAAA | TTTGTAGCTCAT    c.1140
 P  N  L  S  R  L  K  L  A  I  K  Y  E  V  K  K   | F  V  A  H      p.380

          .         .         .         .         .         .       g.99899
 CCAAACTGCCAACAGCAACTTCTCTCCATTTGGTATGAGAATCTTTCTGGTTTACGACAG       c.1200
 P  N  C  Q  Q  Q  L  L  S  I  W  Y  E  N  L  S  G  L  R  Q         p.400

          .         .         .         .         .         .       g.99959
 CAGACAATGGCGGTCAAGTTCCTTGTGGTCCTTGCTGTTGCCATTGGACTGCCCTTCCTG       c.1260
 Q  T  M  A  V  K  F  L  V  V  L  A  V  A  I  G  L  P  F  L         p.420

          .         .         .    | 05    .         .         .    g.105790
 GCTCTCATTTACTGGTTTGCTCCATGCAGCAAG | ATGGGGAAGATAATGCGTGGACCATTC    c.1320
 A  L  I  Y  W  F  A  P  C  S  K   | M  G  K  I  M  R  G  P  F      p.440

          .         .         .         .         .         .       g.105850
 ATGAAGTTTGTAGCACACGCAGCCTCCTTCACCATTTTTCTGGGACTGCTAGTCATGAAT       c.1380
 M  K  F  V  A  H  A  A  S  F  T  I  F  L  G  L  L  V  M  N         p.460

          .         .         .         .         .         .       g.105910
 GCAGCTGACAGATTTGAAGGCACAAAACTCCTTCCTAATGAAACCAGCACAGATAATGCA       c.1440
 A  A  D  R  F  E  G  T  K  L  L  P  N  E  T  S  T  D  N  A         p.480

          .         .         .         .         .         .       g.105970
 AAACAGCTGTTCAGGATGAAAACATCCTGCTTCTCATGGATGGAGATGCTCATTATATCC       c.1500
 K  Q  L  F  R  M  K  T  S  C  F  S  W  M  E  M  L  I  I  S         p.500

          . | 06       .         .         .         .         .    g.112444
 TGGGTAATAG | GCATGATATGGGCTGAATGTAAAGAAATCTGGACTCAGGGCCCCAAGGAA    c.1560
 W  V  I  G |   M  I  W  A  E  C  K  E  I  W  T  Q  G  P  K  E      p.520

          .         .         .         .         .         .       g.112504
 TATTTGTTTGAGTTGTGGAACATGCTTGATTTTGGTATGTTAGCAATTTTCGCAGCATCA       c.1620
 Y  L  F  E  L  W  N  M  L  D  F  G  M  L  A  I  F  A  A  S         p.540

          .         .         .         .         .         .       g.112564
 TTCATTGCGAGATTCATGGCATTTTGGCATGCTTCCAAAGCCCAGAGCATCATTGACGCA       c.1680
 F  I  A  R  F  M  A  F  W  H  A  S  K  A  Q  S  I  I  D  A         p.560

          .         .         .         .         .         .       g.112624
 AATGATACTTTGAAGGACTTGACGAAAGTAACATTGGGAGACAATGTGAAATACTACAAT       c.1740
 N  D  T  L  K  D  L  T  K  V  T  L  G  D  N  V  K  Y  Y  N         p.580

      | 07   .         .         .         .         .         .    g.115211
 TTGG | CCAGGATAAAGTGGGACCCCTCTGATCCTCAAATAATATCTGAAGGTCTTTATGCA    c.1800
 L  A |   R  I  K  W  D  P  S  D  P  Q  I  I  S  E  G  L  Y  A      p.600

          .         .         .         .         .         .       g.115271
 ATTGCTGTAGTTTTAAGTTTCTCTAGGATAGCTTATATTTTACCAGCAAATGAAAGCTTT       c.1860
 I  A  V  V  L  S  F  S  R  I  A  Y  I  L  P  A  N  E  S  F         p.620

          .         .         .         .         .         .       g.115331
 GGACCTCTGCAGATATCACTTGGAAGAACAGTCAAAGACATCTTCAAGTTCATGGTCATA       c.1920
 G  P  L  Q  I  S  L  G  R  T  V  K  D  I  F  K  F  M  V  I         p.640

          .         .         .         .         .         .       g.115391
 TTCATTATGGTGTTTGTGGCCTTTATGATTGGAATGTTCAATCTCTACTCCTACTACATT       c.1980
 F  I  M  V  F  V  A  F  M  I  G  M  F  N  L  Y  S  Y  Y  I         p.660

          .         .          | 08        .         .         .    g.116627
 GGTGCAAAACAAAATGAAGCCTTCACAAC | AGTTGAAGAGAGTTTTAAGACACTGTTCTGG    c.2040
 G  A  K  Q  N  E  A  F  T  T  |  V  E  E  S  F  K  T  L  F  W      p.680

          .         .         .         .         .         .       g.116687
 GCTATATTTGGACTTTCTGAAGTGAAATCAGTGGTCATCAACTATAACCACAAATTCATT       c.2100
 A  I  F  G  L  S  E  V  K  S  V  V  I  N  Y  N  H  K  F  I         p.700

          .         .         .         .         .         .       g.116747
 GAAAACATTGGTTACGTTCTTTATGGAGTCTATAATGTTACGATGGTCATTGTTTTGCTA       c.2160
 E  N  I  G  Y  V  L  Y  G  V  Y  N  V  T  M  V  I  V  L  L         p.720

          .         .         .         .      | 09  .         .    g.117557
 AATATGTTAATTGCCATGATCAACAGTTCATTCCAGGAAATTGAG | GATGACGCTGATGTG    c.2220
 N  M  L  I  A  M  I  N  S  S  F  Q  E  I  E   | D  D  A  D  V      p.740

          .         .         .         .         .         .       g.117617
 GAGTGGAAATTTGCAAGGGCCAAACTCTGGTTTTCCTACTTTGAGGAGGGCAGAACACTT       c.2280
 E  W  K  F  A  R  A  K  L  W  F  S  Y  F  E  E  G  R  T  L         p.760

          .         .         .         .         .         .       g.117677
 CCTGTACCCTTCAATCTGGTGCCGAGTCCAAAGTCCCTGTTTTATCTCTTACTGAAGCTT       c.2340
 P  V  P  F  N  L  V  P  S  P  K  S  L  F  Y  L  L  L  K  L         p.780

          .         .         .         .         .         .       g.117737
 AAAAAATGGATTTCTGAGCTGTTCCAGGGCCATAAAAAAGGTTTCCAGGAAGATGCAGAG       c.2400
 K  K  W  I  S  E  L  F  Q  G  H  K  K  G  F  Q  E  D  A  E         p.800

           | 10        .         .         .         .         .    g.119478
 ATGAACAAG | ATAAATGAAGAAAAGAAACTTGGAATTTTAGGAAGTCATGAAGACCTTTCA    c.2460
 M  N  K   | I  N  E  E  K  K  L  G  I  L  G  S  H  E  D  L  S      p.820

          .         .     | 11   .         .         .         .    g.133863
 AAATTATCACTTGACAAAAAACAG | GTTGGGCACAATAAACAACCAAGTATAAGGAGCTCA    c.2520
 K  L  S  L  D  K  K  Q   | V  G  H  N  K  Q  P  S  I  R  S  S      p.840

          .         .         .         .         | 12         .    g.135215
 GAAGATTTCCATCTAAATAGTTTCAATAATCCTCCAAGACAATATCAG | AAAATAATGAAA    c.2580
 E  D  F  H  L  N  S  F  N  N  P  P  R  Q  Y  Q   | K  I  M  K      p.860

          .         .         .         .         .         .       g.135275
 AGGCTCATTAAAAGATATGTACTGCAGGCCCAGATAGATAAGGAGAGTGATGAAGTGAAC       c.2640
 R  L  I  K  R  Y  V  L  Q  A  Q  I  D  K  E  S  D  E  V  N         p.880

      | 13   .         .         .         .         .         .    g.135878
 GAAG | GGGAACTGAAGGAAATTAAGCAGGACATCTCAAGTCTCCGCTATGAACTCCTTGAA    c.2700
 E  G |   E  L  K  E  I  K  Q  D  I  S  S  L  R  Y  E  L  L  E      p.900

          .         .         .         .         .         .       g.135938
 GAAAAATCTCAGAATACAGAAGACCTAGCAGAACTTATTAGAGAACTTGGAGAGAAATTA       c.2760
 E  K  S  Q  N  T  E  D  L  A  E  L  I  R  E  L  G  E  K  L         p.920

          .         .         .                                     g.135974
 TCCATGGAACCAAATCAAGAGGAAACCAATAGATAA                               c.2796
 S  M  E  P  N  Q  E  E  T  N  R  X                                 p.931

          .         .         .         .         .         .       g.136034
 tgcgaagacttccttagaaattcatatttatttgtccacttgaagccatattattttctg       c.*60

          .         .         .         .         .         .       g.136094
 atttattttcttaagtgccaatgggcccaccttttaaacaagaaaacgttaaataacttg       c.*120

          .         .         .         .         .         .       g.136154
 ggccatcctatcatctggagccctagtatctaatttttttggtgattaaactccattgtt       c.*180

          .         .         .         .         .         .       g.136214
 cagggtaaaggctgtagataatgaggaaaattatgcccagttgtttggtgcttgttttat       c.*240

          .         .         .         .         .         .       g.136274
 aaactgctttcttggatataactaactcttgtgatgatgtcattgccatgtagtgtctgc       c.*300

          .         .         .         .         .         .       g.136334
 ctgaaaatgggtcccagcggacaggggctgacccacgttactccccatgcggtttttcct       c.*360

          .         .         .         .         .         .       g.136394
 ctgaagtttatttcaggttccttcttgcctgctctgtggatcccctgctggggactccca       c.*420

          .         .         .         .         .         .       g.136454
 gctctgaaatttgggaaaaagtagcccatgggcctttagaatgctttaatcctttcttta       c.*480

          .         .         .         .         .         .       g.136514
 gaatgctgtttaaacaccatttaccctacttatccctcaatgcacatgattgataccgtt       c.*540

          .         .         .         .         .         .       g.136574
 catacaaaatggtcttacatctatgtaaaattttctgattcatctatttgaaaacattac       c.*600

          .         .         .         .         .         .       g.136634
 acttaacaatgaaaaaagtttttcctccactgaaccctggaaacatggtccagttttgtg       c.*660

          .         .         .         .         .         .       g.136694
 tgtgtgcgtgtgtgtaaatgtgtacacacagacataaagtacttgccctagtttgtggct       c.*720

          .         .         .         .         .         .       g.136754
 aatgtggacacacaaaagctctttatgttataaatttttattgtcactaaaaaattttac       c.*780

          .         .         .         .         .         .       g.136814
 tgtctaaataagtaccttttattggagaaaaatcaaaaccccaaacaaacactgtggttg       c.*840

          .         .         .         .         .         .       g.136874
 tttggttccattatagcacaattttgtgccatttctgggagcatttacagatgaatcccc       c.*900

          .         .         .         .         .         .       g.136934
 acacttagccattgaatgtaaaggggaaaaataaggtgagaatttgtaaatacttatctg       c.*960

          .         .         .         .         .         .       g.136994
 ttattttcaatatgttctatccttctacccaaatatataaaacaggaatttgcattcatg       c.*1020

          .         .         .         .         .         .       g.137054
 tgcatttaccaagaggttgttgttgttacttactgatcatgtgaagtggtgtcttaaaca       c.*1080

          .         .         .         .         .         .       g.137114
 actaaaagcgatgaaggttcatatgtttactcaaagaccattggcattcagaggatgctg       c.*1140

          .         .         .         .         .         .       g.137174
 gacattaactggaactgctacttccaattcaataatgggagatttcaaatgcaaatcttt       c.*1200

          .         .         .         .         .         .       g.137234
 aacttcatcttaaagatgaaatggttgcagaaaatctgtttagctccaactttggcttaa       c.*1260

          .         .         .         .         .         .       g.137294
 tttaaatcaaagaacatttatgtaaccagatcagaaaatacagctgaaaatttatattca       c.*1320

          .         .         .         .         .         .       g.137354
 gtgattttgtatttgtggatactacttatggaaaagttacttggtgatacataaagatcg       c.*1380

          .                                                         g.137365
 attttcaaata                                                        c.*1391

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transient receptor potential cation channel, subfamily C, member 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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