transient receptor potential cation channel, subfamily M, member 4 (TRPM4) - coding DNA reference sequence

(used for variant description)

(last modified June 22, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_017636.3 in the TRPM4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_027551.1, covering TRPM4 transcript NM_017636.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             aggctggaaagtggaggatccggtttgctctgggcgggtctggaagca       c.-61

 .         .         .         .         .         .                g.5108
 gagccggcggagggagcgccggggccctgggctgcaggaggttgcggcggccgcggcagc       c.-1

          .         .     | 02   .         .         .         .    g.5469
 ATGGTGGTGCCGGAGAAGGAGCAG | AGCTGGATCCCCAAGATCTTCAAGAAGAAGACCTGC    c.60
 M  V  V  P  E  K  E  Q   | S  W  I  P  K  I  F  K  K  K  T  C      p.20

          .         .         .   | 03     .         .         .    g.13310
 ACGACGTTCATAGTTGACTCCACAGATCCGGG | AGGGACCTTGTGCCAGTGTGGGCGCCCC    c.120
 T  T  F  I  V  D  S  T  D  P  G  |  G  T  L  C  Q  C  G  R  P      p.40

          .         .         .         .         .         .       g.13370
 CGGACCGCCCACCCCGCAGTGGCCATGGAGGATGCCTTCGGGGCAGCCGTGGTGACCGTG       c.180
 R  T  A  H  P  A  V  A  M  E  D  A  F  G  A  A  V  V  T  V         p.60

          .         .         .         .         .         .       g.13430
 TGGGACAGCGATGCACACACCACGGAGAAGCCCACCGATGCCTACGGAGAGCTGGACTTC       c.240
 W  D  S  D  A  H  T  T  E  K  P  T  D  A  Y  G  E  L  D  F         p.80

          .         .        | 04.         .         .         .    g.15191
 ACGGGGGCCGGCCGCAAGCACAGCAAT | TTCCTCCGGCTCTCTGACCGAACGGATCCAGCT    c.300
 T  G  A  G  R  K  H  S  N   | F  L  R  L  S  D  R  T  D  P  A      p.100

          .         .         .         .         .         .       g.15251
 GCAGTTTATAGTCTGGTCACACGCACATGGGGCTTCCGTGCCCCGAACCTGGTGGTGTCA       c.360
 A  V  Y  S  L  V  T  R  T  W  G  F  R  A  P  N  L  V  V  S         p.120

          .         .         .         .         .         .       g.15311
 GTGCTGGGGGGATCGGGGGGCCCCGTCCTCCAGACCTGGCTGCAGGACCTGCTGCGTCGT       c.420
 V  L  G  G  S  G  G  P  V  L  Q  T  W  L  Q  D  L  L  R  R         p.140

          .         .         | 05         .         .         .    g.15533
 GGGCTGGTGCGGGCTGCCCAGAGCACAG | GAGCCTGGATTGTCACTGGGGGTCTGCACACG    c.480
 G  L  V  R  A  A  Q  S  T  G |   A  W  I  V  T  G  G  L  H  T      p.160

          .         .         .         .         .         .       g.15593
 GGCATCGGCCGGCATGTTGGTGTGGCTGTACGGGACCATCAGATGGCCAGCACTGGGGGC       c.540
 G  I  G  R  H  V  G  V  A  V  R  D  H  Q  M  A  S  T  G  G         p.180

          .         .         .         .         .         .       g.15653
 ACCAAGGTGGTGGCCATGGGTGTGGCCCCCTGGGGTGTGGTCCGGAATAGAGACACCCTC       c.600
 T  K  V  V  A  M  G  V  A  P  W  G  V  V  R  N  R  D  T  L         p.200

          .   | 06     .         .         .         .         .    g.15842
 ATCAACCCCAAG | GGCTCGTTCCCTGCGAGGTACCGGTGGCGCGGTGACCCGGAGGACGGG    c.660
 I  N  P  K   | G  S  F  P  A  R  Y  R  W  R  G  D  P  E  D  G      p.220

          .         .         .         .         .         .       g.15902
 GTCCAGTTTCCCCTGGACTACAACTACTCGGCCTTCTTCCTGGTGGACGACGGCACACAC       c.720
 V  Q  F  P  L  D  Y  N  Y  S  A  F  F  L  V  D  D  G  T  H         p.240

          .         .         .         .         .         .       g.15962
 GGCTGCCTGGGGGGCGAGAACCGCTTCCGCTTGCGCCTGGAGTCCTACATCTCACAGCAG       c.780
 G  C  L  G  G  E  N  R  F  R  L  R  L  E  S  Y  I  S  Q  Q         p.260

          .       | 07 .         .         .         .         .    g.18642
 AAGACGGGCGTGGGAG | GGACTGGAATTGACATCCCTGTCCTGCTCCTCCTGATTGATGGT    c.840
 K  T  G  V  G  G |   T  G  I  D  I  P  V  L  L  L  L  I  D  G      p.280

          .         | 08         .         .         .         .    g.18861
 GATGAGAAGATGTTGACG | CGAATAGAGAACGCCACCCAGGCTCAGCTCCCATGTCTCCTC    c.900
 D  E  K  M  L  T   | R  I  E  N  A  T  Q  A  Q  L  P  C  L  L      p.300

          .         .         .         .         .         .       g.18921
 GTGGCTGGCTCAGGGGGAGCTGCGGACTGCCTGGCGGAGACCCTGGAAGACACTCTGGCC       c.960
 V  A  G  S  G  G  A  A  D  C  L  A  E  T  L  E  D  T  L  A         p.320

          .         .         .         .         .         .       g.18981
 CCAGGGAGTGGGGGAGCCAGGCAAGGCGAAGCCCGAGATCGAATCAGGCGTTTCTTTCCC       c.1020
 P  G  S  G  G  A  R  Q  G  E  A  R  D  R  I  R  R  F  F  P         p.340

          .         .         . | 09       .         .         .    g.19280
 AAAGGGGACCTTGAGGTCCTGCAGGCCCAG | GTGGAGAGGATTATGACCCGGAAGGAGCTC    c.1080
 K  G  D  L  E  V  L  Q  A  Q   | V  E  R  I  M  T  R  K  E  L      p.360

          .         .         .         .         .         .       g.19340
 CTGACAGTCTATTCTTCTGAGGATGGGTCTGAGGAATTCGAGACCATAGTTTTGAAGGCC       c.1140
 L  T  V  Y  S  S  E  D  G  S  E  E  F  E  T  I  V  L  K  A         p.380

          . | 10       .         .         .         .         .    g.28640
 CTTGTGAAGG | CCTGTGGGAGCTCGGAGGCCTCAGCCTACCTGGATGAGCTGCGTTTGGCT    c.1200
 L  V  K  A |   C  G  S  S  E  A  S  A  Y  L  D  E  L  R  L  A      p.400

          .         .         .         .         .         .       g.28700
 GTGGCTTGGAACCGCGTGGACATTGCCCAGAGTGAACTCTTTCGGGGGGACATCCAATGG       c.1260
 V  A  W  N  R  V  D  I  A  Q  S  E  L  F  R  G  D  I  Q  W         p.420

     | 11    .         .         .         .         .         .    g.29876
 CGG | TCCTTCCATCTCGAAGCTTCCCTCATGGACGCCCTGCTGAATGACCGGCCTGAGTTC    c.1320
 R   | S  F  H  L  E  A  S  L  M  D  A  L  L  N  D  R  P  E  F      p.440

          .         .         .         .         .         .       g.29936
 GTGCGCTTGCTCATTTCCCACGGCCTCAGCCTGGGCCACTTCCTGACCCCGATGCGCCTG       c.1380
 V  R  L  L  I  S  H  G  L  S  L  G  H  F  L  T  P  M  R  L         p.460

          .         .         .         .         .         .       g.29996
 GCCCAACTCTACAGCGCGGCGCCCTCCAACTCGCTCATCCGCAACCTTTTGGACCAGGCG       c.1440
 A  Q  L  Y  S  A  A  P  S  N  S  L  I  R  N  L  L  D  Q  A         p.480

          .         .         .         .         .         .       g.30056
 TCCCACAGCGCAGGCACCAAAGCCCCAGCCCTAAAAGGGGGAGCTGCGGAGCTCCGGCCC       c.1500
 S  H  S  A  G  T  K  A  P  A  L  K  G  G  A  A  E  L  R  P         p.500

          .         .         .         .         .         .       g.30116
 CCTGACGTGGGGCATGTGCTGAGGATGCTGCTGGGGAAGATGTGCGCGCCGAGGTACCCC       c.1560
 P  D  V  G  H  V  L  R  M  L  L  G  K  M  C  A  P  R  Y  P         p.520

          .         .         .         .         | 12         .    g.30331
 TCCGGGGGCGCCTGGGACCCTCACCCAGGCCAGGGCTTCGGGGAGAGC | ATGTATCTGCTC    c.1620
 S  G  G  A  W  D  P  H  P  G  Q  G  F  G  E  S   | M  Y  L  L      p.540

          .         .         .         .         .         .       g.30391
 TCGGACAAGGCCACCTCGCCGCTCTCGCTGGATGCTGGCCTCGGGCAGGCCCCCTGGAGC       c.1680
 S  D  K  A  T  S  P  L  S  L  D  A  G  L  G  Q  A  P  W  S         p.560

          .         .         .         .         .         .       g.30451
 GACCTGCTTCTTTGGGCACTGTTGCTGAACAGGGCACAGATGGCCATGTACTTCTGGGAG       c.1740
 D  L  L  L  W  A  L  L  L  N  R  A  Q  M  A  M  Y  F  W  E         p.580

     | 13    .         .         .         .         .         .    g.35939
 ATG | GGTTCCAATGCAGTTTCCTCAGCTCTTGGGGCCTGTTTGCTGCTCCGGGTGATGGCA    c.1800
 M   | G  S  N  A  V  S  S  A  L  G  A  C  L  L  L  R  V  M  A      p.600

          .         .         .         .         .         .       g.35999
 CGCCTGGAGCCTGACGCTGAGGAGGCAGCACGGAGGAAAGACCTGGCGTTCAAGTTTGAG       c.1860
 R  L  E  P  D  A  E  E  A  A  R  R  K  D  L  A  F  K  F  E         p.620

          .    | 14    .         .         .         .         .    g.36234
 GGGATGGGCGTTG | ACCTCTTTGGCGAGTGCTATCGCAGCAGTGAGGTGAGGGCTGCCCGC    c.1920
 G  M  G  V  D |   L  F  G  E  C  Y  R  S  S  E  V  R  A  A  R      p.640

          .         .         .         .         .         .       g.36294
 CTCCTCCTCCGTCGCTGCCCGCTCTGGGGGGATGCCACTTGCCTCCAGCTGGCCATGCAA       c.1980
 L  L  L  R  R  C  P  L  W  G  D  A  T  C  L  Q  L  A  M  Q         p.660

          .         .         .          | 15        .         .    g.37470
 GCTGACGCCCGTGCCTTCTTTGCCCAGGATGGGGTACAG | TCTCTGCTGACACAGAAGTGG    c.2040
 A  D  A  R  A  F  F  A  Q  D  G  V  Q   | S  L  L  T  Q  K  W      p.680

          .         .         .         .         .         .       g.37530
 TGGGGAGATATGGCCAGCACTACACCCATCTGGGCCCTGGTTCTCGCCTTCTTTTGCCCT       c.2100
 W  G  D  M  A  S  T  T  P  I  W  A  L  V  L  A  F  F  C  P         p.700

          .         .         .   | 16     .         .         .    g.37965
 CCACTCATCTACACCCGCCTCATCACCTTCAG | GAAATCAGAAGAGGAGCCCACACGGGAG    c.2160
 P  L  I  Y  T  R  L  I  T  F  R  |  K  S  E  E  E  P  T  R  E      p.720

          .         .         .         .         . | 17       .    g.43691
 GAGCTAGAGTTTGACATGGATAGTGTCATTAATGGGGAAGGGCCTGTCGG | GACGGCGGAC    c.2220
 E  L  E  F  D  M  D  S  V  I  N  G  E  G  P  V  G  |  T  A  D      p.740

          .         .         .         .         .         .       g.43751
 CCAGCCGAGAAGACGCCGCTGGGGGTCCCGCGCCAGTCGGGCCGTCCGGGTTGCTGCGGG       c.2280
 P  A  E  K  T  P  L  G  V  P  R  Q  S  G  R  P  G  C  C  G         p.760

          .         .         .         .         .         .       g.43811
 GGCCGCTGCGGGGGGCGCCGGTGCCTACGCCGCTGGTTCCACTTCTGGGGCGCGCCGGTG       c.2340
 G  R  C  G  G  R  R  C  L  R  R  W  F  H  F  W  G  A  P  V         p.780

          .         .         .         .         .         .       g.43871
 ACCATCTTCATGGGCAACGTGGTCAGCTACCTGCTGTTCCTGCTGCTTTTCTCGCGGGTG       c.2400
 T  I  F  M  G  N  V  V  S  Y  L  L  F  L  L  L  F  S  R  V         p.800

          .         .         .         .         .         .       g.43931
 CTGCTCGTGGATTTCCAGCCGGCGCCGCCCGGCTCCCTGGAGCTGCTGCTCTATTTCTGG       c.2460
 L  L  V  D  F  Q  P  A  P  P  G  S  L  E  L  L  L  Y  F  W         p.820

          .         .         .         .         .         .       g.43991
 GCTTTCACGCTGCTGTGCGAGGAACTGCGCCAGGGCCTGAGCGGAGGCGGGGGCAGCCTC       c.2520
 A  F  T  L  L  C  E  E  L  R  Q  G  L  S  G  G  G  G  S  L         p.840

          .         .         .         .         .         .       g.44051
 GCCAGCGGGGGCCCCGGGCCTGGCCATGCCTCACTGAGCCAGCGCCTGCGCCTCTACCTC       c.2580
 A  S  G  G  P  G  P  G  H  A  S  L  S  Q  R  L  R  L  Y  L         p.860

          .         .         .         .         .         .       g.44111
 GCCGACAGCTGGAACCAGTGCGACCTAGTGGCTCTCACCTGCTTCCTCCTGGGCGTGGGC       c.2640
 A  D  S  W  N  Q  C  D  L  V  A  L  T  C  F  L  L  G  V  G         p.880

       | 18  .         .         .         .         .         .    g.47596
 TGCCG | GCTGACCCCGGGTTTGTACCACCTGGGCCGCACTGTCCTCTGCATCGACTTCATG    c.2700
 C  R  |  L  T  P  G  L  Y  H  L  G  R  T  V  L  C  I  D  F  M      p.900

          .         .         .         .         .         .       g.47656
 GTTTTCACGGTGCGGCTGCTTCACATCTTCACGGTCAACAAACAGCTGGGGCCCAAGATC       c.2760
 V  F  T  V  R  L  L  H  I  F  T  V  N  K  Q  L  G  P  K  I         p.920

          .         | 19         .         .         .         .    g.47894
 GTCATCGTGAGCAAGATG | ATGAAGGACGTGTTCTTCTTCCTCTTCTTCCTCGGCGTGTGG    c.2820
 V  I  V  S  K  M   | M  K  D  V  F  F  F  L  F  F  L  G  V  W      p.940

          .         .         .         .         .         .       g.47954
 CTGGTAGCCTATGGCGTGGCCACGGAGGGGCTCCTGAGGCCACGGGACAGTGACTTCCCA       c.2880
 L  V  A  Y  G  V  A  T  E  G  L  L  R  P  R  D  S  D  F  P         p.960

          .         .         .         .         .         .       g.48014
 AGTATCCTGCGCCGCGTCTTCTACCGTCCCTACCTGCAGATCTTCGGGCAGATTCCCCAG       c.2940
 S  I  L  R  R  V  F  Y  R  P  Y  L  Q  I  F  G  Q  I  P  Q         p.980

          .    | 20    .         .         .         .         .    g.49252
 GAGGACATGGACG | TGGCCCTCATGGAGCACAGCAACTGCTCGTCGGAGCCCGGCTTCTGG    c.3000
 E  D  M  D  V |   A  L  M  E  H  S  N  C  S  S  E  P  G  F  W      p.1000

          .         .         .         .         .         .       g.49312
 GCACACCCTCCTGGGGCCCAGGCGGGCACCTGCGTCTCCCAGTATGCCAACTGGCTGGTG       c.3060
 A  H  P  P  G  A  Q  A  G  T  C  V  S  Q  Y  A  N  W  L  V         p.1020

          .         .         .         .         .         .       g.49372
 GTGCTGCTCCTCGTCATCTTCCTGCTCGTGGCCAACATCCTGCTGGTCAACTTGCTCATT       c.3120
 V  L  L  L  V  I  F  L  L  V  A  N  I  L  L  V  N  L  L  I         p.1040

          .  | 21      .         .         .         .         .    g.57499
 GCCATGTTCAG | TTACACATTCGGCAAAGTACAGGGCAACAGCGATCTCTACTGGAAGGCG    c.3180
 A  M  F  S  |  Y  T  F  G  K  V  Q  G  N  S  D  L  Y  W  K  A      p.1060

          .         .         .         .         .         .       g.57559
 CAGCGTTACCGCCTCATCCGGGAATTCCACTCTCGGCCCGCGCTGGCCCCGCCCTTTATC       c.3240
 Q  R  Y  R  L  I  R  E  F  H  S  R  P  A  L  A  P  P  F  I         p.1080

          .         .         .         .         .         .       g.57619
 GTCATCTCCCACTTGCGCCTCCTGCTCAGGCAATTGTGCAGGCGACCCCGGAGCCCCCAG       c.3300
 V  I  S  H  L  R  L  L  L  R  Q  L  C  R  R  P  R  S  P  Q         p.1100

          .         .         | 22         .         .         .    g.57983
 CCGTCCTCCCCGGCCCTCGAGCATTTCC | GGGTTTACCTTTCTAAGGAAGCCGAGCGGAAG    c.3360
 P  S  S  P  A  L  E  H  F  R |   V  Y  L  S  K  E  A  E  R  K      p.1120

          .         .         .         .         .         .       g.58043
 CTGCTAACGTGGGAATCGGTGCATAAGGAGAACTTTCTGCTGGCACGCGCTAGGGACAAG       c.3420
 L  L  T  W  E  S  V  H  K  E  N  F  L  L  A  R  A  R  D  K         p.1140

          .         .         .         .  | 23      .         .    g.58275
 CGGGAGAGCGACTCCGAGCGTCTGAAGCGCACGTCCCAGAA | GGTGGACTTGGCACTGAAA    c.3480
 R  E  S  D  S  E  R  L  K  R  T  S  Q  K  |  V  D  L  A  L  K      p.1160

          .         .         .         .         .     | 24   .    g.58411
 CAGCTGGGACACATCCGCGAGTACGAACAGCGCCTGAAAGTGCTGGAGCGGGAG | GTCCAG    c.3540
 Q  L  G  H  I  R  E  Y  E  Q  R  L  K  V  L  E  R  E   | V  Q      p.1180

          .         .         .         .         .         .       g.58471
 CAGTGTAGCCGCGTCCTGGGGTGGGTGGCCGAGGCCCTGAGCCGCTCTGCCTTGCTGCCC       c.3600
 Q  C  S  R  V  L  G  W  V  A  E  A  L  S  R  S  A  L  L  P         p.1200

          .         .         .         . | 25                      g.58755
 CCAGGTGGGCCGCCACCCCCTGACCTGCCTGGGTCCAAAG | ACTGA                   c.3645
 P  G  G  P  P  P  P  D  L  P  G  S  K  D |   X                     p.1214

          .         .         .         .         .         .       g.58815
 gccctgctggcggacttcaaggagaagcccccacaggggattttgctcctagagtaaggc       c.*60

          .         .         .         .         .         .       g.58875
 tcatctgggcctcggcccccgcacctggtggccttgtccttgaggtgagccccatgtcca       c.*120

          .         .         .         .         .         .       g.58935
 tctgggccactgtcaggaccacctttgggagtgtcatccttacaaaccacagcatgcccg       c.*180

          .         .         .         .         .         .       g.58995
 gctcctcccagaaccagtcccagcctgggaggatcaaggcctggatcccgggccgttatc       c.*240

          .         .         .         .         .         .       g.59055
 catctggaggctgcagggtccttggggtaacagggaccacagacccctcaccactcacag       c.*300

          .         .         .         .                           g.59098
 attcctcacactggggaaataaagccatttcagaggaatcgtg                        c.*343

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transient receptor potential cation channel, subfamily M, member 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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