transient receptor potential cation channel, subfamily V, member 4 (TRPV4) - coding DNA reference sequence

(used for variant description)

(last modified February 18, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_021625.4 in the TRPV4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering TRPV4 transcript NM_021625.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                ccggccgggattcaggaagcgcggatctc       c.-61

 .         .         .         | 02         .         .             g.23611
 ccggccgccggcgcccagccgtcccggag | gctgagcagtgcagacgggcctggggcaggc    c.-1

          .         .         .         .         .         .       g.23671
 ATGGCGGATTCCAGCGAAGGCCCCCGCGCGGGGCCCGGGGAGGTGGCTGAGCTCCCCGGG       c.60
 M  A  D  S  S  E  G  P  R  A  G  P  G  E  V  A  E  L  P  G         p.20

          .         .         .         .         .         .       g.23731
 GATGAGAGTGGCACCCCAGGTGGGGAGGCTTTTCCTCTCTCCTCCCTGGCCAATCTGTTT       c.120
 D  E  S  G  T  P  G  G  E  A  F  P  L  S  S  L  A  N  L  F         p.40

          .         .         .         .         .         .       g.23791
 GAGGGGGAGGATGGCTCCCTTTCGCCCTCACCGGCTGATGCCAGTCGCCCTGCTGGCCCA       c.180
 E  G  E  D  G  S  L  S  P  S  P  A  D  A  S  R  P  A  G  P         p.60

          .         .         .         .         .         .       g.23851
 GGCGATGGGCGACCAAATCTGCGCATGAAGTTCCAGGGCGCCTTCCGCAAGGGGGTGCCC       c.240
 G  D  G  R  P  N  L  R  M  K  F  Q  G  A  F  R  K  G  V  P         p.80

          .         .         .         .         .         .       g.23911
 AACCCCATCGATCTGCTGGAGTCCACCCTATATGAGTCCTCGGTGGTGCCTGGGCCCAAG       c.300
 N  P  I  D  L  L  E  S  T  L  Y  E  S  S  V  V  P  G  P  K         p.100

          .         .         .         .         .         .       g.23971
 AAAGCACCCATGGACTCACTGTTTGACTACGGCACCTATCGTCACCACTCCAGTGACAAC       c.360
 K  A  P  M  D  S  L  F  D  Y  G  T  Y  R  H  H  S  S  D  N         p.120

          .         .       | 03 .         .         .         .    g.29973
 AAGAGGTGGAGGAAGAAGATCATAGA | GAAGCAGCCGCAGAGCCCCAAAGCCCCTGCCCCT    c.420
 K  R  W  R  K  K  I  I  E  |  K  Q  P  Q  S  P  K  A  P  A  P      p.140

          .         .         .         .         .         .       g.30033
 CAGCCGCCCCCCATCCTCAAAGTCTTCAACCGGCCTATCCTCTTTGACATCGTGTCCCGG       c.480
 Q  P  P  P  I  L  K  V  F  N  R  P  I  L  F  D  I  V  S  R         p.160

          .         .         .         .         .         .       g.30093
 GGCTCCACTGCTGACCTGGACGGGCTGCTCCCATTCTTGCTGACCCACAAGAAACGCCTA       c.540
 G  S  T  A  D  L  D  G  L  L  P  F  L  L  T  H  K  K  R  L         p.180

          .          | 04        .         .         .         .    g.35305
 ACTGATGAGGAGTTTCGAG | AGCCATCTACGGGGAAGACCTGCCTGCCCAAGGCCTTGCTG    c.600
 T  D  E  E  F  R  E |   P  S  T  G  K  T  C  L  P  K  A  L  L      p.200

          .         .         .         .         .         .       g.35365
 AACCTGAGCAATGGCCGCAACGACACCATCCCTGTGCTGCTGGACATCGCGGAGCGCACC       c.660
 N  L  S  N  G  R  N  D  T  I  P  V  L  L  D  I  A  E  R  T         p.220

          .         .         .         .         .   | 05     .    g.37657
 GGCAACATGAGGGAGTTCATTAACTCGCCCTTCCGTGACATCTACTATCGAG | GTCAGACA    c.720
 G  N  M  R  E  F  I  N  S  P  F  R  D  I  Y  Y  R  G |   Q  T      p.240

          .         .         .         .         .         .       g.37717
 GCCCTGCACATCGCCATTGAGCGTCGCTGCAAACACTACGTGGAACTTCTCGTGGCCCAG       c.780
 A  L  H  I  A  I  E  R  R  C  K  H  Y  V  E  L  L  V  A  Q         p.260

          .         .         .         .         .         .       g.37777
 GGAGCTGATGTCCACGCCCAGGCCCGTGGGCGCTTCTTCCAGCCCAAGGATGAGGGGGGC       c.840
 G  A  D  V  H  A  Q  A  R  G  R  F  F  Q  P  K  D  E  G  G         p.280

          .    | 06    .         .         .         .         .    g.39542
 TACTTCTACTTTG | GGGAGCTGCCCCTGTCGCTGGCTGCCTGCACCAACCAGCCCCACATT    c.900
 Y  F  Y  F  G |   E  L  P  L  S  L  A  A  C  T  N  Q  P  H  I      p.300

          .         .         .         .         .         .       g.39602
 GTCAACTACCTGACGGAGAACCCCCACAAGAAGGCGGACATGCGGCGCCAGGACTCGCGA       c.960
 V  N  Y  L  T  E  N  P  H  K  K  A  D  M  R  R  Q  D  S  R         p.320

          .         .         .         .         .         .       g.39662
 GGCAACACAGTGCTGCATGCGCTGGTGGCCATTGCTGACAACACCCGTGAGAACACCAAG       c.1020
 G  N  T  V  L  H  A  L  V  A  I  A  D  N  T  R  E  N  T  K         p.340

          .         .         .         .         .         .       g.39722
 TTTGTTACCAAGATGTACGACCTGCTGCTGCTCAAGTGTGCCCGCCTCTTCCCCGACAGC       c.1080
 F  V  T  K  M  Y  D  L  L  L  L  K  C  A  R  L  F  P  D  S         p.360

          .         .         .         .         .         .       g.39782
 AACCTGGAGGCCGTGCTCAACAACGACGGCCTCTCGCCCCTCATGATGGCTGCCAAGACG       c.1140
 N  L  E  A  V  L  N  N  D  G  L  S  P  L  M  M  A  A  K  T         p.380

          .   | 07     .         .         .         .         .    g.41751
 GGCAAGATTGGG | ATCTTTCAGCACATCATCCGGCGGGAGGTGACGGATGAGGACACACGG    c.1200
 G  K  I  G   | I  F  Q  H  I  I  R  R  E  V  T  D  E  D  T  R      p.400

          .         .         .         .         .         .       g.41811
 CACCTGTCCCGCAAGTTCAAGGACTGGGCCTATGGGCCAGTGTATTCCTCGCTTTATGAC       c.1260
 H  L  S  R  K  F  K  D  W  A  Y  G  P  V  Y  S  S  L  Y  D         p.420

          .         .         .         .         .         .       g.41871
 CTCTCCTCCCTGGACACGTGTGGGGAAGAGGCCTCCGTGCTGGAGATCCTGGTGTACAAC       c.1320
 L  S  S  L  D  T  C  G  E  E  A  S  V  L  E  I  L  V  Y  N         p.440

          .   | 08     .         .         .         .         .    g.43968
 AGCAAGATTGAG | AACCGCCACGAGATGCTGGCTGTGGAGCCCATCAATGAACTGCTGCGG    c.1380
 S  K  I  E   | N  R  H  E  M  L  A  V  E  P  I  N  E  L  L  R      p.460

          .         .         .         .         .         .       g.44028
 GACAAGTGGCGCAAGTTCGGGGCCGTCTCCTTCTACATCAACGTGGTCTCCTACCTGTGT       c.1440
 D  K  W  R  K  F  G  A  V  S  F  Y  I  N  V  V  S  Y  L  C         p.480

          .         .         .         .         .  | 09      .    g.44394
 GCCATGGTCATCTTCACTCTCACCGCCTACTACCAGCCGCTGGAGGGCACA | CCGCCGTAC    c.1500
 A  M  V  I  F  T  L  T  A  Y  Y  Q  P  L  E  G  T   | P  P  Y      p.500

          .         .         .         .         .         .       g.44454
 CCTTACCGCACCACGGTGGACTACCTGCGGCTGGCTGGCGAGGTCATTACGCTCTTCACT       c.1560
 P  Y  R  T  T  V  D  Y  L  R  L  A  G  E  V  I  T  L  F  T         p.520

          .         .     | 10   .         .         .         .    g.44843
 GGGGTCCTGTTCTTCTTCACCAAC | ATCAAAGACTTGTTCATGAAGAAATGCCCTGGAGTG    c.1620
 G  V  L  F  F  F  T  N   | I  K  D  L  F  M  K  K  C  P  G  V      p.540

          .         .         .         | 11         .         .    g.45612
 AATTCTCTCTTCATTGATGGCTCCTTCCAGCTGCTCTA | CTTCATCTACTCTGTCCTGGTG    c.1680
 N  S  L  F  I  D  G  S  F  Q  L  L  Y  |  F  I  Y  S  V  L  V      p.560

          .         .         .         .         .         .       g.45672
 ATCGTCTCAGCAGCCCTCTACCTGGCAGGGATCGAGGCCTACCTGGCCGTGATGGTCTTT       c.1740
 I  V  S  A  A  L  Y  L  A  G  I  E  A  Y  L  A  V  M  V  F         p.580

          .         .         .         .         .         .       g.45732
 GCCCTGGTCCTGGGCTGGATGAATGCCCTTTACTTCACCCGTGGGCTGAAGCTGACGGGG       c.1800
 A  L  V  L  G  W  M  N  A  L  Y  F  T  R  G  L  K  L  T  G         p.600

          .         .     | 12   .         .         .         .    g.46014
 ACCTATAGCATCATGATCCAGAAG | ATTCTCTTCAAGGACCTTTTCCGATTCCTGCTCGTC    c.1860
 T  Y  S  I  M  I  Q  K   | I  L  F  K  D  L  F  R  F  L  L  V      p.620

          .         .         .  | 13      .         .         .    g.49720
 TACTTGCTCTTCATGATCGGCTACGCTTCAG | CCCTGGTCTCCCTCCTGAACCCGTGTGCC    c.1920
 Y  L  L  F  M  I  G  Y  A  S  A |   L  V  S  L  L  N  P  C  A      p.640

          .         .         .         .         .         .       g.49780
 AACATGAAGGTGTGCAATGAGGACCAGACCAACTGCACAGTGCCCACTTACCCCTCGTGC       c.1980
 N  M  K  V  C  N  E  D  Q  T  N  C  T  V  P  T  Y  P  S  C         p.660

          .         .         .         .         .         .       g.49840
 CGTGACAGCGAGACCTTCAGCACCTTCCTCCTGGACCTGTTTAAGCTGACCATCGGCATG       c.2040
 R  D  S  E  T  F  S  T  F  L  L  D  L  F  K  L  T  I  G  M         p.680

          .         .         .         .         .         .       g.49900
 GGCGACCTGGAGATGCTGAGCAGCACCAAGTACCCCGTGGTCTTCATCATCCTGCTGGTG       c.2100
 G  D  L  E  M  L  S  S  T  K  Y  P  V  V  F  I  I  L  L  V         p.700

          .         .         .         .         .         .       g.49960
 ACCTACATCATCCTCACCTTTGTGCTGCTCCTCAACATGCTCATTGCCCTCATGGGCGAG       c.2160
 T  Y  I  I  L  T  F  V  L  L  L  N  M  L  I  A  L  M  G  E         p.720

          .         .         .         .         | 14         .    g.51582
 ACAGTGGGCCAGGTCTCCAAGGAGAGCAAGCACATCTGGAAGCTGCAG | TGGGCCACCACC    c.2220
 T  V  G  Q  V  S  K  E  S  K  H  I  W  K  L  Q   | W  A  T  T      p.740

          .         .         .         .         .         .       g.51642
 ATCCTGGACATTGAGCGCTCCTTCCCCGTATTCCTGAGGAAGGCCTTCCGCTCTGGGGAG       c.2280
 I  L  D  I  E  R  S  F  P  V  F  L  R  K  A  F  R  S  G  E         p.760

          .         .         .         .         .       | 15 .    g.53974
 ATGGTCACCGTGGGCAAGAGCTCGGACGGCACTCCTGACCGCAGGTGGTGCTTCAG | GGTG    c.2340
 M  V  T  V  G  K  S  S  D  G  T  P  D  R  R  W  C  F  R  |  V      p.780

          .         .         .         .         .         .       g.54034
 GATGAGGTGAACTGGTCTCACTGGAACCAGAACTTGGGCATCATCAACGAGGACCCGGGC       c.2400
 D  E  V  N  W  S  H  W  N  Q  N  L  G  I  I  N  E  D  P  G         p.800

          .         .         .         .         .         | 16    g.54631
 AAGAATGAGACCTACCAGTATTATGGCTTCTCGCATACCGTGGGCCGCCTCCGCAGGG | AT    c.2460
 K  N  E  T  Y  Q  Y  Y  G  F  S  H  T  V  G  R  L  R  R  D |       p.820

          .         .         .         .         .         .       g.54691
 CGCTGGTCCTCGGTGGTACCCCGCGTGGTGGAACTGAACAAGAACTCGAACCCGGACGAG       c.2520
 R  W  S  S  V  V  P  R  V  V  E  L  N  K  N  S  N  P  D  E         p.840

          .         .         .         .         .         .       g.54751
 GTGGTGGTGCCTCTGGACAGCATGGGGAACCCCCGCTGCGATGGCCACCAGCAGGGTTAC       c.2580
 V  V  V  P  L  D  S  M  G  N  P  R  C  D  G  H  Q  Q  G  Y         p.860

          .         .         .                                     g.54787
 CCCCGCAAGTGGAGGACTGATGACGCCCCGCTCTAG                               c.2616
 P  R  K  W  R  T  D  D  A  P  L  X                                 p.871

          .         .         .         .         .         .       g.54847
 ggactgcagcccagccccagcttctctgcccactcatttctagtccagccgcatttcagc       c.*60

          .         .         .         .         .         .       g.54907
 agtgccttctggggtgtccccccacaccctgctttggccccagaggcgagggaccagtgg       c.*120

          .         .         .         .         .         .       g.54967
 aggtgccagggaggccccaggaccctgtggtcccctggctctgcctccccaccctggggt       c.*180

          .         .         .         .         .         .       g.55027
 gggggctcccggccacctgtcttgctcctatggagtcacataagccaacgccagagcccc       c.*240

          .         .         .         .         .         .       g.55087
 tccacctcaggccccagcccctgcctctccattatttatttgctctgctctcaggaagcg       c.*300

          .         .         .         .         .         .       g.55147
 acgtgacccctgccccagctggaacctggcagaggccttaggaccccgttccaagtgcac       c.*360

          .         .         .         .         .         .       g.55207
 tgcccggccaagccccagcctcagcctgcgcctgagctgcatgcgccaccatttttggca       c.*420

          .         .         .         .         .         .       g.55267
 gcgtggcagctttgcaaggggctggggccctcggcgtggggccatgccttctgtgtgttc       c.*480

          .         .         .         .         .                 g.55321
 tgtagtgtctgggatttgccggtgctcaataaatgtttattcattgacggtgga             c.*534

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transient receptor potential cation channel, subfamily V, member 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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