tRNA splicing endonuclease 54 homolog (S. cerevisiae) (TSEN54) - coding DNA reference sequence

(used for variant description)

(last modified November 5, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_207346.2 in the TSEN54 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013041.1, covering TSEN54 transcript NM_207346.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            gtggcggcgcgcgcagcggcaggcggcggcggg       c.-1

          .         .         .         .         .       | 02 .    g.5222
 ATGGAGCCCGAGCCCGAGCCCGCGGCCGTGGAGGTTCCCGCGGGGCGCGTGCTCAG | CGCC    c.60
 M  E  P  E  P  E  P  A  A  V  E  V  P  A  G  R  V  L  S  |  A      p.20

          .         .         .         .         .         .       g.5282
 CGGGAGCTCTTCGCCGCCCGCTCGCGGTCGCAGAAGCTGCCCCAGCGCTCGCATGGCCCC       c.120
 R  E  L  F  A  A  R  S  R  S  Q  K  L  P  Q  R  S  H  G  P         p.40

          .         .         .         .         .         .       g.5342
 AAGGACTTTCTGCCCGACGGCTCGGCAGCTCAGGCCGAGCGGCTGCGCCGGTGCCGGGAA       c.180
 K  D  F  L  P  D  G  S  A  A  Q  A  E  R  L  R  R  C  R  E         p.60

          .         .         .         .  | 03      .         .    g.5500
 GAGCTCTGGCAGCTGCTGGCAGAGCAGCGCGTGGAGCGCCT | GGGCAGCTTGGTGGCTGCC    c.240
 E  L  W  Q  L  L  A  E  Q  R  V  E  R  L  |  G  S  L  V  A  A      p.80

          .         .         .         .      | 04  .         .    g.5648
 GAGTGGAGGCCAGAAGAGGGCTTCGTGGAGTTGAAGTCTCCCGCG | GGCAAATTCTGGCAG    c.300
 E  W  R  P  E  E  G  F  V  E  L  K  S  P  A   | G  K  F  W  Q      p.100

          .         .         .         .         .         .       g.5708
 ACCATGGGCTTCTCAGAGCAGGGCCGGCAGCGCCTTCACCCGGAAGAGGCCTTGTATCTT       c.360
 T  M  G  F  S  E  Q  G  R  Q  R  L  H  P  E  E  A  L  Y  L         p.120

           | 05        .         .         .         .         .    g.6080
 CTGGAGTGT | GGCTCCATCCACCTCTTCCACCAAGACCTGCCACTGTCTATCCAGGAAGCT    c.420
 L  E  C   | G  S  I  H  L  F  H  Q  D  L  P  L  S  I  Q  E  A      p.140

          .         .         .         .         | 06         .    g.7479
 TACCAGCTGCTGCTGACCGACCACACTGTGACCTTCCTGCAGTACCAG | GTCTTCAGCCAC    c.480
 Y  Q  L  L  L  T  D  H  T  V  T  F  L  Q  Y  Q   | V  F  S  H      p.160

          .         .         .         .  | 07      .         .    g.9900
 CTGAAGAGGTTGGGTTATGTGGTTCGACGATTCCAACCAAG | CTCTGTCCTGTCCCCGTAT    c.540
 L  K  R  L  G  Y  V  V  R  R  F  Q  P  S  |  S  V  L  S  P  Y      p.180

          .         .         .         .         .         .       g.9960
 GAGAGGCAGCTTAACCTGGATGCCAGCGTGCAGCACTTGGAGGATGGAGATGGCAAGAGA       c.600
 E  R  Q  L  N  L  D  A  S  V  Q  H  L  E  D  G  D  G  K  R         p.200

          .         .    | 08    .         .         .         .    g.10214
 AAGAGGAGCAGCTCCAGCCCTCG | GTCCATTAATAAGAAGGCCAAGGCCCTGGACAACTCC    c.660
 K  R  S  S  S  S  P  R  |  S  I  N  K  K  A  K  A  L  D  N  S      p.220

          .         .         .         .         .         .       g.10274
 CTGCAACCCAAGAGTCTGGCAGCCTCCAGCCCACCTCCCTGCAGCCAGCCCAGCCAATGC       c.720
 L  Q  P  K  S  L  A  A  S  S  P  P  P  C  S  Q  P  S  Q  C         p.240

          .         .         .         .         .         .       g.10334
 CCAGAGGAGAAACCCCAGGAGTCAAGCCCCATGAAGGGCCCAGGGGGCCCCTTTCAGCTT       c.780
 P  E  E  K  P  Q  E  S  S  P  M  K  G  P  G  G  P  F  Q  L         p.260

          .         .         .         .         .         .       g.10394
 CTGGGGTCCCTGGGCCCCAGCCCTGGCCCGGCCAGGGAGGGGGTGGGGTGCAGCTGGGAG       c.840
 L  G  S  L  G  P  S  P  G  P  A  R  E  G  V  G  C  S  W  E         p.280

          .         .         .         .         .         .       g.10454
 AGTGGCAGAGCCGAGAACGGAGTCACGGGAGCCGGTAAGCGGCGCTGGAACTTCGAGCAG       c.900
 S  G  R  A  E  N  G  V  T  G  A  G  K  R  R  W  N  F  E  Q         p.300

          .         .         .         .         .         .       g.10514
 ATCTCCTTCCCCAACATGGCTTCAGACAGCCGCCACACCCTTCTGCGCGCCCCAGCCCCA       c.960
 I  S  F  P  N  M  A  S  D  S  R  H  T  L  L  R  A  P  A  P         p.320

          .         .         .         .         .         .       g.10574
 GAGCTGCTCCCGGCCAACGTGGCTGGGCGGGAGACAGACGCTGAGTCCTGGTGCCAGAAG       c.1020
 E  L  L  P  A  N  V  A  G  R  E  T  D  A  E  S  W  C  Q  K         p.340

          .         .         .         .         .         .       g.10634
 CTGAACCAGCGCAAGGAGAAGCTCTCCAGGCGGGAACGGGAGCACCACGCGGAGGCCGCG       c.1080
 L  N  Q  R  K  E  K  L  S  R  R  E  R  E  H  H  A  E  A  A         p.360

          .         .         .         .         .         .       g.10694
 CAGTTCCAGGAAGATGTCAACGCCGATCCCGAGGTGCAGCGGTGCTCCAGCTGGCGGGAG       c.1140
 Q  F  Q  E  D  V  N  A  D  P  E  V  Q  R  C  S  S  W  R  E         p.380

          .         .         .         .         .         .       g.10754
 TACAAGGAGCTGCTGCAGCGGCGGCAGGTGCAGAGGAGCCAGCGCCGGGCCCCTCACCTG       c.1200
 Y  K  E  L  L  Q  R  R  Q  V  Q  R  S  Q  R  R  A  P  H  L         p.400

          .         .         .         .         .   | 09     .    g.11755
 TGGGGCCAGCCCGTCACCCCGCTGCTGAGTCCTGGCCAGGCCAGCTCCCCAG | CCGTGGTC    c.1260
 W  G  Q  P  V  T  P  L  L  S  P  G  Q  A  S  S  P  A |   V  V      p.420

          .         .         .         .         .    | 10    .    g.12142
 CTTCAGCATATCTCTGTGCTGCAGACAACACACCTTCCTGATGGAGGTGCCCG | GCTGTTG    c.1320
 L  Q  H  I  S  V  L  Q  T  T  H  L  P  D  G  G  A  R  |  L  L      p.440

          .         .         .         .         .         .       g.12202
 GAGAAGTCTGGGGGCTTGGAAATCATCTTTGATGTTTACCAGGCCGACGCTGTGGCCACA       c.1380
 E  K  S  G  G  L  E  I  I  F  D  V  Y  Q  A  D  A  V  A  T         p.460

          .         .         .         .         . | 11       .    g.12744
 TTCCGAAAGAATAACCCTGGCAAACCCTATGCCCGGATGTGCATTAGTGG | ATTTGATGAG    c.1440
 F  R  K  N  N  P  G  K  P  Y  A  R  M  C  I  S  G  |  F  D  E      p.480

          .         .         .         .         .         .       g.12804
 CCTGTCCCAGACCTCTGCAGCCTCAAGCGGTTGTCTTACCAGAGTGGGGATGTCCCTCTG       c.1500
 P  V  P  D  L  C  S  L  K  R  L  S  Y  Q  S  G  D  V  P  L         p.500

          .         .         .         .         .         .       g.12864
 ATCTTTGCCCTGGTGGATCATGGTGACATCTCCTTCTACAGCTTCAGGGACTTCACGTTG       c.1560
 I  F  A  L  V  D  H  G  D  I  S  F  Y  S  F  R  D  F  T  L         p.520

          .         .                                               g.12885
 CCCCAGGATGTGGGGCACTGA                                              c.1581
 P  Q  D  V  G  H  X                                                p.526

          .         .         .         .         .         .       g.12945
 cctcacagctctgcagaggatggagcttgctccgggggaccgggactgtctgttctcagg       c.*60

          .         .         .         .         .         .       g.13005
 gaccatctcggctgcctcctgtacccagactctaacctgtagcttcagaggccagtctgg       c.*120

          .         .         .         .         .         .       g.13065
 gccttggccctgggtgtctgatactcacagagtgaaactgtgaccctctcccttccctgc       c.*180

          .         .         .         .         .         .       g.13125
 tgccttgcagtgacccctctggaactcaggactcgattttaaggacccaggaggtggggc       c.*240

          .         .         .         .         .         .       g.13185
 agaagagaggactgtgtgcctttaacgagagggtgcctgcttcgtgctataaagccaaag       c.*300

          .         .                                               g.13212
 ccattaaaaatagatttcttttctgct                                        c.*327

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The TRNA splicing endonuclease 54 homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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