tetratricopeptide repeat domain 12 (TTC12) - coding DNA reference sequence

(used for variant description)

(last modified January 24, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_017868.3 in the TTC12 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering TTC12 transcript NM_017868.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5045
                cttggtcccgccccgggcccctggctcctggccccgccccagccc       c.-61

 .         .         .         .         .     | 02   .             g.6729
 aggcaggtcactgcgccatttcctgtccaaagctgggcgaatcag | ggattccggttcaca    c.-1

          .         .         .         .         .         | 03    g.13761
 ATGGATGCTGATAAAGAGAAAGATTTGCAGAAATTTCTTAAAAATGTGGATGAAATCT | CC    c.60
 M  D  A  D  K  E  K  D  L  Q  K  F  L  K  N  V  D  E  I  S |       p.20

          .         .         .         .         .         .       g.13821
 AATTTAATTCAGGAGATGAATTCTGATGACCCAGTTGTGCAACAGAAAGCTGTCCTGGAG       c.120
 N  L  I  Q  E  M  N  S  D  D  P  V  V  Q  Q  K  A  V  L  E         p.40

          .         .         .         .         .         .       g.13881
 ACAGAAAAGAGACTACTGCTTATGGAGGAAGACCAGGAGGAGGATGAATGCAGGACCACC       c.180
 T  E  K  R  L  L  L  M  E  E  D  Q  E  E  D  E  C  R  T  T         p.60

          .         .         .         .   | 04     .         .    g.14483
 TTGAACAAGACTATGATCAGTCCTCCACAAACTGCTATGAAG | AGTGCAGAAGAAATAAAC    c.240
 L  N  K  T  M  I  S  P  P  Q  T  A  M  K   | S  A  E  E  I  N      p.80

      | 05   .         .         .         .         .         .    g.15132
 TCAG | AGGCCTTCTTGGCATCTGTGGAGAAGGATGCAAAGGAACGAGCCAAGAGAAGAAGG    c.300
 S  E |   A  F  L  A  S  V  E  K  D  A  K  E  R  A  K  R  R  R      p.100

          .         .   | 06     .         .         .         .    g.16033
 GAAAACAAAGTCTTGGCGGATG | CCCTAAAAGAAAAAGGGAATGAAGCATTTGCTGAAGGC    c.360
 E  N  K  V  L  A  D  A |   L  K  E  K  G  N  E  A  F  A  E  G      p.120

          .         .         .         .         .         .       g.16093
 AATTATGAAACAGCTATCCTGCGCTACAGTGAGGGTTTGGAGAAGCTGAAGGACATGAAA       c.420
 N  Y  E  T  A  I  L  R  Y  S  E  G  L  E  K  L  K  D  M  K         p.140

          .         .     | 07   .         .         .         .    g.20427
 GTGCTGTACACCAACCGAGCCCAG | GCTTATATGAAACTTGAGGACTATGAGAAGGCACTG    c.480
 V  L  Y  T  N  R  A  Q   | A  Y  M  K  L  E  D  Y  E  K  A  L      p.160

          .         .     | 08   .         .         .         .    g.25473
 GTGGATTGTGAGTGGGCTCTCAAG | TGTGATGAAAAATGCACAAAAGCATATTTTCACATG    c.540
 V  D  C  E  W  A  L  K   | C  D  E  K  C  T  K  A  Y  F  H  M      p.180

          .         .         .       | 09 .         .         .    g.29269
 GGAAAAGCCAACCTGGCCCTGAAGAACTACAGTGTG | TCTAGAGAGTGTTATAAGAAGATC    c.600
 G  K  A  N  L  A  L  K  N  Y  S  V   | S  R  E  C  Y  K  K  I      p.200

          .         .         .        | 10.         .         .    g.29780
 TTAGAAATAAACCCCAAGCTGCAAACCCAGGTGAAAG | GTTACCTGAATCAAGTAGATCTT    c.660
 L  E  I  N  P  K  L  Q  T  Q  V  K  G |   Y  L  N  Q  V  D  L      p.220

          .         .         .         .         .         .       g.29840
 CAGGAAAAAGCAGACCTTCAAGAAAAGGAAGCCCACGAACTGCTGGATTCAGGAAAGAAC       c.720
 Q  E  K  A  D  L  Q  E  K  E  A  H  E  L  L  D  S  G  K  N         p.240

          .         .         .         .         .         .       g.29900
 ACAGCCGTGACCACCAAGAACCTCCTGGAGACCCTTTCCAAGCCTGACCAGATCCCCTTG       c.780
 T  A  V  T  T  K  N  L  L  E  T  L  S  K  P  D  Q  I  P  L         p.260

          .         .         .         .       | 11 .         .    g.31149
 TTCTATGCTGGGGGGATTGAGATCCTGACTGAAATGATAAATGAGT | GCACAGAACAAACT    c.840
 F  Y  A  G  G  I  E  I  L  T  E  M  I  N  E  C |   T  E  Q  T      p.280

          .         .         .         .         .       | 12 .    g.32312
 TTATTCAGAATGCACAATGGATTTAGTATCATCAGTGACAACGAGGTCATAAGAAG | GTGT    c.900
 L  F  R  M  H  N  G  F  S  I  I  S  D  N  E  V  I  R  R  |  C      p.300

          .         .         .         .         .         .       g.32372
 TTTTCCACAGCAGGAAATGATGCAGTTGAAGAAATGGTCTGTGTGTCTGTTCTCAAGCTC       c.960
 F  S  T  A  G  N  D  A  V  E  E  M  V  C  V  S  V  L  K  L         p.320

          .         .      | 13  .         .         .         .    g.34778
 TGGCAAGCAGTGTGCAGCAGGAACG | AGGAAAACCAGCGTGTGCTAGTGATACACCATGAC    c.1020
 W  Q  A  V  C  S  R  N  E |   E  N  Q  R  V  L  V  I  H  H  D      p.340

          .         .         .         .         .         .       g.34838
 AGGGCCAGGCTGTTGGCCGCCCTCTTGTCCTCCAAGGTCCTGGCCATCCGGCAGCAGAGC       c.1080
 R  A  R  L  L  A  A  L  L  S  S  K  V  L  A  I  R  Q  Q  S         p.360

          .         .         .         .         .         .       g.34898
 TTTGCCCTGCTGCTGCATCTCGCCCAGACTGAGAGCGGACGGAGCCTGATCATCAACCAC       c.1140
 F  A  L  L  L  H  L  A  Q  T  E  S  G  R  S  L  I  I  N  H         p.380

          .     | 14   .         .         .         .         .    g.40590
 CTTGACCTGACCAG | ATTATTGGAAGCGCTGGTGTCATTTCTTGATTTCTCGGATAAGGAG    c.1200
 L  D  L  T  R  |  L  L  E  A  L  V  S  F  L  D  F  S  D  K  E      p.400

          .         .         .         .        | 15.         .    g.41723
 GCCAACACTGCTATGGGACTGTTCACAGACTTGGCTCTGGAAGAAAG | ATTCCAAGTCTGG    c.1260
 A  N  T  A  M  G  L  F  T  D  L  A  L  E  E  R  |  F  Q  V  W      p.420

          .         .         .         .         | 16         .    g.42553
 TTCCAGGCCAACCTTCCAGGTGTTCTCCCTGCACTCACAGGCGTTCTG | AAGACAGATCCC    c.1320
 F  Q  A  N  L  P  G  V  L  P  A  L  T  G  V  L   | K  T  D  P      p.440

          .         .         .         .         .         .       g.42613
 AAGGTAAGCAGCTCCTCGGCTCTGTGCCAGTGCATTGCCATCATGGGAAACCTCAGTGCT       c.1380
 K  V  S  S  S  S  A  L  C  Q  C  I  A  I  M  G  N  L  S  A         p.460

          .         .         .         .         .         .       g.42673
 GAGCCCACTACCCGAAGACACATGGCGGCCTGTGAGGAATTTGGGGATGGCTGCTTGAGC       c.1440
 E  P  T  T  R  R  H  M  A  A  C  E  E  F  G  D  G  C  L  S         p.480

        | 17 .         .         .         .         .         .    g.49888
 CTCCTG | GCCAGGTGTGAGGAGGATGTGGACCTGTTCAGAGAGGTTATCTACACACTCCTG    c.1500
 L  L   | A  R  C  E  E  D  V  D  L  F  R  E  V  I  Y  T  L  L      p.500

          .         .         .         .      | 18  .         .    g.50426
 GGACTCATGATGAACCTGTGTCTTCAGGCTCCCTTTGTCTCTGAG | GTTTGGGCTGTGGAG    c.1560
 G  L  M  M  N  L  C  L  Q  A  P  F  V  S  E   | V  W  A  V  E      p.520

          .         .         .         .         .     | 19   .    g.52878
 GTGAGCAGAAGGTGCCTGTCTTTACTAAACAGCCAGGATGGAGGAATCCTGACA | AGAGCT    c.1620
 V  S  R  R  C  L  S  L  L  N  S  Q  D  G  G  I  L  T   | R  A      p.540

          .         .         .         .         .         .       g.52938
 GCTGGTGTTCTGAGCCGGACCCTTTCTTCCTCTCTGAAAATTGTTGAGGAGGCCTTGCGA       c.1680
 A  G  V  L  S  R  T  L  S  S  S  L  K  I  V  E  E  A  L  R         p.560

          .         .         .       | 20 .         .         .    g.54323
 GCAGGAGTGGTAAAGAAAATGATGAAATTCCTGAAG | ACAGGAGGTGAGACTGCATCACGT    c.1740
 A  G  V  V  K  K  M  M  K  F  L  K   | T  G  G  E  T  A  S  R      p.580

          .         .         .         .         .         .       g.54383
 TATGCTATAAAGATACTAGCTATCTGCACGAATAGTTATCATGAAGCTCGGGAAGAAGTA       c.1800
 Y  A  I  K  I  L  A  I  C  T  N  S  Y  H  E  A  R  E  E  V         p.600

          .       | 21 .         .         .         .         .    g.55350
 ATAAGACTGGATAAAA | AGTTGAGCGTTATGATGAAGCTGCTCAGCTCGGAGGATGAGGTT    c.1860
 I  R  L  D  K  K |   L  S  V  M  M  K  L  L  S  S  E  D  E  V      p.620

          .         .         .         .         .         .       g.55410
 CTGGTGGGCAACGCTGCCCTCTGCCTTGGTAACTGCATGGAGGTGCCCAACGTTGCGTCT       c.1920
 L  V  G  N  A  A  L  C  L  G  N  C  M  E  V  P  N  V  A  S         p.640

          .         .         .         .         .         .       g.55470
 TCCCTGCTAAAGACGGACCTTTTGCAGGTCTTGTTAAAGCTTGCAGGCAGTGACACACAG       c.1980
 S  L  L  K  T  D  L  L  Q  V  L  L  K  L  A  G  S  D  T  Q         p.660

          .         .         .         .         .         .       g.55530
 AAGACGGCCGTGCAGGTGAACGCAGGCATTGCTCTGGGGAAGCTGTGCACAGCTGAGCCC       c.2040
 K  T  A  V  Q  V  N  A  G  I  A  L  G  K  L  C  T  A  E  P         p.680

    | 22     .         .         .         .         .         .    g.56754
 AG | ATTTGCTGCTCAACTGAGAAAGCTTCATGGCCTAGAAATTCTCAACTCTACGATGAAA    c.2100
 R  |  F  A  A  Q  L  R  K  L  H  G  L  E  I  L  N  S  T  M  K      p.700

          .                                                         g.56772
 TACATCAGTGATTCTTGA                                                 c.2118
 Y  I  S  D  S  X                                                   p.705

          .         .         .         .         .         .       g.56832
 gagagacagggtttgtgtgcatttggggaacacacagatgcacaccgtgtgttgttccta       c.*60

          .         .         .                                     g.56864
 tgctaataaagacctttgatgtatccacttca                                   c.*92

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tetratricopeptide repeat domain 12 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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