tetratricopeptide repeat domain 39B (TTC39B) - coding DNA reference sequence

(used for variant description)

(last modified September 7, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_152574.2 in the TTC39B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering TTC39B transcript NM_152574.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5037
                        aagtggcccggccagcggcgcggcgtccggggaggaa       c.-1

          .         .         .         .         .         .       g.5097
 ATGGATGCTGTGCTGGCCTGCCGGCTCCGGGGGCGGGGAAATCGAGTAGCTGCACTCAGG       c.60
 M  D  A  V  L  A  C  R  L  R  G  R  G  N  R  V  A  A  L  R         p.20

          .         .         .         .         .         .       g.5157
 CCCCGCCCGAGACCCGGAGGGAGCGCCGGGCCGTCCCCTTTTGCCCTCCTTTGCGCTGGG       c.120
 P  R  P  R  P  G  G  S  A  G  P  S  P  F  A  L  L  C  A  G         p.40

          .         .         .         .         .         .       g.5217
 CTGAGCCCAGAGCCGAGAGCAGGAGTCGGCTCTGAGTTCCCTGCTTGGTTTTTGGGTGGC       c.180
 L  S  P  E  P  R  A  G  V  G  S  E  F  P  A  W  F  L  G  G         p.60

          .         .         .         .         .         .       g.5277
 AGCAGCCAGAGGAGGAATATGGCGCTCTTAGGCAGCCGAGCGGAGCTGGAAGCGGACGAG       c.240
 S  S  Q  R  R  N  M  A  L  L  G  S  R  A  E  L  E  A  D  E         p.80

  | 02       .         .         .      | 03  .         .         . g.86373
  | GACGTTTTCGAAGATGCCTTGGAAACCATCTCAAT | ATCTTCTCACTCAGATATGGCAACA c.300
  | D  V  F  E  D  A  L  E  T  I  S  I  |  S  S  H  S  D  M  A  T   p.100

          .         .         .         .         .         .       g.86433
 AGCAGCCTTCACTTTGCATCATGTGATACACAACAGGCGCCCAGACAGCGCGGAGCGTCT       c.360
 S  S  L  H  F  A  S  C  D  T  Q  Q  A  P  R  Q  R  G  A  S         p.120

          .  | 04      .         .         .         .         .    g.98160
 ACTGTCAGCAG | TTCATCATCAACCAAGGTGGATCTCAAGAGTGGCCTCGAAGAATGTGCT    c.420
 T  V  S  S  |  S  S  S  T  K  V  D  L  K  S  G  L  E  E  C  A      p.140

          .         .         .         .         .         .       g.98220
 GTGGCATTGAACTTATTTCTAAGCAACAAATTTACAGACGCCTTAGAATTGCTTCGCCCC       c.480
 V  A  L  N  L  F  L  S  N  K  F  T  D  A  L  E  L  L  R  P         p.160

    | 05     .         .         .         .         .         .    g.101021
 TG | GGCTAAGGAGAGTATGTACCATGCCTTGGGCTACAGTACCATTGTGGTGTTGCAGGCT    c.540
 W  |  A  K  E  S  M  Y  H  A  L  G  Y  S  T  I  V  V  L  Q  A      p.180

          .         .         .         .         .         .       g.101081
 GTCCTGACCTTCGAGCAACAGGACATCCAGAACGGCATTTCTGCCATGAAGGACGCTTTA       c.600
 V  L  T  F  E  Q  Q  D  I  Q  N  G  I  S  A  M  K  D  A  L         p.200

          .     | 06   .         .         .         .         .    g.102242
 CAAACCTGCCAAAA | ATACAGGAAAAAATACACAGTTGTAGAATCTTTCTCAAGTCTTCTT    c.660
 Q  T  C  Q  K  |  Y  R  K  K  Y  T  V  V  E  S  F  S  S  L  L      p.220

          .         .         .  | 07      .         .         .    g.108499
 TCTAGAGGATCCCTGGAGCAACTGAGTGAAG | AGGAAATGCATGCTGAAATCTGTTATGCC    c.720
 S  R  G  S  L  E  Q  L  S  E  E |   E  M  H  A  E  I  C  Y  A      p.240

          .         .         .          | 08        .         .    g.112456
 GAGTGTCTCCTACAGAAAGCTGCACTCACGTTTGTGCAG | GATGAAAATATGATCAACTTC    c.780
 E  C  L  L  Q  K  A  A  L  T  F  V  Q   | D  E  N  M  I  N  F      p.260

          .         .         .         .     | 09   .         .    g.119681
 ATCAAAGGTGGACTCAAAATTAGAACAAGTTACCAAATATATAA | AGAATGTCTTTCTATC    c.840
 I  K  G  G  L  K  I  R  T  S  Y  Q  I  Y  K  |  E  C  L  S  I      p.280

          .         .         .         .         .         .       g.119741
 CTGCATGAAATTCAGAAGAACAAACTTCAGCAGGAATTCTTCTATGAGTTTGAAGGGGGT       c.900
 L  H  E  I  Q  K  N  K  L  Q  Q  E  F  F  Y  E  F  E  G  G         p.300

          .         .         . | 10       .         .         .    g.121135
 GTCAAGCTTGGCAGTGGGGCCTTTAATTTG | ATGCTGTCCCTTTTACCAGCAAGGATTATC    c.960
 V  K  L  G  S  G  A  F  N  L   | M  L  S  L  L  P  A  R  I  I      p.320

          .         .         .       | 11 .         .         .    g.121722
 AGACTACTAGAATTTATTGGATTTTCTGGGAATAGG | GAGTTGGGCCTCCTGCAGTTACGT    c.1020
 R  L  L  E  F  I  G  F  S  G  N  R   | E  L  G  L  L  Q  L  R      p.340

          .         .         .         .         .         .       g.121782
 GAAGGTGCTTCAGGAAGGAGCATGAGGTCTGCACTGTGCTGCTTAACCATCTTAGCTTTT       c.1080
 E  G  A  S  G  R  S  M  R  S  A  L  C  C  L  T  I  L  A  F         p.360

          .         .      | 12  .         .         .         .    g.122603
 CATACTTACATCTCCCTAATACTTG | GTACAGGAGAAGTGAATGTTGCGGAAGCAGAGCGT    c.1140
 H  T  Y  I  S  L  I  L  G |   T  G  E  V  N  V  A  E  A  E  R      p.380

          .         .         .    | 13    .         .         .    g.122754
 CTCCTGGCACCCTTCCTCCAGCAGTTTCCAAAT | GGCTCACTCGTGTTGTTTTATCATGCC    c.1200
 L  L  A  P  F  L  Q  Q  F  P  N   | G  S  L  V  L  F  Y  H  A      p.400

          .         .         .    | 14    .         .         .    g.124255
 CGAATAGAGTTGCTGAAAGGGAATCTTGAAGAG | GCACAAGAAGTATTTCAAAAATGCATT    c.1260
 R  I  E  L  L  K  G  N  L  E  E   | A  Q  E  V  F  Q  K  C  I      p.420

          .         .         .         .         .         .       g.124315
 TCAGTTCAAGAAGAATGGAAACAGTTTCACCATCTCTGCTACTGGGAGCTAATGTGGATT       c.1320
 S  V  Q  E  E  W  K  Q  F  H  H  L  C  Y  W  E  L  M  W  I         p.440

          .         .         .         .         .         .       g.124375
 AATGTTTTCCAACAAAACTGGATGCAGGCATATTACTATTCAGATCTGCTTTGCAAAGAG       c.1380
 N  V  F  Q  Q  N  W  M  Q  A  Y  Y  Y  S  D  L  L  C  K  E         p.460

          .      | 15  .         .         .         .         .    g.125370
 AGTAAATGGTCCAAG | GCAACTTATGTGTTCTTGAAAGCAGCAATTTTGAGTATGCTTCCA    c.1440
 S  K  W  S  K   | A  T  Y  V  F  L  K  A  A  I  L  S  M  L  P      p.480

          .         .         .         .        | 16.         .    g.126967
 GAGGAGGATGTAGTAGCAACGAATGAGAATGTGGTAACTTTATTCAG | ACAGGTGGACAGC    c.1500
 E  E  D  V  V  A  T  N  E  N  V  V  T  L  F  R  |  Q  V  D  S      p.500

          .         .         .         .         .         .       g.127027
 TTGAAGCAGAGAATTGCCGGGAAATCTATCCCTACTGAGAAGTTTGCTGTGAGGAAGGCT       c.1560
 L  K  Q  R  I  A  G  K  S  I  P  T  E  K  F  A  V  R  K  A         p.520

          .         .         .         .         .     | 17   .    g.129951
 CGGCGTTACTCCGCCTCCTTACCTGCACCTGTGAAGCTCATCTTACCTGCCCTG | GAAATG    c.1620
 R  R  Y  S  A  S  L  P  A  P  V  K  L  I  L  P  A  L   | E  M      p.540

          .         .         .         .         .         .       g.130011
 ATGTATGTCTGGAATGGTTTTTCAATAGTGAGCAAAAGAAAAGACCTTTCTGAAAATCTG       c.1680
 M  Y  V  W  N  G  F  S  I  V  S  K  R  K  D  L  S  E  N  L         p.560

          .         .         .         .    | 18    .         .    g.134563
 TTAGTAACTGTTGAAAAAGCTGAGGCAGCTTTACAAAGTCAAA | ATTTTAACAGCTTCTCT    c.1740
 L  V  T  V  E  K  A  E  A  A  L  Q  S  Q  N |   F  N  S  F  S      p.580

          .         .         .         .         .         .       g.134623
 GTGGATGATGAGTGCTTAGTGAAGTTACTTAAAGGATGTTGCCTCAAGAACTTACAGCGG       c.1800
 V  D  D  E  C  L  V  K  L  L  K  G  C  C  L  K  N  L  Q  R         p.600

          .         .         .         .  | 19      .         .    g.137244
 CCCTTGCAAGCTGAACTATGTTACAATCATGTTGTGGAAAG | TGAAAAGCTACTGAAGTAT    c.1860
 P  L  Q  A  E  L  C  Y  N  H  V  V  E  S  |  E  K  L  L  K  Y      p.620

          .         .         .         .         .         .       g.137304
 GACCACTACCTAGTGCCGTTCACTCTATTTGAATTGGCATCTTTGTATAAAAGCCAGGGG       c.1920
 D  H  Y  L  V  P  F  T  L  F  E  L  A  S  L  Y  K  S  Q  G         p.640

          .         .         .         | 20         .         .    g.140273
 GAAATTGACAAGGCCATAAAGTTCCTAGAAACTGCAAG | GAACAACTACAAAGATTACTCC    c.1980
 E  I  D  K  A  I  K  F  L  E  T  A  R  |  N  N  Y  K  D  Y  S      p.660

          .         .         .         .         .         .       g.140333
 CTGGAGTCCAGACTACACTTCAGAATTCAGGCAGCTCTTCACCTCTGGAGAAAACCTTCC       c.2040
 L  E  S  R  L  H  F  R  I  Q  A  A  L  H  L  W  R  K  P  S         p.680

                                                                    g.140342
 TCAGATTGA                                                          c.2049
 S  D  X                                                            p.682

          .         .         .         .         .         .       g.140402
 tcagaacttgaaggatggaatttttcctcaattagcatcggcatctgctatagattcaac       c.*60

          .         .         .         .         .         .       g.140462
 cttatattaaagtggaaaaatgatcttgtgaataagagacaaaaaaacagtttttttggt       c.*120

          .         .         .         .         .         .       g.140522
 caatattttctatcatctgagagatttactgttggtctacataattttttttcctatgga       c.*180

          .         .         .         .         .         .       g.140582
 atggcattctatattatctagaaaattcttatattttgcctcccccaaaagaatttcata       c.*240

          .         .         .         .         .         .       g.140642
 ttatttgaattagggggcgaagaagtcttttgaaagacttgcagatgcaatagtctaatt       c.*300

          .         .         .         .         .         .       g.140702
 agattatttatttttttaatgtgaaaattaatattgtttagcaaatagcttacaagttga       c.*360

          .         .         .         .         .         .       g.140762
 gccaattttggatttgttgggtagttaaacttcagagatattttgttgcctgtatttaaa       c.*420

          .         .         .         .         .         .       g.140822
 tttcagaagataaataaatatcattgcatttaaaatagcttaacagtgaccttcagaaga       c.*480

          .         .         .         .         .         .       g.140882
 cttctgaaaaagacagtctgagaacatgaacacggatcgatataatgtacttcatgggtt       c.*540

          .         .         .         .         .         .       g.140942
 gaagagacctttctctataaaggatgatgcagtattcagttagtggttttttactcttca       c.*600

          .         .         .         .         .         .       g.141002
 tttgattaaaggtggtgacgttttggagagactgattttgaatgtacttaagtctattat       c.*660

          .         .         .         .         .         .       g.141062
 aataacaaaattcaaaacccctgtgtatctaaagggaaggaagtgtcatattttaggaat       c.*720

          .         .         .         .         .         .       g.141122
 ttttcttaaccttagcaatgagagcctaaaatacatacatggattatttttcttctagga       c.*780

          .         .         .         .         .         .       g.141182
 agtaaatttcctgctgctttaaatgatatgtaaaatatcaataatttttacacttaagat       c.*840

          .         .         .         .         .         .       g.141242
 gttggtaagacctagttttctaatctctctagcactgtgatgtctccttgtagataatct       c.*900

          .         .         .         .         .         .       g.141302
 ggaccttgcttagtcctttagttgggaaacagaatcagggcatagagcagaagagagctt       c.*960

          .         .         .         .         .         .       g.141362
 gacactccatatggtcctggttctgctacccattagcgattagtgaggagacctttaggg       c.*1020

          .         .         .         .         .         .       g.141422
 agtccactgtgccctgtgtgtcaccacattttcttctgtgaaatcaagattaaagaacag       c.*1080

          .         .         .         .         .         .       g.141482
 atgactttcaaggtctttttcagttttataactgtgagtctatgtattaggtatttattt       c.*1140

          .         .         .                                     g.141517
 tcaacaaatgactttaaaatgtcgaatgcaaacca                                c.*1175

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tetratricopeptide repeat domain 39B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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