tetratricopeptide repeat domain 5 (TTC5) - coding DNA reference sequence

(used for variant description)

(last modified November 5, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_138376.2 in the TTC5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000014.8, covering TTC5 transcript NM_138376.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    ggtgagagagggcgtgcgtctctgtggttataaagttgggggtggagtggccgggag       c.-1

          .         .         .         .         .  | 02      .    g.9038
 ATGATGGCTGATGAAGAGGAAGAAGTCAAGCCGATCTTGCAGAAATTGCAG | GAACTCGTG    c.60
 M  M  A  D  E  E  E  E  V  K  P  I  L  Q  K  L  Q   | E  L  V      p.20

          .         .         .         .         .         .       g.9098
 GATCAGCTCTACTCATTTCGAGACTGCTATTTCGAGACACATAGTGTTGAGGATGCTGGG       c.120
 D  Q  L  Y  S  F  R  D  C  Y  F  E  T  H  S  V  E  D  A  G         p.40

          .         .         .         .         .         .       g.9158
 AGGAAGCAACAGGATGTGCAGAAGGAGATGGAGAAAACCCTACAGCAGATGGAAGAAGTA       c.180
 R  K  Q  Q  D  V  Q  K  E  M  E  K  T  L  Q  Q  M  E  E  V         p.60

      | 03   .         .         .         .         .         .    g.10232
 GTGG | GTTCTGTCCAGGGCAAGGCACAAGTTCTAATGCTAACTGGGAAAGCACTAAATGTG    c.240
 V  G |   S  V  Q  G  K  A  Q  V  L  M  L  T  G  K  A  L  N  V      p.80

          .         .         .         .         .         .       g.10292
 ACTCCTGACTATAGCCCTAAGGCTGAGGAGCTTCTGTCAAAGGCTGTGAAGCTGGAGCCC       c.300
 T  P  D  Y  S  P  K  A  E  E  L  L  S  K  A  V  K  L  E  P         p.100

          .         .         .         .         .         .       g.10352
 GAGCTGGTGGAAGCCTGGAACCAGCTGGGTGAGGTGTACTGGAAAAAAGGGGATGTTGCA       c.360
 E  L  V  E  A  W  N  Q  L  G  E  V  Y  W  K  K  G  D  V  A         p.120

          .         .         .       | 04 .         .         .    g.11570
 GCTGCCCACACCTGCTTCTCAGGAGCCCTCACCCAT | TGCAGGAACAAAGTCTCCTTGCAA    c.420
 A  A  H  T  C  F  S  G  A  L  T  H   | C  R  N  K  V  S  L  Q      p.140

          .         .         .         .         .         .       g.11630
 AACCTGTCAATGGTGCTTCGTCAGCTGCGGACTGACACTGAAGATGAACATTCTCACCAT       c.480
 N  L  S  M  V  L  R  Q  L  R  T  D  T  E  D  E  H  S  H  H         p.160

          .         .         .         .         .         .       g.11690
 GTCATGGACAGTGTCCGACAGGCTAAGTTGGCTGTTCAGATGGATGTCCATGATGGCCGC       c.540
 V  M  D  S  V  R  Q  A  K  L  A  V  Q  M  D  V  H  D  G  R         p.180

         | 05.         .         .         .         .         .    g.12159
 TCCTGGT | ATATTCTTGGGAATTCATATCTTTCCCTTTACTTCTCTACTGGCCAGAACCCT    c.600
 S  W  Y |   I  L  G  N  S  Y  L  S  L  Y  F  S  T  G  Q  N  P      p.200

          .         .         .          | 06        .         .    g.14569
 AAGATCTCCCAGCAAGCCCTCAGTGCCTATGCCCAAGCA | GAGAAAGTTGACAGAAAAGCT    c.660
 K  I  S  Q  Q  A  L  S  A  Y  A  Q  A   | E  K  V  D  R  K  A      p.220

          .         .         .       | 07 .         .         .    g.15164
 TCTAGCAATCCTGACCTTCATCTGAACAGGGCGACG | TTGCATAAATATGAAGAGAGTTAT    c.720
 S  S  N  P  D  L  H  L  N  R  A  T   | L  H  K  Y  E  E  S  Y      p.240

          .         .         .         .         .         .       g.15224
 GGGGAGGCCCTGGAGGGCTTCTCTCGGGCTGCAGCCCTGGACCCTGCCTGGCCAGAGCCC       c.780
 G  E  A  L  E  G  F  S  R  A  A  A  L  D  P  A  W  P  E  P         p.260

          .         .         .         .         .         .       g.15284
 CGGCAACGAGAGCAACAACTTCTGGAATTCCTGGATAGATTAACCAGCCTCCTTGAGAGT       c.840
 R  Q  R  E  Q  Q  L  L  E  F  L  D  R  L  T  S  L  L  E  S         p.280

     | 08    .         .         .         .         .         .    g.15525
 AAG | GGAAAGGTGAAGACCAAAAAGCTGCAGAGCATGCTGGGAAGCTTGCGCCCAGCCCAT    c.900
 K   | G  K  V  K  T  K  K  L  Q  S  M  L  G  S  L  R  P  A  H      p.300

          .         .         .         .         .         .       g.15585
 CTAGGCCCTTGCAGTGATGGGCACTATCAGTCAGCCTCTGGGCAGAAAGTGACCCTGGAG       c.960
 L  G  P  C  S  D  G  H  Y  Q  S  A  S  G  Q  K  V  T  L  E         p.320

          .         .         .         .         .         .       g.15645
 CTCAAGCCACTGAGTACGCTTCAGCCTGGGGTGAACAGCGGTGCCGTCATCCTGGGAAAG       c.1020
 L  K  P  L  S  T  L  Q  P  G  V  N  S  G  A  V  I  L  G  K         p.340

          .         .         .         | 09         .         .    g.18889
 GTGGTATTTAGCCTCACCACAGAGGAGAAAGTCCCCTT | TACATTTGGCCTGGTAGATTCA    c.1080
 V  V  F  S  L  T  T  E  E  K  V  P  F  |  T  F  G  L  V  D  S      p.360

          .         .         .         .         .         .       g.18949
 GATGGACCTTGCTATGCAGTGATGGTGTACAATATAGTGCAGAGCTGGGGAGTGCTCATT       c.1140
 D  G  P  C  Y  A  V  M  V  Y  N  I  V  Q  S  W  G  V  L  I         p.380

          .         .         .         .         .         .       g.19009
 GGAGACTCTGTAGCCATTCCTGAGCCCAACCTGCGGCTTCACCGAATTCAGCACAAAGGA       c.1200
 G  D  S  V  A  I  P  E  P  N  L  R  L  H  R  I  Q  H  K  G         p.400

     | 10    .         .         .         .         .         .    g.21305
 AAG | GACTATTCCTTTTCCAGTGTTCGAGTGGAGACGCCCCTCCTGCTAGTGGTGAATGGG    c.1260
 K   | D  Y  S  F  S  S  V  R  V  E  T  P  L  L  L  V  V  N  G      p.420

          .         .         .         .         .         .       g.21365
 AAGCCTCAGGGATCCAGCAGCCAGGCTGTTGCCACAGTGGCATCGCGACCACAGTGTGAA       c.1320
 K  P  Q  G  S  S  S  Q  A  V  A  T  V  A  S  R  P  Q  C  E         p.440

                                                                    g.21368
 TGA                                                                c.1323
 X                                                                  p.440

          .         .         .         .         .         .       g.21428
 cctttgacttgcatgctcaacagggagtggaggagaggagacaaggctctggacagccgg       c.*60

          .         .         .         .         .         .       g.21488
 tccagccacatccagtgattcagcagggatgggaggaatgttttaaatgaagactttctc       c.*120

          .         .         .         .         .         .       g.21548
 tttccctgcctgtattacacttcgtatctcttctctctcctctgtcctcatcatgttcca       c.*180

          .         .         .         .         .         .       g.21608
 gctctctacagggccacatactcttctggcatatctctcctgtctcttccactgctctct       c.*240

          .         .         .         .         .         .       g.21668
 atgttttaagcaaagagcatggaattggtagaagtcttgggatcttgccatgggacagag       c.*300

          .         .         .         .         .         .       g.21728
 tccccaaggttcctgttgttgcctccttcctaagcctcatatgtatatatcagttcagta       c.*360

          .         .         .         .         .         .       g.21788
 tttattgctaaaggagggggcttaattttgtaatggcttttatttttagcaatttttatt       c.*420

          .         .         .         .         .         .       g.21848
 tttatttttgaactttaggtccttcctcttctttggggctggaacagaattaaatttgtt       c.*480

          .                                                         g.21864
 tggaaaaaaaaaaaaa                                                   c.*496

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tetratricopeptide repeat domain 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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