tubulin, beta 1 class VI (TUBB1) - coding DNA reference sequence

(used for variant description)

(last modified November 21, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_030773.3 in the TUBB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023424.1, covering TUBB1 transcript NM_030773.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                ggggcagtattctgtgttgagggaggaaa       c.-241

 .         .         .         .         .         .                g.5089
 aacactcccttccaaaagcatgacaggcagaaagcagagaagggccaggactggctgagg       c.-181

 .         .         .         .         .         .                g.5149
 gcggggagctgggcctctggggtggacacacccttggtcacattgtgagggtagcttggt       c.-121

 .         .         .         .         .         .                g.5209
 tggccagtcccaccactgcagtgaccacagttgtgttgggctcacaccagtgaaccgaag       c.-61

 .         .         .         .         .         .                g.5269
 ctctggattctgagagtctgaggattccgtgaagatctcagacttgggctcagagcaagg       c.-1

          .         .         .         .         .        | 02.    g.8594
 ATGCGTGAAATTGTCCATATTCAGATTGGCCAGTGTGGCAACCAGATCGGAGCCAAG | TTC    c.60
 M  R  E  I  V  H  I  Q  I  G  Q  C  G  N  Q  I  G  A  K   | F      p.20

          .         .         .         .         .         .       g.8654
 TGGGAGATGATTGGTGAGGAACACGGGATCGACTTGGCTGGGAGCGACCGCGGGGCCTCG       c.120
 W  E  M  I  G  E  E  H  G  I  D  L  A  G  S  D  R  G  A  S         p.40

          .         .         .         .       | 03 .         .    g.9250
 GCCTTGCAGCTGGAGAGAATCAGCGTGTACTACAACGAAGCCTACG | GTAGGAAATATGTG    c.180
 A  L  Q  L  E  R  I  S  V  Y  Y  N  E  A  Y  G |   R  K  Y  V      p.60

          .         .         .         .         .         .       g.9310
 CCCCGAGCAGTCTTGGTGGACCTAGAACCTGGGACGATGGACAGCATTCGATCTAGCAAA       c.240
 P  R  A  V  L  V  D  L  E  P  G  T  M  D  S  I  R  S  S  K         p.80

          .         .         .        | 04.         .         .    g.9474
 TTAGGAGCTCTCTTTCAACCCGACAGTTTTGTCCATG | GTAACTCTGGGGCTGGCAACAAC    c.300
 L  G  A  L  F  Q  P  D  S  F  V  H  G |   N  S  G  A  G  N  N      p.100

          .         .         .         .         .         .       g.9534
 TGGGCCAAAGGCCACTACACGGAGGGAGCCGAGCTGATCGAGAATGTCCTAGAGGTGGTG       c.360
 W  A  K  G  H  Y  T  E  G  A  E  L  I  E  N  V  L  E  V  V         p.120

          .         .         .         .         .         .       g.9594
 AGGCACGAGAGTGAGAGCTGTGACTGCCTGCAGGGCTTCCAGATCGTCCACTCCCTGGGC       c.420
 R  H  E  S  E  S  C  D  C  L  Q  G  F  Q  I  V  H  S  L  G         p.140

          .         .         .         .         .         .       g.9654
 GGGGGCACAGGCTCCGGGATGGGCACTCTGCTCATGAACAAGATTAGAGAGGAGTACCCG       c.480
 G  G  T  G  S  G  M  G  T  L  L  M  N  K  I  R  E  E  Y  P         p.160

          .         .         .         .         .         .       g.9714
 GACCGGATCATGAATTCCTTCAGCGTCATGCCTTCTCCCAAGGTGTCGGACACTGTGGTG       c.540
 D  R  I  M  N  S  F  S  V  M  P  S  P  K  V  S  D  T  V  V         p.180

          .         .         .         .         .         .       g.9774
 GAGCCCTACAACGCGGTTCTGTCTATCCACCAGCTGATTGAGAATGCAGATGCCTGTTTC       c.600
 E  P  Y  N  A  V  L  S  I  H  Q  L  I  E  N  A  D  A  C  F         p.200

          .         .         .         .         .         .       g.9834
 TGCATTGACAATGAGGCCCTCTATGACATCTGCTTCCGTACCCTGAAGCTGACGACACCC       c.660
 C  I  D  N  E  A  L  Y  D  I  C  F  R  T  L  K  L  T  T  P         p.220

          .         .         .         .         .         .       g.9894
 ACCTATGGGGATCTCAACCACCTAGTGTCCTTGACCATGAGCGGCATAACCACCTCCCTC       c.720
 T  Y  G  D  L  N  H  L  V  S  L  T  M  S  G  I  T  T  S  L         p.240

          .         .         .         .         .         .       g.9954
 CGGTTCCCGGGTCAGCTCAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTCCCCTTC       c.780
 R  F  P  G  Q  L  N  A  D  L  R  K  L  A  V  N  M  V  P  F         p.260

          .         .         .         .         .         .       g.10014
 CCCCGCCTGCACTTCTTTATGCCCGGCTTTGCCCCACTCACGGCCCAGGGCAGCCAGCAG       c.840
 P  R  L  H  F  F  M  P  G  F  A  P  L  T  A  Q  G  S  Q  Q         p.280

          .         .         .         .         .         .       g.10074
 TACCGAGCCCTCTCCGTGGCCGAGCTCACCCAGCAGATGTTCGATGCCCGCAATACCATG       c.900
 Y  R  A  L  S  V  A  E  L  T  Q  Q  M  F  D  A  R  N  T  M         p.300

          .         .         .         .         .         .       g.10134
 GCTGCCTGTGACCTCCGCCGTGGCCGCTACCTCACAGTGGCCTGCATTTTCCGGGGCAAG       c.960
 A  A  C  D  L  R  R  G  R  Y  L  T  V  A  C  I  F  R  G  K         p.320

          .         .         .         .         .         .       g.10194
 ATGTCCACCAAGGAAGTGGACCAGCAACTGCTCTCCGTGCAGACCAGGAACAGCAGCTGC       c.1020
 M  S  T  K  E  V  D  Q  Q  L  L  S  V  Q  T  R  N  S  S  C         p.340

          .         .         .         .         .         .       g.10254
 TTTGTGGAGTGGATTCCCAACAACGTCAAGGTGGCTGTCTGCGACATCCCGCCCCGGGGG       c.1080
 F  V  E  W  I  P  N  N  V  K  V  A  V  C  D  I  P  P  R  G         p.360

          .         .         .         .         .         .       g.10314
 CTGAGCATGGCCGCCACCTTCATTGGCAACAACACGGCCATCCAAGAGATCTTTAATAGG       c.1140
 L  S  M  A  A  T  F  I  G  N  N  T  A  I  Q  E  I  F  N  R         p.380

          .         .         .         .         .         .       g.10374
 GTCTCTGAGCATTTCTCAGCCATGTTCAAAAGGAAAGCTTTTGTGCACTGGTACACCAGC       c.1200
 V  S  E  H  F  S  A  M  F  K  R  K  A  F  V  H  W  Y  T  S         p.400

          .         .         .         .         .         .       g.10434
 GAAGGGATGGACATAAACGAATTTGGGGAAGCTGAAAATAACATCCATGATTTGGTATCC       c.1260
 E  G  M  D  I  N  E  F  G  E  A  E  N  N  I  H  D  L  V  S         p.420

          .         .         .         .         .         .       g.10494
 GAGTACCAACAATTTCAAGATGCCAAAGCAGTTCTAGAGGAAGATGAAGAGGTCACGGAG       c.1320
 E  Y  Q  Q  F  Q  D  A  K  A  V  L  E  E  D  E  E  V  T  E         p.440

          .         .         .                                     g.10530
 GAGGCAGAAATGGAGCCAGAAGATAAGGGACATTAA                               c.1356
 E  A  E  M  E  P  E  D  K  G  H  X                                 p.451

          .         .         .         .         .         .       g.10590
 ctgtgagagaagctgtgccgcggagtcgcttacagaacagtttctcattagatgagtgtt       c.*60

          .         .         .         .         .         .       g.10650
 tctcctgcagcactccaaaacccactctgcactgcagcacagtgaatgatatgcactcac       c.*120

          .         .         .         .         .         .       g.10710
 cattagcttcgacacagggactgagggagacaggtggggagcagctgacaggcattaggg       c.*180

          .         .         .         .         .         .       g.10770
 tctttgctgacatctactaaccttgaagagtttgatgttcagtgcatacttattaactta       c.*240

          .         .         .         .         .         .       g.10830
 aaaaaatagcaaatttattgtaaagtgctccctttgtttcaaagtgtttgccaggcatcc       c.*300

          .         .         .         .         .         .       g.10890
 agactacacgtgtggatttgcagggagccactggagttggtgttacatttttatacttta       c.*360

          .         .         .         .         .         .       g.10950
 gcagcactgataggcaccctggaatcctcacttggtatccgagggctactaagactcttt       c.*420

          .         .         .         .         .         .       g.11010
 ccttaggttctttcctctgagcaaacactgactggcatcctgctttccagtgcctgccag       c.*480

          .         .         .         .         .         .       g.11070
 cctccagaagagccaggtgcctgactagtacatggggagctacagagccaaggtcaatgt       c.*540

          .         .         .         .         .         .       g.11130
 gagtcaacatccactagaaatatccatgttgtgtagacctgtgcatacaacatgctaact       c.*600

          .         .         .         .         .         .       g.11190
 ggaaaagaggaaaaaagaaaagccacagtcctctccacaaaaatacctggtccaaacaag       c.*660

          .         .         .         .         .         .       g.11250
 aaaaacaaaaagacaagcaaaactaaagaactgcagtcttctgatctttatttctgaaga       c.*720

          .         .         .         .         .         .       g.11310
 gctagcctttaacatatatgtttatatagtttaaatttcttactactgttagatcccagg       c.*780

          .         .         .         .         .         .       g.11370
 aattcattaataatcatccttggctttccttttaaaggctattttgaaatggtcttttca       c.*840

          .         .         .         .         .         .       g.11430
 ctttcattcagtcatcaccccccaaaatgctctgcagcctctctgctctttgagaaaggg       c.*900

          .         .         .         .         .         .       g.11490
 cacaccatgcgctcggcaaccattcaaatgcaggaattaagcagcaatggctgcagtgtc       c.*960

          .         .         .         .         .         .       g.11550
 cttctcagttatggaggacatcgtctcattagggaacttttacagttcaaattaatttgc       c.*1020

          .         .         .         .         .         .       g.11610
 agaagttgccataaatgtttgcataatgacatagctttaagcactacatgattttaatct       c.*1080

          .         .         .         .         .         .       g.11670
 gctcacattataacaggaccaaatacacaagagcgtaatcaaatcatctgtaacttctta       c.*1140

          .         .         .         .         .         .       g.11730
 attacagtttacctatttctgacatgcagcactgccatctcttccagcaccatcagggtt       c.*1200

          .         .         .         .         .         .       g.11790
 ttaatggccctctagaattaccactgagatacactatttgatccatggataaccggtaat       c.*1260

          .         .         .         .         .         .       g.11850
 gggaaaatgctccgaccctcaatgcagtaaatatttacttgcaggcaactgggttctcat       c.*1320

          .         .         .         .         .         .       g.11910
 ctcttgatttgcttttgtaatcagcaataataaaatagcaggtagatggatgacagttgc       c.*1380

          .         .         .         .         .         .       g.11970
 tcattctgagaaacttcactcttttcacttatgcatcacgaggaaataactaaaatacat       c.*1440

          .         .         .         .         .         .       g.12030
 accaagagaaaaataccttgccatcggatcatcaacaagtcttctatttacaaacttcaa       c.*1500

          .         .         .         .         .         .       g.12090
 aaaacacaaaacaacattcatgttttaaatgctttctacttgtggttcaagaagcactag       c.*1560

          .         .         .         .         .         .       g.12150
 atttagtaagaaactctacctatatacttagtttgaagttagtaacttcctgagatgcta       c.*1620

          .         .         .         .         .         .       g.12210
 aagacttacagcctgcgattatacaaggatttacacatgcttcctctggtgctttacttc       c.*1680

          .         .         .         .         .         .       g.12270
 ccaaacctaaaaaagcaatgaaatagatgtaaggaaggagggatttaaaccttttaaaaa       c.*1740

          .         .         .         .         .         .       g.12330
 acttttgctgacttatattactgtaaagatttgtttgctcaatagtaatcattaaactac       c.*1800

          .         .         .         .         .         .       g.12390
 aaagtaattcaattttaaatggcaaaattgctttatttcagactaaataaattccttttc       c.*1860

          .                                                         g.12401
 ttgaagcctaa                                                        c.*1871

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tubulin, beta 1 class VI protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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