tubby homolog (mouse) (TUB) - coding DNA reference sequence

(used for variant description)

(last modified October 28, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_003320.4 in the TUB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering TUB transcript NM_003320.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            c       c.-241

 .         .         .         .         .         .                g.5061
 ttgaggattcagtctggtcctgaagggtttggggggagactgcgaccagaagatgtttcc       c.-181

 .         .         .         .         .         .                g.5121
 atgtcctaattaatgggtgatggtggttgttagtctgactgttgccacggtgatgaaggg       c.-121

 .         .         .         .         .         .                g.5181
 agacatccaagtgctggtttcagtactgaggcgaatacagggaatttcaacaggctccag       c.-61

 .         .         .         .         .         .                g.5241
 gtcttactatgcagcctgaagtgggaccatcccttaaacccactccatcctgtggccacg       c.-1

          .         .         .         .         .         .       g.5301
 ATGGGGGCCAGGACACCTTTGCCTTCTTTCTGGGTTTCTTTCTTTGCCGAGACAGGGATT       c.60
 M  G  A  R  T  P  L  P  S  F  W  V  S  F  F  A  E  T  G  I         p.20

          .         .         .         .         .         .       g.5361
 TTGTTCCCAGGAGGCACTCCCTGGCCCATGGGATCTCAGCATTCAAAGCAGCACAGGAAA       c.120
 L  F  P  G  G  T  P  W  P  M  G  S  Q  H  S  K  Q  H  R  K         p.40

          .         .         .      | 02  .         .         .    g.6037
 CCTGGGCCCCTGAAACGGGGCCACCGAAGAGATCG | GAGAACAACCAGGAGGAAGTACTGG    c.180
 P  G  P  L  K  R  G  H  R  R  D  R  |  R  T  T  R  R  K  Y  W      p.60

          .         .    | 03    .         .         .         .    g.56014
 AAGGAAGGAAGGGAGATCGCTCG | TGTCTTAGATGATGAGGGCAGAAACCTGAGGCAGCAG    c.240
 K  E  G  R  E  I  A  R  |  V  L  D  D  E  G  R  N  L  R  Q  Q      p.80

          .      | 04  .         .         .         .         .    g.56481
 AAGCTTGATCGGCAG | CGGGCCCTGCTGGAGCAGAAGCAGAAGAAGAAGCGCCAGGAGCCC    c.300
 K  L  D  R  Q   | R  A  L  L  E  Q  K  Q  K  K  K  R  Q  E  P      p.100

          .         .         .         .         .         .       g.56541
 CTGATGGTGCAGGCCAATGCAGATGGGCGGCCCCGGAGCCGGCGGGCCCGGCAGTCAGAG       c.360
 L  M  V  Q  A  N  A  D  G  R  P  R  S  R  R  A  R  Q  S  E         p.120

          .         .         .         .         .         | 05    g.60415
 GAACAAGCCCCCCTGGTGGAGTCCTACCTCAGCAGCAGTGGCAGCACCAGCTACCAAG | TT    c.420
 E  Q  A  P  L  V  E  S  Y  L  S  S  S  G  S  T  S  Y  Q  V |       p.140

          .         .         .         .         .         .       g.60475
 CAAGAGGCCGACTCACTCGCCAGTGTGCAGCTGGGAGCCACGCGCCCAACAGCACCAGCT       c.480
 Q  E  A  D  S  L  A  S  V  Q  L  G  A  T  R  P  T  A  P  A         p.160

          .         .         .         .         .         .       g.60535
 TCAGCCAAGAGAACCAAGGCGGCAGCTACAGCAGGGGGCCAGGGTGGCGCCGCTAGGAAG       c.540
 S  A  K  R  T  K  A  A  A  T  A  G  G  Q  G  G  A  A  R  K         p.180

          .         .   | 06     .         .         .         .    g.61903
 GAGAAGAAGGGAAAGCACAAAG | GCACCAGCGGGCCAGCAGCACTGGCAGAAGACAAGTCT    c.600
 E  K  K  G  K  H  K  G |   T  S  G  P  A  A  L  A  E  D  K  S      p.200

          .         .         .         .         .         .       g.61963
 GAGGCCCAAGGCCCAGTGCAGATTCTGACTGTGGGCCAGTCAGACCACGCCCAGGACGCA       c.660
 E  A  Q  G  P  V  Q  I  L  T  V  G  Q  S  D  H  A  Q  D  A         p.220

          .         .         .         .         .         .       g.62023
 GGGGAGACGGCAGCTGGTGGGGGCGAACGGCCCAGCGGGCAGGATCTCCGTGCCACGATG       c.720
 G  E  T  A  A  G  G  G  E  R  P  S  G  Q  D  L  R  A  T  M         p.240

          . | 07       .         .         .         .         .    g.63102
 CAGAGGAAGG | GCATCTCCAGCAGCATGAGCTTTGACGAGGATGAGGAGGATGAGGAGGAG    c.780
 Q  R  K  G |   I  S  S  S  M  S  F  D  E  D  E  E  D  E  E  E      p.260

          .         .         .         .         .         .       g.63162
 AATAGCTCCAGCTCCTCCCAGCTAAATAGTAACACCCGCCCCAGCTCTGCTACTAGCAGG       c.840
 N  S  S  S  S  S  Q  L  N  S  N  T  R  P  S  S  A  T  S  R         p.280

          .   | 08     .         .         .         .         .    g.63643
 AAGTCCGTCAGG | GAGGCAGCCTCAGCCCCTAGCCCAACAGCTCCAGAGCAACCAGTGGAC    c.900
 K  S  V  R   | E  A  A  S  A  P  S  P  T  A  P  E  Q  P  V  D      p.300

          .         .         .         .         .         .       g.63703
 GTTGAGGTCCAGGATCTTGAGGAGTTTGCACTGAGGCCGGCCCCCCAGGGTATCACCATC       c.960
 V  E  V  Q  D  L  E  E  F  A  L  R  P  A  P  Q  G  I  T  I         p.320

          .         .         .         .         .         .       g.63763
 AAATGCCGCATCACTCGGGACAAGAAAGGGATGGACCGGGGCATGTACCCCACCTACTTT       c.1020
 K  C  R  I  T  R  D  K  K  G  M  D  R  G  M  Y  P  T  Y  F         p.340

          .         .         . | 09       .         .         .    g.64111
 CTGCACCTGGACCGTGAGGATGGGAAGAAG | GTGTTCCTCCTGGCGGGAAGGAAGAGAAAG    c.1080
 L  H  L  D  R  E  D  G  K  K   | V  F  L  L  A  G  R  K  R  K      p.360

          .         .         .         .         .         .       g.64171
 AAGAGTAAAACTTCCAATTACCTCATCTCTGTGGACCCAACAGACTTGTCTCGAGGAGGG       c.1140
 K  S  K  T  S  N  Y  L  I  S  V  D  P  T  D  L  S  R  G  G         p.380

          .         .    | 10    .         .         .         .    g.65162
 GACAGCTATATCGGGAAACTGCG | GTCCAACTTGATGGGCACCAAGTTCACTGTTTATGAC    c.1200
 D  S  Y  I  G  K  L  R  |  S  N  L  M  G  T  K  F  T  V  Y  D      p.400

          .         .         .         .         .         .       g.65222
 AATGGAGTCAACCCTCAGAAGGCCTCATCCTCCACTTTGGAAAGTGGAACCTTACGTCAG       c.1260
 N  G  V  N  P  Q  K  A  S  S  S  T  L  E  S  G  T  L  R  Q         p.420

          .         .  | 11      .         .         .         .    g.66909
 GAGCTGGCAGCTGTGTGCTAC | GAGACAAACGTCTTAGGCTTCAAGGGGCCTCGGAAGATG    c.1320
 E  L  A  A  V  C  Y   | E  T  N  V  L  G  F  K  G  P  R  K  M      p.440

          .         .         .         .         .         .       g.66969
 AGCGTGATTGTCCCAGGCATGAACATGGTTCATGAGAGAGTCTCTATCCGCCCCCGCAAC       c.1380
 S  V  I  V  P  G  M  N  M  V  H  E  R  V  S  I  R  P  R  N         p.460

  | 12       .         .         .         .         .         .    g.67253
  | GAGCATGAGACACTGCTAGCACGCTGGCAGAATAAGAACACGGAGAGTATCATCGAGCTG    c.1440
  | E  H  E  T  L  L  A  R  W  Q  N  K  N  T  E  S  I  I  E  L      p.480

          .         .         .         .         .         .       g.67313
 CAAAACAAGACACCTGTCTGGAATGATGACACACAGTCCTATGTACTCAACTTCCATGGG       c.1500
 Q  N  K  T  P  V  W  N  D  D  T  Q  S  Y  V  L  N  F  H  G         p.500

          .         .         .         .         .   | 13     .    g.67861
 CGCGTCACACAGGCCTCCGTGAAGAACTTCCAGATCATCCATGGCAATGACC | CGGACTAC    c.1560
 R  V  T  Q  A  S  V  K  N  F  Q  I  I  H  G  N  D  P |   D  Y      p.520

          .         .         .         .         .         .       g.67921
 ATCGTGATGCAGTTTGGCCGGGTAGCAGAGGATGTGTTCACCATGGATTACAACTACCCG       c.1620
 I  V  M  Q  F  G  R  V  A  E  D  V  F  T  M  D  Y  N  Y  P         p.540

          .         .         .         .         .         .       g.67981
 CTGTGTGCACTGCAGGCCTTTGCCATTGCCCTGTCCAGCTTCGACAGCAAGCTGGCGTGC       c.1680
 L  C  A  L  Q  A  F  A  I  A  L  S  S  F  D  S  K  L  A  C         p.560

                                                                    g.67987
 GAGTAG                                                             c.1686
 E  X                                                               p.561

          .         .         .         .         .         .       g.68047
 aggcctcttcgtgccctttggggttgcccagcctggagcggagcttgcctgcctgcctgt       c.*60

          .         .         .         .         .         .       g.68107
 ggagacagccctgcctatcctctgtatataggccttccgccagatgaagctttggccctc       c.*120

          .         .         .         .         .         .       g.68167
 agtgggctccctggcccagccagccaggaactggctcctttgcctctgctactgaggcag       c.*180

          .         .         .         .         .         .       g.68227
 gggagtagtggagagcgggtgggtgggtgtgaagggatgagaataattctttccatgcca       c.*240

          .         .         .         .         .         .       g.68287
 cgagatcaacacacactcccacccttggggtagtagtgtgttgtagtcgtacttaccaag       c.*300

          .         .         .         .         .         .       g.68347
 ctgagcaacctcttcagctgggaaggccgcaagaggcatagagggagaggaagcacactg       c.*360

          .         .         .         .         .         .       g.68407
 cagggctgctgtggcccagtcgtccgctcagccaaggagtcagatggcaatgggtactcc       c.*420

          .         .         .         .         .         .       g.68467
 agcaggtaggggcacagtgaatgtgtgtatgtatgaaggccacatcaactttatgtagca       c.*480

          .         .         .         .         .         .       g.68527
 aagggcttggtggccaagcctggcccttaaacaactgcagaaagcccttcaacttcagaa       c.*540

          .         .         .         .         .         .       g.68587
 ggcctcactcaagcctgagagaagttgggagggtggtggggacaggtaagtggcaggacc       c.*600

          .         .         .         .         .         .       g.68647
 ctgtcaggattgcaggtgcctggcttgctgtggctatgggaatcagctggtggctaggtt       c.*660

          .         .         .         .         .         .       g.68707
 tctagcgcatttgatttctccaggtttgctgtgtctcacagaggcagtaggaacccagct       c.*720

          .         .         .         .         .         .       g.68767
 ctcagggctgtcttggtggatgggccctgcaagacacaggctcagcatgcagaagtgcat       c.*780

          .         .         .         .         .         .       g.68827
 gaacagggtccctggatcagggttgttctgggagtcctgtcagcttccccaggagctctc       c.*840

          .         .         .         .         .         .       g.68887
 tgctgagcagcccagcacaacccccaggaaacacaaatggggtccaggtcaccagcctga       c.*900

          .         .         .         .         .         .       g.68947
 ctgcacacagctaggcatgcctgggaatcctgctgccagagaaccattcccaagccatgg       c.*960

          .         .         .         .         .         .       g.69007
 catgctccttgaagaatctctcctctctctctctctctggaaagacccaactttctcact       c.*1020

          .         .         .         .         .         .       g.69067
 gctgtcagccaagtcatggttggtaaccatgtaggttcttgggagggaatgggacagggt       c.*1080

          .         .         .         .         .         .       g.69127
 gaataaagcagggaatattttagaaccacaagagatcagcagtggcaggacccttaggaa       c.*1140

          .         .         .         .         .         .       g.69187
 tctagtacaaccttgttgctttaggtgagtcacactcagaaaatggggcttgccctgggt       c.*1200

          .         .         .         .         .         .       g.69247
 cacctagctggttaatggcagcattcagaacttcaagttctcttgatttctttgttccca       c.*1260

          .         .         .         .         .         .       g.69307
 ctgtcccccaagaaactagtatctctggcctcctgggggcccattctgcatgccctcccc       c.*1320

          .         .         .         .         .         .       g.69367
 acttcccccgattcagagacttagaagcatcagagttgataaattagattgaaaccattc       c.*1380

          .         .         .         .         .         .       g.69427
 cagtaggaaatcaggcagttccctgttgaaagttgtctggctttttgcacgtgagtatga       c.*1440

          .         .         .         .         .         .       g.69487
 tccaggattggcctgtgtctggcccctccgcgagggctactcagcagtaagcaggcctta       c.*1500

          .         .         .         .         .         .       g.69547
 gtacggctgctgcacacttctcggtctaggtgggagagagtgcataaaggttctggggct       c.*1560

          .         .         .         .         .         .       g.69607
 gggcctgagcctaactccctccactaccgctatttctccttggatggcaccatccaccct       c.*1620

          .         .         .         .         .         .       g.69667
 gcaggcttgggaactgtaagctcaagcttttgctcatttgtcatttaccctggtggaggc       c.*1680

          .         .         .         .         .         .       g.69727
 ttcttgcccagatagagatctgaaattggtgggaagcaagcaggggtcgtaccttgcttt       c.*1740

          .         .         .         .         .         .       g.69787
 agagtagatgtttggaaaagctaagtagaaattttttaaaatagaagttgtattttaaac       c.*1800

          .         .         .         .         .         .       g.69847
 gtgttaggctttataggtgaaggacttgttttgacttaagtagaagtaatatgctctcat       c.*1860

          .         .         .         .         .         .       g.69907
 ttctttgtaatctagattttcctatgttgaatgcttaaagcaaggcatacctgtcctagc       c.*1920

          .         .         .         .         .         .       g.69967
 aggatctgcccacacctcggccgtacatctctgtgagagaccccctccaacgattagctt       c.*1980

          .         .         .         .         .         .       g.70027
 ttgcaacatggtccagtttctagagggcactagaactttgtgccagcgctggcgagatac       c.*2040

          .         .         .         .         .         .       g.70087
 catggtgccatcctcctttctatagttccagtttagcccttccctgcctttaaggagaag       c.*2100

          .         .         .         .         .         .       g.70147
 agatcttcatggtgacatttgagatgatggaaactagatcgtctctaatgttaggtcaag       c.*2160

          .         .         .         .         .         .       g.70207
 ctatttctctggatctatgattttaagatagaacaggctggttctgagttctggtgagac       c.*2220

          .         .         .         .         .         .       g.70267
 ggagaccccggtggcagtggaaaaatcagaagcacaaaggaaaactcttggcctctgctt       c.*2280

          .         .         .         .         .         .       g.70327
 tctcctgtagcacaaagagggagttggctggatcttttggtggagtcaggaaagacaggc       c.*2340

          .         .         .         .         .         .       g.70387
 tgagctttctagcctaagtgtggagaaggatagcctcagccacaaaactctgtcaggcat       c.*2400

          .         .         .         .         .         .       g.70447
 tgaatgacaagcatcagtagctgagtgcactcctggtgatcctggttttccttgaccact       c.*2460

          .         .         .         .         .         .       g.70507
 ggccctggggccatgggtgcatggactcgtaaagctgctagggcccctagaaaccacctg       c.*2520

          .         .         .         .         .         .       g.70567
 ggttcagcctctcccacaataagagttcttgcccttcataccctctacctggatggatgg       c.*2580

          .         .         .         .         .         .       g.70627
 tctttgggcagggaattaatgacagaatgagcagtccctaatggtattgggcagttggga       c.*2640

          .         .         .         .         .         .       g.70687
 gtgagtttaggcagcttctctgtaaccgcttctggggccacaccccaaaactctacaccc       c.*2700

          .         .         .         .         .         .       g.70747
 tctgccccagaacaattctgcagagtggtgaagttcacttccccaactcttctccaagtc       c.*2760

          .         .         .         .         .         .       g.70807
 tagctttcctttccttctggctccaaggtgctctgtgtccgtctgtgtatgtgtgtgtct       c.*2820

          .         .         .         .         .         .       g.70867
 gtgcgtctgtgtgtttatttggggaaaagggcaatcagcaatcaactgaggtttcttaat       c.*2880

          .         .         .         .         .         .       g.70927
 tgtgattatattcctgagaatgaatgagtaggaaaggaataaggatgttgttatgatcgc       c.*2940

          .         .         .         .         .         .       g.70987
 ctgtggattttgtccattcatctcatgctctctgaacagaaggtatacctgggaagatac       c.*3000

          .         .         .         .         .         .       g.71047
 cagctttttctctcagggttctgagtcagaggacaccatccaagaatgttgttagctttt       c.*3060

          .         .         .         .         .         .       g.71107
 cagttcccgctctgcattgcctgaaaaaactggtatgttgcacgtatgcttttggttgaa       c.*3120

          .         .         .         .         .         .       g.71167
 attgaacatactctagtgaatgtgccttaaaaatcaagacactagttcagaggaagcaca       c.*3180

          .         .         .         .         .         .       g.71227
 taatgtccagatctatggcgaacacaggtgttggaagccaggactgtgataatcagaagc       c.*3240

          .         .         .         .         .         .       g.71287
 tataagagaactttcggagcctgcctccttcagtgacaagtagggcacaaaattctagaa       c.*3300

          .         .         .         .         .         .       g.71347
 gcagaaggttgtttttttttttttttctccattctgaaaatagcaggacatttacctctt       c.*3360

          .         .         .         .         .         .       g.71407
 aaataaacttagcatttagaggtaattctaaatttaacaagtgacagggttggtttcaaa       c.*3420

          .         .         .         .         .         .       g.71467
 gaaaaaggtccatgctttgcttacaatggagtctgcagtgaggggagatgctgggatagc       c.*3480

          .         .         .         .         .         .       g.71527
 catttccatggctctgttatgcaagcacaaatttcatctcctagatggacttcctggttt       c.*3540

          .         .         .         .         .         .       g.71587
 tctcttactgcagtaacactggccttcccttctctaattccttaccccagctgcggcatc       c.*3600

          .         .         .         .         .         .       g.71647
 cctgtgttaactcaggatgccaagtggccctcagattacacttctccagatagctgaatg       c.*3660

          .         .         .         .         .         .       g.71707
 agtctgctttcactgtgactgggacctgaatgacctgcagtcagggcccagagttgggac       c.*3720

          .         .         .         .         .         .       g.71767
 tctatactaccctgggctctggtctgtaggtttgtagtagccaccggtaataagccaagg       c.*3780

          .         .         .         .         .         .       g.71827
 gctaggctcttgtttgagtttatggccacctggaattttcagtcatctcatgatacaggc       c.*3840

          .         .         .         .         .         .       g.71887
 gggaggggcagaacagatagattacgacaggtttggtttttaaattttccaaccaagtgg       c.*3900

          .         .         .         .         .         .       g.71947
 aaaggcaagttggtcttatagaaagcactactgcacttagtagctatgtgattttgagca       c.*3960

          .         .         .         .         .         .       g.72007
 aaccacataatctctctaggtccattttcctaaccacaagataaagatgttacattgtca       c.*4020

          .         .         .         .         .         .       g.72067
 aagcttgccgtaggatttggggtgaatgaaaattattccttgctttcatcactaccttta       c.*4080

          .         .         .         .         .         .       g.72127
 tagctctcatcactacctttatagctcatcactgtgcctttttttctttcctaagaaaga       c.*4140

          .         .         .         .         .         .       g.72187
 catcacatccctctcctctcctcctctgtgctcctgtccctccctccccctagcaaggtc       c.*4200

          .         .         .         .         .         .       g.72247
 caggcaaagctggagatgaggctgagatccagagtttcctagaacgcaacttaggatggc       c.*4260

          .         .         .         .         .         .       g.72307
 taggaaagggaagcctgactgctcggtcaggagggtgcagtatctcttgctgggaacaca       c.*4320

          .         .         .         .         .         .       g.72367
 gccagttttcacaatgcctagactgtgtatgtctatttgcacaagattgtcttttcctat       c.*4380

          .         .         .         .         .         .       g.72427
 tttggagtggtcagacattttatttttgttcaagattatctggcgttttagacaaatttg       c.*4440

          .         .         .         .                           g.72475
 caaaactgtgcttttattgactttttgaataaactttggtattctgga                   c.*4488

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tubby homolog (mouse) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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