Tu translation elongation factor, mitochondrial (TUFM) - coding DNA reference sequence

(used for variant description)

(last modified June 11, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_003321.4 in the TUFM gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008964.1, covering TUFM transcript NM_003321.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          agacactggcggctagagg       c.-121

 .         .         .         .         .         .                g.5079
 ggcccggacttgccctcccagctctaacttccgccggaagtgccttccagccgcaggcgc       c.-61

 .         .         .         .         .         .                g.5139
 ccttcttcttctgtgcgctcgggctcctggtcccggctccccggttaccggggcgcgagt       c.-1

          .         .         .         .         .   | 02     .    g.5310
 ATGACCACAATGGCGGCCGCCACCCTGCTGCGCGCGACGCCCCACTTCAGCG | GTCTCGCC    c.60
 M  T  T  M  A  A  A  T  L  L  R  A  T  P  H  F  S  G |   L  A      p.20

          .         .         .         .         .         .       g.5370
 GCCGGCCGGACCTTCCTGCTGCAGGGTCTGTTGCGGCTGCTGAAAGCCCCGGCATTGCCT       c.120
 A  G  R  T  F  L  L  Q  G  L  L  R  L  L  K  A  P  A  L  P         p.40

          .         .         .         .         .         .       g.5430
 CTCTTGTGCCGCGGCCTGGCCGTGGAGGCCAAGAAGACTTACGTGCGCGACAAGCCACAT       c.180
 L  L  C  R  G  L  A  V  E  A  K  K  T  Y  V  R  D  K  P  H         p.60

          .         .         .         .         .         .       g.5490
 GTGAATGTGGGTACCATCGGCCATGTGGACCACGGGAAGACCACGCTGACTGCAGCCATC       c.240
 V  N  V  G  T  I  G  H  V  D  H  G  K  T  T  L  T  A  A  I         p.80

         | 03.         .         .         .         .         .    g.5981
 ACGAAGA | TTCTAGCTGAGGGAGGTGGGGCTAAGTTCAAGAAGTACGAGGAGATTGACAAT    c.300
 T  K  I |   L  A  E  G  G  G  A  K  F  K  K  Y  E  E  I  D  N      p.100

          .         .         .         .         .         .       g.6041
 GCCCCGGAGGAGCGAGCTCGGGGTATCACCATCAATGCGGCTCATGTGGAGTATAGCACT       c.360
 A  P  E  E  R  A  R  G  I  T  I  N  A  A  H  V  E  Y  S  T         p.120

          .         .         .         .         .     | 04   .    g.6359
 GCCGCCCGCCACTACGCCCACACAGACTGCCCGGGTCATGCAGATTATGTTAAG | AATATG    c.420
 A  A  R  H  Y  A  H  T  D  C  P  G  H  A  D  Y  V  K   | N  M      p.140

          .         .         .         .         .         .       g.6419
 ATCACAGGCACTGCACCCCTCGACGGCTGCATCCTGGTGGTAGCAGCCAATGACGGCCCC       c.480
 I  T  G  T  A  P  L  D  G  C  I  L  V  V  A  A  N  D  G  P         p.160

          .         .         .          | 05        .         .    g.6567
 ATGCCCCAGACCCGAGAGCACTTATTACTGGCCAGACAG | ATTGGGGTGGAGCATGTGGTG    c.540
 M  P  Q  T  R  E  H  L  L  L  A  R  Q   | I  G  V  E  H  V  V      p.180

          .         .         .         .         .         .       g.6627
 GTGTATGTGAACAAGGCTGACGCTGTCCAGGACTCTGAGATGGTGGAACTGGTGGAACTG       c.600
 V  Y  V  N  K  A  D  A  V  Q  D  S  E  M  V  E  L  V  E  L         p.200

          .         .         .         .         .         .       g.6687
 GAGATCCGGGAGCTGCTCACCGAGTTTGGCTATAAAGGGGAGGAGACCCCAGTCATCGTA       c.660
 E  I  R  E  L  L  T  E  F  G  Y  K  G  E  E  T  P  V  I  V         p.220

          .         .     | 06   .         .         .         .    g.6893
 GGCTCTGCTCTCTGTGCCCTTGAG | GGTCGGGACCCTGAGTTAGGCCTGAAGTCTGTGCAG    c.720
 G  S  A  L  C  A  L  E   | G  R  D  P  E  L  G  L  K  S  V  Q      p.240

          .         .         .         .         .         .       g.6953
 AAGCTACTGGATGCTGTGGACACTTACATCCCAGTGCCCGCCCGGGACCTGGAGAAGCCT       c.780
 K  L  L  D  A  V  D  T  Y  I  P  V  P  A  R  D  L  E  K  P         p.260

          .         .         .        | 07.         .         .    g.7097
 TTCCTGCTGCCTGTGGAGGCGGTGTACTCCGTCCCTG | GCCGTGGCACCGTGGTGACAGGT    c.840
 F  L  L  P  V  E  A  V  Y  S  V  P  G |   R  G  T  V  V  T  G      p.280

          .         .         .         .         .         .       g.7157
 ACACTAGAGCGTGGCATTTTAAAGAAGGGAGACGAGTGTGAGCTCCTAGGACATAGCAAG       c.900
 T  L  E  R  G  I  L  K  K  G  D  E  C  E  L  L  G  H  S  K         p.300

          .         .   | 08     .         .         .         .    g.7345
 AACATCCGCACTGTGGTGACAG | GCATTGAGATGTTCCACAAGAGCCTGGAGAGGGCCGAG    c.960
 N  I  R  T  V  V  T  G |   I  E  M  F  H  K  S  L  E  R  A  E      p.320

          .         .         .         .         .         .       g.7405
 GCCGGAGATAACCTCGGGGCCCTGGTCCGAGGCTTGAAGCGGGAGGACTTGCGGCGGGGC       c.1020
 A  G  D  N  L  G  A  L  V  R  G  L  K  R  E  D  L  R  R  G         p.340

          .         .         .         .         .     | 09   .    g.7559
 CTGGTCATGGTCAAGCCAGGTTCCATCAAGCCCCACCAGAAGGTGGAGGCCCAG | GTTTAC    c.1080
 L  V  M  V  K  P  G  S  I  K  P  H  Q  K  V  E  A  Q   | V  Y      p.360

          .         .         .         .         .         .       g.7619
 ATCCTCAGCAAGGAGGAAGGTGGCCGCCACAAGCCCTTTGTGTCCCACTTCATGCCTGTC       c.1140
 I  L  S  K  E  E  G  G  R  H  K  P  F  V  S  H  F  M  P  V         p.380

          .         .         .         .         .     | 10   .    g.8266
 ATGTTCTCCCTGACTTGGGACATGGCCTGTCGGATTATCCTGCCCCCAGAGAAG | GAGCTT    c.1200
 M  F  S  L  T  W  D  M  A  C  R  I  I  L  P  P  E  K   | E  L      p.400

          .         .         .         .         .         .       g.8326
 GCCATGCCCGGGGAGGACCTGAAGTTCAACCTAATCTTGCGGCAGCCAATGATCTTAGAG       c.1260
 A  M  P  G  E  D  L  K  F  N  L  I  L  R  Q  P  M  I  L  E         p.420

          .         .         .         .         .         .       g.8386
 AAAGGCCAGCGTTTCACCCTGCGAGATGGCAACCGGACTATTGGCACCGGTCTAGTCACC       c.1320
 K  G  Q  R  F  T  L  R  D  G  N  R  T  I  G  T  G  L  V  T         p.440

          .         .         .         .                           g.8434
 AACACGCTGGCCATGACTGAGGAGGAGAAGAATATCAAATGGGGTTGA                   c.1368
 N  T  L  A  M  T  E  E  E  K  N  I  K  W  G  X                     p.455

          .         .         .         .         .         .       g.8494
 gtgtgcagatctctgctcagcttcccttgcgtttaaggcctgccctagccagggctccct       c.*60

          .         .         .         .         .         .       g.8554
 cctgcttccagtaccctctcatggcataggctgcaacccagcagagggcagctagatgga       c.*120

          .         .         .         .         .         .       g.8614
 catttcccctgctcggaagggttggcctgcctggctggggaggtcagtaaactttgaata       c.*180

          .         .         .         .         .         .       g.8674
 gtaagccagcctgtgtcctgtgtcctttgtgcaaattggagaggataggggaggacaaaa       c.*240

          .         .         .         .         .         .       g.8734
 agggtgttgaaccccagacagatggggagcttgtgagatcccagagcagttttaacggat       c.*300

          .         .         .         .         .         .       g.8794
 aaatcaagtccagtgagcttagtgattgcctagacacagtaggatgccgttattcagcct       c.*360

          .         .         .         .         .         .       g.8854
 cctgggagatagtgggaaagaatgttctatcgctctggagccagcatggcttcagctcag       c.*420

          .         .         .         .         .         .       g.8914
 gtgccaaacccatcttgtttcctcggaatactaagtgaatgtctagcatccattcacatt       c.*480

          .         .         .         .         .         .       g.8974
 ctgtgggaacagggactggacaggcatacctcagatgctgtaggtttgcttccagactac       c.*540

          .         .                                               g.8998
 cacaataaagcaggtcacaaattt                                           c.*564

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tu translation elongation factor, mitochondrial protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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