tyrosinase-related protein 1 (TYRP1) - coding DNA reference sequence

(used for variant description)

(last modified July 24, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000550.2 in the TYRP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011705.1, covering TYRP1 transcript NM_000550.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   acagttctgacgtgagaggacaagaaacacaagcaaatataaaacattcaattctaag       c.-121

 .         .         .         .     | 02   .         .             g.5551
 agaagttcatcagagacatccttcaggattgtgag | ctggattttcctctacgtgcttcag    c.-61

 .         .         .         .         .         .                g.5611
 tcttctctacacaaagagctgcaaaccaggtctttgttttgcactcttatttcaagcaga       c.-1

          .         .         .         .         .         .       g.5671
 ATGAGTGCTCCTAAACTCCTCTCTCTGGGCTGTATCTTCTTCCCCTTGCTACTTTTTCAG       c.60
 M  S  A  P  K  L  L  S  L  G  C  I  F  F  P  L  L  L  F  Q         p.20

          .         .         .         .         .         .       g.5731
 CAGGCCCGGGCTCAATTCCCAAGACAGTGTGCCACTGTTGAGGCTTTGAGAAGTGGTATG       c.120
 Q  A  R  A  Q  F  P  R  Q  C  A  T  V  E  A  L  R  S  G  M         p.40

          .         .         .         .         .         .       g.5791
 TGTTGCCCAGACCTGTCCCCTGTGTCTGGGCCTGGGACAGACCGCTGTGGCTCATCATCA       c.180
 C  C  P  D  L  S  P  V  S  G  P  G  T  D  R  C  G  S  S  S         p.60

          .         .         .         .         .         .       g.5851
 GGGAGGGGCAGATGTGAGGCAGTGACTGCAGACTCCCGGCCCCACAGCCCTCAGTATCCC       c.240
 G  R  G  R  C  E  A  V  T  A  D  S  R  P  H  S  P  Q  Y  P         p.80

          .         .         .         .         .         .       g.5911
 CATGATGGCAGAGATGATCGGGAGGTCTGGCCCTTGCGCTTCTTCAATAGGACATGTCAC       c.300
 H  D  G  R  D  D  R  E  V  W  P  L  R  F  F  N  R  T  C  H         p.100

          .         .         .         .         .         .       g.5971
 TGCAACGGCAATTTCTCAGGACACAACTGTGGGACGTGCCGTCCTGGCTGGAGAGGAGCT       c.360
 C  N  G  N  F  S  G  H  N  C  G  T  C  R  P  G  W  R  G  A         p.120

          .         .      | 03  .         .         .         .    g.7164
 GCCTGTGACCAGAGGGTTCTCATAG | TCAGGAGAAATCTTCTGGACTTAAGTAAAGAAGAA    c.420
 A  C  D  Q  R  V  L  I  V |   R  R  N  L  L  D  L  S  K  E  E      p.140

          .         .         .         .         .         .       g.7224
 AAGAACCACTTTGTCCGGGCCCTGGATATGGCAAAGCGCACAACTCACCCTTTATTTGTC       c.480
 K  N  H  F  V  R  A  L  D  M  A  K  R  T  T  H  P  L  F  V         p.160

          .         .         .         .         .         .       g.7284
 ATTGCCACCAGGAGATCAGAAGAAATACTGGGGCCAGATGGCAACACGCCACAATTTGAG       c.540
 I  A  T  R  R  S  E  E  I  L  G  P  D  G  N  T  P  Q  F  E         p.180

          .         .         .         .         .         .       g.7344
 AACATTTCCATTTATAACTACTTTGTTTGGACACACTATTACTCAGTCAAAAAGACTTTC       c.600
 N  I  S  I  Y  N  Y  F  V  W  T  H  Y  Y  S  V  K  K  T  F         p.200

          .         .         .         .         .         .       g.7404
 CTTGGGGTAGGACAGGAAAGCTTTGGTGAAGTGGATTTCTCTCATGAGGGACCAGCTTTT       c.660
 L  G  V  G  Q  E  S  F  G  E  V  D  F  S  H  E  G  P  A  F         p.220

          .         .         .         .         | 04         .    g.10077
 CTCACATGGCACAGGTACCACCTCCTGCGTCTGGAGAAAGACATGCAG | GAAATGTTGCAA    c.720
 L  T  W  H  R  Y  H  L  L  R  L  E  K  D  M  Q   | E  M  L  Q      p.240

          .         .         .         .         .         .       g.10137
 GAGCCTTCTTTCTCCCTTCCTTACTGGAATTTTGCAACGGGGAAAAATGTCTGTGATATC       c.780
 E  P  S  F  S  L  P  Y  W  N  F  A  T  G  K  N  V  C  D  I         p.260

          .         .         .         .         .         .       g.10197
 TGCACGGATGACTTGATGGGATCCAGAAGCAACTTTGATTCCACTCTAATAAGCCCAAAC       c.840
 C  T  D  D  L  M  G  S  R  S  N  F  D  S  T  L  I  S  P  N         p.280

          .         .         .         .         .         .       g.10257
 TCTGTCTTTTCTCAATGGCGAGTGGTCTGTGACTCCTTGGAAGATTATGATACCCTGGGA       c.900
 S  V  F  S  Q  W  R  V  V  C  D  S  L  E  D  Y  D  T  L  G         p.300

          .    | 05    .         .         .         .         .    g.13932
 ACACTTTGTAACA | GCACCGAGGATGGGCCAATTAGGAGAAATCCAGCTGGAAATGTGGCC    c.960
 T  L  C  N  S |   T  E  D  G  P  I  R  R  N  P  A  G  N  V  A      p.320

          .         .         .         .         .         .       g.13992
 AGACCAATGGTGCAACGTCTTCCTGAACCACAGGATGTCGCTCAGTGCTTGGAAGTTGGT       c.1020
 R  P  M  V  Q  R  L  P  E  P  Q  D  V  A  Q  C  L  E  V  G         p.340

          .         .         .         .         .         .       g.14052
 TTATTTGACACGCCTCCTTTTTATTCCAACTCTACAAACAGTTTCCGAAACACAGTGGAA       c.1080
 L  F  D  T  P  P  F  Y  S  N  S  T  N  S  F  R  N  T  V  E         p.360

   | 06      .         .         .         .         .         .    g.16199
 G | GTTACAGTGACCCCACGGGAAAGTATGACCCTGCTGTTCGAAGTCTTCACAATTTGGCT    c.1140
 G |   Y  S  D  P  T  G  K  Y  D  P  A  V  R  S  L  H  N  L  A      p.380

          .         .         .         .         .         .       g.16259
 CATCTATTCCTGAATGGAACAGGGGGACAAACCCATTTGTCTCCAAATGATCCTATTTTT       c.1200
 H  L  F  L  N  G  T  G  G  Q  T  H  L  S  P  N  D  P  I  F         p.400

          .         .         .         .         .         .       g.16319
 GTCCTCCTGCACACCTTCACAGATGCAGTCTTTGATGAATGGCTGAGGAGATACAATGCT       c.1260
 V  L  L  H  T  F  T  D  A  V  F  D  E  W  L  R  R  Y  N  A         p.420

   | 07      .         .         .         .         .         .    g.19670
 G | ATATATCCACATTTCCATTGGAAAATGCCCCTATTGGACATAATAGACAATACAACATG    c.1320
 D |   I  S  T  F  P  L  E  N  A  P  I  G  H  N  R  Q  Y  N  M      p.440

          .         .         .         .         .         .       g.19730
 GTGCCATTCTGGCCCCCAGTCACCAACACAGAAATGTTTGTTACTGCTCCAGACAACCTG       c.1380
 V  P  F  W  P  P  V  T  N  T  E  M  F  V  T  A  P  D  N  L         p.460

          .         .         | 08         .         .         .    g.20623
 GGATACACTTATGAAATTCAATGGCCAA | GTCGGGAGTTTAGTGTACCTGAGATAATTGCC    c.1440
 G  Y  T  Y  E  I  Q  W  P  S |   R  E  F  S  V  P  E  I  I  A      p.480

          .         .         .         .         .         .       g.20683
 ATAGCAGTAGTTGGCGCTTTGTTACTGGTTGCACTCATTTTTGGGACTGCTTCTTATCTG       c.1500
 I  A  V  V  G  A  L  L  L  V  A  L  I  F  G  T  A  S  Y  L         p.500

          .         .         .         .         .         .       g.20743
 ATTCGTGCCAGACGCAGTATGGATGAAGCTAACCAGCCTCTCCTCACTGATCAGTATCAA       c.1560
 I  R  A  R  R  S  M  D  E  A  N  Q  P  L  L  T  D  Q  Y  Q         p.520

          .         .         .         .         .                 g.20797
 TGCTATGCTGAAGAATATGAAAAACTCCAGAATCCTAATCAGTCTGTGGTCTAA             c.1614
 C  Y  A  E  E  Y  E  K  L  Q  N  P  N  Q  S  V  V  X               p.537

          .         .         .         .         .         .       g.20857
 caaatgccctactctcttatgcattagtatcacaaaaccacctggttgaatataatagat       c.*60

          .         .         .         .         .         .       g.20917
 tgagttattaactgtattttctttcactttattaccttctttctaatacaagcatatgtt       c.*120

          .         .         .         .         .         .       g.20977
 agcattaaagttctaggcatacttttcaaagctgggaagaccctttcagaatcttttcaa       c.*180

          .         .         .         .         .         .       g.21037
 tgggttttaattttcagttctatttaaaatggtgaatgacactaaactccatgatattta       c.*240

          .         .         .         .         .         .       g.21097
 aggatagtgtgaagatctttggcatgatttaaaggttgagtatgtgaagatataagtaag       c.*300

          .         .         .         .         .         .       g.21157
 tgaactaccatgctttgtttacgtgtaaaggaaaataatgtttgatagtaaatgtccact       c.*360

          .         .         .         .         .         .       g.21217
 taaaatacatgaatgggcatttctaaaatgttaaaacataaacacatttccattcatgga       c.*420

          .         .         .         .         .         .       g.21277
 tatttgtcaacagatttaaagaaaaccacagttattaattaaagaaaattaattatgtgt       c.*480

          .         .         .         .         .         .       g.21337
 agttataaaccaatgaaattttgattaaccttttcaaattaatgttccagtttgaagacc       c.*540

          .         .         .         .         .         .       g.21397
 aatcaaatatattatttagtcaacatatactatttagtctcaggttcaaggctacaacaa       c.*600

          .         .         .         .         .         .       g.21457
 aaatcaccatctttgtcaaactttggagagggaaaatcttcactttcttaagcaacaatg       c.*660

          .         .         .         .         .         .       g.21517
 gatattgcctgtgtttgccactgtgtttccctgcctctcaattcgctgaaaaaggaacta       c.*720

          .         .         .         .         .         .       g.21577
 cctatccttacatttcacctactaatgtctcttctaacatcttagaggtccatggagaag       c.*780

          .         .         .         .         .         .       g.21637
 gcatatggagaacatgttttatactgctctataaatagtattccaatcactgtgcttaat       c.*840

          .         .         .         .         .         .       g.21697
 ttaaatagcattatcttatcatttatcagccttttatgtattttccaagtaaaatattaa       c.*900

          .         .         .         .         .         .       g.21757
 catattatttcattggtcttcttttttatctggttctatatgaatgctattttttccctt       c.*960

          .         .         .         .         .         .       g.21817
 ctcttctaacatgaaatatattttctctttttgatcttgtgctatgaaacaatcttccaa       c.*1020

          .         .         .         .         .         .       g.21877
 agaactgtataaggtggtcataagtgaatattttaattaaaattggtaaaaataaataat       c.*1080

                                                                    g.21881
 aaca                                                               c.*1084

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tyrosinase-related protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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