T, brachyury homolog (mouse) (T) - coding DNA reference sequence

(used for variant description)

(last modified November 11, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_003181.3 in the T gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012135.1, covering T transcript NM_003181.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5013
                      ggaggacacttctcagaaggggttgttttgcttttgctt       c.-481

 .         .         .         .         .         .                g.5073
 atttccgtccatttccctctctgcgcgcggaccttccttttccagatggtgagagccgcg       c.-421

 .         .         .         .         .         .                g.5133
 gggacacccgacgccggggcaggctgatccacgatcctgggtgtgcgtaacgccgcctgg       c.-361

 .         .         .         .         .         .                g.5193
 ggctccgtgggcgagggacgtgtggggacaggtgcaccggaaactgccagactggagagt       c.-301

 .         .         .         .         .         .                g.5253
 tgaggcatcggaggcgcgagaacagcactactactgcggcgagacgagcgcggcgcatcc       c.-241

 .         .         .         .         .         .                g.5313
 caaagcccggccaaatgcgctcgtccctgggaggggagggaggcgcgcctggagcgggga       c.-181

 .   | 02     .         .         .         .         .             g.5932
 cag | tcttggtccgcgccctcctcccgggtctgtgccgggacccgggacccgggagccgtc    c.-121

 .         .         .         .         .         .                g.5992
 gcaggtctcggtccaaggggccccttttctcggaagggcggcggccaagagcagggaagg       c.-61

 .         .         .         .         .         .                g.6052
 tggatctcaggtagcgagtctgggcttcggggacggcggggaggggagccggacgggagg       c.-1

          .         .         .         .         .         .       g.6112
 ATGAGCTCCCCTGGCACCGAGAGCGCGGGAAAGAGCCTGCAGTACCGAGTGGACCACCTG       c.60
 M  S  S  P  G  T  E  S  A  G  K  S  L  Q  Y  R  V  D  H  L         p.20

          .         .         .         .         .         .       g.6172
 CTGAGCGCCGTGGAGAATGAGCTGCAGGCGGGCAGCGAGAAGGGCGACCCCACAGAGCGC       c.120
 L  S  A  V  E  N  E  L  Q  A  G  S  E  K  G  D  P  T  E  R         p.40

          .         .         .         .         .         .       g.6232
 GAACTGCGCGTGGGCCTGGAGGAGAGCGAGCTGTGGCTGCGCTTCAAGGAGCTCACCAAT       c.180
 E  L  R  V  G  L  E  E  S  E  L  W  L  R  F  K  E  L  T  N         p.60

          .         .       | 03 .         .         .         .    g.6821
 GAGATGATCGTGACCAAGAACGGCAG | GAGGATGTTTCCGGTGCTGAAGGTGAACGTGTCT    c.240
 E  M  I  V  T  K  N  G  R  |  R  M  F  P  V  L  K  V  N  V  S      p.80

          .         .         .         .         .         .       g.6881
 GGCCTGGACCCCAACGCCATGTACTCCTTCCTGCTGGACTTCGTGGCGGCGGACAACCAC       c.300
 G  L  D  P  N  A  M  Y  S  F  L  L  D  F  V  A  A  D  N  H         p.100

          .         .         .         .         .         .       g.6941
 CGCTGGAAGTACGTGAACGGGGAATGGGTGCCGGGGGGCAAGCCGGAGCCGCAGGCGCCC       c.360
 R  W  K  Y  V  N  G  E  W  V  P  G  G  K  P  E  P  Q  A  P         p.120

          .         .         .         .         .         .       g.7001
 AGCTGCGTCTACATCCACCCCGACTCGCCCAACTTCGGGGCCCACTGGATGAAGGCTCCC       c.420
 S  C  V  Y  I  H  P  D  S  P  N  F  G  A  H  W  M  K  A  P         p.140

          .         .         .         .         .  | 04      .    g.7812
 GTCTCCTTCAGCAAAGTCAAGCTCACCAACAAGCTCAACGGAGGGGGCCAG | ATCATGCTG    c.480
 V  S  F  S  K  V  K  L  T  N  K  L  N  G  G  G  Q   | I  M  L      p.160

          .         .         .         .         .         .       g.7872
 AACTCCTTGCATAAGTATGAGCCTCGAATCCACATAGTGAGAGTTGGGGGTCCACAGCGC       c.540
 N  S  L  H  K  Y  E  P  R  I  H  I  V  R  V  G  G  P  Q  R         p.180

          .         .         .         .         .         .       g.7932
 ATGATCACCAGCCACTGCTTCCCTGAGACCCAGTTCATAGCGGTGACTGCTTATCAGAAC       c.600
 M  I  T  S  H  C  F  P  E  T  Q  F  I  A  V  T  A  Y  Q  N         p.200

        | 05 .         .         .         .         .         .    g.8836
 GAGGAG | ATCACAGCTCTTAAAATTAAGTACAATCCATTTGCAAAAGCTTTCCTTGATGCA    c.660
 E  E   | I  T  A  L  K  I  K  Y  N  P  F  A  K  A  F  L  D  A      p.220

          | 06         .         .         .         .         .    g.9029
 AAGGAAAG | AAGTGATCACAAAGAGATGATGGAGGAACCCGGAGACAGCCAGCAACCTGGG    c.720
 K  E  R  |  S  D  H  K  E  M  M  E  E  P  G  D  S  Q  Q  P  G      p.240

          . | 07       .         .         .         .         .    g.11073
 TACTCCCAAT | GGGGGTGGCTTCTTCCTGGAACCAGCACCCTGTGTCCACCTGCAAATCCT    c.780
 Y  S  Q  W |   G  W  L  L  P  G  T  S  T  L  C  P  P  A  N  P      p.260

          .         .         .         .         .         .       g.11133
 CATCCTCAGTTTGGAGGTGCCCTCTCCCTCCCCTCCACGCACAGCTGTGACAGGTACCCA       c.840
 H  P  Q  F  G  G  A  L  S  L  P  S  T  H  S  C  D  R  Y  P         p.280

          .         .         .         .         .         .       g.11193
 ACCCTGAGGAGCCACCGGTCCTCACCCTACCCCAGCCCCTATGCTCATCGGAACAATTCT       c.900
 T  L  R  S  H  R  S  S  P  Y  P  S  P  Y  A  H  R  N  N  S         p.300

      | 08   .         .         .         .         .         .    g.12733
 CCAA | CCTATTCTGACAACTCACCTGCATGTTTATCCATGCTGCAATCCCATGACAATTGG    c.960
 P  T |   Y  S  D  N  S  P  A  C  L  S  M  L  Q  S  H  D  N  W      p.320

          .         .         .         .         .         .       g.12793
 TCCAGCCTTGGAATGCCTGCCCATCCCAGCATGCTCCCCGTGAGCCACAATGCCAGCCCA       c.1020
 S  S  L  G  M  P  A  H  P  S  M  L  P  V  S  H  N  A  S  P         p.340

          .     | 09   .         .         .         .         .    g.15101
 CCTACCAGCTCCAG | TCAGTACCCCAGCCTGTGGTCTGTGAGCAACGGCGCCGTCACCCCG    c.1080
 P  T  S  S  S  |  Q  Y  P  S  L  W  S  V  S  N  G  A  V  T  P      p.360

          .         .         .         .         .         .       g.15161
 GGCTCCCAGGCAGCAGCCGTGTCCAACGGGCTGGGGGCCCAGTTCTTCCGGGGCTCCCCC       c.1140
 G  S  Q  A  A  A  V  S  N  G  L  G  A  Q  F  F  R  G  S  P         p.380

          .         .         .         .         .         .       g.15221
 GCGCACTACACACCCCTCACCCATCCGGTCTCGGCGCCCTCTTCCTCGGGATCCCCACTG       c.1200
 A  H  Y  T  P  L  T  H  P  V  S  A  P  S  S  S  G  S  P  L         p.400

          .         .         .         .         .         .       g.15281
 TACGAAGGGGCGGCCGCGGCCACAGACATCGTGGACAGCCAGTACGACGCCGCAGCCCAA       c.1260
 Y  E  G  A  A  A  A  T  D  I  V  D  S  Q  Y  D  A  A  A  Q         p.420

          .         .         .         .                           g.15329
 GGCCGCCTCATAGCCTCATGGACACCTGTGTCGCCACCTTCCATGTGA                   c.1308
 G  R  L  I  A  S  W  T  P  V  S  P  P  S  M  X                     p.435

          .         .         .         .         .         .       g.15389
 agcagcaaggcccaggtcccgaaagatgcagtgactttttgtcgtggcagccagtggtga       c.*60

          .         .         .         .         .         .       g.15449
 ctggattgacctactaggtacccagtggcagtctcaggttaagaaggaaatgcagcctca       c.*120

          .         .         .         .         .         .       g.15509
 gtaacttccttttcaaagcagtggaggagcacacggcacctttccccagagccccagcat       c.*180

          .         .         .         .         .         .       g.15569
 cccttgctcacacctgcagtagcggtgctgtcccaggtggcttacagatgaacccaactg       c.*240

          .         .         .         .         .         .       g.15629
 tggagatgatgcagttggcccaacctcactgacggtgaaaaaatgtttgccagggtccag       c.*300

          .         .         .         .         .         .       g.15689
 aaactttttttggtttatttctcatacagtgtattggcaactttggcacaccagaatttg       c.*360

          .         .         .         .         .         .       g.15749
 taaactccaccagtcctactttagtgagataaaaagcacactcttaatcttcttccttgt       c.*420

          .         .         .         .         .         .       g.15809
 tgctttcaagtagttagagttgagctgttaaggacagaataaaatcatagttgaggacag       c.*480

          .         .         .         .         .         .       g.15869
 caggttttagttgaattgaaaatttgactgctctgccccctagaatgtgtgtattttaag       c.*540

          .         .         .         .         .         .       g.15929
 catatgtagctaatctcttgtgttgttaaactataactgtttcatatttttcttttgaca       c.*600

          .         .         .         .         .                 g.15988
 aagtagccaaagacaatcagcagaaagcattttctgcaaaataaacgcaatatgcaaaa        c.*659

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The T, brachyury homolog (mouse) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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