U2 small nuclear RNA auxiliary factor 2 (U2AF2) - coding DNA reference sequence

(used for variant description)

(last modified November 1, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_007279.2 in the U2AF2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032904.1, covering U2AF2 transcript NM_007279.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5035
                          ggagagcgcgccacagaacgacttttacgcaggcg       c.-1021

 .         .         .         .         .         .                g.5095
 cagaagcctgtttcccctcacccgcggcttccaccctgcgcaggcgcaaaaagccgcgct       c.-961

 .         .         .         .         .         .                g.5155
 ggcaacctccgcagcggtcgcgcgcacccttcacccctcttgctgcttttgtctggcaca       c.-901

 .         .         .         .         .         .                g.5215
 accttctcaggccctccgcgaggccggccctttttttctttcactttccccacccggaga       c.-841

 .         .         .         .         .         .                g.5275
 gccaggtgccgagaactaggacctcgtccccttctctatcccttcccctgatccatctcg       c.-781

 .         .         .         .         .         .                g.5335
 tctctgttctccttcccttttccgttcccgaagccggaaggagccgaggtacccacggaa       c.-721

 .         .         .         .         .         .                g.5395
 aaagtcgaagctgtccccggagagtgaggccttcacgaagcggtggcggaaggagccgaa       c.-661

 .         .         .         .         .         .                g.5455
 gttctctgatcggaggcgtgagcaagtggcatctccggaaagagccgaaacacggactcg       c.-601

 .         .         .         .         .         .                g.5515
 agcttaatcccaggaggggcccgagggcgagatccggaaatctccggaaagagccgaagg       c.-541

 .         .         .         .         .         .                g.5575
 ccgggacggttaggattgtcggaagtggccgattgcttggacagggccggcggagaagat       c.-481

 .         .         .         .         .         .                g.5635
 cggagcaagtccgtggaagaagccaaagactgggacggattgaattgttggaagaacccg       c.-421

 .         .         .         .         .         .                g.5695
 aactcgcagaggggactgggcgcagtggcacacgaggacacacggaaacctccgaacgtt       c.-361

 .         .         .         .         .         .                g.5755
 gaggagataatctcggaaaagttacggaaacctgggaagtcggcgaaaccctacgttcgg       c.-301

 .         .         .         .         .         .                g.5815
 gtgttttcggaagcagccgaagcggccgcctgcttcgccttcgtccagtatccggagata       c.-241

 .         .         .         .         .         .                g.5875
 gccgaggcgcttcggagccaggctcggggggaggggcaagctcgcgggcgggcgggcggg       c.-181

 .         .         .         .         .         .                g.5935
 tgagggggcggagcccgggcggggcggggagggctgccggaggcttgattaggtaggagg       c.-121

 .         .         .         .         .         .                g.5995
 tggcgaagcgccggcggcggccggaagtagccgaagccagcggcggaagtagccgaagcg       c.-61

 .         .         .         .         .         .                g.6055
 gctggagcgggcggcaaggcgaggcgaaagctgcacagggccctacgcggccgcctcagc       c.-1

          .         .         .         .          | 02        .    g.10171
 ATGTCGGACTTCGACGAGTTCGAGCGGCAGCTCAACGAGAATAAACAAG | AGCGGGACAAG    c.60
 M  S  D  F  D  E  F  E  R  Q  L  N  E  N  K  Q  E |   R  D  K      p.20

          .         .         .         .         .         .       g.10231
 GAGAACCGGCATCGGAAGCGCAGCCACAGCCGCTCTCGGAGCCGGGACCGCAAACGCCGG       c.120
 E  N  R  H  R  K  R  S  H  S  R  S  R  S  R  D  R  K  R  R         p.40

          .         .         .         .         .         .       g.10291
 AGCCGGAGCCGCGACCGGCGCAACCGGGACCAGCGGAGCGCCTCCCGGGACAGGCGACGA       c.180
 S  R  S  R  D  R  R  N  R  D  Q  R  S  A  S  R  D  R  R  R         p.60

       | 03  .         .         .         .         . | 04       . g.11476
 CGCAG | CAAACCTTTGACCAGAGGCGCTAAAGAGGAGCACGGTGGACTGAT | TCGTTCCCCC c.240
 R  S  |  K  P  L  T  R  G  A  K  E  E  H  G  G  L  I  |  R  S  P   p.80

          .         .         .         .         .         .       g.11536
 CGCCACGAGAAGAAGAAGAAGGTCCGTAAATACTGGGACGTGCCACCCCCAGGCTTTGAG       c.300
 R  H  E  K  K  K  K  V  R  K  Y  W  D  V  P  P  P  G  F  E         p.100

          .         .         .     | 05   .         .         .    g.12014
 CACATCACCCCAATGCAGTACAAGGCCATGCAAG | CTGCGGGTCAGATTCCAGCCACTGCT    c.360
 H  I  T  P  M  Q  Y  K  A  M  Q  A |   A  G  Q  I  P  A  T  A      p.120

          .         .         .         .         .         .       g.12074
 CTTCTCCCCACCATGACCCCTGACGGTCTGGCTGTGACCCCAACGCCGGTGCCCGTGGTC       c.420
 L  L  P  T  M  T  P  D  G  L  A  V  T  P  T  P  V  P  V  V         p.140

          .         .         .         .         .         .       g.12134
 GGGAGCCAGATGACCAGACAAGCCCGGCGCCTCTACGTGGGCAACATCCCCTTTGGCATC       c.480
 G  S  Q  M  T  R  Q  A  R  R  L  Y  V  G  N  I  P  F  G  I         p.160

        | 06 .         .         .         .         .         .    g.13506
 ACTGAG | GAGGCCATGATGGATTTCTTCAACGCCCAGATGCGCCTGGGGGGGCTGACCCAG    c.540
 T  E   | E  A  M  M  D  F  F  N  A  Q  M  R  L  G  G  L  T  Q      p.180

          .         .         .         .         .         .       g.13566
 GCCCCTGGCAACCCAGTGTTGGCTGTGCAGATTAACCAGGACAAGAATTTTGCCTTTTTG       c.600
 A  P  G  N  P  V  L  A  V  Q  I  N  Q  D  K  N  F  A  F  L         p.200

     | 07    .         .         .         .         .         .    g.14613
 GAG | TTCCGCTCAGTGGACGAGACTACCCAGGCTATGGCCTTTGATGGCATCATCTTCCAG    c.660
 E   | F  R  S  V  D  E  T  T  Q  A  M  A  F  D  G  I  I  F  Q      p.220

          .         .         .         .         .         .       g.14673
 GGCCAGTCACTAAAGATCCGCAGGCCTCACGACTACCAGCCGCTTCCTGGCATGTCAGAG       c.720
 G  Q  S  L  K  I  R  R  P  H  D  Y  Q  P  L  P  G  M  S  E         p.240

          .         .   | 08     .         .         .         .    g.19495
 AACCCCTCCGTCTATGTGCCTG | GGGTTGTGTCCACTGTGGTCCCCGACTCTGCCCACAAG    c.780
 N  P  S  V  Y  V  P  G |   V  V  S  T  V  V  P  D  S  A  H  K      p.260

          .         .         .         .   | 09     .         .    g.19638
 CTGTTCATCGGGGGCTTACCCAACTACCTGAACGATGACCAG | GTCAAAGAGCTGCTGACA    c.840
 L  F  I  G  G  L  P  N  Y  L  N  D  D  Q   | V  K  E  L  L  T      p.280

          .         .         .         .         .         .       g.19698
 TCCTTTGGGCCCCTCAAGGCCTTCAACCTGGTCAAGGACAGTGCCACGGGGCTCTCCAAG       c.900
 S  F  G  P  L  K  A  F  N  L  V  K  D  S  A  T  G  L  S  K         p.300

          .         .         .         .      | 10  .         .    g.20048
 GGCTACGCCTTCTGTGAGTACGTGGACATCAACGTCACGGATCAG | GCCATTGCGGGGCTG    c.960
 G  Y  A  F  C  E  Y  V  D  I  N  V  T  D  Q   | A  I  A  G  L      p.320

          .         .         .         .         .         .       g.20108
 AACGGCATGCAGCTGGGGGATAAGAAGCTGCTGGTCCAGAGGGCGAGTGTGGGAGCCAAG       c.1020
 N  G  M  Q  L  G  D  K  K  L  L  V  Q  R  A  S  V  G  A  K         p.340

          .         .     | 11   .         .         .         .    g.20430
 AATGCCACGCTGGTGAGCCCCCCG | AGCACCATCAATCAGACGCCTGTGACCCTGCAAGTG    c.1080
 N  A  T  L  V  S  P  P   | S  T  I  N  Q  T  P  V  T  L  Q  V      p.360

          .         .         .         .         .         .       g.20490
 CCGGGCTTGATGAGCTCCCAGGTGCAGATGGGCGGCCACCCGACTGAGGTCCTGTGCCTC       c.1140
 P  G  L  M  S  S  Q  V  Q  M  G  G  H  P  T  E  V  L  C  L         p.380

          .         .         .         .         .         .       g.20550
 ATGAACATGGTGCTGCCTGAGGAGCTGCTGGACGACGAGGAGTATGAGGAGATCGTGGAG       c.1200
 M  N  M  V  L  P  E  E  L  L  D  D  E  E  Y  E  E  I  V  E         p.400

          .         .         .         .         .         .       g.20610
 GATGTGCGGGACGAGTGCAGCAAGTACGGGCTTGTCAAGTCCATCGAGATCCCCCGGCCT       c.1260
 D  V  R  D  E  C  S  K  Y  G  L  V  K  S  I  E  I  P  R  P         p.420

          .         .         .    | 12    .         .         .    g.24911
 GTGGACGGCGTCGAGGTGCCCGGCTGCGGAAAG | ATCTTTGTGGAGTTCACCTCTGTGTTT    c.1320
 V  D  G  V  E  V  P  G  C  G  K   | I  F  V  E  F  T  S  V  F      p.440

          .         .         .         .         .         .       g.24971
 GACTGCCAGAAAGCCATGCAGGGCCTGACGGGCCGCAAGTTCGCCAACAGAGTGGTTGTC       c.1380
 D  C  Q  K  A  M  Q  G  L  T  G  R  K  F  A  N  R  V  V  V         p.460

          .         .         .         .                           g.25019
 ACAAAATACTGTGACCCCGACTCTTATCACCGCCGGGACTTCTGGTAG                   c.1428
 T  K  Y  C  D  P  D  S  Y  H  R  R  D  F  W  X                     p.475

          .         .         .         .         .         .       g.25079
 aggcggctgggggagggtgggggcagggctggctgggggcttctccccactcccgccccc       c.*60

          .         .         .         .         .         .       g.25139
 cccttatccccctctgaagacgatgggcagaggagtgacagccgcagacacacgacagcc       c.*120

          .         .         .         .         .         .       g.25199
 ggcagcaactggaatggcagcaattaagggtggggggcgggggttggggggttggggggt       c.*180

          .         .         .         .         .         .       g.25259
 tagggcagggaggggactggggaagtgcgcacacagcccacacagacaacacgcacccac       c.*240

          .         .         .         .         .         .       g.25319
 acagacacagagggaaggggttgggatggggacagggtgcacagcagggcggggtaggac       c.*300

          .         .         .         .         .         .       g.25379
 cccagcccctcccaaaacagcctctccttctcccatagacccctttcttctccccttccc       c.*360

          .         .         .         .         .         .       g.25439
 cacggtaggaacatagcgtgtttatattttatggccaaactattttgaattttgttgtcc       c.*420

          .         .         .         .         .         .       g.25499
 ggccctcagtgccctgccctctcccttaccaggaccacagctctgttccttcggcctctg       c.*480

          .         .         .         .         .         .       g.25559
 gtcctctctggtcccctcctgggtttcttacgtagttgatttttcctctttagtctcccc       c.*540

          .         .         .         .         .         .       g.25619
 cgacctgcgcccagccccgtggcccctgcccctctcctactctctgtggcagtttcatat       c.*600

          .         .         .         .                           g.25667
 ttgctaagacgaatttgctcattaaacattttgttgtattttacttta                   c.*648

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The U2 small nuclear RNA auxiliary factor 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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