ubiquitin-conjugating enzyme E2T (putative) (UBE2T) - coding DNA reference sequence

(used for variant description)

(last modified July 19, 2015)

This file was created to facilitate the description of sequence variants on transcript NM_014176.3 in the UBE2T gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering UBE2T transcript NM_014176.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.5016
                                             agtcagaggtcgcgca       c.-121

 .         .         .         .         .         .      | 02      g.11152
 ggcgctggtaccccgttggtccgcgcgttgctgcgttgtgaggggtgtcagctcag | tgca    c.-61

 .         .         .         .         .         .                g.11212
 tcccaggcagctcttagtgtggagcagtgaactgtgtgtggttccttctacttggggatc       c.-1

          .         .         .         .         .         .       g.11272
 ATGCAGAGAGCTTCACGTCTGAAGAGAGAGCTGCACATGTTAGCCACAGAGCCACCCCCA       c.60
 M  Q  R  A  S  R  L  K  R  E  L  H  M  L  A  T  E  P  P  P         p.20

          .         .         .         .          | 03        .    g.11919
 GGCATCACATGTTGGCAAGATAAAGACCAAATGGATGACCTGCGAGCTC | AAATATTAGGT    c.120
 G  I  T  C  W  Q  D  K  D  Q  M  D  D  L  R  A  Q |   I  L  G      p.40

          .         .         .         .         .          | 04    g.13412
 GGAGCCAACACACCTTATGAGAAAGGTGTTTTTAAGCTAGAAGTTATCATTCCTGAGAG | G    c.180
 G  A  N  T  P  Y  E  K  G  V  F  K  L  E  V  I  I  P  E  R  |      p.60

          .         .         .         .         .         .       g.13472
 TACCCATTTGAACCTCCTCAGATCCGATTTCTCACTCCAATTTATCATCCAAACATTGAT       c.240
 Y  P  F  E  P  P  Q  I  R  F  L  T  P  I  Y  H  P  N  I  D         p.80

          .         .         .         .      | 05  .         .    g.13646
 TCTGCTGGAAGGATTTGTCTGGATGTTCTCAAATTGCCACCAAAA | GGTGCTTGGAGACCA    c.300
 S  A  G  R  I  C  L  D  V  L  K  L  P  P  K   | G  A  W  R  P      p.100

          .         .         .         .         .         .       g.13706
 TCCCTCAACATCGCAACTGTGTTGACCTCTATTCAGCTGCTCATGTCAGAACCCAACCCT       c.360
 S  L  N  I  A  T  V  L  T  S  I  Q  L  L  M  S  E  P  N  P         p.120

          .         .     | 06   .         .         .         .    g.13909
 GATGACCCGCTCATGGCTGACATA | TCCTCAGAATTTAAATATAATAAGCCAGCCTTCCTC    c.420
 D  D  P  L  M  A  D  I   | S  S  E  F  K  Y  N  K  P  A  F  L      p.140

          .         .         .         .         | 07         .    g.15018
 AAGAATGCCAGACAGTGGACAGAGAAGCATGCAAGACAGAAACAAAAG | GCTGATGAGGAA    c.480
 K  N  A  R  Q  W  T  E  K  H  A  R  Q  K  Q  K   | A  D  E  E      p.160

          .         .         .         .         .         .       g.15078
 GAGATGCTTGATAATCTACCAGAGGCTGGTGACTCCAGAGTACACAACTCAACACAGAAA       c.540
 E  M  L  D  N  L  P  E  A  G  D  S  R  V  H  N  S  T  Q  K         p.180

          .         .         .         .         .                 g.15132
 AGGAAGGCCAGTCAGCTAGTAGGCATAGAAAAGAAATTTCATCCTGATGTTTAG             c.594
 R  K  A  S  Q  L  V  G  I  E  K  K  F  H  P  D  V  X               p.197

          .         .         .         .         .         .       g.15192
 gggacttgtcctggttcatcttagttaatgtgttctttgccaaggtgatctaagttgcct       c.*60

          .         .         .         .         .         .       g.15252
 accttgaatttttttttaaatatatttgatgacataatttttgtgtagtttatttatctt       c.*120

          .         .         .         .         .                 g.15310
 gtacatatgtattttgaaatcttttaaacctgaaaaataaatagtcatttaatgttga         c.*178

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Ubiquitin-conjugating enzyme E2T (putative) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.