ubiquitin protein ligase E3B (UBE3B) - coding DNA reference sequence

(used for variant description)

(last modified October 10, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_130466.3 in the UBE3B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering UBE3B transcript NM_130466.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               gttctgaaagcgaa       c.-601

 .         .         .         .         .         .                g.5074
 caccgcggggcaagatggcggtagtgcgtcggctgctgccccgggtctggcagaactcgg       c.-541

 .         .         .         .         .         .                g.5134
 gtgttttgggctgagacagtggcagctgcggccccgaccccaagtgcggggacctccggc       c.-481

 .         .         .         .         .         .                g.5194
 gaataaaggtcggcctgcgggtaggccggtagggcctgcggtccggcctgcgggagaact       c.-421

 .         .         .         .         .         .                g.5254
 gggtcgtcagtcctccgagtggtggggctggggactttgagggagttggctctagggcac       c.-361

 .         .         .         .         .         .                g.5314
 agtccctgcctggccaggtcggaggaacaagtgctgggatctggcgtgtgtgctccaggg       c.-301

 .         .         .         .         .         .                g.5374
 gctctttccgcggccctttccacctcttttcactttggggacggtaggcctttataaacg       c.-241

 .         .         .         .         .         .                g.5434
 gactaatgctgggtgatttgttcctgtggttgttgatgccgaggaaagactctgggcccc       c.-181

 .         .         .         .         .         .   | 02         g.9021
 aggactcacctaaactggagttcgaatactgttcgctcgctgtgtgaccttgg | aaaaaat    c.-121

 .         .         .         .         .         .                g.9081
 aacaagcttttctgaagtgagaagctgttctcagccacgagtcctgtgcaagatcactaa       c.-61

 .         .         .         .         | 03         .             g.10929
 tgattacctggcatttctgcgacacaggcaggtcctcag | ggtttgtgcaagtttgcaaac    c.-1

          .         .         .         .         .         .       g.10989
 ATGTTCACCCTGTCTCAGACCTCGAGAGCATGGTTCATCGATAGAGCCCGTCAGGCACGA       c.60
 M  F  T  L  S  Q  T  S  R  A  W  F  I  D  R  A  R  Q  A  R         p.20

          .         .         .         .         .         .       g.11049
 GAAGAAAGGCTTGTGCAGAAGGAACGGGAGCGGGCAGCTGTTGTGATCCAGGCCCATGTC       c.120
 E  E  R  L  V  Q  K  E  R  E  R  A  A  V  V  I  Q  A  H  V         p.40

          .         .         .         .  | 04      .         .    g.11257
 CGGAGTTTTCTCTGTCGGAGTCGACTGCAGAGAGATATCAG | GAGAGAGATTGATGACTTT    c.180
 R  S  F  L  C  R  S  R  L  Q  R  D  I  R  |  R  E  I  D  D  F      p.60

          .         .         .         .         .         .       g.11317
 TTTAAAGCAGATGACCCTGAGTCCACTAAAAGAAGTGCACTTTGTATTTTCAAGATTGCC       c.240
 F  K  A  D  D  P  E  S  T  K  R  S  A  L  C  I  F  K  I  A         p.80

          .         .         .         .   | 05     .         .    g.13407
 AGGAAACTGCTGTTCCTATTCAGAATCAAAGAGGATAATGAG | AGATTTGAGAAGTTGTGT    c.300
 R  K  L  L  F  L  F  R  I  K  E  D  N  E   | R  F  E  K  L  C      p.100

          .         .         .         .   | 06     .         .    g.13866
 CGCAGCATCCTGAGCAGCATGGATGCTGAGAATGAGCCTAAG | GTGTGGTATGTGTCCCTG    c.360
 R  S  I  L  S  S  M  D  A  E  N  E  P  K   | V  W  Y  V  S  L      p.120

          .         .         .         .         .         .       g.13926
 GCTTGTTCTAAGGACCTCACCCTCCTTTGGATTCAACAGATCAAGAACATTTTGTGGTAC       c.420
 A  C  S  K  D  L  T  L  L  W  I  Q  Q  I  K  N  I  L  W  Y         p.140

          .         .        | 07.         .         .         .    g.15982
 TGCTGTGATTTTCTCAAGCAGCTCAAG | CCTGAAATCCTGCAGGACTCCCGACTCATCACC    c.480
 C  C  D  F  L  K  Q  L  K   | P  E  I  L  Q  D  S  R  L  I  T      p.160

          .         .         .         .         .         .       g.16042
 CTGTACCTCACGATGCTTGTCACCTTCACAGACACTTCAACGTGGAAAATTCTTCGGGGA       c.540
 L  Y  L  T  M  L  V  T  F  T  D  T  S  T  W  K  I  L  R  G         p.180

      | 08   .         .         .         .         .         .    g.17352
 AAAG | GTGAAAGTCTTCGACCAGCGATGAACCACATTTGTGCAAATATAATGGGACATCTC    c.600
 K  G |   E  S  L  R  P  A  M  N  H  I  C  A  N  I  M  G  H  L      p.200

          .         .         . | 09       .         .         .    g.18452
 AACCAGCATGGATTTTATTCTGTGCTGCAG | ATATTGTTAACCCGTGGCCTGGCAAGACCC    c.660
 N  Q  H  G  F  Y  S  V  L  Q   | I  L  L  T  R  G  L  A  R  P      p.220

          .         .         .         .         .    | 10    .    g.25202
 CGTCCTTGTCTATCCAAAGGCACTTTAACAGCAGCTTTTTCTCTAGCGTTACG | CCCTGTG    c.720
 R  P  C  L  S  K  G  T  L  T  A  A  F  S  L  A  L  R  |  P  V      p.240

          .         .         .         .         .         .       g.25262
 ATTGCTGCACAGTTCTCAGACAATCTGATTCGGCCGTTCCTCATCCACATCATGTCTGTG       c.780
 I  A  A  Q  F  S  D  N  L  I  R  P  F  L  I  H  I  M  S  V         p.260

          .         .         .          | 11        .         .    g.25631
 CCTGCTCTGGTGACTCATCTCAGCACAGTGACCCCTGAG | CGCCTCACTGTTTTAGAATCC    c.840
 P  A  L  V  T  H  L  S  T  V  T  P  E   | R  L  T  V  L  E  S      p.280

          .         .         .         .         .         .       g.25691
 CATGACATGCTTCGTAAATTCATCATATTTTTAAGAGACCAAGATCGATGCCGTGATGTA       c.900
 H  D  M  L  R  K  F  I  I  F  L  R  D  Q  D  R  C  R  D  V         p.300

          .         .         .         . | 12       .         .    g.27030
 TGTGAAAGTTTAGAAGGATGCCATACGCTTTGTCTAATGG | GCAACCTCCTACACTTGGGC    c.960
 C  E  S  L  E  G  C  H  T  L  C  L  M  G |   N  L  L  H  L  G      p.320

          .         .         .         .         .         .       g.27090
 TCCCTCAGCCCCAGAGTGTTAGAGGAGGAGACAGATGGGTTCGTGAGTTTGCTCACCCAG       c.1020
 S  L  S  P  R  V  L  E  E  E  T  D  G  F  V  S  L  L  T  Q         p.340

          .         .         .         .         .         .       g.27150
 ACGCTGTGCTACTGTCGGAAGTATGTGTCTCAGAAGAAGTCCAACCTGACCCACTGGCAT       c.1080
 T  L  C  Y  C  R  K  Y  V  S  Q  K  K  S  N  L  T  H  W  H         p.360

          .         .         .         | 13         .         .    g.28770
 CCTGTCCTTGGCTGGTTCTCCCAATCTGTGGATTATGG | CCTTAACGAGTCAATGCACTTG    c.1140
 P  V  L  G  W  F  S  Q  S  V  D  Y  G  |  L  N  E  S  M  H  L      p.380

          .         .         .         .         .         .       g.28830
 ATCACCAAACAGCTGCAGTTCTTGTGGGGGGTGCCTCTGATCCGGATCTTCTTCTGTGAC       c.1200
 I  T  K  Q  L  Q  F  L  W  G  V  P  L  I  R  I  F  F  C  D         p.400

          .         .         .         .         .         .       g.28890
 ATCCTGAGCAAGAAGCTACTGGAGAGCCAGGAGCCAGCCCACGCACAGCCAGCATCCCCT       c.1260
 I  L  S  K  K  L  L  E  S  Q  E  P  A  H  A  Q  P  A  S  P         p.420

          .         .   | 14     .         .         .         .    g.30438
 CAGAATGTGCTCCCAGTGAAGA | GTCTCCTAAAGCGTGCTTTTCAAAAGTCGGCATCAGTC    c.1320
 Q  N  V  L  P  V  K  S |   L  L  K  R  A  F  Q  K  S  A  S  V      p.440

          .         .         .         .         .         .       g.30498
 CGGAATATTCTCAGGCCTGTCGGGGGTAAACGGGTCGACTCTGCAGAAGTCCAGAAGGTT       c.1380
 R  N  I  L  R  P  V  G  G  K  R  V  D  S  A  E  V  Q  K  V         p.460

          .         .         .         .         .         .       g.30558
 TGCAACATCTGTGTCCTCTACCAGACCTCGCTGACAACTCTCACACAGATTCGGCTGCAG       c.1440
 C  N  I  C  V  L  Y  Q  T  S  L  T  T  L  T  Q  I  R  L  Q         p.480

          . | 15       .         .         .         .         .    g.34991
 ATACTCACAG | GTCTCACTTACCTTGATGACCTGCTTCCCAAACTGTGGGCATTTATCTGT    c.1500
 I  L  T  G |   L  T  Y  L  D  D  L  L  P  K  L  W  A  F  I  C      p.500

          .         .         .         .         .         .       g.35051
 GAGCTCGGGCCCCACGGAGGGTTAAAGCTCTTCTTGGAATGCCTGAACAATGACACTGAA       c.1560
 E  L  G  P  H  G  G  L  K  L  F  L  E  C  L  N  N  D  T  E         p.520

          .         .         .         .         .         .       g.35111
 GAGTCCAAGCAACTCTTGGCCATGCTGATGCTGTTCTGTGACTGTTCGCGGCACCTCATC       c.1620
 E  S  K  Q  L  L  A  M  L  M  L  F  C  D  C  S  R  H  L  I         p.540

    | 16     .         .         .         .         .         .    g.37031
 AC | AATCCTTGATGACATTGAAGTTTATGAAGAACAGATTTCATTCAAACTGGAAGAGCTG    c.1680
 T  |  I  L  D  D  I  E  V  Y  E  E  Q  I  S  F  K  L  E  E  L      p.560

          .         .         .         .         .         .       g.37091
 GTCACTATCTCCTCTTTCCTGAATTCTTTTGTGTTTAAGATGATCTGGGATGGAATTGTA       c.1740
 V  T  I  S  S  F  L  N  S  F  V  F  K  M  I  W  D  G  I  V         p.580

   | 17      .         .         .         .         .         .    g.37780
 G | AGAACGCCAAGGGTGAGACCTTGGAGCTGTTCCAGTCTGTCCACGGGTGGCTTATGGTG    c.1800
 E |   N  A  K  G  E  T  L  E  L  F  Q  S  V  H  G  W  L  M  V      p.600

          .         .         .         .         .       | 18 .    g.38585
 CTGTACGAGCGGGACTGCCGGCGGCGCTTCACCCCCGAGGACCACTGGCTGCGAAA | GGAT    c.1860
 L  Y  E  R  D  C  R  R  R  F  T  P  E  D  H  W  L  R  K  |  D      p.620

          .         .         .         .         .         .       g.38645
 CTCAAACCTAGCGTGCTCTTCCAAGAACTCGACAGGGACAGAAAACGGGCACAGTTGATC       c.1920
 L  K  P  S  V  L  F  Q  E  L  D  R  D  R  K  R  A  Q  L  I         p.640

          .         .         .       | 19 .         .         .    g.44166
 CTGCAGTACATCCCACATGTCATCCCTCACAAAAAC | AGAGTTCTACTGTTTCGAACCATG    c.1980
 L  Q  Y  I  P  H  V  I  P  H  K  N   | R  V  L  L  F  R  T  M      p.660

          .         .         .         .         .         .       g.44226
 GTTACCAAGGAGAAGGAGAAACTGGGGCTGGTGGAAACCAGCTCTGCCTCCCCGCATGTC       c.2040
 V  T  K  E  K  E  K  L  G  L  V  E  T  S  S  A  S  P  H  V         p.680

          .         .         .       | 20 .         .         .    g.48549
 ACTCACATCACCATCCGCCGGTCCAGGATGCTGGAG | GACGGCTACGAGCAGCTTAGGCAG    c.2100
 T  H  I  T  I  R  R  S  R  M  L  E   | D  G  Y  E  Q  L  R  Q      p.700

          .         .         .         .         .         .       g.48609
 CTCTCCCAGCACGCCATGAAGGGGGTCATCCGTGTGAAGTTTGTCAATGACCTCGGGGTG       c.2160
 L  S  Q  H  A  M  K  G  V  I  R  V  K  F  V  N  D  L  G  V         p.720

          .         .         .         .         .         .       g.48669
 GACGAAGCAGGGATTGATCAAGACGGTGTTTTTAAGGAGTTCTTGGAAGAGATCATCAAG       c.2220
 D  E  A  G  I  D  Q  D  G  V  F  K  E  F  L  E  E  I  I  K         p.740

          .         .         .    | 21    .         .         .    g.48845
 AGAGTTTTTGACCCAGCACTCAATCTGTTCAAG | ACAACCAGTGGGGATGAGAGGCTGTAC    c.2280
 R  V  F  D  P  A  L  N  L  F  K   | T  T  S  G  D  E  R  L  Y      p.760

          .         .         .         .         .         .       g.48905
 CCCTCACCCACATCCTACATCCATGAGAATTACCTGCAGCTCTTCGAGTTTGTGGGGAAG       c.2340
 P  S  P  T  S  Y  I  H  E  N  Y  L  Q  L  F  E  F  V  G  K         p.780

          .         .     | 22   .         .         .         .    g.51391
 ATGCTGGGGAAGGCTGTGTATGAG | GGAATTGTGGTGGACGTGCCATTTGCATCCTTCTTC    c.2400
 M  L  G  K  A  V  Y  E   | G  I  V  V  D  V  P  F  A  S  F  F      p.800

          .         .         .         .         .         .       g.51451
 CTGAGCCAACTGCTTGGGCACCACCACAGCGTCTTCTATAGCTCGGTGGATGAACTGCCT       c.2460
 L  S  Q  L  L  G  H  H  H  S  V  F  Y  S  S  V  D  E  L  P         p.820

          .         .         .         .   | 23     .         .    g.51833
 TCTCTGGACTCCGAGTTCTATAAAAACCTCACCTCCATCAAG | CGCTATGATGGGGACATC    c.2520
 S  L  D  S  E  F  Y  K  N  L  T  S  I  K   | R  Y  D  G  D  I      p.840

          .         .         .         .         | 24         .    g.53747
 ACTGACCTGGGCCTGACGCTGTCTTACGACGAGGACGTCATGGGTCAG | CTTGTTTGCCAT    c.2580
 T  D  L  G  L  T  L  S  Y  D  E  D  V  M  G  Q   | L  V  C  H      p.860

          .         .         .         .        | 25.         .    g.57280
 GAACTGATTCCTGGAGGGAAGACCATTCCTGTTACAAATGAAAATAA | AATTAGCTACATC    c.2640
 E  L  I  P  G  G  K  T  I  P  V  T  N  E  N  K  |  I  S  Y  I      p.880

          .         .         .         .         .         .       g.57340
 CATCTGATGGCACATTTTCGAATGCACACTCAAATAAAAAACCAAACAGCTGCCCTCATT       c.2700
 H  L  M  A  H  F  R  M  H  T  Q  I  K  N  Q  T  A  A  L  I         p.900

          .         .         .         .         .         .       g.57400
 AGCGGATTCCGTTCCATTATCAAACCCGAGTGGATCCGAATGTTCTCAACTCCTGAACTG       c.2760
 S  G  F  R  S  I  I  K  P  E  W  I  R  M  F  S  T  P  E  L         p.920

          .         .         .         .         . | 26       .    g.57934
 CAGCGTCTCATCTCTGGCGACAATGCTGAGATTGATCTGGAAGATTTAAA | GAAGCACACA    c.2820
 Q  R  L  I  S  G  D  N  A  E  I  D  L  E  D  L  K  |  K  H  T      p.940

          .         .         .         .         .         .       g.57994
 GTCTACTACGGTGGTTTCCATGGAAGTCACAGAGTCATCATCTGGCTCTGGGATATTCTG       c.2880
 V  Y  Y  G  G  F  H  G  S  H  R  V  I  I  W  L  W  D  I  L         p.960

          .         .         .         .   | 27     .         .    g.60861
 GCCTCCGACTTCACACCGGATGAGAGAGCTATGTTTCTGAAG | TTCGTGACCAGCTGCTCC    c.2940
 A  S  D  F  T  P  D  E  R  A  M  F  L  K   | F  V  T  S  C  S      p.980

          .         .         .         .         .         .       g.60921
 AGACCCCCGCTCCTGGGATTCGCCTACCTCAAGCCTCCATTCTCCATCCGCTGCGTGGAG       c.3000
 R  P  P  L  L  G  F  A  Y  L  K  P  P  F  S  I  R  C  V  E         p.1000

          .      | 28  .         .         .         .         .    g.62013
 GTGTCGGACGATCAG | GACACCGGGGACACTCTGGGCAGCGTCCTCCGGGGCTTCTTCACC    c.3060
 V  S  D  D  Q   | D  T  G  D  T  L  G  S  V  L  R  G  F  F  T      p.1020

          .         .         .         .         .         .       g.62073
 ATCCGCAAGCGGGAGCCAGGCGGCCGCCTGCCCACCTCCTCCACCTGCTTCAACCTGCTC       c.3120
 I  R  K  R  E  P  G  G  R  L  P  T  S  S  T  C  F  N  L  L         p.1040

          .         .         .         .         .         .       g.62133
 AAGCTGCCCAACTACAGCAAGAAGAGCGTCCTCCGCGAGAAGCTGCGCTACGCCATCAGC       c.3180
 K  L  P  N  Y  S  K  K  S  V  L  R  E  K  L  R  Y  A  I  S         p.1060

          .         .                                               g.62160
 ATGAACACGGGCTTTGAACTCTCCTAG                                        c.3207
 M  N  T  G  F  E  L  S  X                                          p.1068

          .         .         .         .         .         .       g.62220
 ctcctgtcccagccctgcctccagggctcctgggctgccagggaccttcagctcccagag       c.*60

          .         .         .         .         .         .       g.62280
 gcagtgtggtcctgggaatgtgaccaacatgccaggtgacattggcccctagaccctctc       c.*120

          .         .         .         .         .         .       g.62340
 tatagccatgagactccttgtggcctcaagaaatttagacgcccacgacagcactacaca       c.*180

          .         .         .         .         .         .       g.62400
 gcatctccaggtgatgcccaaggcacagggctgcagaaaataaacctccagattccacca       c.*240

          .         .         .         .         .         .       g.62460
 acacgggtccattcttcctggtgatggcagaggggcttcttttagctagtttgatctttt       c.*300

          .         .         .         .         .         .       g.62520
 gggagtctgtctttccttagccgtctgagtgagctgtgtatgaacaagtcccaggagttc       c.*360

          .         .         .         .         .         .       g.62580
 caagagtctagagtggtttttgcagcatgggttgagtgtacaaagcctactgtgcgtgag       c.*420

          .         .         .         .         .         .       g.62640
 atcctctccttccgtttctgaaatctcttactcaggtaaggcctcgccaagcctctatgc       c.*480

          .         .         .         .         .         .       g.62700
 accccacaaagtttctgcctccatgccgtccacagcgcctcttcccagacagccaggccc       c.*540

          .         .         .         .         .         .       g.62760
 atctgctgcccagggaagcgcaggcgcctgctagggacgctatggacaccgtgagtccaa       c.*600

          .         .         .         .         .         .       g.62820
 ggcgctgctcctgccttgaagccacgcgctccacgccgcggccctcccattttctgcgtc       c.*660

          .         .         .         .         .         .       g.62880
 ctcagcgggctgagctgccagagagtcttcccggacctattcccgtcctatgcattcaca       c.*720

          .         .         .         .         .         .       g.62940
 ttggcatcctggtttgggggaagaaaaacaacggcccttagcagcagccccgtttccaga       c.*780

          .         .         .         .         .         .       g.63000
 atgtgctgcctgttccccaaagcctgcttgtcccgcggaggacggctgcctttgaccctg       c.*840

          .         .         .         .         .         .       g.63060
 cttatttgtctcactggttatctaatgaggaacaaacactaacctaaggtacacatccca       c.*900

          .         .         .         .         .         .       g.63120
 tctgggcggtggcttcactcctgagtctgcaaaatcccaggaaacttgggtcttgctgcc       c.*960

          .         .         .         .         .         .       g.63180
 catccttcctcagcacagggaacccggaagcccgttgcactgacagaggctcacaccctc       c.*1020

          .         .         .         .         .         .       g.63240
 tgggttttttgttttttttttaaacttcatttctcttccaacccattgtgttcctctgcc       c.*1080

          .         .         .         .         .         .       g.63300
 ctcattctttacctttgttgtaagaactttagctccagggaactgaggcagaggccctgt       c.*1140

          .         .         .         .         .         .       g.63360
 ttgtggtctgtgttgacagccacccaccctctcccacctcatgctcctgcacctgcacca       c.*1200

          .         .         .         .         .         .       g.63420
 ccaaggttgatgccggattcgaagccaggaaggcccagtccctcctctgctctcctcaaa       c.*1260

          .         .         .         .         .         .       g.63480
 gacgcaaaacattttccaacaagagctgtcacagtggcagcaaagcaggggccacccgtc       c.*1320

          .         .         .         .         .         .       g.63540
 tccacagtccttcagagtttcagctgcatcctggtgtcccacccaggtcgagcccccagg       c.*1380

          .         .         .         .         .         .       g.63600
 cttctggaaaagagtgtgtgctctactttgatggaaacatggcaaggaatttaaagacag       c.*1440

          .         .         .         .         .         .       g.63660
 gaatgtattaatattattgaaggtgtgttcgtaacctctgattctgtggacttgccactt       c.*1500

          .         .         .         .         .         .       g.63720
 tctccaaacgctcggttcctttgaagatttcttctgaacgtgtgtgcgcacgctgggcgg       c.*1560

          .         .         .         .         .         .       g.63780
 gttcgtgcatacatgcggggaccccagactgtcagcacagggaagatggatcccatccta       c.*1620

          .         .         .         .         .         .       g.63840
 atttttatcacctgaaggttggaaccagtgagggactgggagagagtgatttataagcac       c.*1680

          .         .         .         .         .         .       g.63900
 caatatcaacttcatgtggatttttgacaaggaggggtagtttgtaatttcatttaaatt       c.*1740

          .         .         .         .         .         .       g.63960
 cttttcagcagctggaaatattgcactatctgaaacactgaatctccttttgtaactggt       c.*1800

          .         .         .         .         .         .       g.64020
 gttcactgacaccttgatggctcttgatggctctaaaaagttgtaggattttttgttttt       c.*1860

          .         .         .         .         .         .       g.64080
 gtagctaacttatggattgagatgtgatcaaaggctttattaaatttgtacttcagcata       c.*1920

                                                                    g.64083
 tga                                                                c.*1923

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ubiquitin protein ligase E3B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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