ubiquitin protein ligase E3 component n-recognin 7 (putative) (UBR7) - coding DNA reference sequence

(used for variant description)

(last modified December 22, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_175748.3 in the UBR7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_051089.1, covering UBR7 transcript NM_175748.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5056
     agaacacgacaccgggaagcgccacccggaggcggaaatcagcccgcgtccggcgc       c.-181

 .         .         .         .         .         .                g.5116
 aggcgggagaagggagaggagtgacatccgtttgtcggaagtcgctcctcccccttcctt       c.-121

 .         .         .         .         .         .                g.5176
 cgctttttttccttgtcattggttcctggcactcgggccccacctcctccggctacgccc       c.-61

 .         .         .         .         .         .                g.5236
 ctcacggccgcttttcccgcctccgccggggccgagccgctgttcggctgacagttgagg       c.-1

          .         .         .         .         .         .       g.5296
 ATGGCCGGAGCCGAGGGCGCCGCTGGGCGGCAGTCGGAGCTGGAGCCCGTGGTATCGTTG       c.60
 M  A  G  A  E  G  A  A  G  R  Q  S  E  L  E  P  V  V  S  L         p.20

          .         .         .         .         .         .       g.5356
 GTCGACGTCCTTGAGGAGGACGAGGAGCTGGAGAATGAGGCGTGCGCTGTCCTGGGCGGC       c.120
 V  D  V  L  E  E  D  E  E  L  E  N  E  A  C  A  V  L  G  G         p.40

          .         .         . | 02       .         .         .    g.7799
 AGCGACTCCGAGAAGTGCTCCTACTCTCAG | GGCTCAGTAAAGAGACAAGCACTATATGCC    c.180
 S  D  S  E  K  C  S  Y  S  Q   | G  S  V  K  R  Q  A  L  Y  A      p.60

          .         .         .         .         .         .       g.7859
 TGTAGTACCTGCACCCCAGAGGGAGAAGAACCAGCAGGAATTTGTTTAGCTTGCAGTTAT       c.240
 C  S  T  C  T  P  E  G  E  E  P  A  G  I  C  L  A  C  S  Y         p.80

          .         .         .         .     | 03   .         .    g.8609
 GAATGTCATGGAAGTCACAAACTATTTGAGCTATACACAAAAAG | AAATTTTCGTTGTGAT    c.300
 E  C  H  G  S  H  K  L  F  E  L  Y  T  K  R  |  N  F  R  C  D      p.100

          .         .         .         .      | 04  .         .    g.9992
 TGTGGAAACAGCAAGTTTAAAAATTTGGAATGCAAATTACTTCCT | GACAAAGCAAAGGTA    c.360
 C  G  N  S  K  F  K  N  L  E  C  K  L  L  P   | D  K  A  K  V      p.120

          .         .         .         .         .         .       g.10052
 AATTCTGGCAATAAGTACAATGACAACTTTTTTGGATTGTACTGCATTTGCAAGAGACCT       c.420
 N  S  G  N  K  Y  N  D  N  F  F  G  L  Y  C  I  C  K  R  P         p.140

          .         .  | 05      .         .         .         .    g.12913
 TATCCTGATCCTGAAGACGAG | ATTCCAGATGAGATGATCCAGTGCGTAGTCTGTGAAGAC    c.480
 Y  P  D  P  E  D  E   | I  P  D  E  M  I  Q  C  V  V  C  E  D      p.160

          .      | 06  .         .         .         .         .    g.13166
 TGGTTCCATGGAAGG | CATCTTGGTGCCATTCCCCCTGAGAGTGGGGATTTTCAGGAGATG    c.540
 W  F  H  G  R   | H  L  G  A  I  P  P  E  S  G  D  F  Q  E  M      p.180

          .         .         .         .         .         .       g.13226
 GTATGCCAGGCCTGCATGAAACGTTGTTCTTTTTTGTGGGCTTATGCTGCACAATTGGCA       c.600
 V  C  Q  A  C  M  K  R  C  S  F  L  W  A  Y  A  A  Q  L  A         p.200

   | 07      .         .         .         .         .         .    g.16531
 G | TAACCAAAATATCCACTGAGGATGATGGATTGGTGCGGAACATTGATGGAATAGGTGAT    c.660
 V |   T  K  I  S  T  E  D  D  G  L  V  R  N  I  D  G  I  G  D      p.220

          .         .         .         .         .         .       g.16591
 CAGGAAGTTATCAAACCTGAAAATGGAGAGCATCAAGATAGTACCCTCAAAGAGGATGTT       c.720
 Q  E  V  I  K  P  E  N  G  E  H  Q  D  S  T  L  K  E  D  V         p.240

          .         .         .         .         .         .       g.16651
 CCAGAACAGGGAAAGGATGATGTCCGGGAGGTTAAAGTAGAGCAGAACAGTGAACCATGT       c.780
 P  E  Q  G  K  D  D  V  R  E  V  K  V  E  Q  N  S  E  P  C         p.260

          .         .         . | 08       .         .         .    g.17187
 GCCGGCTCTAGTTCTGAATCTGATCTCCAG | ACAGTGTTTAAGAATGAAAGCCTCAACGCA    c.840
 A  G  S  S  S  E  S  D  L  Q   | T  V  F  K  N  E  S  L  N  A      p.280

          .         .         .         .         .         .       g.17247
 GAATCAAAATCTGGCTGCAAACTTCAGGAGCTTAAAGCTAAGCAGCTTATAAAGAAAGAC       c.900
 E  S  K  S  G  C  K  L  Q  E  L  K  A  K  Q  L  I  K  K  D         p.300

          .         .         .         .         .         .       g.17307
 ACTGCCACCTATTGGCCCCTGAACTGGCGTAGCAAGTTGTGTACCTGCCAAGACTGTATG       c.960
 T  A  T  Y  W  P  L  N  W  R  S  K  L  C  T  C  Q  D  C  M         p.320

  | 09       .         .         .         .         .         .    g.18254
  | AAAATGTATGGAGATCTAGATGTCTTATTCCTGACAGATGAATACGACACAGTTCTGGCT    c.1020
  | K  M  Y  G  D  L  D  V  L  F  L  T  D  E  Y  D  T  V  L  A      p.340

          .         .         .         .         .         .       g.18314
 TATGAAAACAAAGGGAAGATTGCCCAGGCCACTGACAGGAGCGATCCCCTAATGGATACC       c.1080
 Y  E  N  K  G  K  I  A  Q  A  T  D  R  S  D  P  L  M  D  T         p.360

          .         .         .         .    | 10    .         .    g.20275
 CTTAGCAGCATGAATAGAGTCCAGCAAGTGGAACTCATTTGTG | AATACAATGATTTGAAG    c.1140
 L  S  S  M  N  R  V  Q  Q  V  E  L  I  C  E |   Y  N  D  L  K      p.380

          .         .         .         .      | 11  .         .    g.24903
 ACTGAACTTAAAGACTATCTCAAGAGATTTGCTGATGAAGGCACG | GTTGTTAAGAGAGAG    c.1200
 T  E  L  K  D  Y  L  K  R  F  A  D  E  G  T   | V  V  K  R  E      p.400

          .         .         .         .         .         .       g.24963
 GACATTCAGCAGTTCTTTGAAGAGTTTCAGTCAAAAAAGAGAAGAAGAGTGGATGGGATG       c.1260
 D  I  Q  Q  F  F  E  E  F  Q  S  K  K  R  R  R  V  D  G  M         p.420

          .                                                         g.24981
 CAGTATTACTGCAGCTAG                                                 c.1278
 Q  Y  Y  C  S  X                                                   p.425

          .         .         .         .         .         .       g.25041
 agtggagtatgaagctttctcattcaagccaatgaaaatgcgcttcccattcttggaata       c.*60

          .         .         .         .         .         .       g.25101
 aaagaggtgtggttcacatttggccccctttccgtcctcctctgtttggagaggcctcgc       c.*120

          .         .         .         .         .         .       g.25161
 gctcccttcattctctttagctgcagtagccaccgtgtggatgctgacttcacagccagc       c.*180

          .         .         .         .         .         .       g.25221
 gtcctctgtgactcagctgatgcagctcattccacagacttctccagtgtactcctactc       c.*240

          .         .         .         .         .         .       g.25281
 cagtgcacccagggttatttgcatagtttttaagtttgattttgttttgagaaagcaaat       c.*300

          .         .         .         .         .         .       g.25341
 tggtgtcttgtttaatgatctgttatttcactcccagatgtgtgtgttttgccacagagc       c.*360

          .         .         .         .         .         .       g.25401
 tgttgccttccagaacctcctccgcaggcatcacggaaggctctcttcccgtcacctaga       c.*420

          .         .         .         .         .         .       g.25461
 acctctacaggtcccctcgcccctatgatcgtggtgccttgggtcaaagcttcctcaagc       c.*480

          .         .         .         .         .         .       g.25521
 ctggtctgctccttctttcacgtccctgttttctgaggtttggtcatagcttagaaagga       c.*540

          .         .         .         .         .         .       g.25581
 tcttggggcttgttttctctaggcccaacctccagagtagccaggactgatggttttctg       c.*600

          .         .         .         .         .         .       g.25641
 gtctggatgtctgtcacaggcggagagattaacagatgacagggttgaggaagcaagcct       c.*660

          .         .         .         .         .         .       g.25701
 ttgttatgaattttactaatacagttcaagtgaaattttcgttcatgattctattggcac       c.*720

          .         .         .         .         .         .       g.25761
 tagaattagaatttcagtactgtagtgctcacagggcttcctggagaacatttgcccgta       c.*780

          .         .         .         .         .         .       g.25821
 tactagtcccttctctgctgcctagaaaacagaccgggtctcacccctgtgaaatcttgg       c.*840

          .         .         .         .         .         .       g.25881
 tggtttacgaagtcctctggatttcttgatattatcagggatattcataagcatatatca       c.*900

          .         .         .         .         .         .       g.25941
 aaaatggacctattttgatattctgttatgaaaatgttattagaaccccaataaattatt       c.*960

          .         .         .         .         .         .       g.26001
 atttttcccccttgaatctgctaaagaaaacagatcctgacttagcttacttgaaataag       c.*1020

          .         .         .         .         .         .       g.26061
 cagggcagggagccctgttttggaagagacagactgtggaagagattacaaacaaggccc       c.*1080

          .         .         .         .         .         .       g.26121
 gaggctgcacgaatgatgagttttgtgtatataatgttaatgtccaccgccacttcccta       c.*1140

          .         .         .         .         .         .       g.26181
 acgactatgagatcttttttttgaagatcctcatggaaggttgtacagagccccacattt       c.*1200

          .         .         .         .         .         .       g.26241
 gaggggaagtcctttcagttgatatgagatctctttaacacccctcagtctatgtaggaa       c.*1260

          .         .         .         .         .         .       g.26301
 atgccttgtgatacatagagaaccctcagcttctctctgcctctggaggaccaaggtctt       c.*1320

          .         .         .         .         .         .       g.26361
 tcctgacagtcggagacacaccttgatgtatgttaataaaagcatttcaggctgtggggc       c.*1380

          .         .         .         .         .         .       g.26421
 caccatgtatattaatactccttatgtgtccagcatctgtgtattcattcgagtgcccaa       c.*1440

          .         .         .         .         .         .       g.26481
 tccctggatgagatgaactaggccttataaaaagtcaaagcctcaaagaaatggcacaac       c.*1500

          .         .         .         .         .         .       g.26541
 catgttcttcggcactcaggctcctaattgcagatcctcacgaagggtggtatgtggagc       c.*1560

          .         .         .         .         .         .       g.26601
 tggaaggtcttgtggccacaggacatgctggtgagccctgagctggccttgtgcagaggg       c.*1620

          .         .         .         .         .         .       g.26661
 ctccgttcaaaggctcggggtgtctttgaggttgtttatcaagctggggaactcttccaa       c.*1680

          .         .         .         .         .         .       g.26721
 gtctgacaatgtttcgaaccctttttgcaaggttgcactattagtataccatcatgtccg       c.*1740

          .         .         .         .         .         .       g.26781
 gaaaacttttaatcttctcaaatatctgatgtaactaccagaaagtcccttacttcctat       c.*1800

          .         .         .         .         .         .       g.26841
 gaccaatcaggaccaagtcttggaggtgatgtgttacattacgtgcagcacaatagtacc       c.*1860

          .         .         .         .         .         .       g.26901
 gatcagttaactcagcgctgaagggcttgttttatgaaaggtactattccttctttcaca       c.*1920

          .         .         .         .         .         .       g.26961
 ttaactggaaacctctttttttacctgttgttcacaactagttttcttattgactgtatt       c.*1980

          .         .         .         .         .         .       g.27021
 ggactgtctcttcttgtagagactgattttggccaacatattaatgcatgttttatgcaa       c.*2040

          .         .         .         .         .         .       g.27081
 aacacaaatatgatattagttgcttttaaggagttctggcattgtatgtgcatttttgta       c.*2100

          .         .         .         .         .         .       g.27141
 gaaattgttactggacttataattacatacttaactctgatcaggtttctgtaaaattta       c.*2160

          .         .                                               g.27161
 aataaaaccaatacaaaata                                               c.*2180

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ubiquitin protein ligase E3 component n-recognin 7 (putative) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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