UDP-glucose pyrophosphorylase 2 (UGP2) - coding DNA reference sequence

(used for variant description)

(last modified June 15, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_006759.3 in the UGP2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering UGP2 transcript NM_006759.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5922
                                                       tggttt       c.-301

 .         .         .         .         .         .                g.5982
 taccttttccgggagtctccagctggccctcatttgtgtccggagctcaggagttcccaa       c.-241

 .         .         .         .         .         .                g.6042
 accgactcagtcgcaccaagtttccgtcttttggaattggggaaggagtttctttctttc       c.-181

 .         .         .         .         .         .                g.6102
 ttttcttttttcttgagccagttttaatcgctttgaataaatactcccttaagtagttaa       c.-121

 .         .         .         .         .         .                g.6162
 atataggaggagaaagaatacatcggttgttaaagcaggagaggaagagagacctgccct       c.-61

 .         .         .         .         .         .                g.6222
 gtagcgtgactcctctagaaaaaaaaaaaaaaagccggagtattttactaagcccctaaa       c.-1

          .          | 02        .         .         .         .    g.20383
 ATGTCGAGATTTGTACAAG | ATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTC    c.60
 M  S  R  F  V  Q  D |   L  S  K  A  M  S  Q  D  G  A  S  Q  F      p.20

          .         .         .         .         .         .       g.20443
 CAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTC       c.120
 Q  E  V  I  R  Q  E  L  E  L  S  V  K  K  E  L  E  K  I  L         p.40

          .         .        | 03.         .         .         .    g.21898
 ACCACAGCATCATCACATGAATTTGAG | CACACCAAAAAAGACCTGGATGGATTTCGGAAG    c.180
 T  T  A  S  S  H  E  F  E   | H  T  K  K  D  L  D  G  F  R  K      p.60

          .         .         .         .         .         .       g.21958
 CTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGA       c.240
 L  F  H  R  F  L  Q  E  K  G  P  S  V  D  W  G  K  I  Q  R         p.80

          .      | 04  .         .         .         .         .    g.46547
 CCCCCTGAAGATTCG | ATTCAACCCTATGAAAAGATAAAGGCCAGGGGCTTGCCTGATAAT    c.300
 P  P  E  D  S   | I  Q  P  Y  E  K  I  K  A  R  G  L  P  D  N      p.100

          .         .         .         .         .         .       g.46607
 ATATCTTCCGTGTTGAACAAACTAGTGGTGGTGAAACTCAATGGTGGTTTGGGAACCAGC       c.360
 I  S  S  V  L  N  K  L  V  V  V  K  L  N  G  G  L  G  T  S         p.120

          .         .         .         .         .         .       g.46667
 ATGGGCTGCAAAGGCCCTAAAAGTCTGATTGGTGTGAGGAATGAGAATACCTTTCTGGAT       c.420
 M  G  C  K  G  P  K  S  L  I  G  V  R  N  E  N  T  F  L  D         p.140

          .         .  | 05      .         .         .         .    g.48035
 CTGACTGTTCAGCAAATTGAA | CATTTGAATAAAACCTACAATACAGATGTTCCTCTTGTT    c.480
 L  T  V  Q  Q  I  E   | H  L  N  K  T  Y  N  T  D  V  P  L  V      p.160

          .         .         .         .         .         .       g.48095
 TTAATGAACTCTTTTAACACGGATGAAGATACCAAAAAAATACTACAGAAGTACAATCAT       c.540
 L  M  N  S  F  N  T  D  E  D  T  K  K  I  L  Q  K  Y  N  H         p.180

          .         .         .      | 06  .         .         .    g.49650
 TGTCGTGTGAAAATCTACACTTTCAATCAAAGCAG | GTACCCGAGGATTAATAAAGAATCT    c.600
 C  R  V  K  I  Y  T  F  N  Q  S  R  |  Y  P  R  I  N  K  E  S      p.200

          .         .         .         .         .         .       g.49710
 TTACTTCCTGTAGCAAAGGACGTGTCTTACTCAGGGGAAAATACAGAAGCTTGGTACCCT       c.660
 L  L  P  V  A  K  D  V  S  Y  S  G  E  N  T  E  A  W  Y  P         p.220

          .         .         .         .         .         .       g.49770
 CCAGGTCATGGTGATATTTACGCCAGTTTCTACAACTCTGGATTGCTTGATACCTTTATA       c.720
 P  G  H  G  D  I  Y  A  S  F  Y  N  S  G  L  L  D  T  F  I         p.240

          .         .         .         .         .         .       g.49830
 GGAGAAGGCAAAGAGTATATTTTTGTGTCTAACATAGATAATCTGGGTGCCACAGTGGAT       c.780
 G  E  G  K  E  Y  I  F  V  S  N  I  D  N  L  G  A  T  V  D         p.260

          .         .         .         .         .         .       g.49890
 CTGTATATTCTTAATCATCTAATGAACCCACCCAATGGAAAACGCTGTGAATTTGTCATG       c.840
 L  Y  I  L  N  H  L  M  N  P  P  N  G  K  R  C  E  F  V  M         p.280

          .         .         .    | 07    .         .         .    g.50404
 GAAGTCACAAATAAAACACGTGCAGATGTAAAG | GGCGGGACACTCACTCAATATGAAGGC    c.900
 E  V  T  N  K  T  R  A  D  V  K   | G  G  T  L  T  Q  Y  E  G      p.300

          .         .         .         .         .         .       g.50464
 AAACTGAGACTGGTGGAAATTGCTCAAGTGCCAAAAGCACATGTAGACGAGTTCAAGTCT       c.960
 K  L  R  L  V  E  I  A  Q  V  P  K  A  H  V  D  E  F  K  S         p.320

          .         .         .         .         .         .       g.50524
 GTATCAAAGTTCAAAATATTTAATACAAACAACCTATGGATTTCTCTTGCAGCAGTTAAA       c.1020
 V  S  K  F  K  I  F  N  T  N  N  L  W  I  S  L  A  A  V  K         p.340

          .         .         .         .         .  | 08      .    g.51447
 AGACTGCAGGAGCAAAATGCCATTGACATGGAAATCATTGTGAATGCAAAG | ACTTTGGAT    c.1080
 R  L  Q  E  Q  N  A  I  D  M  E  I  I  V  N  A  K   | T  L  D      p.360

          .         .         .         .         .         .       g.51507
 GGAGGCCTGAATGTCATTCAATTAGAAACTGCAGTAGGGGCTGCCATCAAAAGTTTTGAG       c.1140
 G  G  L  N  V  I  Q  L  E  T  A  V  G  A  A  I  K  S  F  E         p.380

          .         .         .         .         .         .       g.51567
 AATTCTCTAGGTATTAATGTGCCAAGGAGCCGTTTTCTGCCTGTCAAAACCACATCAGAT       c.1200
 N  S  L  G  I  N  V  P  R  S  R  F  L  P  V  K  T  T  S  D         p.400

          .         .         .         .         .         .       g.51627
 CTCTTGCTGGTGATGTCAAACCTCTATAGTCTTAATGCAGGATCTCTGACAATGAGTGAA       c.1260
 L  L  L  V  M  S  N  L  Y  S  L  N  A  G  S  L  T  M  S  E         p.420

          .         .         .         .         .     | 09   .    g.54123
 AAGCGGGAATTTCCTACAGTGCCCTTGGTTAAATTAGGCAGTTCTTTTACGAAG | GTTCAA    c.1320
 K  R  E  F  P  T  V  P  L  V  K  L  G  S  S  F  T  K   | V  Q      p.440

          .         .         .         .         .         .       g.54183
 GATTATCTAAGAAGATTTGAAAGTATACCAGATATGCTTGAATTGGATCACCTCACAGTT       c.1380
 D  Y  L  R  R  F  E  S  I  P  D  M  L  E  L  D  H  L  T  V         p.460

          .         .         .          | 10        .         .    g.55177
 TCAGGAGATGTGACATTTGGAAAAAATGTTTCATTAAAG | GGAACGGTTATCATCATTGCA    c.1440
 S  G  D  V  T  F  G  K  N  V  S  L  K   | G  T  V  I  I  I  A      p.480

          .         .         .         .         .         .       g.55237
 AATCATGGTGACAGAATTGATATCCCACCTGGAGCAGTATTAGAGAACAAGATTGTGTCT       c.1500
 N  H  G  D  R  I  D  I  P  P  G  A  V  L  E  N  K  I  V  S         p.500

          .         .                                               g.55264
 GGAAACCTTCGCATCTTGGACCACTGA                                        c.1527
 G  N  L  R  I  L  D  H  X                                          p.508

          .         .         .         .         .         .       g.55324
 aatgaaaaatactgtggacacttaaataatgggctagtttcttacaatgaaatgttctct       c.*60

          .         .         .         .         .         .       g.55384
 aggattctaaaataggcaggtactttactatgttactgtaccctgcagtgttgattttta       c.*120

          .         .         .         .         .         .       g.55444
 aaatagagttttctgcagtatgcttttagtctaagaaaagcacagatggagcaatacttt       c.*180

          .         .         .         .         .         .       g.55504
 ccttctttgaagagaatcccaaaagttagttcatcttaaagtgcaatattgtttaatctt       c.*240

          .         .         .         .         .         .       g.55564
 aaaactgggcaactttggaagaacttttaacagaagcctcaatgatgatcactttgaatt       c.*300

          .         .         .                                     g.55599
 gcttgtgatttcaaaaataaagcagtgaagcaata                                c.*335

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The UDP-glucose pyrophosphorylase 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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