UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) - coding DNA reference sequence

(used for variant description)

(last modified May 1, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000463.2 in the UGT1A1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033238.1, covering UGT1A1 transcript NM_000463.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              aggagcaaaggcgcc       c.-1

          .         .         .         .         .         .       g.5075
 ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG       c.60
 M  A  V  E  S  Q  G  G  R  P  L  V  L  G  L  L  L  C  V  L         p.20

          .         .         .         .         .         .       g.5135
 GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG       c.120
 G  P  V  V  S  H  A  G  K  I  L  L  I  P  V  D  G  S  H  W         p.40

          .         .         .         .         .         .       g.5195
 CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA       c.180
 L  S  M  L  G  A  I  Q  Q  L  Q  Q  R  G  H  E  I  V  V  L         p.60

          .         .         .         .         .         .       g.5255
 GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT       c.240
 A  P  D  A  S  L  Y  I  R  D  G  A  F  Y  T  L  K  T  Y  P         p.80

          .         .         .         .         .         .       g.5315
 GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT       c.300
 V  P  F  Q  R  E  D  V  K  E  S  F  V  S  L  G  H  N  V  F         p.100

          .         .         .         .         .         .       g.5375
 GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT       c.360
 E  N  D  S  F  L  Q  R  V  I  K  T  Y  K  K  I  K  K  D  S         p.120

          .         .         .         .         .         .       g.5435
 GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG       c.420
 A  M  L  L  S  G  C  S  H  L  L  H  N  K  E  L  M  A  S  L         p.140

          .         .         .         .         .         .       g.5495
 GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG       c.480
 A  E  S  S  F  D  V  M  L  T  D  P  F  L  P  C  S  P  I  V         p.160

          .         .         .         .         .         .       g.5555
 GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA       c.540
 A  Q  Y  L  S  L  P  T  V  F  F  L  H  A  L  P  C  S  L  E         p.180

          .         .         .         .         .         .       g.5615
 TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT       c.600
 F  E  A  T  Q  C  P  N  P  F  S  Y  V  P  R  P  L  S  S  H         p.200

          .         .         .         .         .         .       g.5675
 TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC       c.660
 S  D  H  M  T  F  L  Q  R  V  K  N  M  L  I  A  F  S  Q  N         p.220

          .         .         .         .         .         .       g.5735
 TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA       c.720
 F  L  C  D  V  V  Y  S  P  Y  A  T  L  A  S  E  F  L  Q  R         p.240

          .         .         .         .         .         .       g.5795
 GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT       c.780
 E  V  T  V  Q  D  L  L  S  S  A  S  V  W  L  F  R  S  D  F         p.260

          .         .         .         .         .         .       g.5855
 GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC       c.840
 V  K  D  Y  P  R  P  I  M  P  N  M  V  F  V  G  G  I  N  C         p.280

          .         .     | 02   .         .         .         .    g.11797
 CTTCACCAAAATCCACTATCCCAG | GAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT    c.900
 L  H  Q  N  P  L  S  Q   | E  F  E  A  Y  I  N  A  S  G  E  H      p.300

          .         .         .         .         .         .       g.11857
 GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG       c.960
 G  I  V  V  F  S  L  G  S  M  V  S  E  I  P  E  K  K  A  M         p.320

          .         .         .       | 03 .         .         .    g.12600
 GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACA | GTCCTGTGGCGGTACACTGGAACC    c.1020
 A  I  A  D  A  L  G  K  I  P  Q  T   | V  L  W  R  Y  T  G  T      p.340

          .         .         .         .         .         .       g.12660
 CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG       c.1080
 R  P  S  N  L  A  N  N  T  I  L  V  K  W  L  P  Q  N  D  L         p.360

      | 04   .         .         .         .         .         .    g.13003
 CTTG | GTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA    c.1140
 L  G |   H  P  M  T  R  A  F  I  T  H  A  G  S  H  G  V  Y  E      p.380

          .         .         .         .         .         .       g.13063
 AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT       c.1200
 S  I  C  N  G  V  P  M  V  M  M  P  L  F  G  D  Q  M  D  N         p.400

          .         .         .         .         .         .       g.13123
 GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT       c.1260
 A  K  R  M  E  T  K  G  A  G  V  T  L  N  V  L  E  M  T  S         p.420

          .         .         .         .     | 05   .         .    g.17005
 GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAG | TTACAAGGAGAACATC    c.1320
 E  D  L  E  N  A  L  K  A  V  I  N  D  K  S  |  Y  K  E  N  I      p.440

          .         .         .         .         .         .       g.17065
 ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC       c.1380
 M  R  L  S  S  L  H  K  D  R  P  V  E  P  L  D  L  A  V  F         p.460

          .         .         .         .         .         .       g.17125
 TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC       c.1440
 W  V  E  F  V  M  R  H  K  G  A  P  H  L  R  P  A  A  H  D         p.480

          .         .         .         .         .         .       g.17185
 CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG       c.1500
 L  T  W  Y  Q  Y  H  S  L  D  V  I  G  F  L  L  A  V  V  L         p.500

          .         .         .         .         .         .       g.17245
 ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA       c.1560
 T  V  A  F  I  T  F  K  C  C  A  Y  G  Y  R  K  C  L  G  K         p.520

          .         .         .         .                           g.17287
 AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA                         c.1602
 K  G  R  V  K  K  A  H  K  S  K  T  H  X                           p.533

          .         .         .         .         .         .       g.17347
 gaagtgggtgggaaataaggtaaaattttgaaccattccctagtcatttccaaacttgaa       c.*60

          .         .         .         .         .         .       g.17407
 aacagaatcagtgttaaattcattttattcttattaaggaaatactttgcataaattaat       c.*120

          .         .         .         .         .         .       g.17467
 cagccccagagtgctttaaaaaattctcttaaataaaaataatagactcgctagtcagta       c.*180

          .         .         .         .         .         .       g.17527
 aagatatttgaatatgtatcgtgccccctctggtgtctttgatcaggatgacatgtgcca       c.*240

          .         .         .         .         .         .       g.17587
 tttttcagaggacgtgcagacaggctggcattctagattacttttcttactctgaaacat       c.*300

          .         .         .         .         .         .       g.17647
 ggcctgtttgggagtgcgggattcaaaggtggtcccacggctgcccctactgcaaatggc       c.*360

          .         .         .         .         .         .       g.17707
 agttttaatcttatcttttggcttctgcagatggttgcaattgatccttaaccaataatg       c.*420

          .         .         .         .         .         .       g.17767
 gtcagtcctcatctctgtcgtgcttcataggtgccaccttgtgtgtttaaagaagggaag       c.*480

          .         .         .         .         .         .       g.17827
 ctttgtacctttagagtgtaggtgaaatgaatgaatggcttggagtgcactgagaacagc       c.*540

          .         .         .         .         .         .       g.17887
 atatgatttcttgctttggggaaaaagaatgatgctatgaaattggtgggtggtgtattt       c.*600

          .         .         .         .         .         .       g.17947
 gagaagataatcattgcttatgtcaaatggagctgaatttgataaaaacccaaaatacag       c.*660

          .         .         .         .         .         .       g.18007
 ctatgaagtgctgggcaagtttactttttttctgatgtttcctacaactaaaaataaatt       c.*720

          .         .                                               g.18027
 aataaatttatataaattct                                               c.*740

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The UDP glucuronosyltransferase 1 family, polypeptide A1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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