unc-13 homolog D (C. elegans) (UNC13D) - coding DNA reference sequence

(used for variant description)

(last modified February 25, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_199242.2 in the UNC13D gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007266.1, covering UNC13D transcript NM_199242.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         gttcagcccagcctgggcac       c.-361

 .         .         .         .         .         .                g.5080
 agcacatggatggggcaggatgctgcccgcctgttctgggcccccccgccccctgctgag       c.-301

 .         .         .         .         .         .                g.5140
 agcgttgtccccttcccagggcctctgtaggagggtggggcggggccaggcctgcccacg       c.-241

 .         .         .         .         .         .                g.5200
 gggtccaccttctgctccagccagaggagggtcctgtagggatcccagctggggaaggtg       c.-181

 .         .         .         .         .         .                g.5260
 cagggggcctgggagactgcctctccgaagcggtgaaaccctcacccttccgtccctccc       c.-121

 .         .         .         .         .         .                g.5320
 agccaccctccctaaaacttcccctgacagagggtggcagccccaggctctttgcataat       c.-61

 .         .         .         .         .         .                g.5380
 cctgtggcttcgctgtcttcacccagcaccagcggacagggaagggcagagaaggccacc       c.-1

          .         .         .         .         .         .       g.5440
 ATGGCGACACTCCTCTCCCATCCGCAGCAGCGCCCTCCCTTCTTGCGCCAGGCCATCAAG       c.60
 M  A  T  L  L  S  H  P  Q  Q  R  P  P  F  L  R  Q  A  I  K         p.20

          .         .         .         .         .        | 02.    g.6201
 ATAAGGCGCCGCAGAGTCAGAGATCTACAGGATCCCCCGCCCCAAATGGCCCCGGAG | ATC    c.120
 I  R  R  R  R  V  R  D  L  Q  D  P  P  P  Q  M  A  P  E   | I      p.40

          .         .         .    | 03    .         .         .    g.6478
 CAGCCTCCATCCCACCACTTCTCCCCCGAGCAG | CGGGCCCTGCTCTACGAGGACGCACTC    c.180
 Q  P  P  S  H  H  F  S  P  E  Q   | R  A  L  L  Y  E  D  A  L      p.60

          .         .         .         .         .         .       g.6538
 TACACTGTCTTGCACCGCCTGGGTCATCCTGAGCCCAACCATGTGACGGAGGCCTCTGAG       c.240
 Y  T  V  L  H  R  L  G  H  P  E  P  N  H  V  T  E  A  S  E         p.80

          .         .  | 04      .         .         .         .    g.6683
 CTGCTGCGATACCTGCAGGAG | GCCTTCCACGTGGAGCCCGAGGAGCACCAGCAGACACTG    c.300
 L  L  R  Y  L  Q  E   | A  F  H  V  E  P  E  E  H  Q  Q  T  L      p.100

          .         .  | 05      .         .         .         .    g.6833
 CAGCGGGTCAGGGAGCTTGAG | AAGCCAATATTTTGTCTGAAGGCAACAGTGAAACAGGCC    c.360
 Q  R  V  R  E  L  E   | K  P  I  F  C  L  K  A  T  V  K  Q  A      p.120

          .         .         | 06         .         .         .    g.7136
 AAGGGCATTCTGGGCAAAGATGTCAGTG | GGTTCAGCGACCCCTACTGCCTGCTGGGCATT    c.420
 K  G  I  L  G  K  D  V  S  G |   F  S  D  P  Y  C  L  L  G  I      p.140

          .         .         .         .         .         .       g.7196
 GAGCAGGGGGTAGGTGTGCCAGGGGGCAGCCCCGGGTCCCGGCATCGGCAGAAGGCTGTG       c.480
 E  Q  G  V  G  V  P  G  G  S  P  G  S  R  H  R  Q  K  A  V         p.160

          .         .         .         .         .         .       g.7256
 GTGAGGCACACCATCCCCGAGGAGGAGACCCACCGCACGCAGGTCATCACCCAGACACTC       c.540
 V  R  H  T  I  P  E  E  E  T  H  R  T  Q  V  I  T  Q  T  L         p.180

          .         .          | 07        .         .         .    g.8747
 AACCCCGTCTGGGACGAGACCTTCATCCT | GGAGTTTGAGGACATCACCAATGCGAGCTTT    c.600
 N  P  V  W  D  E  T  F  I  L  |  E  F  E  D  I  T  N  A  S  F      p.200

          .     | 08   .         .         .         .         .    g.8933
 CATCTGGACATGTG | GGACCTGGACACTGTGGAGTCTGTCCGACAGAAGCTTGGGGAGCTC    c.660
 H  L  D  M  W  |  D  L  D  T  V  E  S  V  R  Q  K  L  G  E  L      p.220

          .         .    | 09    .         .         .         .    g.9178
 ACGGATCTGCATGGGCTTCGCAG | GATCTTTAAAGAGGCCCGGAAGGACAAAGGCCAGGAC    c.720
 T  D  L  H  G  L  R  R  |  I  F  K  E  A  R  K  D  K  G  Q  D      p.240

          .         .         .    | 10    .         .         .    g.9415
 GACTTTCTGGGGAACGTGGTTCTGAGGCTGCAG | GACCTGCGCTGCCGAGAGGACCAGTGG    c.780
 D  F  L  G  N  V  V  L  R  L  Q   | D  L  R  C  R  E  D  Q  W      p.260

          .         .         .         .         .         .       g.9475
 TACCCCCTGGAACCCCGCACTGAGACCTACCCAGACCGAGGCCAGTGCCACCTCCAGTTC       c.840
 Y  P  L  E  P  R  T  E  T  Y  P  D  R  G  Q  C  H  L  Q  F         p.280

          .         | 11         .         .         .         .    g.9649
 CAACTCATCCATAAGCGG | AGAGCCACTTCGGCCAGCCGCTCGCAGCCGAGCTACACCGTG    c.900
 Q  L  I  H  K  R   | R  A  T  S  A  S  R  S  Q  P  S  Y  T  V      p.300

          .         .         .         .         .  | 12      .    g.9784
 CACCTCCACCTCCTGCAGCAGCTTGTGTCCCACGAGGTCACCCAGCACGAG | GCGGGAAGC    c.960
 H  L  H  L  L  Q  Q  L  V  S  H  E  V  T  Q  H  E   | A  G  S      p.320

          .         .         .         .         .         .       g.9844
 ACCTCCTGGGACGGGTCGCTGAGTCCCCAGGCTGCCACCGTCCTCTTTCTGCACGCCACA       c.1020
 T  S  W  D  G  S  L  S  P  Q  A  A  T  V  L  F  L  H  A  T         p.340

          .         .         .      | 13  .         .         .    g.12824
 CAGAAGGACCTATCCGACTTCCACCAGTCCATGGC | GCAGTGGCTGGCCTACAGCCGCCTC    c.1080
 Q  K  D  L  S  D  F  H  Q  S  M  A  |  Q  W  L  A  Y  S  R  L      p.360

          .         .         .         .         .         .       g.12884
 TACCAGAGCCTGGAGTTCCCCAGCAGCTGCCTCCTGCACCCCATCACCAGCATCGAGTAC       c.1140
 Y  Q  S  L  E  F  P  S  S  C  L  L  H  P  I  T  S  I  E  Y         p.380

          .         .         .    | 14    .         .         .    g.13048
 CAGTGGATCCAGGGTCGGCTCAAGGCAGAACAG | CAGGAGGAGCTGGCCGCCTCATTCAGC    c.1200
 Q  W  I  Q  G  R  L  K  A  E  Q   | Q  E  E  L  A  A  S  F  S      p.400

          .         .         .         .         .         .       g.13108
 TCCCTGCTGACCTACGGCCTCTCCCTCATCCGGAGGTTCCGCTCTGTCTTCCCCCTCTCT       c.1260
 S  L  L  T  Y  G  L  S  L  I  R  R  F  R  S  V  F  P  L  S         p.420

          .         .         .         | 15         .         .    g.13310
 GTCTCGGACTCCCCAGCCCGGCTGCAGTCTCTTCTCAG | GGTCCTGGTACAGATGTGCAAG    c.1320
 V  S  D  S  P  A  R  L  Q  S  L  L  R  |  V  L  V  Q  M  C  K      p.440

          .         .         .         .         .         .       g.13370
 ATGAAGGCCTTTGGAGAACTGTGCCCCAACACCGCCCCATTGCCCCAGCTGGTGACTGAG       c.1380
 M  K  A  F  G  E  L  C  P  N  T  A  P  L  P  Q  L  V  T  E         p.460

           | 16        .         .         .         .         .    g.13512
 GCCCTGCAG | ACTGGCACCACTGAATGGTTCCACCTGAAGCAGCAGCACCATCAACCCATG    c.1440
 A  L  Q   | T  G  T  T  E  W  F  H  L  K  Q  Q  H  H  Q  P  M      p.480

        | 17 .         .         .         .         .         .    g.13662
 GTGCAG | GGCATCCCGGAGGCAGGCAAGGCCTTGCTGGGCCTGGTACAGGATGTCATTGGC    c.1500
 V  Q   | G  I  P  E  A  G  K  A  L  L  G  L  V  Q  D  V  I  G      p.500

          .         .         .         .     | 18   .         .    g.13827
 GACCTGCACCAGTGCCAGCGCACATGGGACAAGATCTTCCACAA | TACCCTCAAGATCCAC    c.1560
 D  L  H  Q  C  Q  R  T  W  D  K  I  F  H  N  |  T  L  K  I  H      p.520

          .         .         .       | 19 .         .         .    g.13964
 CTCTTCTCCATGGCTTTCCGGGAGCTGCAGTGGCTG | GTGGCCAAGCGGGTGCAGGACCAC    c.1620
 L  F  S  M  A  F  R  E  L  Q  W  L   | V  A  K  R  V  Q  D  H      p.540

          .         .         .         .         .         .       g.14024
 ACGACGGTTGTGGGTGATGTAGTGTCCCCAGAGATGGGCGAGAGTCTGTTCCAGCTCTAC       c.1680
 T  T  V  V  G  D  V  V  S  P  E  M  G  E  S  L  F  Q  L  Y         p.560

          .         .         .         .        | 20.         .    g.14201
 ATCAGCCTCAAGGAGCTCTGCCAGCTGCGCATGAGCTCCTCAGAGAG | GGATGGAGTCCTG    c.1740
 I  S  L  K  E  L  C  Q  L  R  M  S  S  S  E  R  |  D  G  V  L      p.580

          .         .         .         .         .         .       g.14261
 GCCCTGGATAATTTCCACCGCTGGTTCCAGCCGGCCATCCCCTCCTGGCTGCAGAAGACG       c.1800
 A  L  D  N  F  H  R  W  F  Q  P  A  I  P  S  W  L  Q  K  T         p.600

          .         .         .         .         | 21         .    g.14666
 TACAACGAGGCCCTGGCGCGGGTGCAGCGCGCTGTGCAGATGGATGAG | CTGGTGCCCCTG    c.1860
 Y  N  E  A  L  A  R  V  Q  R  A  V  Q  M  D  E   | L  V  P  L      p.620

          .         .         .         .         .         .       g.14726
 GGTGAACTGACCAAGCACAGCACATCAGCGGTGGATCTATCCACCTGCTTTGCCCAGATC       c.1920
 G  E  L  T  K  H  S  T  S  A  V  D  L  S  T  C  F  A  Q  I         p.640

          .         .         .         .         .         .       g.14786
 AGCCACACTGCCCGGCAGCTGGACTGGCCAGACCCAGAGGAGGCCTTCATGATTACCGTC       c.1980
 S  H  T  A  R  Q  L  D  W  P  D  P  E  E  A  F  M  I  T  V         p.660

          .   | 22     .         .         .         .         .    g.15049
 AAGTTTGTGGAG | GACACCTGTCGCCTGGCCCTGGTGTACTGCAGCCTTATAAAGGCCCGG    c.2040
 K  F  V  E   | D  T  C  R  L  A  L  V  Y  C  S  L  I  K  A  R      p.680

          .         .         .         .         .  | 23      .    g.15195
 GCCCGCGAGCTCTCTTCAGGCCAGAAGGACCAAGGCCAGGCAGCCAACATG | CTGTGTGTG    c.2100
 A  R  E  L  S  S  G  Q  K  D  Q  G  Q  A  A  N  M   | L  C  V      p.700

          .         .         .         .         .         .       g.15255
 GTGGTGAATGACATGGAGCAGCTGCGGCTGGTGATCGGCAAGTTGCCCGCCCAGCTGGCA       c.2160
 V  V  N  D  M  E  Q  L  R  L  V  I  G  K  L  P  A  Q  L  A         p.720

          .         .         .         .         .         .       g.15315
 TGGGAGGCCCTGGAGCAGCGGGTAGGGGCCGTGCTGGAGCAGGGGCAGCTGCAGAACACG       c.2220
 W  E  A  L  E  Q  R  V  G  A  V  L  E  Q  G  Q  L  Q  N  T         p.740

          .         .         .         .         .         .       g.15375
 CTGCATGCCCAGCTGCAGAGCGCGCTGGCCGGGCTGGGCCATGAGATCCGCACTGGCGTC       c.2280
 L  H  A  Q  L  Q  S  A  L  A  G  L  G  H  E  I  R  T  G  V         p.760

          .         | 24         .         .         .         .    g.15616
 CGCACCCTGGCCGAGCAG | TTGGAGGTGGGCATCGCCAAGCACATCCAGAAACTGGTGGGC    c.2340
 R  T  L  A  E  Q   | L  E  V  G  I  A  K  H  I  Q  K  L  V  G      p.780

          .         .        | 25.         .         .         .    g.16705
 GTCAGGGAGTCTGTCCTGCCTGAGGAT | GCCATTCTGCCCCTGATGAAGTTCCTGGAGGTG    c.2400
 V  R  E  S  V  L  P  E  D   | A  I  L  P  L  M  K  F  L  E  V      p.800

          .         .         .         .        | 26.         .    g.18382
 GAGCTTTGCTACATGAACACCAACTTGGTGCAGGAGAACTTCAGCAG | CCTCCTGACCCTG    c.2460
 E  L  C  Y  M  N  T  N  L  V  Q  E  N  F  S  S  |  L  L  T  L      p.820

          .         .         .         .         .         .       g.18442
 CTCTGGACCCACACACTCACAGTGCTGGTGGAGGCGGCCGCCTCCCAGCGCAGCTCATCC       c.2520
 L  W  T  H  T  L  T  V  L  V  E  A  A  A  S  Q  R  S  S  S         p.840

          .         .         .    | 27    .         .         .    g.18575
 CTGGCTTCCAACAGGCTGAAGATTGCCCTGCAG | AACCTGGAGATCTGCTTCCACGCTGAG    c.2580
 L  A  S  N  R  L  K  I  A  L  Q   | N  L  E  I  C  F  H  A  E      p.860

          .         .         .         .      | 28  .         .    g.19071
 GGCTGTGGCCTGCCACCCAAGGCCCTGCACACTGCCACCTTCCAG | GCTCTGCAGAGGGAC    c.2640
 G  C  G  L  P  P  K  A  L  H  T  A  T  F  Q   | A  L  Q  R  D      p.880

          .         .         .         .         .         .       g.19131
 CTGGAGCTGCAGGCGGCCTCCAGCCGGGAACTCATCCGGAAGTACTTCTGCAGCCGAATC       c.2700
 L  E  L  Q  A  A  S  S  R  E  L  I  R  K  Y  F  C  S  R  I         p.900

           | 29        .         .         .         .         .    g.19286
 CAGCAGCAG | GCAGAAACCACCTCTGAGGAGCTGGGGGCTGTGACAGTCAAGGCCTCCTAC    c.2760
 Q  Q  Q   | A  E  T  T  S  E  E  L  G  A  V  T  V  K  A  S  Y      p.920

          .         .         .         .         .         .       g.19346
 CGCGCCTCTGAGCAGAAGCTGCGTGTGGAGCTGCTCAGCGCCTCCAGCCTGCTGCCCCTG       c.2820
 R  A  S  E  Q  K  L  R  V  E  L  L  S  A  S  S  L  L  P  L         p.940

          . | 30       .         .         .         .         .    g.19616
 GACTCCAATG | GCTCCAGCGACCCCTTTGTCCAGCTGACCTTGGAGCCCAGGCATGAGTTC    c.2880
 D  S  N  G |   S  S  D  P  F  V  Q  L  T  L  E  P  R  H  E  F      p.960

          .         .         .         .         .         .       g.19676
 CCTGAGCTGGCCGCCCGGGAGACCCAGAAGCACAAGAAGGACCTTCACCCATTGTTTGAT       c.2940
 P  E  L  A  A  R  E  T  Q  K  H  K  K  D  L  H  P  L  F  D         p.980

          .     | 31   .         .         .         .         .    g.20780
 GAGACCTTTGAATT | CCTGGTGCCTGCTGAGCCGTGCCGCAAGGCTGGGGCATGCCTCCTG    c.3000
 E  T  F  E  F  |  L  V  P  A  E  P  C  R  K  A  G  A  C  L  L      p.1000

          .         .         .         .         .         .       g.20840
 CTCACCGTGCTGGACTACGACACGCTGGGGGCCGACGACCTGGAAGGCGAGGCCTTCCTG       c.3060
 L  T  V  L  D  Y  D  T  L  G  A  D  D  L  E  G  E  A  F  L         p.1020

          .         .         .         .         .         .       g.20900
 CCGCTGCGTGAGGTGCCCGGGCTGAGTGGCTCTGAGGAGCCTGGTGAGGTGCCTCAGACC       c.3120
 P  L  R  E  V  P  G  L  S  G  S  E  E  P  G  E  V  P  Q  T         p.1040

          .         .         .  | 32      .         .         .    g.21660
 CGCCTGCCCCTCACGTACCCCGCACCCAACG | GGGACCCAATCCTGCAGCTGCTGGAGGGC    c.3180
 R  L  P  L  T  Y  P  A  P  N  G |   D  P  I  L  Q  L  L  E  G      p.1060

          .         .         .         .         .         .       g.21720
 CGGAAGGGTGACCGAGAAGCCCAGGTCTTTGTGAGGCTGCGGCGGCACCGGGCCAAGCAG       c.3240
 R  K  G  D  R  E  A  Q  V  F  V  R  L  R  R  H  R  A  K  Q         p.1080

          .         .         .                                     g.21753
 GCCTCCCAGCATGCCTTGCGGCCGGCACCGTAG                                  c.3273
 A  S  Q  H  A  L  R  P  A  P  X                                    p.1090

          .         .         .         .         .         .       g.21813
 ccgtagaggtttgcggtggggctgggtccccggtggggacttgcaagggctttcctgtag       c.*60

          .         .         .         .         .         .       g.21873
 ggtctggggcttccccgccacatcgcggccctccagcctggcctaacacttggggagccc       c.*120

          .         .         .         .         .         .       g.21933
 cagcatgcggagtgcccagagtgcagacctcccctgcctcccatggtgatgggggctcag       c.*180

          .         .         .         .         .         .       g.21993
 cagcgacatctctactcccgcctccctgcctccagccctggctgcaatgtctctaccaca       c.*240

          .         .         .         .         .         .       g.22053
 tcccagcaccagggggagcaaaccctgcccctgcccgcctctcagaaaagctgctgtggt       c.*300

          .         .         .         .         .         .       g.22113
 gggcaggggattgggccatctgtctcctggccctggcccatctgcctcctggccttcctg       c.*360

          .         .         .         .         .         .       g.22173
 ttccagccactggggtgggggccaggttcactgggaccagggctacaggcacagagtctc       c.*420

          .         .         .         .         .         .       g.22233
 ctggaaaagggagaggggaccctgccaaagatgaggctccagctgccctggggggagggt       c.*480

          .         .         .         .         .         .       g.22293
 ggtggccattactagagggggcctgggtcctctccccaggggctgccagcatccaggcca       c.*540

          .         .         .         .         .         .       g.22353
 ggaagcctggagccaagaaccttctggctctgagggagcaagagctggcaggcggcaggg       c.*600

          .         .         .         .         .         .       g.22413
 ctggcacagacagacggaagcagaaaggacagtttggctgctgtgtctgctgcgcacgcc       c.*660

          .         .         .         .         .         .       g.22473
 ccctccccggacagcacctgccacctagaaactttcttagcaaaaaaattaataaaaaca       c.*720

          .         .                                               g.22493
 aatccattgtcctcttaaaa                                               c.*740

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Unc-13 homolog D (C. elegans) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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