unc-45 homolog A (C. elegans) (UNC45A) - coding DNA reference sequence

(used for variant description)

(last modified March 24, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001039675.1 in the UNC45A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering UNC45A transcript NM_001039675.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5055
      acttaacaaccgaagtaacccgcaatgcggaagggcgaggggattgcgagtcacc       c.-781

 .         .         . | 02       .         .         .             g.8836
 gagtttcccgcgcggcttgag | tcacggcctagaaagagagatgttggggttcccaggacc    c.-721

 .         .         .         .         .         .                g.8896
 aggacagaggtggtagtgaactctcatgggcatccagagaaggtcaggccccttgctgac       c.-661

 .         .         .         .         .         .                g.8956
 aggcctatctgtggggctactgctgctcttcagctgggtgacccttgtccagccaacctc       c.-601

 .        | 03.         .         .         .         .             g.9211
 tctctcag | ctctggtccaccaccctcacttgtgccagaccacccgggatgtccatggccg    c.-541

 .         .         .         .         .         .                g.9271
 tcactaccctggtttcttttgccctcgtctgtctgattctccagaggaagcctactgctg       c.-481

 .         .         .         .         .         .                g.9331
 ccacctgcaggctgcagggggctcctgctgcacccgggctgaatttgaggccctgtacca       c.-421

 .         .         .         .         | 04         .             g.9785
 agtcaatctgtccgctcttccgcccccgcccatcctcag | gggcccaggcccgctcctagt    c.-361

 .         .         .         .         .         .                g.9845
 gctgggcctctacaacctactggttgtgaccctgatgaccgtagacctcgtgcacttctg       c.-301

 .         .         .         .         .         .                g.9905
 ctgcggtcggggccggagtctgggctggagccaccgcaggcctccctctgggtcctccgc       c.-241

 .         .         .         .         .         .                g.9965
 cgcgagctccctgcaggtctctgcggggacagcttaggtgcgcccggagcttgcctgcac       c.-181

 .         .         .         .         .         .                g.10025
 ctgcgatccagagccaagcgccccgcccctgcccgggcgcgctccctccttagccctgcc       c.-121

 .         .         .         .         .         .                g.10085
 cctctctgaccccacctccgacgcaagagtggggcggggcagctgccggtggcgtcccga       c.-61

 .         .         .         .         .         .                g.10145
 acccagactcgccccgccccagagactgcgcctgcgcgggcacgagacaacctctccgcg       c.-1

        | 05 .         .         .         .         .         .    g.10418
 ATGACT | GCCAGCTCAGTGGAGCAGCTGCGGAAGGAGGGCAATGAGCTGTTCAAATGTGGA    c.60
 M  T   | A  S  S  V  E  Q  L  R  K  E  G  N  E  L  F  K  C  G      p.20

          .         .         .         .         .         .       g.10478
 GACTACGGGGGCGCCCTGGCGGCCTACACTCAGGCCCTGGGTCTGGACGCGACGCCCCAG       c.120
 D  Y  G  G  A  L  A  A  Y  T  Q  A  L  G  L  D  A  T  P  Q         p.40

          .         .         .         .         | 06         .    g.10778
 GACCAGGCCGTTCTGCACCGGAACCGGGCCGCCTGCCACCTCAAGCTG | GAAGATTACGAC    c.180
 D  Q  A  V  L  H  R  N  R  A  A  C  H  L  K  L   | E  D  Y  D      p.60

          .         .      | 07  .         .         .         .    g.11140
 AAAGCAGAAACAGAGGCATCCAAAG | CCATTGAAAAGGATGGTGGGGATGTCAAAGCACTC    c.240
 K  A  E  T  E  A  S  K  A |   I  E  K  D  G  G  D  V  K  A  L      p.80

          .         .         .         .         .         .       g.11200
 TACCGGCGGAGCCAAGCCCTAGAGAAGCTGGGCCGCCTGGACCAGGCTGTCCTTGACCTG       c.300
 Y  R  R  S  Q  A  L  E  K  L  G  R  L  D  Q  A  V  L  D  L         p.100

          .         .         .         .         .         .       g.11260
 CAGAGATGTGTGAGCTTGGAGCCCAAGAACAAAGTTTTCCAGGAGGCCTTGCGGAACATC       c.360
 Q  R  C  V  S  L  E  P  K  N  K  V  F  Q  E  A  L  R  N  I         p.120

          .         .  | 08      .         .         .         .    g.14590
 GGGGGCCAGATTCAGGAGAAG | GTGCGATACATGTCCTCGACGGATGCCAAAGTGGAACAG    c.420
 G  G  Q  I  Q  E  K   | V  R  Y  M  S  S  T  D  A  K  V  E  Q      p.140

          .         .         .         .         .     | 09   .    g.15132
 ATGTTTCAGATACTGTTGGACCCAGAAGAGAAGGGCACTGAGAAAAAGCAAAAG | GCTTCT    c.480
 M  F  Q  I  L  L  D  P  E  E  K  G  T  E  K  K  Q  K   | A  S      p.160

          .         .         .         .         .         .       g.15192
 CAGAACCTGGTGGTGCTGGCCAGGGAGGATGCTGGAGCGGAGAAGATCTTCCGGAGTAAT       c.540
 Q  N  L  V  V  L  A  R  E  D  A  G  A  E  K  I  F  R  S  N         p.180

          .         .         .         .         .         .       g.15252
 GGGGTTCAGCTCTTGCAACGTTTACTGGACATGGGAGAGACTGACCTCATGCTGGCGGCT       c.600
 G  V  Q  L  L  Q  R  L  L  D  M  G  E  T  D  L  M  L  A  A         p.200

          .         .         .         .   | 10     .         .    g.17275
 CTGCGTACGCTGGTTGGCATTTGCTCTGAGCATCAGTCACGG | ACAGTGGCAACCCTGAGC    c.660
 L  R  T  L  V  G  I  C  S  E  H  Q  S  R   | T  V  A  T  L  S      p.220

          .         .         .         .         .         .       g.17335
 ATACTGGGAACTCGGCGAGTAGTCTCCATCCTGGGCGTGGAAAGCCAGGCTGTGTCCCTG       c.720
 I  L  G  T  R  R  V  V  S  I  L  G  V  E  S  Q  A  V  S  L         p.240

          .         .         .         .         .         .       g.17395
 GCTGCCTGCCACCTGCTGCAGGTTATGTTTGATGCCCTCAAGGAAGGTGTCAAAAAAGGC       c.780
 A  A  C  H  L  L  Q  V  M  F  D  A  L  K  E  G  V  K  K  G         p.260

          .         .         .  | 11      .         .         .    g.17761
 TTCCGAGGCAAAGAAGGTGCCATCATTGTGG | ATCCTGCCCGGGAGCTGAAGGTCCTCATC    c.840
 F  R  G  K  E  G  A  I  I  V  D |   P  A  R  E  L  K  V  L  I      p.280

          .         .         .         .         .         .       g.17821
 AGTAACCTCTTAGATCTGCTGACAGAGGTGGGGGTCTCTGGCCAAGGCCGAGACAATGCC       c.900
 S  N  L  L  D  L  L  T  E  V  G  V  S  G  Q  G  R  D  N  A         p.300

          .         .         .         .         .         .       g.17881
 CTGACCCTCCTGATTAAAGCGGTGCCCCGGAAGTCTCTCAAGGACCCCAACAACAGCCTC       c.960
 L  T  L  L  I  K  A  V  P  R  K  S  L  K  D  P  N  N  S  L         p.320

          .         .   | 12     .         .         .         .    g.19750
 ACCCTCTGGGTCATCGACCAAG | GTCTGAAAAAGATTTTGGAAGTGGGGGGCTCTCTACAG    c.1020
 T  L  W  V  I  D  Q  G |   L  K  K  I  L  E  V  G  G  S  L  Q      p.340

          .         .         .         .         .         .       g.19810
 GACCCTCCTGGGGAGCTCGCAGTGACCGCAAACAGCCGCATGAGCGCCTCTATTCTCCTC       c.1080
 D  P  P  G  E  L  A  V  T  A  N  S  R  M  S  A  S  I  L  L         p.360

          .         .         .         .         .         .       g.19870
 AGCAAGCTCTTTGATGACCTCAAGTGTGATGCGGAGAGGGAGAATTTCCACAGACTTTGT       c.1140
 S  K  L  F  D  D  L  K  C  D  A  E  R  E  N  F  H  R  L  C         p.380

          .     | 13   .         .         .         .         .    g.21480
 GAAAACTACATCAA | GAGCTGGTTTGAGGGCCAAGGGCTGGCCGGGAAGCTACGGGCCATC    c.1200
 E  N  Y  I  K  |  S  W  F  E  G  Q  G  L  A  G  K  L  R  A  I      p.400

          .         .         .         .         .         .       g.21540
 CAGACGGTGTCCTGCCTCCTGCAGGGCCCATGTGACGCTGGCAACCGGGCCTTGGAGCTG       c.1260
 Q  T  V  S  C  L  L  Q  G  P  C  D  A  G  N  R  A  L  E  L         p.420

          .         .         .         .         .         .       g.21600
 AGCGGTGTCATGGAGAGTGTGATTGCTCTGTGTGCCTCTGAGCAGGAGGAGGAGCAGCTG       c.1320
 S  G  V  M  E  S  V  I  A  L  C  A  S  E  Q  E  E  E  Q  L         p.440

          .         .         .         .         .         .       g.21660
 GTGGCCGTGGAGGCTCTGATCCATGCAGCCGGCAAGGCTAAGCGGGCCTCATTCATCACT       c.1380
 V  A  V  E  A  L  I  H  A  A  G  K  A  K  R  A  S  F  I  T         p.460

          .         .         .         .         .         .       g.21720
 GCCAATGGTGTCTCGCTGCTGAAGGACCTATATAAGTGCAGCGAGAAGGACAGCATCCGC       c.1440
 A  N  G  V  S  L  L  K  D  L  Y  K  C  S  E  K  D  S  I  R         p.480

          .      | 14  .         .         .         .         .    g.22661
 ATCCGGGCGCTAGTG | GGACTCTGTAAGCTCGGTTCGGCTGGAGGGACTGACTTCAGCATG    c.1500
 I  R  A  L  V   | G  L  C  K  L  G  S  A  G  G  T  D  F  S  M      p.500

          .         .         .         .         . | 15       .    g.22972
 AAGCAGTTTGCTGAAGGCTCCACTCTCAAACTGGCTAAGCAGTGTCGAAA | GTGGCTGTGC    c.1560
 K  Q  F  A  E  G  S  T  L  K  L  A  K  Q  C  R  K  |  W  L  C      p.520

          .         .         .         .         .         .       g.23032
 AATGACCAGATCGACGCAGGCACTCGGCGCTGGGCAGTGGAGGGCCTGGCTTACCTGACC       c.1620
 N  D  Q  I  D  A  G  T  R  R  W  A  V  E  G  L  A  Y  L  T         p.540

          .         .         .         .         .         .       g.23092
 TTTGATGCCGACGTGAAGGAAGAGTTTGTGGAGGATGCGGCTGCTCTGAAAGCTCTGTTC       c.1680
 F  D  A  D  V  K  E  E  F  V  E  D  A  A  A  L  K  A  L  F         p.560

          .   | 16     .         .         .         .         .    g.23522
 CAGCTCAGCAGG | TTGGAGGAGAGGTCAGTGCTCTTTGCGGTGGCCTCAGCGCTGGTGAAC    c.1740
 Q  L  S  R   | L  E  E  R  S  V  L  F  A  V  A  S  A  L  V  N      p.580

          .         .         .         .         .         .       g.23582
 TGCACCAACAGCTATGACTACGAGGAGCCCGACCCCAAGATGGTGGAGCTGGCCAAGTAT       c.1800
 C  T  N  S  Y  D  Y  E  E  P  D  P  K  M  V  E  L  A  K  Y         p.600

          .         .         .    | 17    .         .         .    g.24163
 GCCAAGCAGCATGTGCCCGAGCAGCACCCCAAG | GACAAGCCAAGCTTCGTGCGGGCTCGG    c.1860
 A  K  Q  H  V  P  E  Q  H  P  K   | D  K  P  S  F  V  R  A  R      p.620

          .         .         .         .         .         .       g.24223
 GTGAAGAAGCTGCTGGCAGCGGGTGTGGTGTCGGCCATGGTGTGCATGGTGAAGACGGAG       c.1920
 V  K  K  L  L  A  A  G  V  V  S  A  M  V  C  M  V  K  T  E         p.640

          .         .         .         .  | 18      .         .    g.24493
 AGCCCTGTGCTGACCAGTTCCTGCAGAGAGCTGCTCTCCAG | GGTCTTCTTGGCTTTAGTG    c.1980
 S  P  V  L  T  S  S  C  R  E  L  L  S  R  |  V  F  L  A  L  V      p.660

          .         .         .         .         | 19         .    g.24986
 GAAGAGGTAGAGGACCGAGGCACTGTGGTTGCCCAGGGAGGCGGCAGG | GCGCTGATCCCG    c.2040
 E  E  V  E  D  R  G  T  V  V  A  Q  G  G  G  R   | A  L  I  P      p.680

          .         .         .         .         .         .       g.25046
 CTGGCCCTGGAAGGCACGGACGTGGGGCAGACAAAGGCAGCCCAGGCCCTTGCCAAGCTC       c.2100
 L  A  L  E  G  T  D  V  G  Q  T  K  A  A  Q  A  L  A  K  L         p.700

          .         .         .         .   | 20     .         .    g.25338
 ACCATCACCTCCAACCCGGAGATGACCTTCCCTGGCGAGCGG | ATCTATGAGGTGGTCCGG    c.2160
 T  I  T  S  N  P  E  M  T  F  P  G  E  R   | I  Y  E  V  V  R      p.720

          .         .         .         .         .         .       g.25398
 CCCCTCGTCTCCCTGTTGCACCTCAACTGCTCAGGCCTGCAGAACTTCGAGGCGCTCATG       c.2220
 P  L  V  S  L  L  H  L  N  C  S  G  L  Q  N  F  E  A  L  M         p.740

          .         .         .         | 21         .         .    g.27771
 GCCCTAACAAACCTGGCTGGGATCAGCGAGAGGCTCCG | GCAGAAGATCCTGAAGGAGAAG    c.2280
 A  L  T  N  L  A  G  I  S  E  R  L  R  |  Q  K  I  L  K  E  K      p.760

          .         .         .         .         .         .       g.27831
 GCTGTGCCCATGATAGAAGGCTACATGTTTGAGGAGCATGAGATGATCCGCCGGGCAGCC       c.2340
 A  V  P  M  I  E  G  Y  M  F  E  E  H  E  M  I  R  R  A  A         p.780

          .         .         .       | 22 .         .         .    g.27999
 ACGGAGTGCATGTGTAACTTGGCCATGAGCAAGGAG | GTGCAGGACCTCTTCGAAGCCCAG    c.2400
 T  E  C  M  C  N  L  A  M  S  K  E   | V  Q  D  L  F  E  A  Q      p.800

          .         .         .         .         .         .       g.28059
 GGCAATGACCGACTGAAGCTGCTGGTGCTGTACAGTGGAGAGGATGATGAGCTGCTACAG       c.2460
 G  N  D  R  L  K  L  L  V  L  Y  S  G  E  D  D  E  L  L  Q         p.820

          .         .         .         .         .         .       g.28119
 CGGGCAGCTGCCGGGGGCTTGGCCATGCTTACCTCCATGCGGCCCACGCTCTGCAGCCGC       c.2520
 R  A  A  A  G  G  L  A  M  L  T  S  M  R  P  T  L  C  S  R         p.840

          .   | 23     .         .         .         .         .    g.28327
 ATTCCCCAAGTG | ACCACACACTGGCTGGAGATCCTGCAGGCCCTGCTTCTGAGCTCCAAC    c.2580
 I  P  Q  V   | T  T  H  W  L  E  I  L  Q  A  L  L  L  S  S  N      p.860

          .         .         .         .         .         .       g.28387
 CAGGAGCTGCAGCACCGGGGTGCTGTGGTGGTGCTGAACATGGTGGAGGCCTCGAGGGAG       c.2640
 Q  E  L  Q  H  R  G  A  V  V  V  L  N  M  V  E  A  S  R  E         p.880

          .         .         .         .         .         .       g.28447
 ATTGCCAGCACCCTGATGGAGAGTGAGATGATGGAGATCTTGTCAGTGCTAGCTAAGGGT       c.2700
 I  A  S  T  L  M  E  S  E  M  M  E  I  L  S  V  L  A  K  G         p.900

          .         .         .         .         .         .       g.28507
 GACCACAGCCCTGTCACAAGGGCTGCTGCAGCCTGCCTGGACAAAGCAGTGGAATATGGG       c.2760
 D  H  S  P  V  T  R  A  A  A  A  C  L  D  K  A  V  E  Y  G         p.920

          .         .         .                                     g.28537
 CTTATCCAACCCAACCAAGATGGAGAGTGA                                     c.2790
 L  I  Q  P  N  Q  D  G  E  X                                       p.929

          .         .         .         .         .         .       g.28597
 gggggttgtccctgggcccaaggctcatgcacacgctacctattgtggcacggagagtaa       c.*60

          .         .         .         .         .         .       g.28657
 ggacggaagcagctttggctggtggtggctggcatgcccaatactcttgcccatcctcgc       c.*120

          .         .         .         .         .         .       g.28717
 ttgctgccctaggatgtcctctgttctgagtcagcggccacgttcagtcacacagccctg       c.*180

          .         .         .         .         .         .       g.28777
 cttggccagcactgcctgcagcctcactcagaggggccctttttctgtactactgtagtc       c.*240

          .         .         .         .         .         .       g.28837
 agctgggaatggggaaggtgcatcccaacacagcctgtggatcctggggcatctggaagg       c.*300

          .         .         .         .         .         .       g.28897
 gcgcacacatcagcagcctcaccagctgtgagcctgctatcaggcctgcccctccaataa       c.*360

          .                                                         g.28914
 aagtgtgtagaactcca                                                  c.*377

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Unc-45 homolog A (C. elegans) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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