unc-45 homolog B (C. elegans) (UNC45B) - coding DNA reference sequence

(used for variant description)

(last modified January 16, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_173167.2 in the UNC45B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering UNC45B transcript NM_173167.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5037
                        agactgaggctggctggctggaggttgacacaggagt       c.-61

 .         .         .         .         .         .       | 02     g.5447
 gctcaggggagcagcatcacaagagggcagatcgaaagcatcgtccttgctgaaaaa | cag    c.-1

          .         .         .         .         .         .       g.5507
 ATGGCAGAGGTGGAAGCGGTACAGCTGAAGGAGGAAGGAAACCGGCATTTCCAGCTCCAG       c.60
 M  A  E  V  E  A  V  Q  L  K  E  E  G  N  R  H  F  Q  L  Q         p.20

          .         .         .         .         .         .       g.5567
 GACTACAAGGCCGCCACAAATAGCTACAGCCAGGCCCTGAAGCTGACCAAGGACAAGGCC       c.120
 D  Y  K  A  A  T  N  S  Y  S  Q  A  L  K  L  T  K  D  K  A         p.40

          .         .         .         .         | 03         .    g.6168
 CTGCTGGCCACGCTTTATCGGAACCGGGCAGCCTGTGGCCTGAAAACG | GAGAGCTACGTC    c.180
 L  L  A  T  L  Y  R  N  R  A  A  C  G  L  K  T   | E  S  Y  V      p.60

          .         .      | 04  .         .         .         .    g.7266
 CAGGCAGCTTCAGATGCCTCCAGAG | CCATCGACATCAACTCCTCGGACATCAAGGCTCTG    c.240
 Q  A  A  S  D  A  S  R  A |   I  D  I  N  S  S  D  I  K  A  L      p.80

          .         .         .         .         .         .       g.7326
 TATCGGCGATGCCAGGCACTGGAGCACCTGGGGAAGCTGGACCAGGCCTTCAAAGACGTG       c.300
 Y  R  R  C  Q  A  L  E  H  L  G  K  L  D  Q  A  F  K  D  V         p.100

          .         .         .         .         .         .       g.7386
 CAGCGTTGTGCCACCCTCGAGCCACGGAACCAGAACTTCCAGGAGATGCTGAGGAGACTC       c.360
 Q  R  C  A  T  L  E  P  R  N  Q  N  F  Q  E  M  L  R  R  L         p.120

          .         .  | 05      .         .         .         .    g.10115
 AACACCAGCATTCAGGAGAAG | CTCCGAGTGCAGTTCTCCACAGACTCGAGGGTACAGAAG    c.420
 N  T  S  I  Q  E  K   | L  R  V  Q  F  S  T  D  S  R  V  Q  K      p.140

          .         .         .         .         .  | 06      .    g.11766
 ATGTTTGAGATCCTCTTGGATGAAAACAGTGAGGCTGATAAGCGGGAAAAG | GCTGCCAAC    c.480
 M  F  E  I  L  L  D  E  N  S  E  A  D  K  R  E  K   | A  A  N      p.160

          .         .         .         .         .         .       g.11826
 AATCTCATTGTCCTAGGCCGTGAGGAAGCAGGGGCTGAGAAGATCTTCCAGAACAATGGA       c.540
 N  L  I  V  L  G  R  E  E  A  G  A  E  K  I  F  Q  N  N  G         p.180

          .         .         .         .         .         .       g.11886
 GTAGCCTTGCTACTGCAGCTTCTGGACACTAAGAAGCCTGAGCTGGTGCTGGCTGCAGTG       c.600
 V  A  L  L  L  Q  L  L  D  T  K  K  P  E  L  V  L  A  A  V         p.200

          .         .         .          | 07        .         .    g.12500
 CGGACCCTGTCGGGCATGTGCAGCGGCCACCAAGCCAGA | GCCACAGTGATTCTGCATGCA    c.660
 R  T  L  S  G  M  C  S  G  H  Q  A  R   | A  T  V  I  L  H  A      p.220

          .         .         .         .         .         .       g.12560
 GTGCGGATAGACCGAATCTGTAGCCTCATGGCCGTGGAGAATGAGGAGATGTCTCTGGCT       c.720
 V  R  I  D  R  I  C  S  L  M  A  V  E  N  E  E  M  S  L  A         p.240

          .         .         .         .         .         .       g.12620
 GTCTGCAACCTGCTCCAAGCCATCATTGACTCCTTGTCTGGGGAGGACAAGCGGGAGCAT       c.780
 V  C  N  L  L  Q  A  I  I  D  S  L  S  G  E  D  K  R  E  H         p.260

          .         .         | 08         .         .         .    g.16590
 CGAGGGAAGGAGGAGGCCCTGGTTCTAG | ACACCAAGAAGGACCTGAAGCAGATCACCAGC    c.840
 R  G  K  E  E  A  L  V  L  D |   T  K  K  D  L  K  Q  I  T  S      p.280

          .         .         .         .         .         .       g.16650
 CACCTGCTGGACATGCTAGTCAGCAAGAAGGTGTCTGGCCAGGGCAGGGATCAGGCGCTG       c.900
 H  L  L  D  M  L  V  S  K  K  V  S  G  Q  G  R  D  Q  A  L         p.300

          .         .         .         .         .         .       g.16710
 AACCTGCTCAATAAGAATGTTCCCAGGAAGGACCTTGCCATTCATGACAACTCACGTACC       c.960
 N  L  L  N  K  N  V  P  R  K  D  L  A  I  H  D  N  S  R  T         p.320

          .          | 09        .         .         .         .    g.21219
 ATCTATGTGGTGGATAATG | GTCTGAGGAAGATCCTGAAGGTTGTGGGGCAGGTTCCAGAT    c.1020
 I  Y  V  V  D  N  G |   L  R  K  I  L  K  V  V  G  Q  V  P  D      p.340

          .         .         .         .         .         .       g.21279
 CTGCCATCCTGCCTGCCCCTGACTGACAACACCCGCATGCTGGCCTCTATCCTCATCAAC       c.1080
 L  P  S  C  L  P  L  T  D  N  T  R  M  L  A  S  I  L  I  N         p.360

          .         .         .         .         .         .       g.21339
 AAGCTCTATGATGACCTGCGCTGTGACCCGGAGCGCGATCACTTCCGCAAGATCTGTGAG       c.1140
 K  L  Y  D  D  L  R  C  D  P  E  R  D  H  F  R  K  I  C  E         p.380

          .  | 10      .         .         .         .         .    g.25293
 GAATATATCAC | GGGCAAGTTTGACCCCCAGGACATGGACAAGAACTTGAATGCCATCCAG    c.1200
 E  Y  I  T  |  G  K  F  D  P  Q  D  M  D  K  N  L  N  A  I  Q      p.400

          .         .         .         .         .         .       g.25353
 ACAGTGTCAGGGATCCTGCAGGGCCCCTTTGACCTGGGCAACCAGCTGCTGGGACTGAAA       c.1260
 T  V  S  G  I  L  Q  G  P  F  D  L  G  N  Q  L  L  G  L  K         p.420

          .         .         .         .         .         .       g.25413
 GGTGTGATGGAGATGATGGTGGCACTATGTGGCTCAGAGCGCGAGACGGACCAGCTGGTG       c.1320
 G  V  M  E  M  M  V  A  L  C  G  S  E  R  E  T  D  Q  L  V         p.440

          .         .         .         .         .         .       g.25473
 GCCGTGGAGGCCCTCATCCATGCCTCCACGAAGCTCAGCCGCGCCACCTTCATCATCACC       c.1380
 A  V  E  A  L  I  H  A  S  T  K  L  S  R  A  T  F  I  I  T         p.460

          .         .         .         .         .         .       g.25533
 AATGGAGTGTCACTGCTCAAACAGATCTACAAGACCACCAAAAATGAGAAGATCAAGATC       c.1440
 N  G  V  S  L  L  K  Q  I  Y  K  T  T  K  N  E  K  I  K  I         p.480

          .   | 11     .         .         .         .         .    g.27068
 CGCACACTGGTG | GGACTCTGTAAGCTCGGCTCTGCAGGTGGCACAGACTACGGTCTCAGG    c.1500
 R  T  L  V   | G  L  C  K  L  G  S  A  G  G  T  D  Y  G  L  R      p.500

          .         .         .         .        | 12.         .    g.27310
 CAGTTTGCGGAAGGGTCGACAGAAAAACTGGCCAAACAGTGTCGCAA | GTGGCTGTGCAAT    c.1560
 Q  F  A  E  G  S  T  E  K  L  A  K  Q  C  R  K  |  W  L  C  N      p.520

          .         .         .         .         .         .       g.27370
 ATGTCCATAGACACTCGGACCCGACGCTGGGCAGTGGAGGGCCTGGCCTACCTCACGCTG       c.1620
 M  S  I  D  T  R  T  R  R  W  A  V  E  G  L  A  Y  L  T  L         p.540

          .         .         .         .         .         .       g.27430
 GACGCTGATGTGAAGGACGACTTTGTCCAGGACGTCCCTGCCCTGCAGGCCATGTTTGAG       c.1680
 D  A  D  V  K  D  D  F  V  Q  D  V  P  A  L  Q  A  M  F  E         p.560

          .      | 13  .         .         .         .         .    g.28550
 CTGGCCAAGGCAGGT | ACCAGTGACAAGACCATCCTGTACTCGGTGGCCACCACCCTGGTG    c.1740
 L  A  K  A  G   | T  S  D  K  T  I  L  Y  S  V  A  T  T  L  V      p.580

          .         .         .         .         .         .       g.28610
 AACTGCACCAACAGCTACGATGTCAAGGAGGTCATCCCAGAGCTTGTCCAGCTCGCCAAG       c.1800
 N  C  T  N  S  Y  D  V  K  E  V  I  P  E  L  V  Q  L  A  K         p.600

          .         .         .       | 14 .         .         .    g.31449
 TTCTCCAAGCAGCATGTGCCCGAGGAACACCCCAAG | GACAAGAAGGACTTTATAGACATG    c.1860
 F  S  K  Q  H  V  P  E  E  H  P  K   | D  K  K  D  F  I  D  M      p.620

          .         .         .         .         .         .       g.31509
 CGGGTGAAGCGGCTTCTGAAGGCGGGTGTCATCTCTGCCCTGGCTTGCATGGTGAAAGCA       c.1920
 R  V  K  R  L  L  K  A  G  V  I  S  A  L  A  C  M  V  K  A         p.640

          .         .         .         .     | 15   .         .    g.33167
 GATAGTGCCATCCTCACTGACCAGACCAAGGAGCTGCTGGCCAG | GGTATTCCTGGCACTG    c.1980
 D  S  A  I  L  T  D  Q  T  K  E  L  L  A  R  |  V  F  L  A  L      p.660

          .         .         .         .         .  | 16      .    g.34209
 TGTGACAACCCAAAGGACCGAGGCACCATTGTGGCTCAAGGTGGTGGCAAG | GCCCTGATT    c.2040
 C  D  N  P  K  D  R  G  T  I  V  A  Q  G  G  G  K   | A  L  I      p.680

          .         .         .         .         .         .       g.34269
 CCCCTGGCTTTGGAGGGCACAGATGTGGGCAAGGTGAAGGCAGCCCACGCTCTAGCAAAG       c.2100
 P  L  A  L  E  G  T  D  V  G  K  V  K  A  A  H  A  L  A  K         p.700

          .         .         .         .      | 17  .         .    g.34693
 ATCGCTGCTGTCTCCAATCCGGACATTGCTTTTCCTGGGGAGCGG | GTGTATGAGGTGGTG    c.2160
 I  A  A  V  S  N  P  D  I  A  F  P  G  E  R   | V  Y  E  V  V      p.720

          .         .         .         .         .         .       g.34753
 CGGCCCCTTGTAAGACTCTTGGACACACAGAGGGATGGGCTTCAGAACTATGAGGCTCTC       c.2220
 R  P  L  V  R  L  L  D  T  Q  R  D  G  L  Q  N  Y  E  A  L         p.740

          .         .         .         .  | 18      .         .    g.37761
 CTAGGCCTCACCAACCTGTCTGGGCGGAGTGACAAACTCCG | GCAGAAGATCTTTAAGGAG    c.2280
 L  G  L  T  N  L  S  G  R  S  D  K  L  R  |  Q  K  I  F  K  E      p.760

          .         .         .         .         .         .       g.37821
 AGGGCCTTGCCAGACATCGAGAACTACATGTTTGAGAATCATGATCAGCTGCGGCAGGCG       c.2340
 R  A  L  P  D  I  E  N  Y  M  F  E  N  H  D  Q  L  R  Q  A         p.780

          .         .         .          | 19        .         .    g.40631
 GCCACCGAGTGCATGTGCAACATGGTGCTCCACAAGGAG | GTACAGGAAAGGTTCTTGGCT    c.2400
 A  T  E  C  M  C  N  M  V  L  H  K  E   | V  Q  E  R  F  L  A      p.800

          .         .         .         .         .         .       g.40691
 GACGGGAATGACCGGCTGAAGCTGGTGGTGCTGCTCTGCGGGGAGGATGATGATAAGGTG       c.2460
 D  G  N  D  R  L  K  L  V  V  L  L  C  G  E  D  D  D  K  V         p.820

          .         .         .         .         .         .       g.40751
 CAGAATGCGGCTGCAGGGGCTCTGGCCATGCTGACAGCAGCACACAAGAAACTGTGCCTC       c.2520
 Q  N  A  A  A  G  A  L  A  M  L  T  A  A  H  K  K  L  C  L         p.840

          .      | 20  .         .         .         .         .    g.43527
 AAGATGACTCAAGTG | ACAACCCAGTGGTTGGAGATCCTCCAGCGGCTTTGCCTGCACGAC    c.2580
 K  M  T  Q  V   | T  T  Q  W  L  E  I  L  Q  R  L  C  L  H  D      p.860

          .         .         .         .         .         .       g.43587
 CAGCTGTCTGTCCAACACCGGGGCCTGGTCATTGCCTACAACCTACTGGCAGCCGATGCT       c.2640
 Q  L  S  V  Q  H  R  G  L  V  I  A  Y  N  L  L  A  A  D  A         p.880

          .         .         .         .         .         .       g.43647
 GAGCTGGCCAAGAAGCTGGTGGAGAGTGAGCTGCTGGAGATCCTGACTGTGGTGGGCAAA       c.2700
 E  L  A  K  K  L  V  E  S  E  L  L  E  I  L  T  V  V  G  K         p.900

          .         .         .         .         .         .       g.43707
 CAGGAGCCAGATGAGAAGAAGGCAGAAGTGGTTCAGACAGCCCGAGAATGTCTCATCAAG       c.2760
 Q  E  P  D  E  K  K  A  E  V  V  Q  T  A  R  E  C  L  I  K         p.920

          .         .         .                                     g.43743
 TGCATGGATTATGGTTTCATTAAACCAGTGTCTTAG                               c.2796
 C  M  D  Y  G  F  I  K  P  V  S  X                                 p.931

          .         .         .         .         .         .       g.43803
 acagcgaccctcagggatgctgggagtggtcctgtactgtgcagagtcctgggttggttg       c.*60

          .         .         .         .         .         .       g.43863
 ggttctcctgaagagtcaggtcatctagggatcatagcagtgacaatgaagtctcaatat       c.*120

          .         .         .         .         .         .       g.43923
 aaaggaaagacttgattgttctctgagttgtgagtcttctcctttgtcctgacagagttt       c.*180

          .         .         .         .         .         .       g.43983
 ggatgtttcactctctctcttgcttcctgtctccttatatttgtcatgtttcagaaattc       c.*240

          .         .         .         .         .         .       g.44043
 ccagaataattttcacccatgattagaaataggttggatcattctttctgtacccattct       c.*300

          .         .         .         .         .         .       g.44103
 gaaggccaggataataggttgaagttctttatattttggaaaatggattttgtggtaagg       c.*360

          .         .         .         .         .         .       g.44163
 taggaactaacgggtgtgtgcatataaaggttaatgctgttgtatttggatgctgatctg       c.*420

          .         .         .         .         .         .       g.44223
 tgctgttttcatgacctctctcccacactatttgaatcagtctgttcagaactgtgtgtt       c.*480

          .         .         .         .         .         .       g.44283
 tcacctgcagtgctctgtcccagtcccatgcccattcccatcacttcactgtgatggaaa       c.*540

          .         .         .         .         .         .       g.44343
 tagagtttatgttcaacagtggggcatgacctctgcaatttgcttgggaaagtcttccaa       c.*600

          .         .         .         .         .         .       g.44403
 gcaagatggacatgatgaatacaaataagatctactcaaagtacttcaaacaaaaaataa       c.*660

          .         .         .         .         .         .       g.44463
 ataattcattggctcatgtatcttggccacccagggaaggtctgacattgttagttagat       c.*720

          .         .         .         .         .         .       g.44523
 ccagagtttcaaatgtcatcaccatggatgtgtctttttctctctctcatttcccctccc       c.*780

          .         .         .         .         .         .       g.44583
 catatcttgtcttttatttattataggtttgtctcattccctggcaggctctctccctgt       c.*840

          .         .         .         .         .         .       g.44643
 gataggaaagagagtccccagcagccccagggtgacatagttgttatagttcattatgga       c.*900

          .         .         .         .         .         .       g.44703
 atagaagagagaagagcattctcaataacccggcaaagttcccagggatgactctgatat       c.*960

          .         .         .         .         .         .       g.44763
 gtctatgtctcaggtcacatttccatctatgaaccaatcatattcagaggtggaatgcta       c.*1020

          .         .         .         .         .         .       g.44823
 attggccaggcctgggtcatatatacaagtctagggaagaaatgagcttcatccctgtcc       c.*1080

          .         .         .         .         .         .       g.44883
 aattgacatggactgattaggggtattaatggaagaggtgtgccaccacaaaagaatgta       c.*1140

          .         .         .         .         .         .       g.44943
 ccctgggcagatcaaagaacatattctgtatgtcaggcttggccacaaaagaatgacaca       c.*1200

          .         .         .         .         .         .       g.45003
 agtaatatgctgtagatcagaacctctctgctaatattgcctttttagcatggttaagat       c.*1260

          .         .         .         .         .         .       g.45063
 agctaagatctagtactgtcactccagtatgtcccaattctacctacgtttattgaaggg       c.*1320

          .         .         .         .         .         .       g.45123
 tcaacagttctgatctcagcattgggtaaagggtgggacattcagatttacggtccttga       c.*1380

          .         .         .         .         .         .       g.45183
 taaaaacaatttacaacgttccgttgtgtaataaatgtaagtgtacatatgcctgggaca       c.*1440

          .         .         .         .         .         .       g.45243
 tcagctggaaaagggacagactatcagagagttgcactgttgcggtatgggccaaatcca       c.*1500

          .         .         .         .         .         .       g.45303
 acataatacccgctgtacctctagagaactaaaaccttaatttctcagatcttttctgca       c.*1560

          .         .         .         .         .         .       g.45363
 ctaatggtctttacatacagcctacattttaactaactcttgcatgggcttgtttcacag       c.*1620

          .         .         .         .         .         .       g.45423
 caggaaactatattcatcatatccttattatgatagagaatgacaacattcaaaagggtg       c.*1680

          .         .         .         .         .         .       g.45483
 tggtgcttctgaaaatatacacaataaatggcatgatttgacctctgtcaaattcttctt       c.*1740

          .         .         .         .         .         .       g.45543
 tcctgctttcctcatatgtgggcttgagtgggtgtatttagctcctttaaaggaaactct       c.*1800

          .         .         .         .         .         .       g.45603
 ttcacaggcagggccacactcttactcgttttgatctcatgaggttacatctgccagtgg       c.*1860

          .         .         .         .         .         .       g.45663
 cgttcagggccagttagataaagttcatcttgtttggattggagagactttttttttttt       c.*1920

          .         .         .         .         .         .       g.45723
 tttttttgagacagggtcttgctctgtaacctaggctcaagtgcagtgcagtggtgcagt       c.*1980

          .         .         .         .         .         .       g.45783
 catggctcaccgcagccttggtctcctgggctcaagtgatctttctacttcagcctcctc       c.*2040

          .         .         .         .         .         .       g.45843
 aatagctgggactacaggcacacaccaccacccccaggtaattaaaaaatttttttttgt       c.*2100

          .         .         .         .         .         .       g.45903
 agagacagggtctcactatgttgcccagtctgggagaccacattctttaacatgaatatt       c.*2160

          .         .         .         .         .         .       g.45963
 ttgtaaatagtccaagaagatctagaggaaagctgaattccttcatctgatttttgccac       c.*2220

          .         .         .         .         .         .       g.46023
 tgggctgcctcccattgtctggctaagtcttcatgggaggcctttaagaaaagctgtgac       c.*2280

          .         .         .         .         .         .       g.46083
 aaatacctttgtttcccactgcctaggttacataagtagttggcttttccagcctagact       c.*2340

          .         .         .         .         .         .       g.46143
 cttatattgttgcttgtaagagggcccttctttgcagatttcttttttttttcatctatg       c.*2400

          .         .         .         .         .         .       g.46203
 ctttcaaataggcagatgctagcctgagatcatctctttattgaggtagtttgcccaaaa       c.*2460

          .         .         .         .         .         .       g.46263
 acagcaaggaacagccaatacctgccaactttctaggtttttccaaccaattctcttaca       c.*2520

          .         .         .         .         .         .       g.46323
 gaaaatctataaatatcttagaggtatgtttcttagtttcccaacatataatgggaaaat       c.*2580

          .         .         .         .         .         .       g.46383
 tcatcatttatattattacttttaactgaagtatgttgttatcagagaacttggtctgtg       c.*2640

          .         .         .         .         .         .       g.46443
 tcatattaatcctttgccatttgagaagcatacagttttaaagtttatatctccaaaagg       c.*2700

          .         .         .         .         .         .       g.46503
 atattttgtaaaaatttaacccctttgactcttagtcttctcatttgtgaaaggtaaata       c.*2760

          .         .                                               g.46529
 ataaagaatttctgttcctagtaaga                                         c.*2786

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Unc-45 homolog B (C. elegans) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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