Usher syndrome 1G (autosomal recessive) (USH1G) - coding DNA reference sequence

(used for variant description)

(last modified April 2, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_173477.2 in the USH1G gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007882.1, covering USH1G transcript NM_173477.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          cag       c.-181

 .         .         .         .         .         .                g.5063
 atgtcttggtagtcgcggctctggcgctccgcaccctccgtctgcggcagcgggggctgg       c.-121

 .         .         .         .         .         .                g.5123
 cggccccggcccctgcccggccccgtcctccaacctcatgcctcagccctaataccgccg       c.-61

 .         .         .         .         .         .                g.5183
 ccctcccctgcggggggcctttctccgtgtcccccgcccgccccgtccacttcgggcgcc       c.-1

          .         .         .         .         .         .       g.5243
 ATGAACGACCAGTACCACCGGGCAGCCCGGGATGGCTACCTGGAGCTCCTCAAGGAGGCC       c.60
 M  N  D  Q  Y  H  R  A  A  R  D  G  Y  L  E  L  L  K  E  A         p.20

          .         .         .         .         .         .       g.5303
 ACCCGAAAGGAGCTGAATGCCCCCGACGAGGATGGCATGACCCCCACTCTCTGGGCTGCC       c.120
 T  R  K  E  L  N  A  P  D  E  D  G  M  T  P  T  L  W  A  A         p.40

          .         .         .         .     | 02   .         .    g.7601
 TACCATGGCAACCTCGAGTCGCTGCGTCTCATTGTGAGCCGCGG | GGGTGACCCGGACAAG    c.180
 Y  H  G  N  L  E  S  L  R  L  I  V  S  R  G  |  G  D  P  D  K      p.60

          .         .         .         .         .         .       g.7661
 TGTGACATCTGGGGCAACACACCCCTGCATCTGGCAGCTTCCAATGGCCACTTGCACTGC       c.240
 C  D  I  W  G  N  T  P  L  H  L  A  A  S  N  G  H  L  H  C         p.80

          .         .         .         .         .         .       g.7721
 CTGTCCTTCCTGGTGTCCTTCGGAGCCAACATCTGGTGCCTAGACAACGACTACCACACG       c.300
 L  S  F  L  V  S  F  G  A  N  I  W  C  L  D  N  D  Y  H  T         p.100

          .         .         .         .         .         .       g.7781
 CCGCTGGACATGGCTGCCATGAAGGGCCACATGGAATGCGTGCGCTACCTGGACTCCATC       c.360
 P  L  D  M  A  A  M  K  G  H  M  E  C  V  R  Y  L  D  S  I         p.120

          .         .         .         .         .         .       g.7841
 GCGGCCAAGCAGAGCAGCCTCAACCCCAAGCTGGTGGGTAAGCTGAAGGACAAGGCCTTC       c.420
 A  A  K  Q  S  S  L  N  P  K  L  V  G  K  L  K  D  K  A  F         p.140

          .         .         .         .         .         .       g.7901
 CGCGAGGCGGAGCGGCGCATCCGCGAGTGCGCCAAGCTGCAGCGGAGGCACCACGAACGC       c.480
 R  E  A  E  R  R  I  R  E  C  A  K  L  Q  R  R  H  H  E  R         p.160

          .         .         .         .         .         .       g.7961
 ATGGAGCGGCGATACCGGCGCGAGCTGGCCGAGCGTTCCGACACCCTCAGCTTCTCCAGC       c.540
 M  E  R  R  Y  R  R  E  L  A  E  R  S  D  T  L  S  F  S  S         p.180

          .         .         .         .         .         .       g.8021
 CTCACGTCCAGCACCCTGAGCCGCCGGCTGCAGCATCTGGCGCTGGGCAGCCACCTGCCG       c.600
 L  T  S  S  T  L  S  R  R  L  Q  H  L  A  L  G  S  H  L  P         p.200

          .         .         .         .         .         .       g.8081
 TACTCTCAGGCCACGCTGCACGGCACGGCCAGGGGCAAGACCAAGATGCAGAAGAAGCTG       c.660
 Y  S  Q  A  T  L  H  G  T  A  R  G  K  T  K  M  Q  K  K  L         p.220

          .         .         .         .         .         .       g.8141
 GAGCGGCGCAAGCAGGGCGGCGAAGGCACCTTCAAGGTCTCCGAGGATGGGCGCAAGAGC       c.720
 E  R  R  K  Q  G  G  E  G  T  F  K  V  S  E  D  G  R  K  S         p.240

          .         .         .         .         .         .       g.8201
 GCCCGCTCGCTCTCGGGCCTGCAGCTGGGCAGCGACGTGATGTTCGTGCGCCAGGGCACC       c.780
 A  R  S  L  S  G  L  Q  L  G  S  D  V  M  F  V  R  Q  G  T         p.260

          .         .         .         .         .         .       g.8261
 TACGCCAATCCCAAGGAGTGGGGCCGAGCCCCGCTCCGGGACATGTTCCTCTCGGACGAG       c.840
 Y  A  N  P  K  E  W  G  R  A  P  L  R  D  M  F  L  S  D  E         p.280

          .         .         .         .         .         .       g.8321
 GACAGCGTCTCCCGTGCCACGCTGGCGGCCGAGCCTGCCCACTCGGAGGTCAGCACCGAC       c.900
 D  S  V  S  R  A  T  L  A  A  E  P  A  H  S  E  V  S  T  D         p.300

          .         .         .         .         .         .       g.8381
 TCAGGCCACGACTCCCTGTTTACCCGCCCCGGCCTGGGCACCATGGTGTTCCGCAGAAAT       c.960
 S  G  H  D  S  L  F  T  R  P  G  L  G  T  M  V  F  R  R  N         p.320

          .         .         .         .         .         .       g.8441
 TACTTGAGCAGTGGGCTGCACGGACTGGGCCGCGAGGATGGGGGTCTGGATGGGGTGGGA       c.1020
 Y  L  S  S  G  L  H  G  L  G  R  E  D  G  G  L  D  G  V  G         p.340

          .         .         .         .         .         .       g.8501
 GCGCCGCGGGGTCGGCTGCAGAGCTCCCCCAGCCTGGACGATGACAGCCTGGGCAGTGCC       c.1080
 A  P  R  G  R  L  Q  S  S  P  S  L  D  D  D  S  L  G  S  A         p.360

          .         .         .         .         .         .       g.8561
 AACAGCCTGCAGGACCGCAGCTGTGGGGAGGAGCTGCCCTGGGATGAGCTCGATTTAGGC       c.1140
 N  S  L  Q  D  R  S  C  G  E  E  L  P  W  D  E  L  D  L  G         p.380

          .         .         .         .         .         .       g.8621
 TTGGACGAGGACCTGGAGCCCGAGACTAGCCCGCTGGAGACCTTCCTGGCCTCTCTGCAC       c.1200
 L  D  E  D  L  E  P  E  T  S  P  L  E  T  F  L  A  S  L  H         p.400

          .         .         .         .         .         .       g.8681
 ATGGAGGACTTTGCCGCCCTCCTGCGGCAGGAGAAGATCGACCTCGAGGCTTTGATGCTG       c.1260
 M  E  D  F  A  A  L  L  R  Q  E  K  I  D  L  E  A  L  M  L         p.420

          .         .         .         .         .         .       g.8741
 TGCTCTGACCTCGACCTCCGCAGCATCAGCGTCCCACTGGGGCCCCGAAAGAAGATCTTG       c.1320
 C  S  D  L  D  L  R  S  I  S  V  P  L  G  P  R  K  K  I  L         p.440

          .         .         .         .         .         .       g.8801
 GGGGCCGTGAGGAGGCGGCGGCAGGCGATGGAGCGCCCGCCGGCCCTGGAGGACACAGAG       c.1380
 G  A  V  R  R  R  R  Q  A  M  E  R  P  P  A  L  E  D  T  E         p.460

    | 03                                                            g.10238
 CT | ATAA                                                          c.1386
 L  |  X                                                            p.461

          .         .         .         .         .         .       g.10298
 ccgggggctcctctccccagaccaaaatgaattgcaagttgccacaacctatggtggggt       c.*60

          .         .         .         .         .         .       g.10358
 ctcgaggtcctcacagttgccagccctgcagcccccttccccaggagcaaggaccagttg       c.*120

          .         .         .         .         .         .       g.10418
 gggcgactcctttgaaagtctgtctgcaccttgaagctgagggtgtggcctggaggcacc       c.*180

          .         .         .         .         .         .       g.10478
 agaggggcaagagaatgttccggaactccagttctgaggggtcttgaaggccctgagcca       c.*240

          .         .         .         .         .         .       g.10538
 cccattctgagcagccgtaaaggacatgtagacttgggggaggcctgccccagagggagg       c.*300

          .         .         .         .         .         .       g.10598
 gcaggggcatcggaactggatgagagtgtgggaggtggatgcgggagggtgcacctgtcc       c.*360

          .         .         .         .         .         .       g.10658
 cgggcgccgtaggcctctcccacccctcccctgatggtcttgttctcttgtgctcaggcc       c.*420

          .         .         .         .         .         .       g.10718
 agagacttgctcacttcctgcattgttgtgaagggaagagtttgggctgcctcccctcct       c.*480

          .         .         .         .         .         .       g.10778
 cccgtccaccccagaggggaagttcctcagccagactcttcagccaaatgccccaacttt       c.*540

          .         .         .         .         .         .       g.10838
 cagtctgtaccccatcccaagcatagccagctccccctccttcacctagtggtcaaggcc       c.*600

          .         .         .         .         .         .       g.10898
 cggagctggaaagccgggttggggtggggtgggggtactgacgcccttcccagctcatcc       c.*660

          .         .         .         .         .         .       g.10958
 aggggtggagcctggcctgtcttcctccaacctccccctttttcgttgtgcagcctggcc       c.*720

          .         .         .         .         .         .       g.11018
 ccccagggaccccagagggccagggcgctagatgcaaggtgctagaccaatgggctgcag       c.*780

          .         .         .         .         .         .       g.11078
 tattatagcccccaggcctggcaggcatgcgctgggctagagaaaggtgtccgccaacct       c.*840

          .         .         .         .         .         .       g.11138
 cctcagtctcccaggcctgggacaggcagaacagggtgtggctgggtgtcaggcctgggg       c.*900

          .         .         .         .         .         .       g.11198
 tgggtaagtcctgcgatgtggacactggagaaagtggatcctctaaactgcagattgtcc       c.*960

          .         .         .         .         .         .       g.11258
 ccaggtcaccagggctgtgtgcgtgtgcatgtttgtgtgcatgtatgcgtgtgtgcatgc       c.*1020

          .         .         .         .         .         .       g.11318
 atgtgtgtgtaagtatgtggtatgtgtgagcacgggtgtgtgcttgggtgtgtgtgtgtt       c.*1080

          .         .         .         .         .         .       g.11378
 cttgcatacatgtgtacgtgtgtgtgcacgtgaacgcgtgcgtgtttgtgtgtgtgcatg       c.*1140

          .         .         .         .         .         .       g.11438
 catgtgtgtgcatgtgtgtgtgtgcatgcatgtgtgtgtgtgtgcatgtgtgcgtgtgtg       c.*1200

          .         .         .         .         .         .       g.11498
 cacactcacgttgggtggtgtttggtaggtttccctccaggtctggtagggactgggctg       c.*1260

          .         .         .         .         .         .       g.11558
 ttgcgtgattctgcgtggatcgggggtaagagagctcacctgtgtcccagccctctgatg       c.*1320

          .         .         .         .         .         .       g.11618
 gtggtgagaccaggggaaaggccagctcagagggtggtcacagcatgtgtcctctgacgt       c.*1380

          .         .         .         .         .         .       g.11678
 atgcccccaaagctctccagccagactgaggtcacagatgtgggagagtccctgatgagc       c.*1440

          .         .         .         .         .         .       g.11738
 ccgctgacacgtgtgcgcccctttgcaccccatgcagaggtgctctcctcctttctcagc       c.*1500

          .         .         .         .         .         .       g.11798
 catggccccccatccctgacctcagcttgggaagcagctcctgctgggagcatggcctca       c.*1560

          .         .         .         .         .         .       g.11858
 gcccccagcatctcctggggcccccatggctggggcaggggaaagagagccctcaaaggc       c.*1620

          .         .         .         .         .         .       g.11918
 ctctttctggtctgtctgggggttcccattcccacacatgtgcccagagtagggggcatg       c.*1680

          .         .         .         .         .         .       g.11978
 gaggagatggtccctgtcctactgcaggacactgagggcttggctgcctgccaccgccat       c.*1740

          .         .         .         .         .         .       g.12038
 ctggagcccaccacagctcttctccctgttctctgggcctgagcctggggccacccccaa       c.*1800

          .         .         .         .         .         .       g.12098
 gtgccgacttgtttctcccagagccccaggtgctgccccttctctcctgttcctcgtccg       c.*1860

          .         .         .         .         .         .       g.12158
 tttactgccgcagcccctcctggttcttctggtgctggggtggagcaggctctgtgctcc       c.*1920

          .         .         .         .         .         .       g.12218
 caccactgtaccccgaatccctcctgcaggctcattgccacttttgtagagaatgttctc       c.*1980

          .                                                         g.12230
 tatcagtatcgt                                                       c.*1992

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Usher syndrome 1G (autosomal recessive) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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