ubiquitin specific peptidase 48 (USP48) - coding DNA reference sequence

(used for variant description)

(last modified June 11, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_032236.5 in the USP48 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_047203.1, covering USP48 transcript NM_032236.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   aacgtccgcgggcgcggggtgtgtcgggtgtcgacggcggcgctttgcggccggtcgt       c.-181

 .         .         .         .         .         .                g.5118
 gcgggtcgggcgcgggcgggcgcggcggcagtggcgcgcacaggtgattgactggccagc       c.-121

 .         .         .         .         .         .                g.5178
 tgcctgaaggagcgccaggtcctccttgctggcaggtggcgaagcccattggggcggcgg       c.-61

 .         .         .         .         .         .                g.5238
 tgcagaccgcggcggcggctgcggcggtctggctcgggaggcgttcctggggccaaggcc       c.-1

          .         .         .         .         .         .       g.5298
 ATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCC       c.60
 M  A  P  R  L  Q  L  E  K  A  A  W  R  W  A  E  T  V  R  P         p.20

          .         .         .         .         .         .       g.5358
 GAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATT       c.120
 E  E  V  S  Q  E  H  I  E  T  A  Y  R  I  W  L  E  P  C  I         p.40

          .     | 02   .         .         .         .         .    g.30458
 CGCGGCGTGTGCAG | ACGAAACTGCAAAGGAAATCCGAATTGCTTGGTTGGTATTGGTGAG    c.180
 R  G  V  C  R  |  R  N  C  K  G  N  P  N  C  L  V  G  I  G  E      p.60

          .         .         .         .         .         .       g.30518
 CATATTTGGTTAGGAGAAATAGATGAAAATAGTTTTCATAACATCGATGATCCCAACTGT       c.240
 H  I  W  L  G  E  I  D  E  N  S  F  H  N  I  D  D  P  N  C         p.80

          .      | 03  .         .         .         .         .    g.31538
 GAGAGGAGAAAAAAG | AACTCATTTGTGGGCCTGACTAACCTTGGAGCCACTTGTTATGTC    c.300
 E  R  R  K  K   | N  S  F  V  G  L  T  N  L  G  A  T  C  Y  V      p.100

          .         .         .         .         .         .       g.31598
 AACACATTTCTTCAAGTGTGGTTTCTCAACTTGGAGCTTCGGCAGGCACTCTACTTATGT       c.360
 N  T  F  L  Q  V  W  F  L  N  L  E  L  R  Q  A  L  Y  L  C         p.120

          .         .         .         .         .   | 04     .    g.35084
 CCAAGCACTTGTAGTGACTACATGCTGGGAGACGGCATCCAAGAAGAAAAAG | ATTATGAG    c.420
 P  S  T  C  S  D  Y  M  L  G  D  G  I  Q  E  E  K  D |   Y  E      p.140

          .         .         .         .         .         .       g.35144
 CCTCAAACAATTTGTGAGCATCTCCAGTACTTGTTTGCCTTGTTGCAAAACAGTAATAGG       c.480
 P  Q  T  I  C  E  H  L  Q  Y  L  F  A  L  L  Q  N  S  N  R         p.160

          .         .         .         .         .         .       g.35204
 CGATACATTGATCCATCAGGATTTGTTAAAGCCTTGGGCCTGGACACTGGACAACAGCAG       c.540
 R  Y  I  D  P  S  G  F  V  K  A  L  G  L  D  T  G  Q  Q  Q         p.180

  | 05       .         .         .         .         .         .    g.35604
  | GATGCTCAAGAATTTTCAAAGCTCTTTATGTCTCTATTGGAAGATACTTTGTCTAAACAA    c.600
  | D  A  Q  E  F  S  K  L  F  M  S  L  L  E  D  T  L  S  K  Q      p.200

          .         .         .         .         .         .       g.35664
 AAGAATCCAGATGTGCGCAATATTGTTCAACAGCAGTTCTGTGGAGAATATGCCTATGTA       c.660
 K  N  P  D  V  R  N  I  V  Q  Q  Q  F  C  G  E  Y  A  Y  V         p.220

       | 06  .         .         .         .         .         .    g.36635
 ACTGT | TTGCAACCAGTGTGGCAGAGAGTCTAAGCTTTTGTCAAAATTTTATGAGCTGGAG    c.720
 T  V  |  C  N  Q  C  G  R  E  S  K  L  L  S  K  F  Y  E  L  E      p.240

          .         .         .         .         .     | 07   .    g.39930
 TTAAATATCCAAGGCCACAAACAGTTAACAGATTGTATCTCGGAATTTTTGAAG | GAAGAA    c.780
 L  N  I  Q  G  H  K  Q  L  T  D  C  I  S  E  F  L  K   | E  E      p.260

          .         .         .         .         .         .       g.39990
 AAATTAGAAGGAGACAATCGCTATTTTTGCGAGAACTGTCAAAGCAAACAGAATGCAACA       c.840
 K  L  E  G  D  N  R  Y  F  C  E  N  C  Q  S  K  Q  N  A  T         p.280

          .         .         .         .         .         .       g.40050
 AGAAAGATTCGACTTCTTAGCCTTCCTTGCACTCTGAACTTGCAGCTAATGCGTTTTGTC       c.900
 R  K  I  R  L  L  S  L  P  C  T  L  N  L  Q  L  M  R  F  V         p.300

          | 08         .         .         .         .         .    g.41098
 TTTGACAG | GCAAACTGGACATAAGAAAAAGCTGAATACCTACATTGGCTTCTCAGAAATT    c.960
 F  D  R  |  Q  T  G  H  K  K  K  L  N  T  Y  I  G  F  S  E  I      p.320

          .         .         .  | 09      .         .         .    g.51599
 TTGGATATGGAGCCTTATGTGGAACATAAAG | GTGGGTCCTACGTGTATGAACTCAGCGCA    c.1020
 L  D  M  E  P  Y  V  E  H  K  G |   G  S  Y  V  Y  E  L  S  A      p.340

          .         .         .         .         .         .       g.51659
 GTCCTCATACACAGAGGAGTGAGTGCTTATTCTGGCCACTACATCGCCCACGTGAAAGAT       c.1080
 V  L  I  H  R  G  V  S  A  Y  S  G  H  Y  I  A  H  V  K  D         p.360

          .         .         .         .         .         .       g.51719
 CCACAGTCTGGTGAATGGTATAAGTTTAATGATGAAGACATAGAAAAGATGGAGGGGAAG       c.1140
 P  Q  S  G  E  W  Y  K  F  N  D  E  D  I  E  K  M  E  G  K         p.380

          .         .         .  | 10      .         .         .    g.58392
 AAATTACAACTAGGGATTGAGGAAGATCTAG | CAGAACCTTCTAAGTCTCAGACACGTAAA    c.1200
 K  L  Q  L  G  I  E  E  D  L  A |   E  P  S  K  S  Q  T  R  K      p.400

          .         .         .         .         .         .       g.58452
 CCCAAGTGTGGCAAAGGAACTCATTGCTCTCGAAATGCATATATGTTGGTTTATAGACTG       c.1260
 P  K  C  G  K  G  T  H  C  S  R  N  A  Y  M  L  V  Y  R  L         p.420

          .         .         .         . | 11       .         .    g.59496
 CAAACTCAAGAAAAGCCCAACACTACTGTTCAAGTTCCAG | CCTTTCTTCAAGAGCTGGTA    c.1320
 Q  T  Q  E  K  P  N  T  T  V  Q  V  P  A |   F  L  Q  E  L  V      p.440

          .         .         .         .         .         .       g.59556
 GATCGGGATAATTCCAAATTTGAGGAGTGGTGTATTGAAATGGCTGAGATGCGTAAGCAA       c.1380
 D  R  D  N  S  K  F  E  E  W  C  I  E  M  A  E  M  R  K  Q         p.460

          .         .         .         .         .         .       g.59616
 AGTGTGGATAAAGGAAAAGCAAAACACGAAGAGGTTAAGGAGCTGTACCAAAGGTTACCT       c.1440
 S  V  D  K  G  K  A  K  H  E  E  V  K  E  L  Y  Q  R  L  P         p.480

          . | 12       .         .         .         .         .    g.64150
 GCTGGAGCTG | AGCCCTATGAGTTTGTCTCTCTGGAATGGCTGCAAAAGTGGTTGGATGAA    c.1500
 A  G  A  E |   P  Y  E  F  V  S  L  E  W  L  Q  K  W  L  D  E      p.500

          .         .         .         .         .         .       g.64210
 TCAACACCTACCAAACCTATTGATAATCACGCTTGCCTGTGTTCCCATGACAAGCTTCAC       c.1560
 S  T  P  T  K  P  I  D  N  H  A  C  L  C  S  H  D  K  L  H         p.520

          .         .         .         .         .         .       g.64270
 CCGGATAAAATATCAATTATGAAGAGGATATCTGAATATGCAGCTGACATTTTCTATAGT       c.1620
 P  D  K  I  S  I  M  K  R  I  S  E  Y  A  A  D  I  F  Y  S         p.540

          .         .         | 13         .         .         .    g.66463
 AGATATGGAGGAGGTCCAAGACTAACTG | TGAAAGCCCTGTGTAAGGAATGTGTAGTAGAA    c.1680
 R  Y  G  G  G  P  R  L  T  V |   K  A  L  C  K  E  C  V  V  E      p.560

          .         .         .         .         .         .       g.66523
 CGTTGTCGCATATTGCGTCTGAAGAACCAACTAAATGAAGATTATAAAACTGTTAATAAT       c.1740
 R  C  R  I  L  R  L  K  N  Q  L  N  E  D  Y  K  T  V  N  N         p.580

          .         .    | 14    .         .         .         .    g.67066
 CTGCTGAAAGCAGCAGTAAAGGG | CAGCGATGGATTTTGGGTGGGGAAGTCCTCCTTGCGG    c.1800
 L  L  K  A  A  V  K  G  |  S  D  G  F  W  V  G  K  S  S  L  R      p.600

          .         .         .         .         .         .       g.67126
 AGTTGGCGCCAGCTAGCTCTTGAACAGCTGGATGAGCAAGATGGTGATGCAGAACAAAGC       c.1860
 S  W  R  Q  L  A  L  E  Q  L  D  E  Q  D  G  D  A  E  Q  S         p.620

          .         .         .     | 15   .         .         .    g.72764
 AACGGAAAGATGAACGGTAGCACCTTAAATAAAG | ATGAATCAAAGGAAGAAAGAAAAGAA    c.1920
 N  G  K  M  N  G  S  T  L  N  K  D |   E  S  K  E  E  R  K  E      p.640

          .         .         .         .    | 16    .         .    g.81344
 GAGGAGGAATTAAATTTTAATGAAGATATTCTGTGTCCACATG | GTGAGTTATGCATATCT    c.1980
 E  E  E  L  N  F  N  E  D  I  L  C  P  H  G |   E  L  C  I  S      p.660

          .         .         .         .         .         .       g.81404
 GAAAATGAAAGAAGGCTTGTTTCTAAAGAGGCTTGGAGCAAACTGCAGCAGTACTTTCCA       c.2040
 E  N  E  R  R  L  V  S  K  E  A  W  S  K  L  Q  Q  Y  F  P         p.680

          .         .         .         .         | 17         .    g.81618
 AAGGCTCCTGAGTTTCCAAGTTACAAAGAGTGCTGTTCACAGTGCAAG | ATTTTAGAAAGA    c.2100
 K  A  P  E  F  P  S  Y  K  E  C  C  S  Q  C  K   | I  L  E  R      p.700

          .         .         .         .         .         .       g.81678
 GAAGGGGAAGAAAATGAAGCCTTACATAAGATGATTGCAAACGAGCAAAAGACTTCTCTC       c.2160
 E  G  E  E  N  E  A  L  H  K  M  I  A  N  E  Q  K  T  S  L         p.720

          .         .         .         .         .  | 18      .    g.82017
 CCAAATTTGTTCCAGGATAAAAACAGACCGTGTCTCAGTAACTGGCCAGAG | GATACGGAT    c.2220
 P  N  L  F  Q  D  K  N  R  P  C  L  S  N  W  P  E   | D  T  D      p.740

          .         .         .         .         .    | 19    .    g.82365
 GTCCTCTACATCGTGTCTCAGTTCTTTGTAGAAGAGTGGCGGAAATTTGTTAG | AAAGCCT    c.2280
 V  L  Y  I  V  S  Q  F  F  V  E  E  W  R  K  F  V  R  |  K  P      p.760

          .         .         .         .         .         .       g.82425
 ACAAGATGCAGCCCTGTGTCATCAGTTGGGAACAGTGCTCTTTTGTGTCCCCACGGGGGC       c.2340
 T  R  C  S  P  V  S  S  V  G  N  S  A  L  L  C  P  H  G  G         p.780

          .         .         .         .     | 20   .         .    g.83819
 CTCATGTTTACATTTGCTTCCATGACCAAAGAAGATTCTAAACT | TATAGCTCTCATATGG    c.2400
 L  M  F  T  F  A  S  M  T  K  E  D  S  K  L  |  I  A  L  I  W      p.800

          .         .         .         .         .         .       g.83879
 CCCAGTGAGTGGCAAATGATACAAAAGCTCTTTGTTGTGGATCATGTAATTAAAATCACG       c.2460
 P  S  E  W  Q  M  I  Q  K  L  F  V  V  D  H  V  I  K  I  T         p.820

          .         .         .         .         .      | 21  .    g.84582
 AGAATTGAAGTGGGAGATGTAAACCCTTCAGAAACACAGTATATTTCTGAGCCCA | AACTC    c.2520
 R  I  E  V  G  D  V  N  P  S  E  T  Q  Y  I  S  E  P  K |   L      p.840

          .         .         .         .         .         .       g.84642
 TGTCCAGAATGCAGAGAAGGCTTATTGTGTCAGCAGCAGAGGGACCTGCGTGAATACACT       c.2580
 C  P  E  C  R  E  G  L  L  C  Q  Q  Q  R  D  L  R  E  Y  T         p.860

          .         .         .         .   | 22     .         .    g.86611
 CAAGCCACCATCTATGTCCATAAAGTTGTGGATAATAAAAAG | GTGATGAAGGATTCGGCT    c.2640
 Q  A  T  I  Y  V  H  K  V  V  D  N  K  K   | V  M  K  D  S  A      p.880

          .         .         .         .         .         .       g.86671
 CCGGAACTGAATGTGAGTAGTTCTGAAACAGAGGAGGACAAGGAAGAAGCTAAACCAGAT       c.2700
 P  E  L  N  V  S  S  S  E  T  E  E  D  K  E  E  A  K  P  D         p.900

          .         .        | 23.         .         .         .    g.93007
 GGAGAAAAAGATCCAGATTTTAATCAA | AGCAATGGTGGAACAAAGCGGCAAAAGATATCC    c.2760
 G  E  K  D  P  D  F  N  Q   | S  N  G  G  T  K  R  Q  K  I  S      p.920

          .         .         .         .         .         .       g.93067
 CATCAAAATTATATAGCCTATCAAAAGCAAGTTATTCGCCGAAGTATGCGACATAGAAAA       c.2820
 H  Q  N  Y  I  A  Y  Q  K  Q  V  I  R  R  S  M  R  H  R  K         p.940

          .         .         .         .         .         .       g.93127
 GTTCGTGGTGAGAAAGCACTTCTCGTTTCTGCTAATCAGACGTTAAAAGAATTGAAAATT       c.2880
 V  R  G  E  K  A  L  L  V  S  A  N  Q  T  L  K  E  L  K  I         p.960

     | 24    .         .         .         .         .         .    g.98153
 CAG | ATCATGCATGCATTTTCAGTTGCTCCTTTTGACCAGAATTTGTCAATTGATGGAAAG    c.2940
 Q   | I  M  H  A  F  S  V  A  P  F  D  Q  N  L  S  I  D  G  K      p.980

          .         .         .         .         .         .       g.98213
 ATTTTAAGTGATGACTGTGCCACCCTAGGCACCCTTGGCGTCATTCCTGAATCTGTCATT       c.3000
 I  L  S  D  D  C  A  T  L  G  T  L  G  V  I  P  E  S  V  I         p.1000

           | 25        .         .         .         .         | 26 g.107363
 TTATTGAAG | GCTGATGAACCAATTGCAGATTATGCTGCAATGGATGATGTCATGCAAG | TT c.3060
 L  L  K   | A  D  E  P  I  A  D  Y  A  A  M  D  D  V  M  Q  V |    p.1020

          .         .      | 27  .         .                        g.108791
 TGTATGCCAGAAGAAGGGTTTAAAG | GTACTGGTCTTCTTGGACATTAA                c.3108
 C  M  P  E  E  G  F  K  G |   T  G  L  L  G  H  X                  p.1035

          .         .         .         .         .         .       g.108851
 tctttgaatacttgctgactgctaagaaatgaccagaggggaagaggagtttgacatgtt       c.*60

          .         .         .         .         .         .       g.108911
 agggcattaaagcaaaggtggatttaagaattaaaccattacatgccccttccaaaaggc       c.*120

          .         .         .         .         .         .       g.108971
 agaaatccattcaaacgtgactgtcccaaatgccttatgtcaaataaagcagattgcact       c.*180

          .         .         .         .         .         .       g.109031
 gatggacatcagacttgaaggaaatgtttccaattttatatttaaggggggtggtgggtg       c.*240

          .         .         .         .         .         .       g.109091
 ggagggggcaagtaaagacggaacaagtttagtagcagtaatagtaaatcatgtttacat       c.*300

          .         .         .         .         .         .       g.109151
 atgagatttatagtcgtgggaggggaataaagttctgttatatttccttgctcgagtttc       c.*360

          .         .         .         .         .         .       g.109211
 ataccagatgcgttggtccataaaggattgtatcaagtagatgggacaacattctgctct       c.*420

          .         .         .         .         .         .       g.109271
 gaacgaaaagtaattttagagacataacctgcttaccaatgcctgtctttgattcatatt       c.*480

          .         .         .         .         .         .       g.109331
 ctactttcaataaagcatgaaagtgaagaacttgtcctaagtgtggaaaagtgtcttcag       c.*540

          .         .         .         .         .         .       g.109391
 atttagactcttctccatgtcagctgcagcgccacccgccttacacctgcccggccgtct       c.*600

          .         .         .         .         .         .       g.109451
 gtctcttggtattgggtaaaggagggggcacctgcatgtctcctgcaatgagcaaggaat       c.*660

          .         .         .         .         .         .       g.109511
 tatgtctcatgttttgacttcagaggctttttgctttggtgcatttcagaaaggatggag       c.*720

          .         .         .         .         .         .       g.109571
 aacatttattatgtgtgaaagcatcctcttccggttttgctgttattcaaaagtgggaaa       c.*780

          .         .         .         .         .         .       g.109631
 tgtacctggcacgtttgaaaataaaaaatctgactacctatcagaagagtaaatcagact       c.*840

          .         .         .         .         .         .       g.109691
 gaagtacatttggataacacaaggtttctataaaatttgttcttcctgtcctccatgtca       c.*900

          .         .         .         .         .         .       g.109751
 ctgtttcttggacctcagttctctttttgaaagcattattccaaaatgccctgagagggt       c.*960

          .         .         .         .         .         .       g.109811
 ctcttagatcattgtttaaaaaaggaaaaaagtatatggatgtgctgtccatccaactca       c.*1020

          .         .         .         .         .         .       g.109871
 ggattatcattcttagcaacacgtaaccgaagcaatattcttaagaatattgaaggggtt       c.*1080

          .         .         .                                     g.109910
 tttttaattgaacttaagactggagtttttcctttgaaa                            c.*1119

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ubiquitin specific peptidase 48 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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