valyl-tRNA synthetase 2, mitochondrial (VARS2) - coding DNA reference sequence

(used for variant description)

(last modified August 8, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_020442.4 in the VARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_034224.1, covering VARS2 transcript NM_020442.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              gccagctgctgcgcatgcgccggccggggccccgcccccatgcgccg       c.-121

 .         .         .         .         .         .                g.5107
 cgcggctccagggccacgttccagggtcgggtttggtggattcctcagtccctgccgccg       c.-61

 .         .         .         .   | 02     .         .             g.5632
 cggggcgccctgggatagcggcggggcctcctg | atctcggcccctttccaaacactcctg    c.-1

          .         .         .         .         .         .       g.5692
 ATGCCTCATTTGCCTCTCGCCTCTTTTCGACCACCATTTTGGGGGCTGAGGCACTCACGG       c.60
 M  P  H  L  P  L  A  S  F  R  P  P  F  W  G  L  R  H  S  R         p.20

          .         .         .         .         .         .       g.5752
 GGCCTCCCCAGGTTTCACTCCGTTTCTACACAGTCGGAGCCCCATGGATCTCCCATCTCC       c.120
 G  L  P  R  F  H  S  V  S  T  Q  S  E  P  H  G  S  P  I  S         p.40

          .         .         .         .         .         .       g.5812
 CGGAGGAACCGTGAAGCCAAACAGAAGCGCCTGCGAGAGAAGCAGGCGACTCTGGAGGCT       c.180
 R  R  N  R  E  A  K  Q  K  R  L  R  E  K  Q  A  T  L  E  A         p.60

          .         .  | 03      .         .         .         .    g.5990
 GAGATAGCAGGGGAGAGCAAG | TCACCTGCAGAATCCATTAAGGCCTGGAGGCCTAAGGAG    c.240
 E  I  A  G  E  S  K   | S  P  A  E  S  I  K  A  W  R  P  K  E      p.80

          .         .         .         .    | 04    .         .    g.6167
 TTAGTATTGTATGAAATCCCTACGAAACCCGGTGAAAAGAAAG | ATGTCTCTGGGCCCCTG    c.300
 L  V  L  Y  E  I  P  T  K  P  G  E  K  K  D |   V  S  G  P  L      p.100

          .         .         .         .         .         .       g.6227
 CCTCCTGCATACAGCCCCCGATATGTTGAGGCTGCCTGGTACCCGTGGTGGGTACGAGAG       c.360
 P  P  A  Y  S  P  R  Y  V  E  A  A  W  Y  P  W  W  V  R  E         p.120

          .         .     | 05   .         .         .         .    g.6577
 GGCTTCTTCAAACCAGAATATCAG | GCCCGGCTGCCCCAAGCTACAGGGGAGACCTTTTCC    c.420
 G  F  F  K  P  E  Y  Q   | A  R  L  P  Q  A  T  G  E  T  F  S      p.140

          .         .         .         .         .         .       g.6637
 ATGTGTATCCCACCTCCCAATGTCACTGGCTCCCTGCACATTGGCCACGCACTCACGGTG       c.480
 M  C  I  P  P  P  N  V  T  G  S  L  H  I  G  H  A  L  T  V         p.160

          .         .       | 06 .         .         .         .    g.6810
 GCCATACAGGATGCCCTCGTGCGCTG | GCACCGGATGCGTGGGGATCAAGTGCTGTGGGTC    c.540
 A  I  Q  D  A  L  V  R  W  |  H  R  M  R  G  D  Q  V  L  W  V      p.180

          .         .         .    | 07    .         .         .    g.6974
 CCTGGTTCAGATCATGCAGGAATTGCTACACAA | GCTGTGGTGGAGAAACAACTGTGGAAG    c.600
 P  G  S  D  H  A  G  I  A  T  Q   | A  V  V  E  K  Q  L  W  K      p.200

          .         .         .         .         .         .       g.7034
 GAACGGGGAGTGAGGAGACATGAGCTGAGCCGGGAGGCCTTCCTTAGGGAGGTGTGGCAG       c.660
 E  R  G  V  R  R  H  E  L  S  R  E  A  F  L  R  E  V  W  Q         p.220

          .  | 08      .         .         .         .         .    g.7722
 TGGAAGGAGGC | GAAAGGTGGAGAGATCTGTGAGCAGCTGCGAGCTCTGGGTGCCTCCCTG    c.720
 W  K  E  A  |  K  G  G  E  I  C  E  Q  L  R  A  L  G  A  S  L      p.240

          .         .         .    | 09    .         .         .    g.7927
 GACTGGGATCGAGAGTGTTTTACCATGGATGTT | GGCTCCTCAGTGGCTGTGACTGAAGCT    c.780
 D  W  D  R  E  C  F  T  M  D  V   | G  S  S  V  A  V  T  E  A      p.260

          .         .         .         .         .         .       g.7987
 TTTGTGCGGCTCTACAAGGCGGGGTTGCTGTACCGGAACCATCAGCTTGTCAACTGGTCA       c.840
 F  V  R  L  Y  K  A  G  L  L  Y  R  N  H  Q  L  V  N  W  S         p.280

          .         .         .    | 10    .         .         .    g.8517
 TGTGCTTTAAGATCAGCCATCTCGGACATTGAG | GTGGAGAACCGGCCCCTGCCTGGCCAC    c.900
 C  A  L  R  S  A  I  S  D  I  E   | V  E  N  R  P  L  P  G  H      p.300

          .         .         .         .         .         .       g.8577
 ACACAGCTTCGACTGCCTGGCTGCCCCACCCCCGTGTCTTTTGGCCTCCTATTTTCTGTT       c.960
 T  Q  L  R  L  P  G  C  P  T  P  V  S  F  G  L  L  F  S  V         p.320

          .         .      | 11  .         .         .         .    g.9657
 GCCTTCCCCGTGGATGGAGAGCCTG | ATGCAGAGGTTGTGGTAGGAACCACAAGGCCAGAG    c.1020
 A  F  P  V  D  G  E  P  D |   A  E  V  V  V  G  T  T  R  P  E      p.340

          .         .         .         .         .     | 12   .    g.10559
 ACGCTGCCTGGAGATGTGGCTGTGGCCGTTCATCCAGACGACTCGCGATACACA | CATCTA    c.1080
 T  L  P  G  D  V  A  V  A  V  H  P  D  D  S  R  Y  T   | H  L      p.360

          .         .         .         .         .         .       g.10619
 CACGGGCGACAGCTTCGTCACCCCTTGATGGGGCAGCCTCTTCCCCTCATCACAGACTAT       c.1140
 H  G  R  Q  L  R  H  P  L  M  G  Q  P  L  P  L  I  T  D  Y         p.380

          .         .      | 13  .         .         .         .    g.10919
 GCTGTTCAGCCACATGTGGGCACGG | GGGCAGTGAAGGTGACTCCAGCTCACAGTCCTGCC    c.1200
 A  V  Q  P  H  V  G  T  G |   A  V  K  V  T  P  A  H  S  P  A      p.400

          .         .         .         .         .         .       g.10979
 GATGCTGAGATGGGGGCCCGACATGGCTTGAGCCCCTTGAATGTCATTGCGGAGGATGGG       c.1260
 D  A  E  M  G  A  R  H  G  L  S  P  L  N  V  I  A  E  D  G         p.420

          .         .         .    | 14    .         .         .    g.11155
 ACCATGACCTCCCTCTGCGGGGACTGGCTGCAG | GGTCTTCACCGGTTTGTGGCCCGGGAA    c.1320
 T  M  T  S  L  C  G  D  W  L  Q   | G  L  H  R  F  V  A  R  E      p.440

          .         .         .         .         .         .       g.11215
 AAGATAATGTCTGTGCTGAGTGAATGGGGCCTGTTCCGGGGCCTCCAGAACCACCCCATG       c.1380
 K  I  M  S  V  L  S  E  W  G  L  F  R  G  L  Q  N  H  P  M         p.460

          .        | 15.         .         .         .         .    g.11506
 GTACTGCCCATCTGCAG | CCGTTCTGGGGATGTGATAGAATACCTGCTGAAGAACCAGTGG    c.1440
 V  L  P  I  C  S  |  R  S  G  D  V  I  E  Y  L  L  K  N  Q  W      p.480

          .         .         .          | 16        .         .    g.11881
 TTTGTCCGCTGCCAGGAAATGGGGGCCCGAGCTGCCAAG | GCTGTGGAGTCGGGGGCCCTG    c.1500
 F  V  R  C  Q  E  M  G  A  R  A  A  K   | A  V  E  S  G  A  L      p.500

          .         .         .         .         .       | 17 .    g.12029
 GAGCTCAGTCCCTCCTTCCACCAGAAGAACTGGCAGCACTGGTTTTCCCATATTGG | GGAC    c.1560
 E  L  S  P  S  F  H  Q  K  N  W  Q  H  W  F  S  H  I  G  |  D      p.520

          .         .         .         .         .         .       g.12089
 TGGTGTGTCTCCCGGCAGCTGTGGTGGGGCCATCAGATTCCAGCCTACCTGGTTGTAGAG       c.1620
 W  C  V  S  R  Q  L  W  W  G  H  Q  I  P  A  Y  L  V  V  E         p.540

          .   | 18     .         .         .         .         .    g.12432
 GACCATGCGCAG | GGAGAAGAGGACTGTTGGGTGGTTGGGCGGTCAGAGGCTGAGGCCAGA    c.1680
 D  H  A  Q   | G  E  E  D  C  W  V  V  G  R  S  E  A  E  A  R      p.560

          .         .         .         .         .      | 19  .    g.12725
 GAGGTAGCAGCGGAACTGACAGGGAGGCCAGGGGCAGAGCTGACCCTGGAGAGGG | ATCCT    c.1740
 E  V  A  A  E  L  T  G  R  P  G  A  E  L  T  L  E  R  D |   P      p.580

          .         .         .         .         .         .       g.12785
 GATGTCCTAGACACATGGTTTTCTTCTGCCCTGTTCCCCTTTTCTGCCCTGGGCTGGCCC       c.1800
 D  V  L  D  T  W  F  S  S  A  L  F  P  F  S  A  L  G  W  P         p.600

        | 20 .         .         .         .         .         .    g.12965
 CAAGAG | ACCCCAGACCTTGCTCGTTTCTACCCCCTGTCACTTTTGGAAACGGGCAGCGAC    c.1860
 Q  E   | T  P  D  L  A  R  F  Y  P  L  S  L  L  E  T  G  S  D      p.620

          .         .         .         .         .         .       g.13025
 CTTCTGCTGTTCTGGGTGGGCCGCATGGTCATGTTGGGGACCCAGCTCACAGGGCAGCTG       c.1920
 L  L  L  F  W  V  G  R  M  V  M  L  G  T  Q  L  T  G  Q  L         p.640

          .   | 21     .         .         .         .         .    g.13293
 CCCTTCAGCAAG | GTGCTTCTTCATCCCATGGTTCGGGACAGGCAGGGCCGGAAGATGAGC    c.1980
 P  F  S  K   | V  L  L  H  P  M  V  R  D  R  Q  G  R  K  M  S      p.660

          .         .         .         .         .        | 22.    g.13504
 AAGTCCCTGGGGAATGTGCTGGACCCAAGAGACATCATCAGTGGGGTGGAGATGCAG | GTG    c.2040
 K  S  L  G  N  V  L  D  P  R  D  I  I  S  G  V  E  M  Q   | V      p.680

          .         .         .         .         .         .       g.13564
 CTGCAGGAAAAGCTGAGAAGCGGAAATTTGGACCCTGCAGAGCTGGCCATTGTGGCTGCA       c.2100
 L  Q  E  K  L  R  S  G  N  L  D  P  A  E  L  A  I  V  A  A         p.700

        | 23 .         .         .         .         .         .    g.13747
 GCACAG | AAAAAGGACTTTCCTCACGGGATCCCTGAGTGTGGGACAGATGCCCTGAGATTC    c.2160
 A  Q   | K  K  D  F  P  H  G  I  P  E  C  G  T  D  A  L  R  F      p.720

          .         .      | 24  .         .         .         .    g.13934
 ACACTCTGCTCCCATGGAGTTCAGG | CGGGCGACTTGCACCTGTCAGTCTCTGAGGTCCAG    c.2220
 T  L  C  S  H  G  V  Q  A |   G  D  L  H  L  S  V  S  E  V  Q      p.740

          .         .         .         .         .         .       g.13994
 AGCTGCCGACATTTCTGCAACAAGATCTGGAATGCTCTTCGCTTTATCCTCAATGCTTTA       c.2280
 S  C  R  H  F  C  N  K  I  W  N  A  L  R  F  I  L  N  A  L         p.760

          .         .         .    | 25    .         .         .    g.14175
 GGGGAGAAATTTGTGCCACAGCCTGCTGAGGAG | CTGTCTCCCTCCTCCCCGATGGATGCC    c.2340
 G  E  K  F  V  P  Q  P  A  E  E   | L  S  P  S  S  P  M  D  A      p.780

          .         .         .         .         .         .       g.14235
 TGGATCCTGAGCCGCCTTGCCCTGGCTGCCCAGGAGTGTGAGCGGGGCTTCCTCACCCGA       c.2400
 W  I  L  S  R  L  A  L  A  A  Q  E  C  E  R  G  F  L  T  R         p.800

          .         .         .         .         .         .       g.14295
 GAGCTCTCGCTCGTCACTCATGCCCTGCACCACTTCTGGCTTCACAACCTCTGTGACGTC       c.2460
 E  L  S  L  V  T  H  A  L  H  H  F  W  L  H  N  L  C  D  V         p.820

        | 26 .         .         .         .         .         .    g.15203
 TACCTG | GAGGCTGTGAAGCCCGTGCTGTGGCACTCGCCCCGCCCCCTGGGGCCCCCTCAG    c.2520
 Y  L   | E  A  V  K  P  V  L  W  H  S  P  R  P  L  G  P  P  Q      p.840

          .         .         .         .         .         .       g.15263
 GTCCTGTTCTCCTGCGCTGACCTCGGCCTCCGCCTCCTGGCCCCACTGATGCCCTTCCTG       c.2580
 V  L  F  S  C  A  D  L  G  L  R  L  L  A  P  L  M  P  F  L         p.860

          .         .         .         .         .         .       g.15323
 GCTGAAGAGCTCTGGCAGAGGCTGCCCCCCAGGCCTGGTTGCCCCCCTGCCCCCAGCATC       c.2640
 A  E  E  L  W  Q  R  L  P  P  R  P  G  C  P  P  A  P  S  I         p.880

          .         .         .    | 27    .         .         .    g.16096
 TCGGTTGCCCCCTACCCCAGCGCCTGCAGCTTG | GAGCACTGGCGCCAGCCAGAGCTGGAG    c.2700
 S  V  A  P  Y  P  S  A  C  S  L   | E  H  W  R  Q  P  E  L  E      p.900

          .         .         .         .         .         .       g.16156
 CGGCGCTTCTCCCGGGTCCAAGAGGTCGTGCAGGTGCTAAGGGCTCTCCGAGCCACGTAC       c.2760
 R  R  F  S  R  V  Q  E  V  V  Q  V  L  R  A  L  R  A  T  Y         p.920

          .         .      | 28  .         .         .         .    g.16374
 CAGCTCACCAAAGCCCGGCCCCGAG | TGCTGCTGCAGAGCTCAGAGCCTGGGGACCAGGGC    c.2820
 Q  L  T  K  A  R  P  R  V |   L  L  Q  S  S  E  P  G  D  Q  G      p.940

          .         .         .         .         .         .       g.16434
 CTCTTCGAGGCCTTCTTGGAGCCCCTGGGCACCCTGGGCTACTGTGGGGCTGTGGGCCTG       c.2880
 L  F  E  A  F  L  E  P  L  G  T  L  G  Y  C  G  A  V  G  L         p.960

          .         .         .         .         .         .       g.16494
 TTACCCCCAGGCGCAGCAGCTCCCTCCGGCTGGGCCCAGGCTCCACTCAGTGACACGGCT       c.2940
 L  P  P  G  A  A  A  P  S  G  W  A  Q  A  P  L  S  D  T  A         p.980

          .         .  | 29      .         .         .         .    g.16714
 CAAGTCTACATGGAGCTGCAG | GGCCTGGTGGACCCGCAGATCCAGCTACCTCTGTTAGCC    c.3000
 Q  V  Y  M  E  L  Q   | G  L  V  D  P  Q  I  Q  L  P  L  L  A      p.1000

          .         .         .         .         .         .       g.16774
 GCCCGAAGGTACAAGTTGCAGAAGCAGCTTGACAGCCTCACAGCCAGGACCCCATCAGAA       c.3060
 A  R  R  Y  K  L  Q  K  Q  L  D  S  L  T  A  R  T  P  S  E         p.1020

          .         .         . | 30       .         .         .    g.16934
 GGGGAGGCAGGGACTCAGAGGCAACAAAAG | CTTTCTTCCCTCCAGCTGGAATTGTCAAAA    c.3120
 G  E  A  G  T  Q  R  Q  Q  K   | L  S  S  L  Q  L  E  L  S  K      p.1040

          .         .         .         .         .         .       g.16994
 CTGGACAAGGCAGCCTCTCACCTCCGGCAGCTGATGGATGAGCCTCCAGCCCCAGGGAGC       c.3180
 L  D  K  A  A  S  H  L  R  Q  L  M  D  E  P  P  A  P  G  S         p.1060

          .                                                         g.17006
 CCGGAGCTCTAA                                                       c.3192
 P  E  L  X                                                         p.1063

          .         .         .         .         .         .       g.17066
 ctcatcatccccatcagttttcctccctctcagacctgtctttgaggacaaacagatttg       c.*60

          .         .         .         .         .         .       g.17126
 tcagctgtcagggtgcagtgggacgtcagagactatgtggtccatcgccttcattgtgta       c.*120

          .         .         .         .         .         .       g.17186
 aatgaggacacagactggcttggtcgcagtgactgtggtgtccttgagatgctcacatta       c.*180

          .         .         .         .         .         .       g.17246
 ctgcccggcctgcctcccacctggaagtctgggaatgaggagattgagataaacttttga       c.*240

                                                                    g.17255
 aatcccaaa                                                          c.*249

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Valyl-tRNA synthetase 2, mitochondrial protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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