vinculin (VCL) - coding DNA reference sequence

(used for variant description)

(last modified June 18, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_014000.2 in the VCL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008868.1, covering VCL transcript NM_014000.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           gtagtcgctgcacagtctgtctcttcgccggttc       c.-61

 .         .         .         .         .         .                g.5094
 ccggccccgtggatcctacttctctgtcgcccgcggttcgccgccccgctcgccgccgcg       c.-1

          .         .         .         .         .         .       g.5154
 ATGCCAGTGTTTCATACGCGCACGATCGAGAGCATCCTGGAGCCGGTGGCACAGCAGATC       c.60
 M  P  V  F  H  T  R  T  I  E  S  I  L  E  P  V  A  Q  Q  I         p.20

          .         .         .         .         .         .       g.5214
 TCCCACCTGGTGATAATGCACGAGGAGGGCGAGGTGGACGGCAAAGCCATTCCTGACCTC       c.120
 S  H  L  V  I  M  H  E  E  G  E  V  D  G  K  A  I  P  D  L         p.40

          .         .         .         .         | 02         .    g.49981
 ACCGCGCCCGTGGCCGCCGTGCAGGCGGCCGTCAGCAACCTCGTCCGG | GTTGGAAAAGAG    c.180
 T  A  P  V  A  A  V  Q  A  A  V  S  N  L  V  R   | V  G  K  E      p.60

          .         .         .         .         .          | 03    g.77557
 ACTGTTCAAACCACTGAGGATCAGATTTTGAAGAGAGATATGCCACCAGCATTTATTAA | G    c.240
 T  V  Q  T  T  E  D  Q  I  L  K  R  D  M  P  P  A  F  I  K  |      p.80

          .         .         .         .         .         .       g.77617
 GTTGAGAATGCTTGCACCAAGCTTGTCCAGGCAGCTCAGATGCTTCAGTCAGACCCTTAC       c.300
 V  E  N  A  C  T  K  L  V  Q  A  A  Q  M  L  Q  S  D  P  Y         p.100

          .         .         .         .         .         .       g.77677
 TCAGTGCCTGCTCGAGATTATCTAATTGATGGGTCAAGGGGCATCCTCTCTGGAACATCA       c.360
 S  V  P  A  R  D  Y  L  I  D  G  S  R  G  I  L  S  G  T  S         p.120

          .         .         . | 04       .         .         .    g.77891
 GACCTGCTCCTTACCTTCGATGAGGCTGAG | GTCCGTAAAATTATTAGAGTTTGCAAAGGA    c.420
 D  L  L  L  T  F  D  E  A  E   | V  R  K  I  I  R  V  C  K  G      p.140

          .         .         .         .         .         .       g.77951
 ATTTTGGAATATCTTACAGTGGCAGAGGTGGTGGAGACTATGGAAGATTTGGTCACTTAC       c.480
 I  L  E  Y  L  T  V  A  E  V  V  E  T  M  E  D  L  V  T  Y         p.160

          .          | 05        .         .         .         .    g.79657
 ACAAAGAATCTTGGGCCAG | GAATGACTAAGATGGCCAAGATGATTGACGAGAGACAGCAG    c.540
 T  K  N  L  G  P  G |   M  T  K  M  A  K  M  I  D  E  R  Q  Q      p.180

          .         .         .         .         .         .       g.79717
 GAGCTCACTCACCAGGAGCACCGAGTGATGTTGGTGAACTCGATGAACACCGTGAAAGAG       c.600
 E  L  T  H  Q  E  H  R  V  M  L  V  N  S  M  N  T  V  K  E         p.200

          .         .   | 06     .         .         .         .    g.81667
 TTGCTGCCAGTTCTCATTTCAG | CTATGAAGATTTTTGTAACAACTAAAAACTCAAAAAAC    c.660
 L  L  P  V  L  I  S  A |   M  K  I  F  V  T  T  K  N  S  K  N      p.220

          .         .         .         .         .         .       g.81727
 CAAGGCATAGAGGAAGCTTTAAAAAATCGCAATTTTACTGTAGAAAAAATGAGTGCTGAA       c.720
 Q  G  I  E  E  A  L  K  N  R  N  F  T  V  E  K  M  S  A  E         p.240

          .         .         .         .         .         .       g.81787
 ATTAATGAGATAATTCGTGTGTTACAACTCACCTCTTGGGATGAAGATGCCTGGGCCAGC       c.780
 I  N  E  I  I  R  V  L  Q  L  T  S  W  D  E  D  A  W  A  S         p.260

     | 07    .         .         .         .         .         .    g.89397
 AAG | GACACTGAAGCCATGAAGAGAGCATTGGCCTCCATAGACTCCAAACTGAACCAGGCC    c.840
 K   | D  T  E  A  M  K  R  A  L  A  S  I  D  S  K  L  N  Q  A      p.280

          .         .         .     | 08   .         .         .    g.90278
 AAAGGTTGGCTCCGTGACCCTAGTGCCTCCCCAG | GGGATGCTGGTGAGCAGGCCATCAGA    c.900
 K  G  W  L  R  D  P  S  A  S  P  G |   D  A  G  E  Q  A  I  R      p.300

          .         .         .         .         .         .       g.90338
 CAGATCTTAGATGAAGCTGGAAAAGTTGGTGAACTCTGTGCAGGCAAAGAACGCAGGGAG       c.960
 Q  I  L  D  E  A  G  K  V  G  E  L  C  A  G  K  E  R  R  E         p.320

          .         .         .         .         .         .       g.90398
 ATTCTGGGAACTTGCAAAATGCTAGGGCAGATGACTGATCAAGTGGCTGACCTCCGTGCC       c.1020
 I  L  G  T  C  K  M  L  G  Q  M  T  D  Q  V  A  D  L  R  A         p.340

    | 09     .         .         .         .         .         .    g.96140
 AG | AGGACAAGGATCCTCACCGGTGGCCATGCAGAAAGCTCAGCAGGTATCTCAGGGTCTG    c.1080
 R  |  G  Q  G  S  S  P  V  A  M  Q  K  A  Q  Q  V  S  Q  G  L      p.360

          .         .         .         .         .         .       g.96200
 GATGTGCTCACAGCAAAAGTGGAAAATGCAGCTCGCAAGCTGGAAGCCATGACCAACTCA       c.1140
 D  V  L  T  A  K  V  E  N  A  A  R  K  L  E  A  M  T  N  S         p.380

          .         .         .       | 10 .         .         .    g.96933
 AAGCAGAGCATTGCAAAGAAGATCGATGCTGCTCAG | AACTGGCTTGCAGATCCAAATGGT    c.1200
 K  Q  S  I  A  K  K  I  D  A  A  Q   | N  W  L  A  D  P  N  G      p.400

          .         .         .         .         .         .       g.96993
 GGACCGGAAGGAGAAGAGCAGATTCGAGGTGCTTTGGCTGAAGCTCGGAAAATAGCAGAA       c.1260
 G  P  E  G  E  E  Q  I  R  G  A  L  A  E  A  R  K  I  A  E         p.420

          .         .         .         .         .         .       g.97053
 TTATGTGATGATCCTAAAGAAAGAGATGACATTCTACGTTCCCTTGGGGAAATATCTGCT       c.1320
 L  C  D  D  P  K  E  R  D  D  I  L  R  S  L  G  E  I  S  A         p.440

          .         .         .   | 11     .         .         .    g.101185
 CTGACTTCTAAATTAGCAGATCTACGAAGACA | GGGGAAAGGAGATTCTCCAGAGGCTCGA    c.1380
 L  T  S  K  L  A  D  L  R  R  Q  |  G  K  G  D  S  P  E  A  R      p.460

          .         .         .         .         .         .       g.101245
 GCCTTGGCCAAACAGGTGGCCACGGCCCTGCAGAACCTGCAGACCAAAACCAACCGGGCT       c.1440
 A  L  A  K  Q  V  A  T  A  L  Q  N  L  Q  T  K  T  N  R  A         p.480

          .         .         .         .         .         .       g.101305
 GTGGCCAACAGCAGACCGGCCAAAGCAGCTGTACACCTTGAGGGCAAGATTGAGCAAGCA       c.1500
 V  A  N  S  R  P  A  K  A  A  V  H  L  E  G  K  I  E  Q  A         p.500

          .         .         .         .    | 12    .         .    g.102559
 CAGCGGTGGATTGATAATCCCACAGTGGATGACCGTGGAGTCG | GTCAGGCTGCCATCCGG    c.1560
 Q  R  W  I  D  N  P  T  V  D  D  R  G  V  G |   Q  A  A  I  R      p.520

          .         .         .         .         .         .       g.102619
 GGGCTTGTGGCCGAAGGGCATCGTCTGGCTAATGTTATGATGGGGCCTTATCGGCAAGAT       c.1620
 G  L  V  A  E  G  H  R  L  A  N  V  M  M  G  P  Y  R  Q  D         p.540

          .         .         .         .         .         .       g.102679
 CTTCTCGCCAAGTGTGACCGAGTGGACCAGCTGACAGCCCAGCTGGCTGACCTGGCTGCC       c.1680
 L  L  A  K  C  D  R  V  D  Q  L  T  A  Q  L  A  D  L  A  A         p.560

          .         .         .         .         .         .       g.102739
 AGAGGGGAAGGGGAGAGTCCTCAGGCACGAGCACTTGCATCTCAGCTCCAAGACTCCTTA       c.1740
 R  G  E  G  E  S  P  Q  A  R  A  L  A  S  Q  L  Q  D  S  L         p.580

     | 13    .         .         .         .         .         .    g.104147
 AAG | GATCTAAAAGCTCGGATGCAGGAGGCCATGACTCAGGAAGTGTCAGATGTTTTCAGC    c.1800
 K   | D  L  K  A  R  M  Q  E  A  M  T  Q  E  V  S  D  V  F  S      p.600

          .         .         .         .         .         .       g.104207
 GATACCACAACTCCCATCAAGCTGTTGGCAGTGGCAGCCACGGCGCCTCCTGATGCGCCT       c.1860
 D  T  T  T  P  I  K  L  L  A  V  A  A  T  A  P  P  D  A  P         p.620

          .   | 14     .         .         .         .         .    g.107882
 AACAGGGAAGAG | GTATTTGATGAGAGGGCAGCTAACTTTGAAAACCATTCAGGAAAGCTT    c.1920
 N  R  E  E   | V  F  D  E  R  A  A  N  F  E  N  H  S  G  K  L      p.640

          .         .         .         .         .         .       g.107942
 GGTGCTACGGCCGAGAAGGCGGCTGCGGTTGGTACTGCTAATAAATCAACAGTGGAAGGC       c.1980
 G  A  T  A  E  K  A  A  A  V  G  T  A  N  K  S  T  V  E  G         p.660

          .         .         .         .   | 15     .         .    g.110724
 ATTCAGGCCTCAGTGAAGACGGCCCGAGAACTCACACCCCAG | GTGGTCTCGGCTGCTCGT    c.2040
 I  Q  A  S  V  K  T  A  R  E  L  T  P  Q   | V  V  S  A  A  R      p.680

          .         .         .         .         .         .       g.110784
 ATCTTACTTAGGAACCCTGGAAATCAAGCTGCTTATGAACATTTTGAGACCATGAAGAAC       c.2100
 I  L  L  R  N  P  G  N  Q  A  A  Y  E  H  F  E  T  M  K  N         p.700

          .         .         .  | 16      .         .         .    g.111966
 CAGTGGATCGATAATGTTGAAAAAATGACAG | GGCTGGTGGACGAAGCCATTGATACCAAA    c.2160
 Q  W  I  D  N  V  E  K  M  T  G |   L  V  D  E  A  I  D  T  K      p.720

          .         .         .         .         .         .       g.112026
 TCTCTGTTGGATGCTTCAGAAGAAGCAATTAAAAAAGACCTGGACAAGTGCAAGGTAGCT       c.2220
 S  L  L  D  A  S  E  E  A  I  K  K  D  L  D  K  C  K  V  A         p.740

          .         .         .         .         .         .       g.112086
 ATGGCCAACATTCAGCCTCAGATGCTGGTTGCTGGGGCAACCAGTATTGCTCGTCGGGCC       c.2280
 M  A  N  I  Q  P  Q  M  L  V  A  G  A  T  S  I  A  R  R  A         p.760

          .         .         .         .         .         .       g.112146
 AACCGGATCCTGCTGGTGGCTAAGAGGGAGGTGGAGAATTCCGAGGATCCCAAGTTCCGT       c.2340
 N  R  I  L  L  V  A  K  R  E  V  E  N  S  E  D  P  K  F  R         p.780

          .         .         .         .         .         .       g.112206
 GAGGCTGTGAAAGCTGCCTCTGATGAATTGAGCAAAACCATCTCCCCGATGGTGATGGAT       c.2400
 E  A  V  K  A  A  S  D  E  L  S  K  T  I  S  P  M  V  M  D         p.800

          .         .         .     | 17   .         .         .    g.114142
 GCAAAAGCTGTGGCTGGAAACATTTCCGACCCTG | GACTGCAAAAGAGCTTCCTGGACTCA    c.2460
 A  K  A  V  A  G  N  I  S  D  P  G |   L  Q  K  S  F  L  D  S      p.820

          .         .         .         .         .         .       g.114202
 GGATATCGGATCCTGGGAGCTGTGGCCAAGGTCAGAGAAGCCTTCCAACCTCAGGAGCCT       c.2520
 G  Y  R  I  L  G  A  V  A  K  V  R  E  A  F  Q  P  Q  E  P         p.840

          .         .         .          | 18        .         .    g.115878
 GACTTCCCGCCGCCTCCACCAGACCTTGAACAACTCCGA | CTAACAGATGAGCTTGCTCCT    c.2580
 D  F  P  P  P  P  P  D  L  E  Q  L  R   | L  T  D  E  L  A  P      p.860

          .         .         .         .         .         .       g.115938
 CCCAAACCACCTCTGCCTGAAGGTGAGGTCCCTCCACCTAGGCCTCCACCACCAGAGGAA       c.2640
 P  K  P  P  L  P  E  G  E  V  P  P  P  R  P  P  P  P  E  E         p.880

          .         .         .         .         .         .       g.115998
 AAGGATGAAGAGTTCCCTGAGCAGAAGGCCGGGGAGGTGATTAACCAGCCAATGATGATG       c.2700
 K  D  E  E  F  P  E  Q  K  A  G  E  V  I  N  Q  P  M  M  M         p.900

          .         .         .         .      | 19  .         .    g.118810
 GCTGCCAGACAGCTCCATGATGAAGCTCGCAAATGGTCCAGCAAG | CCGGGCATCCCAGCC    c.2760
 A  A  R  Q  L  H  D  E  A  R  K  W  S  S  K   | P  G  I  P  A      p.920

          .         .         .         .         .         .       g.118870
 GCTGAGGTGGGTATAGGTGTTGTAGCTGAGGCAGATGCGGCCGATGCTGCTGGCTTCCCT       c.2820
 A  E  V  G  I  G  V  V  A  E  A  D  A  A  D  A  A  G  F  P         p.940

          .         .         .         .         .         .       g.118930
 GTCCCCCCTGACATGGAAGACGATTACGAACCTGAGCTGCTGTTAATGCCATCCAATCAG       c.2880
 V  P  P  D  M  E  D  D  Y  E  P  E  L  L  L  M  P  S  N  Q         p.960

          .         .         .         .         .         .       g.118990
 CCGGTCAACCAGCCCATTCTGGCCGCGGCTCAGTCCTTGCATCGGGAAGCTACCAAGTGG       c.2940
 P  V  N  Q  P  I  L  A  A  A  Q  S  L  H  R  E  A  T  K  W         p.980

           | 20        .         .         .         .         .    g.121121
 TCTAGTAAG | GGCAATGACATCATTGCAGCAGCCAAGCGCATGGCTCTGCTGATGGCTGAG    c.3000
 S  S  K   | G  N  D  I  I  A  A  A  K  R  M  A  L  L  M  A  E      p.1000

          .         .         .         .         .         .       g.121181
 ATGTCTCGGCTGGTAAGAGGGGGCAGTGGTACCAAGCGGGCACTCATTCAGTGTGCCAAG       c.3060
 M  S  R  L  V  R  G  G  S  G  T  K  R  A  L  I  Q  C  A  K         p.1020

          .         .         .         .         .         .       g.121241
 GACATCGCCAAGGCCTCAGATGAGGTGACTCGGTTGGCCAAGGAGGTTGCCAAGCAGTGC       c.3120
 D  I  A  K  A  S  D  E  V  T  R  L  A  K  E  V  A  K  Q  C         p.1040

          .         .         .    | 21    .         .         .    g.121708
 ACAGATAAACGGATTAGAACCAACCTCTTACAG | GTATGTGAGCGAATCCCAACCATAAGC    c.3180
 T  D  K  R  I  R  T  N  L  L  Q   | V  C  E  R  I  P  T  I  S      p.1060

          .         .         .         .         .         .       g.121768
 ACCCAGCTCAAAATCCTGTCCACAGTGAAGGCCACCATGCTGGGCCGGACCAACATCAGT       c.3240
 T  Q  L  K  I  L  S  T  V  K  A  T  M  L  G  R  T  N  I  S         p.1080

          .         | 22         .         .         .         .    g.124951
 GATGAGGAGTCTGAGCAG | GCCACAGAGATGCTGGTTCACAATGCCCAGAACCTCATGCAG    c.3300
 D  E  E  S  E  Q   | A  T  E  M  L  V  H  N  A  Q  N  L  M  Q      p.1100

          .         .         .         .         .         .       g.125011
 TCTGTGAAGGAGACTGTGCGGGAAGCTGAAGCTGCTTCAATCAAAATTCGAACAGATGCT       c.3360
 S  V  K  E  T  V  R  E  A  E  A  A  S  I  K  I  R  T  D  A         p.1120

          .         .         .         .                           g.125056
 GGATTTACACTGCGCTGGGTTAGAAAGACTCCCTGGTACCAGTAG                      c.3405
 G  F  T  L  R  W  V  R  K  T  P  W  Y  Q  X                        p.1134

          .         .         .         .         .         .       g.125116
 gcacctggctgagcctggctggcacagaaacctctactaaaaagaaggaaaatgatctga       c.*60

          .         .         .         .         .         .       g.125176
 gtcccaggagctgcccagagttgctgggagctgaaaaatcacatcctggcctggcacatc       c.*120

          .         .         .         .         .         .       g.125236
 agaaaggaatgggggcctcttcaaattagaagacatttatactcttttttcatggacact       c.*180

          .         .         .         .         .         .       g.125296
 ttgaaatgtgtttctgtataaagcctgtattctcaaacacagttacacttgtgcaccctc       c.*240

          .         .         .         .         .         .       g.125356
 tatcccaataggcagactgggtttctagcccatggacttcacataagctcagaatccaag       c.*300

          .         .         .         .         .         .       g.125416
 tgaacactagccagacactctgctctgcccttgttccctaggggacacttccctctgttt       c.*360

          .         .         .         .         .         .       g.125476
 ctctttccttggctcccattcactcttccagaatcccaagacccagggcccaggcaaatc       c.*420

          .         .         .         .         .         .       g.125536
 agttactaagaagaaaattgctgtgcctcccaaaattgttttgagctttccatgttgctg       c.*480

          .         .         .         .         .         .       g.125596
 ccaaccataccttccttccctgggctgtgctacctgggtccttttcagaagtgagctttg       c.*540

          .         .         .         .         .         .       g.125656
 ctgctacaggggaaggtggcctctgtggagccccagcatatgggggcctggattcatttc       c.*600

          .         .         .         .         .         .       g.125716
 ctgcccttcctcagtttaatccttctagtttcccacaatataaaactgtacttcactgtc       c.*660

          .         .         .         .         .         .       g.125776
 aggaagaaatcacagaatcatatgattctgcttttaccatgcccctgagcaatgtctgtg       c.*720

          .         .         .         .         .         .       g.125836
 ctagggaaacttcccgtcccatatcctgcctcagcccgccaaggtagccatcccatgaac       c.*780

          .         .         .         .         .         .       g.125896
 acactgtgtcctggtgctctctgccactggaagggcagagtagccagggtgtggccctgc       c.*840

          .         .         .         .         .         .       g.125956
 catcttcccagcagggccactcccggcactccatgcttagtcactgcctgcagaggtctg       c.*900

          .         .         .         .         .         .       g.126016
 tgctgaggccttatcattcattcttagctcttaattgttcattttgagctgaaatgctgc       c.*960

          .         .         .         .         .         .       g.126076
 attttaattttaaccaaaacatgtctcctatcctggtttttgtagccttcctccacatcc       c.*1020

          .         .         .         .         .         .       g.126136
 tttctaaacaagattttaaagacatgtaggtgtttgttcatctgtaactctaaaagatcc       c.*1080

          .         .         .         .         .         .       g.126196
 tttttaaattcagtcctaagaaagaggagtgcttgtcccctaagagtgtttaatggcaag       c.*1140

          .         .         .         .         .         .       g.126256
 gcagccctgtctgaaggacacttcctgcctaagggagagtggtatttgcagactagaatt       c.*1200

          .         .         .         .         .         .       g.126316
 ctagtgctgctgaagatgaatcaatgggaaatactactcctgtaattcctacctccctgc       c.*1260

          .         .         .         .         .         .       g.126376
 aaccaactacaaccaagctctctgcatctactcccaagtatggggttcaagagagtaatg       c.*1320

          .         .         .         .         .         .       g.126436
 ggtttcatatttcttatcaccacagtaagttcctactaggcaaaatgagagggcagtgtt       c.*1380

          .         .         .         .         .         .       g.126496
 tcctttttggtacttattactgctaagtatttcccagcacatgaaaccttattttttccc       c.*1440

          .         .         .         .         .         .       g.126556
 aaagccagaaccagatgagtaaaggagtaagaaccttgcctgaacatccttccttcccac       c.*1500

          .         .         .         .         .         .       g.126616
 ccatcgctgtgtgttagttcccaacatcgaatgtgtacaacttaagttggtcctttacac       c.*1560

          .         .         .         .         .         .       g.126676
 tcaggctttcactatttcctttataatgaggatgattattttcaaggccctcagcatatt       c.*1620

          .         .         .         .         .         .       g.126736
 tgtatagttgcttgcctgatataaatgcaatattaatgcctttaaagtatgaatctatgc       c.*1680

          .         .         .         .         .         .       g.126796
 caaagatcacttgttgttttactaaagaaagattacttagaggaaataagaaaaatcatg       c.*1740

          .         .         .         .         .         .       g.126856
 tttgctctcccggttcttccagtggtttgagacactggtttacactttatgccggatgtg       c.*1800

          .         .         .         .         .         .       g.126916
 cttttctccaatatcagtgctcgagacacagtgaagcaaattaaaaaaaaaaaaaaaaaa       c.*1860

          .         .         .         .         .         .       g.126976
 aatccctgaatgatgattagagacatcaccgctaaaaaactacatttataagctaggatt       c.*1920

          .         .         .         .         .         .       g.127036
 tgttatatgcaaatattttctgcctcttcttttgttctgtttaaaacaataaaatgcatt       c.*1980

          .                                                         g.127047
 tgtataaaaaa                                                        c.*1991

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Vinculin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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