vitamin D (1,25- dihydroxyvitamin D3) receptor (VDR) - coding DNA reference sequence

(used for variant description)

(last modified April 26, 2026)


This file was created to facilitate the description of sequence variants on transcript NM_000376.2 in the VDR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering VDR transcript NM_000376.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5040
                     ctgcttgtcaaaaggcggcagcggagccgtgtgcgccggg       c.-121

 .         .         .         .       | 02 .         .             g.27280
 agcgcggaacagcttgtccacccgccggccggaccag | aagcctttgggtctgaagtgtct    c.-61

 .         .         .         .         .         .        | 03    g.30918
 gtgagacctcacagaagagcacccctgggctccacttacctgccccctgctccttcag | gg    c.-1

          .         .         .         .         .         .       g.30978
 ATGGAGGCAATGGCGGCCAGCACTTCCCTGCCTGACCCTGGAGACTTTGACCGGAACGTG       c.60
 M  E  A  M  A  A  S  T  S  L  P  D  P  G  D  F  D  R  N  V         p.20

          .         .         .         .         .         .       g.31038
 CCCCGGATCTGTGGGGTGTGTGGAGACCGAGCCACTGGCTTTCACTTCAATGCTATGACC       c.120
 P  R  I  C  G  V  C  G  D  R  A  T  G  F  H  F  N  A  M  T         p.40

          .         .       | 04 .         .         .         .    g.44888
 TGTGAAGGCTGCAAAGGCTTCTTCAG | GCGAAGCATGAAGCGGAAGGCACTATTCACCTGC    c.180
 C  E  G  C  K  G  F  F  R  |  R  S  M  K  R  K  A  L  F  T  C      p.60

          .         .         .         .         .         .       g.44948
 CCCTTCAACGGGGACTGCCGCATCACCAAGGACAACCGACGCCACTGCCAGGCCTGCCGG       c.240
 P  F  N  G  D  C  R  I  T  K  D  N  R  R  H  C  Q  A  C  R         p.80

          .         .         .        | 05.         .         .    g.52366
 CTCAAACGCTGTGTGGACATCGGCATGATGAAGGAGT | TCATTCTGACAGATGAGGAAGTG    c.300
 L  K  R  C  V  D  I  G  M  M  K  E  F |   I  L  T  D  E  E  V      p.100

          .         .         .         .         .         .       g.52426
 CAGAGGAAGCGGGAGATGATCCTGAAGCGGAAGGAGGAGGAGGCCTTGAAGGACAGTCTG       c.360
 Q  R  K  R  E  M  I  L  K  R  K  E  E  E  A  L  K  D  S  L         p.120

          .         .         .         .         .         .       g.52486
 CGGCCCAAGCTGTCTGAGGAGCAGCAGCGCATCATTGCCATACTGCTGGACGCCCACCAT       c.420
 R  P  K  L  S  E  E  Q  Q  R  I  I  A  I  L  L  D  A  H  H         p.140

          .         .         .         .   | 06     .         .    g.52800
 AAGACCTACGACCCCACCTACTCCGACTTCTGCCAGTTCCGG | CCTCCAGTTCGTGTGAAT    c.480
 K  T  Y  D  P  T  Y  S  D  F  C  Q  F  R   | P  P  V  R  V  N      p.160

          .         .         .         .         .         .       g.52860
 GATGGTGGAGGGAGCCATCCTTCCAGGCCCAACTCCAGACACACTCCCAGCTTCTCTGGG       c.540
 D  G  G  G  S  H  P  S  R  P  N  S  R  H  T  P  S  F  S  G         p.180

          .         .         .         .    | 07    .         .    g.54247
 GACTCCTCCTCCTCCTGCTCAGATCACTGTATCACCTCTTCAG | ACATGATGGACTCGTCC    c.600
 D  S  S  S  S  C  S  D  H  C  I  T  S  S  D |   M  M  D  S  S      p.200

          .         .         .         .         .         .       g.54307
 AGCTTCTCCAATCTGGATCTGAGTGAAGAAGATTCAGATGACCCTTCTGTGACCCTAGAG       c.660
 S  F  S  N  L  D  L  S  E  E  D  S  D  D  P  S  V  T  L  E         p.220

          .         .         .         .         .         .       g.54367
 CTGTCCCAGCTCTCCATGCTGCCCCACCTGGCTGACCTGGTCAGTTACAGCATCCAAAAG       c.720
 L  S  Q  L  S  M  L  P  H  L  A  D  L  V  S  Y  S  I  Q  K         p.240

          .         .         .      | 08  .         .         .    g.63248
 GTCATTGGCTTTGCTAAGATGATACCAGGATTCAG | AGACCTCACCTCTGAGGACCAGATC    c.780
 V  I  G  F  A  K  M  I  P  G  F  R  |  D  L  T  S  E  D  Q  I      p.260

          .         .         .         .         .         .       g.63308
 GTACTGCTGAAGTCAAGTGCCATTGAGGTCATCATGTTGCGCTCCAATGAGTCCTTCACC       c.840
 V  L  L  K  S  S  A  I  E  V  I  M  L  R  S  N  E  S  F  T         p.280

          .         .         .         .         .         .       g.63368
 ATGGACGACATGTCCTGGACCTGTGGCAACCAAGACTACAAGTACCGCGTCAGTGACGTG       c.900
 M  D  D  M  S  W  T  C  G  N  Q  D  Y  K  Y  R  V  S  D  V         p.300

         | 09.         .         .         .         .         .    g.63633
 ACCAAAG | CCGGACACAGCCTGGAGCTGATTGAGCCCCTCATCAAGTTCCAGGTGGGACTG    c.960
 T  K  A |   G  H  S  L  E  L  I  E  P  L  I  K  F  Q  V  G  L      p.320

          .         .         .         .         .         .       g.63693
 AAGAAGCTGAACTTGCATGAGGAGGAGCATGTCCTGCTCATGGCCATCTGCATCGTCTCC       c.1020
 K  K  L  N  L  H  E  E  E  H  V  L  L  M  A  I  C  I  V  S         p.340

      | 10   .         .         .         .         .         .    g.65082
 CCAG | ATCGTCCTGGGGTGCAGGACGCCGCGCTGATTGAGGCCATCCAGGACCGCCTGTCC    c.1080
 P  D |   R  P  G  V  Q  D  A  A  L  I  E  A  I  Q  D  R  L  S      p.360

          .         .         .         .         .         .       g.65142
 AACACACTGCAGACGTACATCCGCTGCCGCCACCCGCCCCCGGGCAGCCACCTGCTCTAT       c.1140
 N  T  L  Q  T  Y  I  R  C  R  H  P  P  P  G  S  H  L  L  Y         p.380

          .         .         .         .         .         .       g.65202
 GCCAAGATGATCCAGAAGCTAGCCGACCTGCGCAGCCTCAATGAGGAGCACTCCAAGCAG       c.1200
 A  K  M  I  Q  K  L  A  D  L  R  S  L  N  E  E  H  S  K  Q         p.400

          .         .         .         .         .         .       g.65262
 TACCGCTGCCTCTCCTTCCAGCCTGAGTGCAGCATGAAGCTAACGCCCCTTGTGCTCGAA       c.1260
 Y  R  C  L  S  F  Q  P  E  C  S  M  K  L  T  P  L  V  L  E         p.420

          .         .                                               g.65286
 GTGTTTGGCAATGAGATCTCCTGA                                           c.1284
 V  F  G  N  E  I  S  X                                             p.427

          .         .         .         .         .         .       g.65346
 ctaggacagcctgtggcggtgcctgggtggggctgctcctccagggccacgtgccaggcc       c.*60

          .         .         .         .         .         .       g.65406
 cggggctggcggctactcagcagccctcctcaccccgtctggggttcagcccctcctctg       c.*120

          .         .         .         .         .         .       g.65466
 ccacctcccctatccacccagcccattctctctcctgtccaacctaacccctttcctgcg       c.*180

          .         .         .         .         .         .       g.65526
 ggcttttccccggtcccttgagacctcagccatgaggagttgctgtttgtttgacaaaga       c.*240

          .         .         .         .         .         .       g.65586
 aacccaagtgggggcagagggcagaggctggaggcagggccttgcccagagatgcctcca       c.*300

          .         .         .         .         .         .       g.65646
 ccgctgcctaagtggctgctgactgatgttgagggaacagacaggagaaatgcatccatt       c.*360

          .         .         .         .         .         .       g.65706
 cctcagggacagagacacctgcacctccccccactgcaggccccgcttgtccagcgccta       c.*420

          .         .         .         .         .         .       g.65766
 gtggggtctccctctcctgcctactcacgataaataatcggcccacagctcccaccccac       c.*480

          .         .         .         .         .         .       g.65826
 ccccttcagtgcccaccaacatcccattgccctggttatattctcacgggcagtagctgt       c.*540

          .         .         .         .         .         .       g.65886
 ggtgaggtgggttttcttcccatcactggagcaccaggcacgaacccacctgctgagaga       c.*600

          .         .         .         .         .         .       g.65946
 cccaaggaggaaaaacagacaaaaacagcctcacagaagaatatgacagctgtccctgtc       c.*660

          .         .         .         .         .         .       g.66006
 accaagctcacagttcctcgccctgggtctaaggggttggttgaggtggaagccctcctt       c.*720

          .         .         .         .         .         .       g.66066
 ccacggatccatgtagcaggactgaattgtccccagtttgcagaaaagcacctgccgacc       c.*780

          .         .         .         .         .         .       g.66126
 tcgtcctccccctgccagtgccttacctcctgcccaggagagccagccctccctgtcctc       c.*840

          .         .         .         .         .         .       g.66186
 ctcggatcaccgagagtagccgagagcctgctcccccaccccctccccaggggagagggt       c.*900

          .         .         .         .         .         .       g.66246
 ctggagaagcagtgagccgcatcttctccatctggcagggtgggatggaggagaagaatt       c.*960

          .         .         .         .         .         .       g.66306
 ttcagaccccagcggctgagtcatgatctccctgccgcctcaatgtggttgcaaggccgc       c.*1020

          .         .         .         .         .         .       g.66366
 tgttcacccacagggctaagagctagcgctgccgcaccccagagtgtgggaagggagagc       c.*1080

          .         .         .         .         .         .       g.66426
 ggggcagtctcgggtggctagtcagagagagtgtttgggggttccgtgatgtagggtaag       c.*1140

          .         .         .         .         .         .       g.66486
 gtgccttcttattctcactccaccacccaaaagtcaaaaggtgcctgtgaggcaggggcg       c.*1200

          .         .         .         .         .         .       g.66546
 gagtgatacaacttcaagtgcatgctctctgcagccagcccagcccagctggtgggaagc       c.*1260

          .         .         .         .         .         .       g.66606
 gtctgtccgtttactccaaggtggggtctttgtgagagtgagctgtaggtgtgcgggacc       c.*1320

          .         .         .         .         .         .       g.66666
 ggtacagaaaggcgttcttcgaggtggatcacagaggcttcttcagatcagtgcttgagt       c.*1380

          .         .         .         .         .         .       g.66726
 ttggggaatgcggccgcattccctgagtcaccaggaatgttaaagtcagtgggaacgtga       c.*1440

          .         .         .         .         .         .       g.66786
 ctgccccaactcctggaagctgtgtccttgcacctgcatccgtagttccctgaaaaccca       c.*1500

          .         .         .         .         .         .       g.66846
 gagaggaatcagacttcacactgcaagagccttggtgtccacctggccccatgtctctca       c.*1560

          .         .         .         .         .         .       g.66906
 gaattcttcaggtggaaaaacatctgaaagccacgttccttactgcagaatagcatatat       c.*1620

          .         .         .         .         .         .       g.66966
 atcgcttaatcttaaatttattagatatgagttgttttcagactcagactccatttgtat       c.*1680

          .         .         .         .         .         .       g.67026
 tatagtctaatatacagggtagcaggtaccactgatttggagatatttatggggggagaa       c.*1740

          .         .         .         .         .         .       g.67086
 cttacattgtgaaacttctgtacattaattattattgctgttgttattttacaagggtct       c.*1800

          .         .         .         .         .         .       g.67146
 agggagagacccttgtttgattttagctgcagaacgtattggtccagcttgctcttcagt       c.*1860

          .         .         .         .         .         .       g.67206
 gggagaaaacacttgtaagttgctaaacgagtcaatcccctcattcaggaaaactgacag       c.*1920

          .         .         .         .         .         .       g.67266
 aggagggcgtgactcacccaagcatatataactagctagaagtgggccaggacaggcccg       c.*1980

          .         .         .         .         .         .       g.67326
 gcgcggtggctcacgcctgtaatcccagcagtttgggaggtcgaggtaggtggatcacct       c.*2040

          .         .         .         .         .         .       g.67386
 gaggtcgggagttcgagaccaacctgaccaacatggagaaaccctgtctctattaaaaat       c.*2100

          .         .         .         .         .         .       g.67446
 acaaaaaaaaaaaaaaaaaaaatagccgggcatggtggcgcaagcctgtaatcccagcta       c.*2160

          .         .         .         .         .         .       g.67506
 ctcaggaggctgaggcagaagaattgaacccaggaggtggaggttgcagtgagctgagat       c.*2220

          .         .         .         .         .         .       g.67566
 cgtgccgttactctccaacctggacaacaagagcgaaactccgtcttagaagtggaccag       c.*2280

          .         .         .         .         .         .       g.67626
 gacaggaccagattttggagtcatggtccggtgtccttttcactacaccatgtttgagct       c.*2340

          .         .         .         .         .         .       g.67686
 cagacccccactctcattccccaggtggctgacccagtccctgggggaagccctggattt       c.*2400

          .         .         .         .         .         .       g.67746
 cagaaagagcaagtctggatctgggaccctttccttccttccctggcttgtaactccacc       c.*2460

          .         .         .         .         .         .       g.67806
 aacccatcagaaggagaaggaaggagactcacctctgcctcaatgtgaatcagaccctac       c.*2520

          .         .         .         .         .         .       g.67866
 cccaccacgatgtggccctggcctgctgggctctccacctcagccttggataatgctgtt       c.*2580

          .         .         .         .         .         .       g.67926
 gcctcatctataacatgcatttgtctttgtaatgtcaccaccttcccagctctccctctg       c.*2640

          .         .         .         .         .         .       g.67986
 gccctgccttcttcggggaactcctggaaatatcagttactcagccctgggccccaccac       c.*2700

          .         .         .         .         .         .       g.68046
 ctaggccactcctccaaaggaagtctaggagctgggaggaaaagaaaagaggggaaaatg       c.*2760

          .         .         .         .         .         .       g.68106
 agtttttatggggctgaacggggagaaaaggtcatcatcgattctactttagaatgagag       c.*2820

          .         .         .         .         .         .       g.68166
 tgtgaaatagacatttgtaaatgtaaaacttttaaggtatatcattataactgaaggaga       c.*2880

          .         .         .         .         .         .       g.68226
 aggtgccccaaaatgcaagattttccacaagattcccagagacaggaaaatcctctggct       c.*2940

          .         .         .         .         .         .       g.68286
 ggctaactggaagcatgtaggagaatccaagcgaggtcaacagagaaggcaggaatgtgt       c.*3000

          .         .         .         .         .         .       g.68346
 ggcagatttagtgaaagctagagatatggcagcgaaaggatgtaaacagtgcctgctgaa       c.*3060

          .         .         .         .         .         .       g.68406
 tgatttccaaagagaaaaaaagtttgccagaagtttgtcaagtcaaccaatgtagaaagc       c.*3120

          .         .         .         .         .         .       g.68466
 tttgcttatggtaataaaaatggctcatacttatatagcacttactttgttgcaagtact       c.*3180

          .         .                                               g.68495
 gctgtaaataaatgctttatgcaaaccaa                                      c.*3209

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Vitamin D (1,25- dihydroxyvitamin D3) receptor protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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