vascular endothelial growth factor C (VEGFC) - coding DNA reference sequence

(used for variant description)

(last modified November 26, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_005429.2 in the VEGFC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering VEGFC transcript NM_005429.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   cggggaaggg       c.-421

 .         .         .         .         .         .                g.5070
 gagggaggagggggacgagggctctggcgggtttggaggggctgaacatcgcggggtgtt       c.-361

 .         .         .         .         .         .                g.5130
 ctggtgtcccccgccccgcctctccaaaaagctacaccgacgcggaccgcggcggcgtcc       c.-301

 .         .         .         .         .         .                g.5190
 tccctcgccctcgcttcacctcgcgggctccgaatgcggggagctcggatgtccggtttc       c.-241

 .         .         .         .         .         .                g.5250
 ctgtgaggcttttacctgacacccgccgcctttccccggcactggctgggagggcgccct       c.-181

 .         .         .         .         .         .                g.5310
 gcaaagttgggaacgcggagccccggacccgctcccgccgcctccggctcgcccaggggg       c.-121

 .         .         .         .         .         .                g.5370
 ggtcgccgggaggagcccgggggagagggaccaggaggggcccgcggcctcgcaggggcg       c.-61

 .         .         .         .         .         .                g.5430
 cccgcgcccccacccctgcccccgccagcggaccggtcccccacccccggtccttccacc       c.-1

          .         .         .         .         .         .       g.5490
 ATGCACTTGCTGGGCTTCTTCTCTGTGGCGTGTTCTCTGCTCGCCGCTGCGCTGCTCCCG       c.60
 M  H  L  L  G  F  F  S  V  A  C  S  L  L  A  A  A  L  L  P         p.20

          .         .         .         .         .         .       g.5550
 GGTCCTCGCGAGGCGCCCGCCGCCGCCGCCGCCTTCGAGTCCGGACTCGACCTCTCGGAC       c.120
 G  P  R  E  A  P  A  A  A  A  A  F  E  S  G  L  D  L  S  D         p.40

          .         .        | 02.         .         .         .    g.68028
 GCGGAGCCCGACGCGGGCGAGGCCACG | GCTTATGCAAGCAAAGATCTGGAGGAGCAGTTA    c.180
 A  E  P  D  A  G  E  A  T   | A  Y  A  S  K  D  L  E  E  Q  L      p.60

          .         .         .         .         .         .       g.68088
 CGGTCTGTGTCCAGTGTAGATGAACTCATGACTGTACTCTACCCAGAATATTGGAAAATG       c.240
 R  S  V  S  S  V  D  E  L  M  T  V  L  Y  P  E  Y  W  K  M         p.80

          .         .         .         .         .         .       g.68148
 TACAAGTGTCAGCTAAGGAAAGGAGGCTGGCAACATAACAGAGAACAGGCCAACCTCAAC       c.300
 Y  K  C  Q  L  R  K  G  G  W  Q  H  N  R  E  Q  A  N  L  N         p.100

          .         .         .         .         .         .       g.68208
 TCAAGGACAGAAGAGACTATAAAATTTGCTGCAGCACATTATAATACAGAGATCTTGAAA       c.360
 S  R  T  E  E  T  I  K  F  A  A  A  H  Y  N  T  E  I  L  K         p.120

   | 03      .         .         .         .         .         .    g.69832
 A | GTATTGATAATGAGTGGAGAAAGACTCAATGCATGCCACGGGAGGTGTGTATAGATGTG    c.420
 S |   I  D  N  E  W  R  K  T  Q  C  M  P  R  E  V  C  I  D  V      p.140

          .         .         .         .         .         .       g.69892
 GGGAAGGAGTTTGGAGTCGCGACAAACACCTTCTTTAAACCTCCATGTGTGTCCGTCTAC       c.480
 G  K  E  F  G  V  A  T  N  T  F  F  K  P  P  C  V  S  V  Y         p.160

          .         .         .         .         .         .       g.69952
 AGATGTGGGGGTTGCTGCAATAGTGAGGGGCTGCAGTGCATGAACACCAGCACGAGCTAC       c.540
 R  C  G  G  C  C  N  S  E  G  L  Q  C  M  N  T  S  T  S  Y         p.180

          .   | 04     .         .         .         .         .    g.86139
 CTCAGCAAGACG | TTATTTGAAATTACAGTGCCTCTCTCTCAAGGCCCCAAACCAGTAACA    c.600
 L  S  K  T   | L  F  E  I  T  V  P  L  S  Q  G  P  K  P  V  T      p.200

          .         .         .         .         .         .       g.86199
 ATCAGTTTTGCCAATCACACTTCCTGCCGATGCATGTCTAAACTGGATGTTTACAGACAA       c.660
 I  S  F  A  N  H  T  S  C  R  C  M  S  K  L  D  V  Y  R  Q         p.220

          .         .         .         .     | 05   .         .    g.109830
 GTTCATTCCATTATTAGACGTTCCCTGCCAGCAACACTACCACA | GTGTCAGGCAGCGAAC    c.720
 V  H  S  I  I  R  R  S  L  P  A  T  L  P  Q  |  C  Q  A  A  N      p.240

          .         .         .         .         .         .       g.109890
 AAGACCTGCCCCACCAATTACATGTGGAATAATCACATCTGCAGATGCCTGGCTCAGGAA       c.780
 K  T  C  P  T  N  Y  M  W  N  N  H  I  C  R  C  L  A  Q  E         p.260

          .         .         .  | 06      .         .         .    g.110250
 GATTTTATGTTTTCCTCGGATGCTGGAGATG | ACTCAACAGATGGATTCCATGACATCTGT    c.840
 D  F  M  F  S  S  D  A  G  D  D |   S  T  D  G  F  H  D  I  C      p.280

          .         .         .         .         .         .       g.110310
 GGACCAAACAAGGAGCTGGATGAAGAGACCTGTCAGTGTGTCTGCAGAGCGGGGCTTCGG       c.900
 G  P  N  K  E  L  D  E  E  T  C  Q  C  V  C  R  A  G  L  R         p.300

          .         .         .         .         .         .       g.110370
 CCTGCCAGCTGTGGACCCCACAAAGAACTAGACAGAAACTCATGCCAGTGTGTCTGTAAA       c.960
 P  A  S  C  G  P  H  K  E  L  D  R  N  S  C  Q  C  V  C  K         p.320

          .         .         .         .         .         .       g.110430
 AACAAACTCTTCCCCAGCCAATGTGGGGCCAACCGAGAATTTGATGAAAACACATGCCAG       c.1020
 N  K  L  F  P  S  Q  C  G  A  N  R  E  F  D  E  N  T  C  Q         p.340

          .         .         .         .         .         .       g.110490
 TGTGTATGTAAAAGAACCTGCCCCAGAAATCAACCCCTAAATCCTGGAAAATGTGCCTGT       c.1080
 C  V  C  K  R  T  C  P  R  N  Q  P  L  N  P  G  K  C  A  C         p.360

          .         .         .         .         .         .       g.110550
 GAATGTACAGAAAGTCCACAGAAATGCTTGTTAAAAGGAAAGAAGTTCCACCACCAAACA       c.1140
 E  C  T  E  S  P  Q  K  C  L  L  K  G  K  K  F  H  H  Q  T         p.380

       | 07  .         .         .         .         .         .    g.113756
 TGCAG | CTGTTACAGACGGCCATGTACGAACCGCCAGAAGGCTTGTGAGCCAGGATTTTCA    c.1200
 C  S  |  C  Y  R  R  P  C  T  N  R  Q  K  A  C  E  P  G  F  S      p.400

          .         .         .         .         .         .       g.113816
 TATAGTGAAGAAGTGTGTCGTTGTGTCCCTTCATATTGGAAAAGACCACAAATGATGAGC       c.1260
 Y  S  E  E  V  C  R  C  V  P  S  Y  W  K  R  P  Q  M  M  S         p.420

                                                                    g.113819
 TAA                                                                c.1263
 X                                                                  p.420

          .         .         .         .         .         .       g.113879
 gattgtactgttttccagttcatcgattttctattatggaaaactgtgttgccacagtag       c.*60

          .         .         .         .         .         .       g.113939
 aactgtctgtgaacagagagacccttgtgggtccatgctaacaaagacaaaagtctgtct       c.*120

          .         .         .         .         .         .       g.113999
 ttcctgaaccatgtggataactttacagaaatggactggagctcatctgcaaaaggcctc       c.*180

          .         .         .         .         .         .       g.114059
 ttgtaaagactggttttctgccaatgaccaaacagccaagattttcctcttgtgatttct       c.*240

          .         .         .         .         .         .       g.114119
 ttaaaagaatgactatataatttatttccactaaaaatattgtttctgcattcattttta       c.*300

          .         .         .         .         .         .       g.114179
 tagcaacaacaattggtaaaactcactgtgatcaatatttttatatcatgcaaaatatgt       c.*360

          .         .                                               g.114205
 ttaaaataaaatgaaaattgtattat                                         c.*386

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Vascular endothelial growth factor C protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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