vimentin (VIM) - coding DNA reference sequence

(used for variant description)

(last modified November 26, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_003380.3 in the VIM gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012413.1, covering VIM transcript NM_003380.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5053
        gcctctccaaaggctgcagaagtttcttgctaacaaaaagtccgcacattcga       c.-361

 .         .         .         .         .         .                g.5113
 gcaaagacaggctttagcgagttattaaaaacttaggggcgctcttgtcccccacagggc       c.-301

 .         .         .         .         .         .                g.5173
 ccgaccgcacacagcaaggcgatggcccagctgtaagttggtagcactgagaactagcag       c.-241

 .         .         .         .         .         .                g.5233
 cgcgcgcggagcccgctgagacttgaatcaatctggtctaacggtttcccctaaaccgct       c.-181

 .         .         .         .   | 02     .         .             g.6044
 aggagccctcaatcggcgggacagcagggcgcg | tcctctgccactctcgctccgaggtcc    c.-121

 .         .         .         .         .         .                g.6104
 ccgcgccagagacgcagccgcgctcccaccacccacacccaccgcgccctcgttcgcctc       c.-61

 .         .         .         .         .         .                g.6164
 ttctccgggagccagtccgcgccaccgccgccgcccaggccatcgccaccctccgcagcc       c.-1

          .         .         .         .         .         .       g.6224
 ATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCGCAGGATGTTCGGCGGCCCGGGCACC       c.60
 M  S  T  R  S  V  S  S  S  S  Y  R  R  M  F  G  G  P  G  T         p.20

          .         .         .         .         .         .       g.6284
 GCGAGCCGGCCGAGCTCCAGCCGGAGCTACGTGACTACGTCCACCCGCACCTACAGCCTG       c.120
 A  S  R  P  S  S  S  R  S  Y  V  T  T  S  T  R  T  Y  S  L         p.40

          .         .         .         .         .         .       g.6344
 GGCAGCGCGCTGCGCCCCAGCACCAGCCGCAGCCTCTACGCCTCGTCCCCGGGCGGCGTG       c.180
 G  S  A  L  R  P  S  T  S  R  S  L  Y  A  S  S  P  G  G  V         p.60

          .         .         .         .         .         .       g.6404
 TATGCCACGCGCTCCTCTGCCGTGCGCCTGCGGAGCAGCGTGCCCGGGGTGCGGCTCCTG       c.240
 Y  A  T  R  S  S  A  V  R  L  R  S  S  V  P  G  V  R  L  L         p.80

          .         .         .         .         .         .       g.6464
 CAGGACTCGGTGGACTTCTCGCTGGCCGACGCCATCAACACCGAGTTCAAGAACACCCGC       c.300
 Q  D  S  V  D  F  S  L  A  D  A  I  N  T  E  F  K  N  T  R         p.100

          .         .         .         .         .         .       g.6524
 ACCAACGAGAAGGTGGAGCTGCAGGAGCTGAATGACCGCTTCGCCAACTACATCGACAAG       c.360
 T  N  E  K  V  E  L  Q  E  L  N  D  R  F  A  N  Y  I  D  K         p.120

          .         .         .         .         .         .       g.6584
 GTGCGCTTCCTGGAGCAGCAGAATAAGATCCTGCTGGCCGAGCTCGAGCAGCTCAAGGGC       c.420
 V  R  F  L  E  Q  Q  N  K  I  L  L  A  E  L  E  Q  L  K  G         p.140

          .         .         .         .         .         .       g.6644
 CAAGGCAAGTCGCGCCTGGGGGACCTCTACGAGGAGGAGATGCGGGAGCTGCGCCGGCAG       c.480
 Q  G  K  S  R  L  G  D  L  Y  E  E  E  M  R  E  L  R  R  Q         p.160

          .         .         .         .         .         .       g.6704
 GTGGACCAGCTAACCAACGACAAAGCCCGCGTCGAGGTGGAGCGCGACAACCTGGCCGAG       c.540
 V  D  Q  L  T  N  D  K  A  R  V  E  V  E  R  D  N  L  A  E         p.180

          .         .    | 03    .         .         .         .    g.7428
 GACATCATGCGCCTCCGGGAGAA | ATTGCAGGAGGAGATGCTTCAGAGAGAGGAAGCCGAA    c.600
 D  I  M  R  L  R  E  K  |  L  Q  E  E  M  L  Q  R  E  E  A  E      p.200

          .         .     | 04   .         .         .         .    g.10364
 AACACCCTGCAATCTTTCAGACAG | GATGTTGACAATGCGTCTCTGGCACGTCTTGACCTT    c.660
 N  T  L  Q  S  F  R  Q   | D  V  D  N  A  S  L  A  R  L  D  L      p.220

          .         .         .         .         .         .       g.10424
 GAACGCAAAGTGGAATCTTTGCAAGAAGAGATTGCCTTTTTGAAGAAACTCCACGAAGAG       c.720
 E  R  K  V  E  S  L  Q  E  E  I  A  F  L  K  K  L  H  E  E         p.240

  | 05       .         .         .         .         .         .    g.10571
  | GAAATCCAGGAGCTGCAGGCTCAGATTCAGGAACAGCATGTCCAAATCGATGTGGATGTT    c.780
  | E  I  Q  E  L  Q  A  Q  I  Q  E  Q  H  V  Q  I  D  V  D  V      p.260

          .         .         .         .         .         .       g.10631
 TCCAAGCCTGACCTCACGGCTGCCCTGCGTGACGTACGTCAGCAATATGAAAGTGTGGCT       c.840
 S  K  P  D  L  T  A  A  L  R  D  V  R  Q  Q  Y  E  S  V  A         p.280

          .         .         .         .   | 06     .         .    g.11452
 GCCAAGAACCTGCAGGAGGCAGAAGAATGGTACAAATCCAAG | TTTGCTGACCTCTCTGAG    c.900
 A  K  N  L  Q  E  A  E  E  W  Y  K  S  K   | F  A  D  L  S  E      p.300

          .         .         .         .         .         .       g.11512
 GCTGCCAACCGGAACAATGACGCCCTGCGCCAGGCAAAGCAGGAGTCCACTGAGTACCGG       c.960
 A  A  N  R  N  N  D  A  L  R  Q  A  K  Q  E  S  T  E  Y  R         p.320

          .         .         .         .         | 07         .    g.11922
 AGACAGGTGCAGTCCCTCACCTGTGAAGTGGATGCCCTTAAAGGAACC | AATGAGTCCCTG    c.1020
 R  Q  V  Q  S  L  T  C  E  V  D  A  L  K  G  T   | N  E  S  L      p.340

          .         .         .         .         .         .       g.11982
 GAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGAC       c.1080
 E  R  Q  M  R  E  M  E  E  N  F  A  V  E  A  A  N  Y  Q  D         p.360

          .         .         .         .         .         .       g.12042
 ACTATTGGCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAATGGCTCGTCACCTT       c.1140
 T  I  G  R  L  Q  D  E  I  Q  N  M  K  E  E  M  A  R  H  L         p.380

          .         .         .         .         .         .       g.12102
 CGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCCTTGACATTGAGATTGCCACCTAC       c.1200
 R  E  Y  Q  D  L  L  N  V  K  M  A  L  D  I  E  I  A  T  Y         p.400

          .         .          | 08        .         .         .    g.12618
 AGGAAGCTGCTGGAAGGCGAGGAGAGCAG | GATTTCTCTGCCTCTTCCAAACTTTTCCTCC    c.1260
 R  K  L  L  E  G  E  E  S  R  |  I  S  L  P  L  P  N  F  S  S      p.420

          .    | 09    .         .         .         .         .    g.13082
 CTGAACCTGAGGG | AAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGG    c.1320
 L  N  L  R  E |   T  N  L  D  S  L  P  L  V  D  T  H  S  K  R      p.440

          .         .         .          | 10        .         .    g.13992
 ACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAG | GTTATCAACGAAACTTCTCAG    c.1380
 T  L  L  I  K  T  V  E  T  R  D  G  Q   | V  I  N  E  T  S  Q      p.460

          .         .                                               g.14013
 CATCACGATGACCTTGAATAA                                              c.1401
 H  H  D  D  L  E  X                                                p.466

          .         .         .         .         .         .       g.14073
 aaattgcacacactcagtgcagcaatatattaccagcaagaataaaaaagaaatccatat       c.*60

          .         .         .         .         .         .       g.14133
 cttaaagaaacagctttcaagtgcctttctgcagtttttcaggagcgcaagatagatttg       c.*120

          .         .         .         .         .         .       g.14193
 gaataggaataagctctagttcttaacaaccgacactcctacaagatttagaaaaaagtt       c.*180

          .         .         .         .         .         .       g.14253
 tacaacataatctagtttacagaaaaatcttgtgctagaatactttttaaaaggtatttt       c.*240

          .         .         .         .         .         .       g.14313
 gaataccattaaaactgcttttttttttccagcaagtatccaaccaacttggttctgctt       c.*300

          .         .                                               g.14335
 caataaatctttggaaaaactc                                             c.*322

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Vimentin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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