vacuolar protein sorting 33 homolog B (yeast) (VPS33B) - coding DNA reference sequence

(used for variant description)

(last modified November 29, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_018668.3 in the VPS33B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012162.1, covering VPS33B transcript NM_018668.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5054
       gagatctaggaagtcgcttctttttctggtagaaggcggggttctcctcgtacg       c.-301

 .         .         .         .         .         .                g.5114
 ctgcggagtctctgcggggtgtagaccggaatcctgctgacgggcagagtggatcaggga       c.-241

 .         .         .         .         .         .                g.5174
 gggagggtcgagacacggtggctgcaggtctgagacaaggctgctccgaggtagtagctc       c.-181

 .         .         .         .         .         .                g.5234
 tcttgcctggaggtggccattcattcctggagtgctgctgaggagcgagggcccatctgg       c.-121

 .         .         .         .         .         .                g.5294
 ggtctctggaagtcggtgcccaggcctgaaggatagccccccttgcgcttccctgggctg       c.-61

 .         .         .         .         .         .                g.5354
 cggccggccttctcagaacgaagggcgtccttccaccccgcggcgcaggtgaccgctgcc       c.-1

          .         .         .         .         .         .       g.5414
 ATGGCTTTTCCCCATCGGCCGGACGCCCCTGAGCTGCCTGACTTCTCCATGCTGAAGAGG       c.60
 M  A  F  P  H  R  P  D  A  P  E  L  P  D  F  S  M  L  K  R         p.20

          .         .         .       | 02 .         .         .    g.9742
 CTGGCTCGAGACCAGCTCATCTATCTGCTGGAGCAG | CTTCCTGGAAAAAAGGATTTATTC    c.120
 L  A  R  D  Q  L  I  Y  L  L  E  Q   | L  P  G  K  K  D  L  F      p.40

          .         .         .         .         .        | 03.    g.10582
 ATTGAGGCAGATCTCATGAGCCCTTTGGATCGAATTGCCAATGTCTCCATCCTGAAG | CAA    c.180
 I  E  A  D  L  M  S  P  L  D  R  I  A  N  V  S  I  L  K   | Q      p.60

          .         .         .         .         .          | 04    g.13171
 CACGAAGTAGACAAGCTATACAAGGTGGAGAACAAGCCAGCCCTCAGCTCCAATGAACA | A    c.240
 H  E  V  D  K  L  Y  K  V  E  N  K  P  A  L  S  S  N  E  Q  |      p.80

          .         .         .         .          | 05        .    g.13743
 TTGTGCTTCTTGGTCAGACCCCGCATCAAGAATATGCGATACATTGCCA | GTCTTGTCAAT    c.300
 L  C  F  L  V  R  P  R  I  K  N  M  R  Y  I  A  S |   L  V  N      p.100

          .         .         .         .         .        | 06.    g.17760
 GCTGACAAATTGGCTGGCCGAACTCGCAAATACAAAGTGATCTTCAGCCCTCAAAAG | TTC    c.360
 A  D  K  L  A  G  R  T  R  K  Y  K  V  I  F  S  P  Q  K   | F      p.120

          .         .         .         .    | 07    .         .    g.19656
 TATGCGTGTGAGATGGTGCTTGAGGAAGAGGGAATCTATGGAG | ATGTGAGCTGTGATGAA    c.420
 Y  A  C  E  M  V  L  E  E  E  G  I  Y  G  D |   V  S  C  D  E      p.140

          .         .         .         .         .         .       g.19716
 TGGGCCTTCTCTTTGCTGCCTCTTGATGTGGATCTGCTGAGCATGGAACTACCAGAATTT       c.480
 W  A  F  S  L  L  P  L  D  V  D  L  L  S  M  E  L  P  E  F         p.160

          .         | 08         .         .         .         .    g.20072
 TTCAGGGATTACTTTCTG | GAAGGAGATCAGCGTTGGATCAACACTGTAGCTCAGGCCTTA    c.540
 F  R  D  Y  F  L   | E  G  D  Q  R  W  I  N  T  V  A  Q  A  L      p.180

          .         .         .         .         .         .       g.20132
 CACCTTCTCAGCACTCTCTATGGACCCTTTCCAAACTGCTATGGAATTGGCAGGTGCGCC       c.600
 H  L  L  S  T  L  Y  G  P  F  P  N  C  Y  G  I  G  R  C  A         p.200

     | 09    .         .         .         .         .         .    g.20614
 AAG | ATGGCATATGAATTGTGGAGGAACCTGGAGGAGGAGGAGGATGGCGAAACCAAGGGC    c.660
 K   | M  A  Y  E  L  W  R  N  L  E  E  E  E  D  G  E  T  K  G      p.220

          .         .         .         . | 10       .         .    g.20894
 CGAAGGCCAGAGATTGGACATATCTTTCTCTTGGACAGAG | ATGTGGACTTTGTGACAGCA    c.720
 R  R  P  E  I  G  H  I  F  L  L  D  R  D |   V  D  F  V  T  A      p.240

          .         .         .         .         .         | 11    g.21160
 CTTTGCTCCCAAGTGGTTTATGAGGGCCTAGTAGATGACACCTTCCGCATCAAGTGTG | GG    c.780
 L  C  S  Q  V  V  Y  E  G  L  V  D  D  T  F  R  I  K  C  G |       p.260

          .         .         .         .         .         .       g.21220
 AGTGTCGACTTTGGCCCAGAAGTCACATCCTCTGACAAGAGCCTGAAGGTGCTACTCAAT       c.840
 S  V  D  F  G  P  E  V  T  S  S  D  K  S  L  K  V  L  L  N         p.280

          .   | 12     .         .         .         .         .    g.21592
 GCCGAGGACAAG | GTGTTTAATGAGATTCGGAACGAGCACTTCTCCAATGTCTTTGGCTTC    c.900
 A  E  D  K   | V  F  N  E  I  R  N  E  H  F  S  N  V  F  G  F      p.300

          .         .         .          | 13        .         .    g.21840
 TTGAGCCAGAAGGCCCGGAACTTGCAGGCCCAGTATGAT | CGCCGGAGAGGCATGGACATT    c.960
 L  S  Q  K  A  R  N  L  Q  A  Q  Y  D   | R  R  R  G  M  D  I      p.320

          .         .         .         .         .         .       g.21900
 AAGCAGATGAAGAATTTCGTGTCCCAGGAGCTCAAGGGCCTGAAACAGGAGCACCGCCTG       c.1020
 K  Q  M  K  N  F  V  S  Q  E  L  K  G  L  K  Q  E  H  R  L         p.340

          . | 14       .         .         .         .         .    g.22199
 CTGAGTCTCC | ATATTGGGGCCTGTGAATCCATCATGAAGAAGAAAACCAAGCAGGATTTC    c.1080
 L  S  L  H |   I  G  A  C  E  S  I  M  K  K  K  T  K  Q  D  F      p.360

          .         .      | 15  .         .         .         .    g.22519
 CAGGAGCTAATCAAGACTGAGCATG | CACTGCTAGAGGGGTTCAACATCCGGGAGAGCACC    c.1140
 Q  E  L  I  K  T  E  H  A |   L  L  E  G  F  N  I  R  E  S  T      p.380

          .         .         . | 16       .         .         .    g.22702
 AGCTACATTGAGGAACACATAGACCGGCAG | GTGTCGCCTATAGAAAGCCTGCGCCTCATG    c.1200
 S  Y  I  E  E  H  I  D  R  Q   | V  S  P  I  E  S  L  R  L  M      p.400

          .         .      | 17  .         .         .         .    g.24507
 TGCCTTTTGTCCATCACTGAGAATG | GTTTGATCCCCAAGGATTACCGATCTCTGAAAACA    c.1260
 C  L  L  S  I  T  E  N  G |   L  I  P  K  D  Y  R  S  L  K  T      p.420

          .   | 18     .         .         .         .         .    g.25469
 CAGTATCTGCAG | AGCTATGGCCCTGAGCACCTGCTAACCTTCTCCAATCTGCGAAGAGCT    c.1320
 Q  Y  L  Q   | S  Y  G  P  E  H  L  L  T  F  S  N  L  R  R  A      p.440

          .         .         .         .         .         .       g.25529
 GGGCTCCTAACGGAGCAGGCCCCCGGGGACACCCTCACAGCCGTGGAGAGTAAAGTGAGC       c.1380
 G  L  L  T  E  Q  A  P  G  D  T  L  T  A  V  E  S  K  V  S         p.460

          .         .      | 19  .         .         .         .    g.26176
 AAGCTGGTGACCGACAAGGCTGCAG | GAAAGATTACTGATGCCTTCAGTTCTCTGGCCAAG    c.1440
 K  L  V  T  D  K  A  A  G |   K  I  T  D  A  F  S  S  L  A  K      p.480

          .         .         .          | 20        .         .    g.27033
 AGGAGCAATTTTCGTGCCATCAGCAAAAAGCTGAATTTG | ATCCCACGTGTGGACGGCGAG    c.1500
 R  S  N  F  R  A  I  S  K  K  L  N  L   | I  P  R  V  D  G  E      p.500

          .         .         .         .         .         .       g.27093
 TATGATCTGAAAGTGCCCCGAGACATGGCTTACGTCTTCGGTGGTGCTTATGTGCCCCTG       c.1560
 Y  D  L  K  V  P  R  D  M  A  Y  V  F  G  G  A  Y  V  P  L         p.520

          .         .  | 21      .         .         .         .    g.27667
 AGCTGCCGAATCATTGAGCAG | GTGCTAGAGCGGCGAAGCTGGCAGGGCCTTGATGAGGTG    c.1620
 S  C  R  I  I  E  Q   | V  L  E  R  R  S  W  Q  G  L  D  E  V      p.540

          .         .         .        | 22.         .         .    g.27833
 GTACGGCTGCTCAACTGCAGTGACTTTGCATTCACAG | ATATGACTAAGGAAGACAAGGCT    c.1680
 V  R  L  L  N  C  S  D  F  A  F  T  D |   M  T  K  E  D  K  A      p.560

          .         .         .         .         .         .       g.27893
 TCCAGTGAGTCCCTGCGCCTCATCTTGGTGGTGTTCTTGGGTGGTTGTACATTCTCTGAG       c.1740
 S  S  E  S  L  R  L  I  L  V  V  F  L  G  G  C  T  F  S  E         p.580

          .         .         .     | 23   .         .         .    g.28575
 ATCTCAGCCCTCCGGTTCCTGGGCAGAGAGAAAG | GCTACAGGTTCATTTTCCTGACGACA    c.1800
 I  S  A  L  R  F  L  G  R  E  K  G |   Y  R  F  I  F  L  T  T      p.600

          .         .         .         .         .                 g.28629
 GCAGTCACAAACAGCGCTCGCCTTATGGAGGCCATGAGTGAGGTGAAAGCCTGA             c.1854
 A  V  T  N  S  A  R  L  M  E  A  M  S  E  V  K  A  X               p.617

          .         .         .         .         .         .       g.28689
 tgtttttcccggccagtgttgacatcttccctgaacacattcctcagtgagatgcaggca       c.*60

          .         .         .         .         .         .       g.28749
 tctggcacccagctgctataaccaagtgtccaccaactacctgctaagagccgggagcat       c.*120

          .         .         .         .         .         .       g.28809
 ggaacgtgttgggatttagagaacattatctgagaaaagagttcacttcctgctcccagg       c.*180

          .         .         .         .         .         .       g.28869
 atatttctcttttctgtttatgaagtacaacccatgctgctaagatgcgagcaggaagag       c.*240

          .         .         .         .         .         .       g.28929
 gcatcctttgctaaatcctgtttgaatgtcattgtaaataaagcctctgctctcagatgt       c.*300

          .         .         .         .         .         .       g.28989
 aatacgttggtcgttctggacacgcacttccatctttattagtgaaagcccattggagct       c.*360

          .         .         .         .         .         .       g.29049
 tgctacaggggcttcctgtgcttcttggcctggactttgtagtggctccaggcctggtct       c.*420

          .                                                         g.29060
 ggttcttccct                                                        c.*431

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Vacuolar protein sorting 33 homolog B (yeast) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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