vacuolar protein sorting 4 homolog A (S. cerevisiae) (VPS4A) - coding DNA reference sequence

(used for variant description)

(last modified November 24, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_013245.2 in the VPS4A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering VPS4A transcript NM_013245.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5008
                                                     cctgcccg       c.-121

 .         .         .         .         .         .                g.5068
 cgcaccgcgctcagcgcccaccgccgggcttcccgcgccggacccagtacctcggctccc       c.-61

 .         .         .         .         .         .                g.5128
 cggggccggaccgaggccgcaagcagcgccgcggggtgtggggcggacccaggagatgaa       c.-1

          .         .  | 02      .         .         .         .    g.9663
 ATGACAACGTCAACCCTCCAG | AAAGCCATTGATCTGGTGACGAAAGCCACAGAGGAGGAC    c.60
 M  T  T  S  T  L  Q   | K  A  I  D  L  V  T  K  A  T  E  E  D      p.20

          .         .         .         .         .         .       g.9723
 AAAGCCAAGAACTACGAGGAGGCGCTGCGGCTGTACCAGCATGCGGTGGAGTACTTCCTC       c.120
 K  A  K  N  Y  E  E  A  L  R  L  Y  Q  H  A  V  E  Y  F  L         p.40

          .    | 03    .         .         .         .         .    g.9888
 CACGCTATCAAGT | ATGAGGCCCACAGCGACAAGGCCAAGGAGAGCATTCGAGCCAAGTGC    c.180
 H  A  I  K  Y |   E  A  H  S  D  K  A  K  E  S  I  R  A  K  C      p.60

          .         .         .         .         .         .       g.9948
 GTGCAGTACCTAGACCGGGCCGAGAAGCTGAAGGATTATTTACGAAGCAAAGAGAAACAC       c.240
 V  Q  Y  L  D  R  A  E  K  L  K  D  Y  L  R  S  K  E  K  H         p.80

          .         .         .         .  | 04      .         .    g.12285
 GGCAAGAAGCCAGTCAAAGAGAACCAGAGTGAGGGCAAGGG | CAGTGACAGTGACAGTGAA    c.300
 G  K  K  P  V  K  E  N  Q  S  E  G  K  G  |  S  D  S  D  S  E      p.100

          .         .         .         .    | 05    .         .    g.12456
 GGGGATAATCCGGAGAAAAAGAAACTGCAAGAACAGCTGATGG | GTGCCGTCGTGATGGAG    c.360
 G  D  N  P  E  K  K  K  L  Q  E  Q  L  M  G |   A  V  V  M  E      p.120

          .         .         .         .         .         .       g.12516
 AAGCCCAACATACGGTGGAACGACGTGGCCGGGCTGGAGGGGGCCAAGGAGGCCCTCAAA       c.420
 K  P  N  I  R  W  N  D  V  A  G  L  E  G  A  K  E  A  L  K         p.140

          .         .         .         .    | 06    .         .    g.13020
 GAAGCTGTCATTTTGCCAATCAAATTCCCACACTTGTTCACAG | GCAAGCGCACCCCCTGG    c.480
 E  A  V  I  L  P  I  K  F  P  H  L  F  T  G |   K  R  T  P  W      p.160

          .         .         .         .         .         .       g.13080
 CGGGGGATTCTGCTGTTCGGACCCCCTGGCACAGGGAAATCCTACCTGGCCAAAGCCGTG       c.540
 R  G  I  L  L  F  G  P  P  G  T  G  K  S  Y  L  A  K  A  V         p.180

          .         .         .         .         .         .       g.13140
 GCAACAGAGGCCAACAACTCCACCTTCTTCTCTGTGTCCTCCTCAGATCTGATGTCCAAG       c.600
 A  T  E  A  N  N  S  T  F  F  S  V  S  S  S  D  L  M  S  K         p.200

          .         . | 07       .         .         .         .    g.13797
 TGGCTGGGGGAGAGTGAAAA | GCTGGTCAAGAACCTGTTTGAGCTGGCCAGGCAGCACAAG    c.660
 W  L  G  E  S  E  K  |  L  V  K  N  L  F  E  L  A  R  Q  H  K      p.220

          .         .         .         .         .         .       g.13857
 CCCTCCATCATCTTCATCGATGAGGTGGATTCCCTCTGCGGGTCCCGAAATGAAAATGAG       c.720
 P  S  I  I  F  I  D  E  V  D  S  L  C  G  S  R  N  E  N  E         p.240

          .         .         .         .          | 08        .    g.14315
 AGTGAGGCCGCCCGGAGGATCAAAACGGAGTTCTTGGTCCAGATGCAGG | GGGTGGGGAAT    c.780
 S  E  A  A  R  R  I  K  T  E  F  L  V  Q  M  Q  G |   V  G  N      p.260

          .         .         .         .         .         .       g.14375
 AACAATGATGGGACTCTGGTTCTTGGAGCCACAAACATCCCATGGGTGTTGGATTCGGCC       c.840
 N  N  D  G  T  L  V  L  G  A  T  N  I  P  W  V  L  D  S  A         p.280

          .  | 09      .         .         .         .         .    g.14716
 ATCAGGAGGAG | GTTTGAAAAACGAATTTATATCCCCTTGCCGGAGGAAGCTGCCCGCGCC    c.900
 I  R  R  R  |  F  E  K  R  I  Y  I  P  L  P  E  E  A  A  R  A      p.300

          .         .         .         .         .         .       g.14776
 CAGATGTTCCGGTTGCATCTCGGGAGCACTCCCCACAACCTCACGGATGCAAACATCCAC       c.960
 Q  M  F  R  L  H  L  G  S  T  P  H  N  L  T  D  A  N  I  H         p.320

          .         .         .         .         .         .       g.14836
 GAGCTGGCCCGGAAGACGGAAGGCTACTCGGGCGCGGACATCAGCATCATCGTGCGGGAC       c.1020
 E  L  A  R  K  T  E  G  Y  S  G  A  D  I  S  I  I  V  R  D         p.340

          .         .         .         .         .  | 10      .    g.16185
 TCTCTCATGCAGCCCGTGAGGAAGGTGCAGTCGGCCACACACTTCAAAAAG | GTCTGTGGC    c.1080
 S  L  M  Q  P  V  R  K  V  Q  S  A  T  H  F  K  K   | V  C  G      p.360

          .         .         .         .         .         .       g.16245
 CCCTCTCGCACCAACCCCAGCATGATGATTGATGACCTCCTGACTCCATGCTCACCAGGG       c.1140
 P  S  R  T  N  P  S  M  M  I  D  D  L  L  T  P  C  S  P  G         p.380

          .         .         .         .         .         .       g.16305
 GACCCAGGAGCCATGGAGATGACTTGGATGGATGTCCCTGGGGACAAACTCTTAGAGCCT       c.1200
 D  P  G  A  M  E  M  T  W  M  D  V  P  G  D  K  L  L  E  P         p.400

          .   | 11     .         .         .         .         .    g.17872
 GTGGTTTGCATG | TCGGACATGCTGCGGTCTCTGGCCACCACCCGGCCCACGGTGAATGCA    c.1260
 V  V  C  M   | S  D  M  L  R  S  L  A  T  T  R  P  T  V  N  A      p.420

          .         .         .         .         .                 g.17926
 GACGACCTCCTGAAAGTGAAGAAATTCTCAGAGGACTTTGGGCAAGAGAGTTAA             c.1314
 D  D  L  L  K  V  K  K  F  S  E  D  F  G  Q  E  S  X               p.437

          .         .         .         .         .         .       g.17986
 aagctgcttcacttgggcaatggtgaaggtgggaggttgattggggcaaatccaggcact       c.*60

          .         .         .         .         .         .       g.18046
 ccccatgtcaacagccagacagggctccagggcttgtcccagtcaatacagagttccctc       c.*120

          .         .         .         .         .         .       g.18106
 tgctgtctggccgtctgccagggagccagaaggaagggccttgcagccacagagacactc       c.*180

          .         .         .         .         .         .       g.18166
 cactgccctggggcacacagtggacactgctcttcctacttcctcctctcctggatgctc       c.*240

          .         .         .         .         .         .       g.18226
 atcagctccttctgcctcccccccttttttttccatcttttgttcccctaaattaatgct       c.*300

          .         .         .         .         .         .       g.18286
 gcttggattttcatcttatttataaagataaaatcacctggaagtgtcaaggagtggggc       c.*360

          .         .         .         .         .         .       g.18346
 ggggtggcgggggagaagcagccgtgctgccaggtcacccagacctccagacagccggct       c.*420

          .         .         .         .         .         .       g.18406
 agccccactgcccgttccttttacgcccaagttttgctccttgagagcagattggctgat       c.*480

          .         .         .         .         .         .       g.18466
 gcccctgcaaccccagcccaagctctgcctcaaagaccgagtgacataagccattcccac       c.*540

          .         .         .         .         .         .       g.18526
 cctcctaggttcacatccagggctgtgtcttccttgggggaggagatggtgtcgtttaga       c.*600

          .         .         .         .         .         .       g.18586
 tcagggtaaggcagtcaggcgggtgttcaccactgccttttcttcctctgagcgtgagaa       c.*660

          .         .         .         .         .         .       g.18646
 cactgaacccagccactgcccctgggtccctgtcctggaaatggtctaataaatcctttt       c.*720

          .                                                         g.18660
 cccttcttgagcta                                                     c.*734

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Vacuolar protein sorting 4 homolog A (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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