von Willebrand factor A domain containing 3B (VWA3B) - coding DNA reference sequence

(used for variant description)

(last modified January 23, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_144992.4 in the VWA3B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_054753.1, covering VWA3B transcript NM_144992.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5024
                                     ggagacgccgtcgtcaacagaccg       c.-241

 .         .         .         .         .         .                g.5084
 cgctcggaaccagaggcgcgggtcacagagacctagaacagctggaatccttcgcccccg       c.-181

 .         .         .         .         .         .                g.5144
 gcgcgcagccttcgcccgccggaatcgctgccttatccaccagcgggatgcttacctcgc       c.-121

 .         .         .         .         .         .                g.5204
 ccgccctctcgggtcaggcgggcccgggaggatgggagggtggctgctgagcgggagccg       c.-61

 .         .         .        | 02.         .         .             g.10961
 ccacgtcttccacccgacatattgccta | gagtttgctgtgacttagatcttgattcagag    c.-1

          .         .         .         .         .         .       g.11021
 ATGGAGAAATCAGGCCCATCTTCTACCATCTCTGAGCAGCAGCTGCAGAGGCAAGAGGGA       c.60
 M  E  K  S  G  P  S  S  T  I  S  E  Q  Q  L  Q  R  Q  E  G         p.20

          .         .         .         .         .         .       g.11081
 TGGATTAACACCAAAACAGACTTGGCTGAGCAGAGTCTCATTTCATCTGAGAAATGGCTT       c.120
 W  I  N  T  K  T  D  L  A  E  Q  S  L  I  S  S  E  K  W  L         p.40

          .         .         .         .         .         .       g.11141
 CAACTGCATGGGCTTAAGAGCAACAAATTGACCTTGAAACAGATTTTGTCACAGATCGGA       c.180
 Q  L  H  G  L  K  S  N  K  L  T  L  K  Q  I  L  S  Q  I  G         p.60

          .       | 03 .         .         .         .         .    g.33564
 TTCCCACATTGTGAAG | ATTATGTGGCGTCTCTGGGGAGACCTGTGGCTTCTCGGTATGCT    c.240
 F  P  H  C  E  D |   Y  V  A  S  L  G  R  P  V  A  S  R  Y  A      p.80

          .         .         .         .         .  | 04      .    g.37390
 GATGGTCTGTTTCCACAGCTCTACAGAGCAGAAGATGGCAGAGTATACAAT | CTGACAGCT    c.300
 D  G  L  F  P  Q  L  Y  R  A  E  D  G  R  V  Y  N   | L  T  A      p.100

          .         .         .         .         .         .       g.37450
 AAATCAGAACTGATTTATCAGTTTGTGGAACATTTAACACAAGCTGTGGAGAGCTACAAG       c.360
 K  S  E  L  I  Y  Q  F  V  E  H  L  T  Q  A  V  E  S  Y  K         p.120

          .         .         .         .         .         .       g.37510
 CAGCGAATGGACTGGCTCACCAGCAAGAGCCGGCAGATTTTTGGTGTCATCTTGGAACAG       c.420
 Q  R  M  D  W  L  T  S  K  S  R  Q  I  F  G  V  I  L  E  Q         p.140

          .         .         .         .         .         .       g.37570
 TGCGTCACCATAGTGCTGGATTTTGGCGGCATTCTGGAGGGGGAGCTTGATCTGTGCCGA       c.480
 C  V  T  I  V  L  D  F  G  G  I  L  E  G  E  L  D  L  C  R         p.160

          .         .         .         .         .         .       g.37630
 GAGGCTCTAACAATGGTTCTCCAGGAGCAGGTGGCTCACATAACCGAGTTCAATATCATA       c.540
 E  A  L  T  M  V  L  Q  E  Q  V  A  H  I  T  E  F  N  I  I         p.180

    | 05     .         .         .         .         .         .    g.39225
 CG | GGTTTCTCAAGAGCCTGTGAAGTGGCAGGAAAATGCTACTCCTGTGACCGAACAGTCC    c.600
 R  |  V  S  Q  E  P  V  K  W  Q  E  N  A  T  P  V  T  E  Q  S      p.200

          .         .         .         .         .         .       g.39285
 ATAGCTACTGCCATCAGTTGGGTTGAGAAACTGACGGTTGAGCTGACTGTGAGCGAGGCT       c.660
 I  A  T  A  I  S  W  V  E  K  L  T  V  E  L  T  V  S  E  A         p.220

          .         .         .         .   | 06     .         .    g.46125
 GGCCGCCTGGATGCTCTGCTGGAAGCCGGGAGAGACAAGACT | ATTGAATCCATTTACTAC    c.720
 G  R  L  D  A  L  L  E  A  G  R  D  K  T   | I  E  S  I  Y  Y      p.240

          .         .         .         .         .         .       g.46185
 TTTGTGGTGGGGGATGTTCCTGAAGAATCCAAGGAGCTTCTCCTCCAGAGGGCCTTGGAG       c.780
 F  V  V  G  D  V  P  E  E  S  K  E  L  L  L  Q  R  A  L  E         p.260

          .         .         .         .         .         .       g.46245
 ATCCCGTGTCCAGTCTACACAGTGTCCTTCAACGCCAGAGGAGAAGGCACTATAGCTTTT       c.840
 I  P  C  P  V  Y  T  V  S  F  N  A  R  G  E  G  T  I  A  F         p.280

          .         .         .   | 07     .         .         .    g.51720
 CTAAAGGATCTGAGTGCCAAGACCCACAGCAG | ATTCCACGCATTTGCCGAGAGAACAGAG    c.900
 L  K  D  L  S  A  K  T  H  S  R  |  F  H  A  F  A  E  R  T  E      p.300

          .         .         .         .         .         .       g.51780
 TGTGTAGAATTTCCTGCATTCTCCACAAAGGATGGTGACAATGTGATGACTTGGAATTCA       c.960
 C  V  E  F  P  A  F  S  T  K  D  G  D  N  V  M  T  W  N  S         p.320

          .         .         | 08         .         .         .    g.80751
 AGGAAACTGAAAGGAAAACTCCCTCCAG | GAGCTGGAGTCAGAGAGGACGTGTTTCTCGTT    c.1020
 R  K  L  K  G  K  L  P  P  G |   A  G  V  R  E  D  V  F  L  V      p.340

          .         .         .         .         .         .       g.80811
 TGGCAAGAGATGGAGGAAGCCTGCAGCACGCTGGCCCAGATCCAGAGGCTGGTGGCCGAG       c.1080
 W  Q  E  M  E  E  A  C  S  T  L  A  Q  I  Q  R  L  V  A  E         p.360

          .         .         .     | 09   .         .         .    g.98910
 CCTCCCAAGCCCGACGTGGCCACTGTGGACTGCG | AGTCAGAAACAACCTCTGTTGAGATT    c.1140
 P  P  K  P  D  V  A  T  V  D  C  E |   S  E  T  T  S  V  E  I      p.380

          .         .         .         .         .         .       g.98970
 GCATCGAATCCAGAAGACACCTGGGACTCTAAGACATGGCTGCAGAAATATGGCTTGAAG       c.1200
 A  S  N  P  E  D  T  W  D  S  K  T  W  L  Q  K  Y  G  L  K         p.400

          .         .         .         .         .         .       g.99030
 GCCCAGAAGCTATCCTTGTATGATGTGCTTGCCGACTGCTCTTTCCGCCACGCTGATGGG       c.1260
 A  Q  K  L  S  L  Y  D  V  L  A  D  C  S  F  R  H  A  D  G         p.420

          .         .         .         .         .  | 10      .    g.105852
 GTTGTGGATATAAAAGCCAAACCGGAGAATGAGTCCGTGCAGACCAGTGCG | GAGACGAAC    c.1320
 V  V  D  I  K  A  K  P  E  N  E  S  V  Q  T  S  A   | E  T  N      p.440

          .         .         .         .         .         .       g.105912
 AAGAAGACAGTCCATGCAAAATATTGCAGCAGGTTTGTCCATGCTCCCTGGAAGGATGGG       c.1380
 K  K  T  V  H  A  K  Y  C  S  R  F  V  H  A  P  W  K  D  G         p.460

          .         .         .         .         .         .       g.105972
 AGCTTGGTCCACGTCAACATTACCAAAGAGAAGTGCAAGTGGTACAGTGAGAGAATCCAC       c.1440
 S  L  V  H  V  N  I  T  K  E  K  C  K  W  Y  S  E  R  I  H         p.480

          .         .       | 11 .         .         .         .    g.110800
 ACAGCCCTGGCCCGGATCCGAAGGAG | GATTAAATGGCTACAGGATGGGAGTCAAAGCCTC    c.1500
 T  A  L  A  R  I  R  R  R  |  I  K  W  L  Q  D  G  S  Q  S  L      p.500

          .         .         .         .         .         .       g.110860
 TTTGGAAGATTGCATAATGATTGCATCTACATTCTCATTGACACGTCTCACTCAATGAAG       c.1560
 F  G  R  L  H  N  D  C  I  Y  I  L  I  D  T  S  H  S  M  K         p.520

          .         .         .         .      | 12  .         .    g.112244
 AGCAAACTGGACTTGGTGAAGGACAAGATCATTCAGTTCATACAG | GAACAGCTGAAATAT    c.1620
 S  K  L  D  L  V  K  D  K  I  I  Q  F  I  Q   | E  Q  L  K  Y      p.540

          .         .         .         .         .         .       g.112304
 AAAAGTAAGTTTAACTTTGTGAAGTTTGATGGTCAAGCAGTTGCTTGGCGGGAACAACTT       c.1680
 K  S  K  F  N  F  V  K  F  D  G  Q  A  V  A  W  R  E  Q  L         p.560

          .         .         .         .         .        | 13.    g.129801
 GCTGAAGTCAATGAAGATAATTTGGAACAGGCTCAGTCCTGGATTAGAGACATAAAG | ATT    c.1740
 A  E  V  N  E  D  N  L  E  Q  A  Q  S  W  I  R  D  I  K   | I      p.580

          .         .         .         .         .         .       g.129861
 GGAAGCTCCACAAACACCCTGAGTGCCCTGAAAACTGCTTTTGCTGATAAAGAAACACAG       c.1800
 G  S  S  T  N  T  L  S  A  L  K  T  A  F  A  D  K  E  T  Q         p.600

          .         .         .       | 14 .         .         .    g.135738
 GCAATCTACCTTCTGACCGATGGGAGACCTGATCAG | CCACCTGAAACAGTTATAGACCAG    c.1860
 A  I  Y  L  L  T  D  G  R  P  D  Q   | P  P  E  T  V  I  D  Q      p.620

          .         .         .         .         .         .       g.135798
 GTCAAACGTTTTCAGGAAATTCCTATTTATACCATCTCCTTCAATTACAATGATGAGATT       c.1920
 V  K  R  F  Q  E  I  P  I  Y  T  I  S  F  N  Y  N  D  E  I         p.640

          .         .         .         .         .         .       g.135858
 GCAAACAGGTTTTTGAAAGAGGTTGCTGCTTTGACTGGAGGAGAGTTCCATTTTTATAAT       c.1980
 A  N  R  F  L  K  E  V  A  A  L  T  G  G  E  F  H  F  Y  N         p.660

          .         .         .          | 15        .         .    g.146091
 TTTGGTTGCAAGGATCCCACTCCCCCAGAGGCTGTTCAG | AATGAAGATCTGACTCTTTTA    c.2040
 F  G  C  K  D  P  T  P  P  E  A  V  Q   | N  E  D  L  T  L  L      p.680

          .         .         .         .         .         .       g.146151
 GTTAAGGAAATGGAACAGGGTCACAGTGATCTGGAGAAGATGCAAGACCTTTATTCTGAG       c.2100
 V  K  E  M  E  Q  G  H  S  D  L  E  K  M  Q  D  L  Y  S  E         p.700

          .         .         .         .         . | 16       .    g.147928
 TCCTTGATCATGGACTGGTGGTACAATGCAGAAAAGGATGGAGACAGCAA | GCATCAAAAG    c.2160
 S  L  I  M  D  W  W  Y  N  A  E  K  D  G  D  S  K  |  H  Q  K      p.720

          .         .         .         .         .         .       g.147988
 GAAATCTGTTCTATGATTTCAACCCCAGAAAAGTGTGCAAAGCCTCAATCTGATGTCGAT       c.2220
 E  I  C  S  M  I  S  T  P  E  K  C  A  K  P  Q  S  D  V  D         p.740

          .         .         .         .         .         .       g.148048
 TCAACACAAACTTCATCTCTGAATATGTTGAAGGGACCATGGGGCCTTTCAGATCAAAAG       c.2280
 S  T  Q  T  S  S  L  N  M  L  K  G  P  W  G  L  S  D  Q  K         p.760

          .         .         | 17         .         .         .    g.152548
 GTTCAGAAAAAGAAAGTCCTTCACGCAG | AATCAACCAAAACCAGCCTGCTCAGAAGCCAG    c.2340
 V  Q  K  K  K  V  L  H  A  E |   S  T  K  T  S  L  L  R  S  Q      p.780

          .         .         .         .         .         .       g.152608
 ATGTCCTCCCTCAGGAGCTCAGCTTGCAGTGAAAGGAAGGATGGCCTCTCCAATGCCAGC       c.2400
 M  S  S  L  R  S  S  A  C  S  E  R  K  D  G  L  S  N  A  S         p.800

          .         .         | 18         .         .         .    g.154290
 AGCCGGAGGACTGCTCTAAGTGACAAAG | AAATGAGCATCTTGCTGGCTGAGGAGTGGCTG    c.2460
 S  R  R  T  A  L  S  D  K  E |   M  S  I  L  L  A  E  E  W  L      p.820

          .         .         .         .         .       | 19 .    g.154446
 GATGACAAATCGTCAGAAAAGGTGACGCGAGAAGGAAGCCAGGTTTATGACCACGA | TTCT    c.2520
 D  D  K  S  S  E  K  V  T  R  E  G  S  Q  V  Y  D  H  D  |  S      p.840

          .         .         .         .         .         .       g.154506
 TCAGATGTGTCTTCAGAAAACTGGCTGAAGACCTATGGCTTGGTCGCCAAGAAACTCACC       c.2580
 S  D  V  S  S  E  N  W  L  K  T  Y  G  L  V  A  K  K  L  T         p.860

          .         .         .         .         .         .       g.154566
 CTCATGGATGCCTTGTCAGTGGCAGCAGTCCCGCACAGCTCCACCTATGTTCCCGTCCTG       c.2640
 L  M  D  A  L  S  V  A  A  V  P  H  S  S  T  Y  V  P  V  L         p.880

          .         .         .    | 20    .         .         .    g.168213
 GACAAGCATGTCGTGTCTAAGGTCTTTGATGAG | GTGTTCCCTCTGGCACATGTGTGCAAC    c.2700
 D  K  H  V  V  S  K  V  F  D  E   | V  F  P  L  A  H  V  C  N      p.900

          .         .         .         .         .         .       g.168273
 GACACAAATAAGATGACATTAATTAACCCCCAAGGAGCCAAACTCAATATCTACAAGCGA       c.2760
 D  T  N  K  M  T  L  I  N  P  Q  G  A  K  L  N  I  Y  K  R         p.920

          .         .         .   | 21     .         .         .    g.174020
 AAAGTGGAACAGGCAATTCAATCCTATGAAAA | GCGCTTGAATAAAATTGTTTGGCGAGCA    c.2820
 K  V  E  Q  A  I  Q  S  Y  E  K  |  R  L  N  K  I  V  W  R  A      p.940

          .         .    | 22    .         .         .         .    g.188587
 TTATCTCAAGAGGAAAAAGAAAA | GTTAGATGCAAACAAACCAATACAGTACTTGGAAAAC    c.2880
 L  S  Q  E  E  K  E  K  |  L  D  A  N  K  P  I  Q  Y  L  E  N      p.960

          .         .         .         .         .         .       g.188647
 AAAACAGTTTTAAACCAGGCTTTAGAACGGTTGAATTGGCCCATTTCACTGAAAGAGCTG       c.2940
 K  T  V  L  N  Q  A  L  E  R  L  N  W  P  I  S  L  K  E  L         p.980

          .         .         .         .         .         .       g.188707
 TCGATGCTGGAAAGTGAAATCCTAGCTGGGAAAATGTACATCCAGCAGGCCATGGAACTC       c.3000
 S  M  L  E  S  E  I  L  A  G  K  M  Y  I  Q  Q  A  M  E  L         p.1000

          .         .         .         .      | 23  .         .    g.208394
 CAGGAGGCTGCCAAGAAGAATTATGCAAACAAGGCCCCGGGAGAG | CAACAGAAATTGCAA    c.3060
 Q  E  A  A  K  K  N  Y  A  N  K  A  P  G  E   | Q  Q  K  L  Q      p.1020

          .         .         .         .         .         .       g.208454
 GGAAATCCAACAAAGAAAACCAAATCAAAAAGACCAGATCCCCTCAAAGGACAGAAGGTT       c.3120
 G  N  P  T  K  K  T  K  S  K  R  P  D  P  L  K  G  Q  K  V         p.1040

          .         .         .        | 24.         .         .    g.215798
 ATTGCAAGATGTGATGAAAATGGCTTTTATTTTCCAG | GGGTTGTGAAGAAGTGTGTGAGC    c.3180
 I  A  R  C  D  E  N  G  F  Y  F  P  G |   V  V  K  K  C  V  S      p.1060

          .         .         .         .         .         .       g.215858
 CGCACCCAAGCACTGGTGGGCTTCAGTTACGGAGACACCAAGGTCGTGTCCACCTCCTTC       c.3240
 R  T  Q  A  L  V  G  F  S  Y  G  D  T  K  V  V  S  T  S  F         p.1080

          .         .         .         .   | 25     .         .    g.217965
 ATCACGCCTGTGGGGGGCGCCATGCCCTGCCCGCTGCTCCAG | GTTGGAGATTATGTGTTT    c.3300
 I  T  P  V  G  G  A  M  P  C  P  L  L  Q   | V  G  D  Y  V  F      p.1100

          .         .         .         .         .         .       g.218025
 GCCAAAATTGTGATACCCAAAGGATTTGACTTCTATGTCCCTGCCATTGTCATAGCACTT       c.3360
 A  K  I  V  I  P  K  G  F  D  F  Y  V  P  A  I  V  I  A  L         p.1120

          .         .         .         .         .         .       g.218085
 CCCAATAAGCATGTGGCCACAGAAAAATTCTACACAGTTTTGAAGTGTAACAACCGGAGA       c.3420
 P  N  K  H  V  A  T  E  K  F  Y  T  V  L  K  C  N  N  R  R         p.1140

  | 26       .         .         .         .         .         .    g.221630
  | GAATTTTGCCCTCGGAGTGCACTTATTAAGATCAGCCAAAACAAGTATGCGCTCTCTTGC    c.3480
  | E  F  C  P  R  S  A  L  I  K  I  S  Q  N  K  Y  A  L  S  C      p.1160

          .         .         .         .  | 27      .         .    g.229706
 TCTCATATAAAGTCACCCCCAATTCCTGAGGATCCAGAAGT | AGAGGATGTGGAGGCGAGG    c.3540
 S  H  I  K  S  P  P  I  P  E  D  P  E  V  |  E  D  V  E  A  R      p.1180

          .         .         .         .         .         .       g.229766
 AACTCTGCTTTCCTCTTCTGGCCACTGAAAGAAGCGGACACGCAGGATTCCAGAGAGCCA       c.3600
 N  S  A  F  L  F  W  P  L  K  E  A  D  T  Q  D  S  R  E  P         p.1200

          .         .         .         .         .         .       g.229826
 AGACGAGAGAAGCCCAGGAGGAAAAAGAGGCCCGCCAAGCAGCCACTCCAGCAGGCGGCG       c.3660
 R  R  E  K  P  R  R  K  K  R  P  A  K  Q  P  L  Q  Q  A  A         p.1220

          .         .         .         .         .         .       g.229886
 CCCTCGGACTCGGACGGCTCCTCCCACGGCATCAGCTCCCATGGGTCCTGCCAGGGGACA       c.3720
 P  S  D  S  D  G  S  S  H  G  I  S  S  H  G  S  C  Q  G  T         p.1240

          .      | 28  .         .         .         .         .    g.230113
 CACCCCGAGCCCAGG | ACAGCCCACCTCCACTTCCCCGCGGCCGGGCGTCTAGGACTCAGC    c.3780
 H  P  E  P  R   | T  A  H  L  H  F  P  A  A  G  R  L  G  L  S      p.1260

          .         .         .         .         .         .       g.230173
 AGCCACGCCATCATTGCCACACCTCCACCTCGAGCAGCCCTGCCCTGTACTCTCCAAGCC       c.3840
 S  H  A  I  I  A  T  P  P  P  R  A  A  L  P  C  T  L  Q  A         p.1280

          .         .         .         .                           g.230218
 ACCCACAGCAGCAAAGGGCTGAGGAGCGTCCCTGAGACACTTTAA                      c.3885
 T  H  S  S  K  G  L  R  S  V  P  E  T  L  X                        p.1294

          .         .         .         .         .         .       g.230278
 ggccgtctggtggcagctatgtttaagagaccagcgtccttccaggctgttcagacctca       c.*60

          .         .         .         .         .         .       g.230338
 gcgttgacactgaaactggcccctccgcggaggtaaggccgccctccgcgccgcctatgc       c.*120

          .         .         .         .         .         .       g.230398
 ctgccctgtctgtagcaaagactcctctcccctccatccctgctgcctcccctacccgtt       c.*180

          .         .         .         .         .         .       g.230458
 tgacgacttggttctggctttttctgactgttctttatcctgttttccccctgcactcac       c.*240

          .         .         .         .         .         .       g.230518
 aaaattgtattccatcttctggtagacgccccacccccagaagttttaacctgaaggatg       c.*300

          .         .         .         .         .         .       g.230578
 actgtcacaggactttcaaattgtttagcagtcagcatagtcaggatccaagcccgcaat       c.*360

          .         .         .         .         .         .       g.230638
 cttgttttaaattaattatcacatctaaattagagaatttgtcacccaatattaggactg       c.*420

          .         .         .         .         .         .       g.230698
 aaattcagactcggtaacttgtctgagatctgcaagactgaacatcccctactgtatagt       c.*480

          .         .         .         .         .         .       g.230758
 ttcctgacattttcatttagcctttcctaattatttttgtctatagtctgttgtaggtaa       c.*540

          .         .         .         .         .                 g.230816
 ctctaattgagcccgaaaccagaataaaaactcttacattggaaacatttcaaaacca         c.*598

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Von Willebrand factor A domain containing 3B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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