WW domain containing adaptor with coiled-coil (WAC) - coding DNA reference sequence

(used for variant description)

(last modified November 27, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_016628.4 in the WAC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering WAC transcript NM_016628.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.6027
                                 cgcccgccgccgccgccgcctgcgcgcc       c.-61

 .         .         .         .         .         .                g.6087
 cgcccgcctttcgcggccgctctcccccctccccgacacacactcacaggccgggcattg       c.-1

          .         .         .         .  | 02      .         .    g.6524
 ATGGTAATGTATGCGAGGAAACAGCAGAGACTCAGTGATGG | CTGTCACGACCGGAGGGGG    c.60
 M  V  M  Y  A  R  K  Q  Q  R  L  S  D  G  |  C  H  D  R  R  G      p.20

          .         | 03         .         .         .         .    g.8111
 GACTCGCAGCCTTACCAG | GCACTTAAGTATTCATCGAAGAGTCACCCCAGTAGCGGTGAT    c.120
 D  S  Q  P  Y  Q   | A  L  K  Y  S  S  K  S  H  P  S  S  G  D      p.40

          .         .         .         .         .         .       g.8171
 CACAGACATGAAAAGATGCGAGACGCCGGAGATCCTTCACCACCAAATAAAATGTTGCGG       c.180
 H  R  H  E  K  M  R  D  A  G  D  P  S  P  P  N  K  M  L  R         p.60

          .         .         .         .         .         .       g.8231
 AGATCTGATAGTCCTGAAAACAAATACAGTGACAGCACAGGTCACAGTAAGGCCAAAAAT       c.240
 R  S  D  S  P  E  N  K  Y  S  D  S  T  G  H  S  K  A  K  N         p.80

          .         .         .     | 04   .         .         .    g.55932
 GTGCATACTCACAGAGTTAGAGAGAGGGATGGTG | GGACCAGTTACTCTCCACAAGAAAAT    c.300
 V  H  T  H  R  V  R  E  R  D  G  G |   T  S  Y  S  P  Q  E  N      p.100

          .         .         .         .         .         .       g.55992
 TCACACAACCACAGTGCTCTTCATAGTTCAAATTCACATTCTTCTAATCCAAGCAATAAC       c.360
 S  H  N  H  S  A  L  H  S  S  N  S  H  S  S  N  P  S  N  N         p.120

          .         .  | 05      .         .         .         .    g.62282
 CCAAGCAAAACTTCAGATGCA | CCTTATGATTCTGCAGATGACTGGTCTGAGCATATTAGC    c.420
 P  S  K  T  S  D  A   | P  Y  D  S  A  D  D  W  S  E  H  I  S      p.140

          .         .         .         .         .         .       g.62342
 TCTTCTGGGAAAAAGTACTACTACAATTGTCGAACAGAAGTTTCACAATGGGAAAAACCA       c.480
 S  S  G  K  K  Y  Y  Y  N  C  R  T  E  V  S  Q  W  E  K  P         p.160

          .        | 06.         .         .         .         .    g.63270
 AAAGAGTGGCTTGAAAG | AGAACAGAGACAAAAAGAAGCAAACAAGATGGCAGTCAACAGC    c.540
 K  E  W  L  E  R  |  E  Q  R  Q  K  E  A  N  K  M  A  V  N  S      p.180

          .         .         .         .         .         .       g.63330
 TTCCCAAAAGATAGGGATTACAGAAGAGAGGTGATGCAAGCAACAGCCACTAGTGGGTTT       c.600
 F  P  K  D  R  D  Y  R  R  E  V  M  Q  A  T  A  T  S  G  F         p.200

          . | 07       .         .         .         .         .    g.68290
 GCCAGTGGAA | TGGAAGACAAGCATTCCAGTGATGCCAGTAGTTTGCTCCCACAGAATATT    c.660
 A  S  G  M |   E  D  K  H  S  S  D  A  S  S  L  L  P  Q  N  I      p.220

          .         .         .         .         .         .       g.68350
 TTGTCTCAAACAAGCAGACACAATGACAGAGACTACAGACTGCCAAGAGCAGAGACTCAC       c.720
 L  S  Q  T  S  R  H  N  D  R  D  Y  R  L  P  R  A  E  T  H         p.240

          .         .         .         .         .         .       g.68410
 AGTAGTTCTACGCCAGTACAGCACCCCATCAAACCAGTGGTTCATCCAACTGCTACCCCA       c.780
 S  S  S  T  P  V  Q  H  P  I  K  P  V  V  H  P  T  A  T  P         p.260

          .         .         .         .         .         .       g.68470
 AGCACTGTTCCTTCTAGTCCATTTACGCTACAGTCTGATCACCAGCCAAAGAAATCATTT       c.840
 S  T  V  P  S  S  P  F  T  L  Q  S  D  H  Q  P  K  K  S  F         p.280

          .         .         .         .         .         .       g.68530
 GATGCTAATGGAGCATCTACTTTATCAAAACTGCCTACACCCACATCTTCTGTCCCTGCA       c.900
 D  A  N  G  A  S  T  L  S  K  L  P  T  P  T  S  S  V  P  A         p.300

          .          | 08        .         .         .         .    g.80734
 CAGAAAACAGAAAGAAAAG | AATCTACATCAGGAGACAAACCCGTATCACATTCTTGCACA    c.960
 Q  K  T  E  R  K  E |   S  T  S  G  D  K  P  V  S  H  S  C  T      p.320

          .         .         .         .         .         .       g.80794
 ACTCCTTCCACGTCTTCTGCCTCTGGACTGAACCCCACATCTGCACCTCCAACATCTGCT       c.1020
 T  P  S  T  S  S  A  S  G  L  N  P  T  S  A  P  P  T  S  A         p.340

          .         .         .         .         .         .       g.80854
 TCAGCGGTCCCTGTTTCTCCTGTTCCACAGTCGCCAATACCTCCCTTACTTCAGGACCCA       c.1080
 S  A  V  P  V  S  P  V  P  Q  S  P  I  P  P  L  L  Q  D  P         p.360

          .         .         .         .         .         .       g.80914
 AATCTTCTTAGACAATTGCTTCCTGCTTTGCAAGCCACGCTGCAGCTTAATAATTCTAAT       c.1140
 N  L  L  R  Q  L  L  P  A  L  Q  A  T  L  Q  L  N  N  S  N         p.380

          .         .      | 09  .         .         .         .    g.83241
 GTGGACATATCTAAAATAAATGAAG | TTCTTACAGCAGCTGTGACACAAGCCTCACTGCAG    c.1200
 V  D  I  S  K  I  N  E  V |   L  T  A  A  V  T  Q  A  S  L  Q      p.400

          .         .         .         .         .         .       g.83301
 TCTATAATTCATAAGTTTCTTACTGCTGGACCATCTGCTTTCAACATAACGTCTCTGATT       c.1260
 S  I  I  H  K  F  L  T  A  G  P  S  A  F  N  I  T  S  L  I         p.420

          .         .         | 10         .         .         .    g.84313
 TCTCAAGCTGCTCAGCTCTCTACACAAG | CCCAGCCATCTAATCAGTCTCCGATGTCTTTA    c.1320
 S  Q  A  A  Q  L  S  T  Q  A |   Q  P  S  N  Q  S  P  M  S  L      p.440

          .         .         .         .         .         .       g.84373
 ACATCTGATGCGTCATCCCCAAGATCATATGTTTCTCCAAGAATAAGCACACCTCAAACT       c.1380
 T  S  D  A  S  S  P  R  S  Y  V  S  P  R  I  S  T  P  Q  T         p.460

          .         .         .         .         .        | 11.    g.87077
 AACACAGTCCCTATCAAACCTTTGATCAGTACTCCTCCTGTTTCATCACAGCCAAAG | GTT    c.1440
 N  T  V  P  I  K  P  L  I  S  T  P  P  V  S  S  Q  P  K   | V      p.480

          .         .         .         .         .         .       g.87137
 AGTACTCCAGTAGTTAAGCAAGGACCAGTGTCACAGTCAGCCACACAGCAGCCTGTAACT       c.1500
 S  T  P  V  V  K  Q  G  P  V  S  Q  S  A  T  Q  Q  P  V  T         p.500

          .         .         .         .         .       | 12 .    g.88684
 GCTGACAAGCAGCAAGGTCATGAACCTGTCTCTCCTCGAAGTCTTCAGCGCTCAAG | TAGC    c.1560
 A  D  K  Q  Q  G  H  E  P  V  S  P  R  S  L  Q  R  S  S  |  S      p.520

          .         .         .         .         .         .       g.88744
 CAGAGAAGTCCATCACCTGGTCCCAATCATACTTCTAATAGTAGTAATGCATCAAATGCA       c.1620
 Q  R  S  P  S  P  G  P  N  H  T  S  N  S  S  N  A  S  N  A         p.540

          .         .         .         .         .         .       g.88804
 ACAGTTGTACCACAGAATTCTTCTGCCCGATCCACGTGTTCATTAACGCCTGCACTAGCA       c.1680
 T  V  V  P  Q  N  S  S  A  R  S  T  C  S  L  T  P  A  L  A         p.560

          .         .         .         .         .         .       g.88864
 GCACACTTCAGTGAAAATCTCATAAAACACGTTCAAGGATGGCCTGCAGATCATGCAGAG       c.1740
 A  H  F  S  E  N  L  I  K  H  V  Q  G  W  P  A  D  H  A  E         p.580

        | 13 .         .         .         .         .         .    g.90218
 AAGCAG | GCATCAAGATTACGCGAAGAAGCGCATAACATGGGAACTATTCACATGTCCGAA    c.1800
 K  Q   | A  S  R  L  R  E  E  A  H  N  M  G  T  I  H  M  S  E      p.600

          .         .         .         .         .         .       g.90278
 ATTTGTACTGAATTAAAAAATTTAAGATCTTTAGTCCGAGTATGTGAAATTCAAGCAACT       c.1860
 I  C  T  E  L  K  N  L  R  S  L  V  R  V  C  E  I  Q  A  T         p.620

          .     | 14   .         .         .         .         .    g.92090
 TTGCGAGAGCAAAG | GATACTATTTTTGAGACAACAAATTAAGGAACTTGAAAAGCTAAAA    c.1920
 L  R  E  Q  R  |  I  L  F  L  R  Q  Q  I  K  E  L  E  K  L  K      p.640

          .         .                                               g.92114
 AATCAGAATTCCTTCATGGTGTGA                                           c.1944
 N  Q  N  S  F  M  V  X                                             p.647

          .         .         .         .         .         .       g.92174
 agatgtgaataattgcacatggttttgagaacaggaactgtaaatctgttgcccaatctt       c.*60

          .         .         .         .         .         .       g.92234
 aacatttttgagctgcatttaagtagactttggaccgttaagctgggcaaaggaaatgac       c.*120

          .         .         .         .         .         .       g.92294
 aaggggacggggtctgtgagagtcaattcaggggaaagatacaagattgatttgtaaaac       c.*180

          .         .         .         .         .         .       g.92354
 ccttgaaatgtagatttcttgtagatgtatccttcacgttgtaaatatgttttgtagagt       c.*240

          .         .         .         .         .         .       g.92414
 gaagccatgggaagccatgtgtaacagagcttagacatccaaaactaatcaatgctgagg       c.*300

          .         .         .         .         .         .       g.92474
 tggctaaatacctagccttttacatgtaaacctgtctgcaaaattagcttttttaaaaaa       c.*360

          .         .         .         .         .         .       g.92534
 aaaaaaaaaaaaattgggggggttaatttatcattcagaaatcttgcattttcaaaaatt       c.*420

          .         .         .         .         .         .       g.92594
 cagtgcaagcgccaggcgatttgtgtctaaggatacgattttgaaccatatgggcagtgt       c.*480

          .         .         .         .         .         .       g.92654
 acaaaatatgaaacaactgtttccacacttgcacctgatcaagagcagtgcttctccatt       c.*540

          .         .         .         .         .         .       g.92714
 tgttttgcagagaaatgtttttcatttcccgtgtgtttccatttccttctgaaattctga       c.*600

          .         .         .         .         .         .       g.92774
 ttttatccatttttttaaggctcctctttatctcctttcttaaggcactgttgctatggc       c.*660

          .         .         .         .         .         .       g.92834
 acttttctataaccttttcattcctgtgtacagtagcttaaaattgcagtgattgagcat       c.*720

          .         .         .         .         .         .       g.92894
 aacctacttgtttgtataaattattgaaatccatttgcaccctgttaagaatggacttaa       c.*780

          .         .         .         .         .         .       g.92954
 aagtactgctggacaggcatgtgtgctcaaagtacattgattgctcaaatataaggaaat       c.*840

          .         .         .         .         .         .       g.93014
 ggcccaatgaacgtggttgtgggaggggaaagaggaaacagagctagtcagatgtgaatt       c.*900

          .         .         .         .         .         .       g.93074
 gtatctgttgtaataaacatgttaaaacaaacaaaaattgttatttttcttttccttcgg       c.*960

          .         .         .         .         .         .       g.93134
 tcagtgcacattagcatttgaactacctggggattctttatcagaactgttcttgttgaa       c.*1020

          .         .         .         .         .         .       g.93194
 tatttatacttaattgaaataattccttaagggaggttttgtttaaaacgtattaacagg       c.*1080

          .         .         .         .         .         .       g.93254
 aaattgtgtatgagatatttaatgaaataagaaattcaacaagaatgattaagtcacttc       c.*1140

          .         .         .         .         .         .       g.93314
 ccaagtggttgtcatttgttaaaccctggtttacctgtcttgctattatgacatttcatt       c.*1200

          .         .         .         .         .         .       g.93374
 tggaaggatgtttgtgttgtagctaactgttcaagtctggtgctgactgctgttcttagc       c.*1260

          .         .         .         .         .         .       g.93434
 catcacaaaacgctaaatttgtgtaattggagcttcctgctgttatctggaaatagcagg       c.*1320

          .         .         .         .         .         .       g.93494
 aaagcgcagctttgtatattgtttcctaaagtatattaaaataaaaaaagaaactattgc       c.*1380

          .         .         .         .         .         .       g.93554
 tactataaaattaccttgactttttttttcctttgctgaaatattagtcacatagcctta       c.*1440

          .         .         .         .         .         .       g.93614
 gcttcacactgccagtaatgtatcaaatcacaagggtttccgcatgaaaaaaatcttttc       c.*1500

          .         .         .         .         .         .       g.93674
 ttcccccacaaaaaaacctttaccatcaaaatcttgccatctgatttagaaaggtgtttc       c.*1560

          .         .         .         .         .         .       g.93734
 ttcttcttcttcttttttttctttaaattggtttagggttttttggtgattttttttttt       c.*1620

          .         .         .         .         .         .       g.93794
 tttttttttctgttggggcagataagtgcttccaaaactggcagcaccaagggcttattt       c.*1680

          .         .         .         .         .         .       g.93854
 tttatgttagacatcaatgtcaatgttactacattctcggatgctaacataaattttgaa       c.*1740

          .         .         .         .         .         .       g.93914
 attgctcttgtgctttaagcatatattgaaagtatggaagttaaatgttcaggcttttca       c.*1800

          .         .         .         .         .         .       g.93974
 gtaagctcaaaaagttaactgtaagcgatagtgttggtgttttctaaaatacaaaaatgt       c.*1860

          .         .         .         .         .         .       g.94034
 tccagtgtaattaaaaggaattaaaatcttgaagatattttcctgtaatttaaggatact       c.*1920

          .         .         .         .         .         .       g.94094
 ttttaaatgtaagaaaagacatgtcattaatttattgtcatgtttatacctctgtgagat       c.*1980

          .         .         .         .         .         .       g.94154
 tgttaacatctgctgaatttaactagtgcatgtaaatgaaaccccaaagagctgtgtgtt       c.*2040

          .         .         .         .         .         .       g.94214
 cagctagaaaccttactgtatctttcctggaaagaagtgagcaatttgttgtaataggca       c.*2100

          .         .         .         .         .         .       g.94274
 aatgtttcctgatcagatggcaatttgtgatttaggtaaatttgaatttgatttgcttat       c.*2160

          .         .         .         .         .         .       g.94334
 agtctactggtctgtgtacctatgttttgtttttcaaaaaagtttacatccctaaatgaa       c.*2220

          .         .         .         .         .         .       g.94394
 ttagtcacatatatttaggagaagatgcctaatttggtatttcttaatagtgaatttttt       c.*2280

          .         .         .         .         .         .       g.94454
 tttttcttgagacagagtttcactcttgttgcccaggctggagtgcaatggcacgatctc       c.*2340

          .         .         .         .         .         .       g.94514
 ggctcaccgcaacctctgcctcctgggttcaagcgattctcctgcctcggcgttccgagt       c.*2400

          .         .         .         .         .         .       g.94574
 agctgggattacaggcatgcaccaccacgcctggctaattttgtatttttagtagagatg       c.*2460

          .         .         .         .         .         .       g.94634
 gggtttctccatgttggtcaggctggtcttgaactgccaacttcaggtgatctgcctgcc       c.*2520

          .         .         .         .         .         .       g.94694
 ttggcctcccaaagtgctgggattacaggcgtgagccaccgctcctggccagtagtgaat       c.*2580

          .         .         .         .         .         .       g.94754
 ttttaaacacagaaaatctaaaattttgtggaaatattttaaatattgcaccttaataca       c.*2640

          .         .         .         .         .         .       g.94814
 aggtatccagctcctaaccttaactagggaatatctattaaaataagcataatgttctgg       c.*2700

          .         .         .         .         .         .       g.94874
 actagagtattccttatctagttggttatggatttgaacatgtaccttggtttagatact       c.*2760

          .         .         .         .         .         .       g.94934
 ttgaaaatagaagtactgaatagcctctagggaacttgagtggcctttccctccccctgc       c.*2820

          .         .         .         .         .         .       g.94994
 ccccccccccccccccccgttttaaaagatcagtagtctctattcaaacttttaaaatgt       c.*2880

          .         .         .         .         .         .       g.95054
 cgtggtattgtaacaatatatttgatgaaagaaggttacagactcccctgaagaaccagc       c.*2940

          .         .         .         .         .         .       g.95114
 tttcctacgctttttatttttctaacttgtctaacctgattttaaaatgactgcaattcc       c.*3000

          .         .         .         .         .         .       g.95174
 agactaaaaacatgcttcagccctgtttcaagacattatgcttcttttaacagtccaaat       c.*3060

          .         .         .         .         .         .       g.95234
 tagtagttttatttttcttctaaatctttgtttcacacttgtaaaatcttgggaaggagg       c.*3120

          .         .         .         .         .         .       g.95294
 ttcttaaaactttgccaggaattgttacccatttccaaaaacagtttattatgttcaaaa       c.*3180

          .         .         .         .         .         .       g.95354
 accaccatatctttgagggactgtttgaaaggggagagggcaacgcgggaaataattcac       c.*3240

          .         .         .         .         .         .       g.95414
 tctgcgcaccggaactattgtagttcaggacttccagctactgtatttagatgttgggtt       c.*3300

          .         .         .         .         .         .       g.95474
 tgaatatacagatttcttttcaatacctgtaaatatggctatattcttgtatttgtacgg       c.*3360

          .         .         .         .         .         .       g.95534
 gagtgtacaaaatgacactgaaaagtaataaatatgttttgactatattgtgcagttatt       c.*3420

          .         .         .         .         .         .       g.95594
 tcagaactgtgttttgaaagtcttagaatgcataatttgcatttgagtaaggaaatttaa       c.*3480

          .         .                                               g.95620
 aatacagattactgctgagattttaa                                         c.*3506

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The WW domain containing adaptor with coiled-coil protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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