tryptophanyl tRNA synthetase 2, mitochondrial (WARS2) - coding DNA reference sequence

(used for variant description)

(last modified December 23, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_015836.3 in the WARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering WARS2 transcript NM_015836.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5028
                                 caaacaagacggctccgcccttctcaag       c.-1

          .         .         .         .         .         .       g.5088
 ATGGCGCTGCACTCAATGCGGAAAGCGCGTGAGCGCTGGAGCTTCATCCGGGCACTTCAT       c.60
 M  A  L  H  S  M  R  K  A  R  E  R  W  S  F  I  R  A  L  H         p.20

          .         .         . | 02       .         .         .    g.69095
 AAGGGATCCGCAGCTGCTCCCGCTCTCCAG | AAAGACAGCAAGAAGCGAGTATTTTCCGGC    c.120
 K  G  S  A  A  A  P  A  L  Q   | K  D  S  K  K  R  V  F  S  G      p.40

          .         .         .         .         .         .       g.69155
 ATTCAACCTACAGGAATCCTCCACCTGGGCAATTACCTGGGAGCCATTGAGAGCTGGGTG       c.180
 I  Q  P  T  G  I  L  H  L  G  N  Y  L  G  A  I  E  S  W  V         p.60

          .         .         .         .         .         .       g.69215
 AGGTTACAGGATGAATATGACTCTGTATTATACAGCATTGTTGACCTCCACTCCATTACT       c.240
 R  L  Q  D  E  Y  D  S  V  L  Y  S  I  V  D  L  H  S  I  T         p.80

          .         .         .         .         .         .       g.69275
 GTCCCCCAAGACCCAGCTGTCCTTCGGCAGAGCATCCTGGACATGACTGCTGTTCTTCTT       c.300
 V  P  Q  D  P  A  V  L  R  Q  S  I  L  D  M  T  A  V  L  L         p.100

          .         .         .         .         | 03         .    g.100022
 GCCTGTGGCATAAACCCGGAAAAAAGCATCCTTTTCCAACAATCTCAG | GTGTCTGAACAC    c.360
 A  C  G  I  N  P  E  K  S  I  L  F  Q  Q  S  Q   | V  S  E  H      p.120

          .         .         .         .         .         .       g.100082
 ACACAATTAAGTTGGATCCTTTCCTGCATGGTCAGACTACCTCGATTACAACATTTACAT       c.420
 T  Q  L  S  W  I  L  S  C  M  V  R  L  P  R  L  Q  H  L  H         p.140

           | 04        .         .         .         .         .    g.103374
 CAGTGGAAG | GCAAAGACTACCAAGCAGAAGCACGATGGCACGGTGGGCCTGCTCACATAC    c.480
 Q  W  K   | A  K  T  T  K  Q  K  H  D  G  T  V  G  L  L  T  Y      p.160

          .         .         .      | 05  .         .         .    g.111484
 CCAGTACTCCAGGCAGCCGACATTCTGTTGTACAA | GTCCACACACGTTCCTGTTGGGGAG    c.540
 P  V  L  Q  A  A  D  I  L  L  Y  K  |  S  T  H  V  P  V  G  E      p.180

          .         .         .         .         .         .       g.111544
 GATCAAGTCCAGCACATGGAACTAGTTCAGGATCTAGCACAAGGTTTCAACAAGAAGTAT       c.600
 D  Q  V  Q  H  M  E  L  V  Q  D  L  A  Q  G  F  N  K  K  Y         p.200

          .         .         .     | 06   .         .         .    g.112339
 GGGGAGTTCTTTCCAGTGCCCGAGTCCATTCTCA | CATCCATGAAGAAGGTAAAATCCCTA    c.660
 G  E  F  F  P  V  P  E  S  I  L  T |   S  M  K  K  V  K  S  L      p.220

          .         .         .         .         .         .       g.112399
 CGTGATCCTTCTGCCAAAATGTCGAAATCAGACCCTGACAAACTGGCCACCGTCCGAATA       c.720
 R  D  P  S  A  K  M  S  K  S  D  P  D  K  L  A  T  V  R  I         p.240

          .         .         .         .         .         .       g.112459
 ACAGACAGCCCAGAGGAGATAGTGCAGAAATTCCGCAAGGCTGTGACAGACTTCACCTCG       c.780
 T  D  S  P  E  E  I  V  Q  K  F  R  K  A  V  T  D  F  T  S         p.260

          .         .         .         .         .         .       g.112519
 GAGGTCACCTATGACCCGGCTGGCCGCGCTGGCGTGTCCAACATAGTGGCGGTGCATGCC       c.840
 E  V  T  Y  D  P  A  G  R  A  G  V  S  N  I  V  A  V  H  A         p.280

          .         .         .         .         .         .       g.112579
 GCGGTGACGGGGCTCTCCGTGGAGGAAGTGGTGCGCCGCAGCGCGGGCATGAACACTGCT       c.900
 A  V  T  G  L  S  V  E  E  V  V  R  R  S  A  G  M  N  T  A         p.300

          .         .         .         .         .         .       g.112639
 CGCTACAAGCTGGCCGTGGCAGATGCTGTGATTGAGAAGTTTGCCCCAATTAAGCGTGAA       c.960
 R  Y  K  L  A  V  A  D  A  V  I  E  K  F  A  P  I  K  R  E         p.320

          .         .         .         .         .         .       g.112699
 ATTGAAAAACTGAAGCTGGACAAGGACCATTTAGAGAAGGTTTTACAAATTGGATCAGCA       c.1020
 I  E  K  L  K  L  D  K  D  H  L  E  K  V  L  Q  I  G  S  A         p.340

          .         .         .         .         .         .       g.112759
 AAAGCCAAAGAATTAGCATACACTGTGTGCCAGGAGGTGAAGAAATTGGTGGGTTTTCTA       c.1080
 K  A  K  E  L  A  Y  T  V  C  Q  E  V  K  K  L  V  G  F  L         p.360

                                                                    g.112762
 TAG                                                                c.1083
 X                                                                  p.360

          .         .         .         .         .         .       g.112822
 gaagtttcaacgaatcacagcaaggcttttgtgccttgcactccatgcattctgataacg       c.*60

          .         .         .         .         .         .       g.112882
 gcagctttcctaaaaagaaaaagttatagttttgggacatttaatttggtatagctgatt       c.*120

          .         .         .         .         .         .       g.112942
 attggctttatttgatgaatattgctttgtagctttgaaatacgacagtgttccaaatcc       c.*180

          .         .         .         .         .         .       g.113002
 catcaacaaaatgctgtgaacaacaacaacaaaaaataaatcaagaaggcatagctgtct       c.*240

          .         .         .         .         .         .       g.113062
 gaatccccaattattgaggcacactccttggcctgcagaaatgtgattgaagtaaggagt       c.*300

          .         .         .         .         .         .       g.113122
 aatttgggaaatggagtatcatttgtgcttctctctggagtacttactgtaacagatgca       c.*360

          .         .         .         .         .         .       g.113182
 cacgttatctacttcaacccttttataaagcaatatatagaggtcttagatgtataatcc       c.*420

          .         .         .         .         .         .       g.113242
 ttgagatgccatttgatcagatgccaatttgtattcagagctcataaaaacaagtccatt       c.*480

          .         .         .         .         .         .       g.113302
 cttatagtttgtttgtcactgagacggtgcctgatttaatatatttaagctgcttaactt       c.*540

          .         .         .         .         .         .       g.113362
 gttttccaagagataacaccaactgttccagcaataatttgttttttaattcagagatat       c.*600

          .         .         .         .         .         .       g.113422
 gggatatgatcttctaaggaggttgcattattttgacctgatttatttattgtacaagag       c.*660

          .         .         .         .         .         .       g.113482
 cccaagtccctgaattatattcttaataagtgctttcttgcattcatttcagtttagtct       c.*720

          .         .         .         .         .         .       g.113542
 caccaaccccctatgaattaggagaattattgtcattttacacatgaggaaagtgaggct       c.*780

          .         .         .         .         .         .       g.113602
 gagagaatccaattagcttgtacgatatcactccataagagaagcaaatctgagagtaaa       c.*840

          .         .         .         .         .         .       g.113662
 acccttaccccttattcttaagaatagtgcttgtttattcagtacaaaaaaaatgctgaa       c.*900

          .         .         .         .         .         .       g.113722
 aggcagcgttttttagactctaaacattctgattttgaaggtgggtgttggaacgactga       c.*960

          .         .         .         .         .         .       g.113782
 tgatgttttttatatcatcaattcagccaatggatgcgaacttaaaatctggattcacag       c.*1020

          .         .         .         .         .         .       g.113842
 aaccgtggtcacatttccccatcaaaatccccaaggcgggtcccaagttctctcctctac       c.*1080

          .         .         .         .         .         .       g.113902
 gctcattgcagaaatactttgaaataggttctgccagtctacaatagcagtgaagactga       c.*1140

          .         .         .         .         .         .       g.113962
 caaatcagatattcccaatgactgacagcttctcatcttgcctctacctcagttaagtaa       c.*1200

          .         .         .         .         .         .       g.114022
 tgtcaccctgaaacctagcttttctgcacttccatttctgacacctgaaaatgaaaatga       c.*1260

          .         .         .         .         .         .       g.114082
 taatcctaacttatacaccaagacctgttagcaagatcgattttgtaacagaaattgctt       c.*1320

          .         .         .         .         .         .       g.114142
 ataagttttttatcagtaaggaccatgatcaccatttgtacatacataactaggttgttg       c.*1380

          .         .         .         .         .         .       g.114202
 agcaaagcatttttgctcatgtttcttaaggaagtagagtagtccttgtgtcagaacaca       c.*1440

          .         .         .         .         .         .       g.114262
 tgttaatccacaaaacgccccatcccagattccaaattaaaacatcgtttttaggattct       c.*1500

          .         .         .         .         .         .       g.114322
 tggagctagcctggatcatgggtaaaggaaacattttgccttttgtatcttatactggaa       c.*1560

          .         .         .         .         .         .       g.114382
 tgggatgtctgtaagtcctagaacctctttgagcatatttcttacaagcctctgtttttt       c.*1620

          .         .         .         .         .         .       g.114442
 cccctttaaaggaaactttgaaaggattgtgaatactggaaaatgacaaaactaaaggta       c.*1680

          .                                                         g.114457
 gatctatcaagccaa                                                    c.*1695

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tryptophanyl tRNA synthetase 2, mitochondrial protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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