tryptophanyl-tRNA synthetase (WARS) - coding DNA reference sequence

(used for variant description)

(last modified April 20, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_004184.3 in the WARS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000014.8, covering WARS transcript NM_004184.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5774
                                        tcgattctcaagagggtttca       c.-361

 .         .         .         .         .         .                g.5834
 ttggtctcaacctggccccccaggcaacccacccctgattggacagtctcatcaagaagg       c.-301

 .         .         .         .         .         .                g.5894
 ttggtcaagagctcaagtgtttctgagaatctgggtgatttataagaaacccttagctga       c.-241

 .         .         .         .         .         .                g.5954
 atgcagggtggggagaacgaaagacaaaagcatcttttttcagaagggaaactgaaagaa       c.-181

 .         .         .         .         .         .                g.6014
 agaggggaagagtattaaagaccatttctggctgggcagggcactctcagcagctcaact       c.-121

 .         .         .         .         .       | 02 .             g.12098
 gcccagcgtgaccagtggccacctctgcagtgtcttccacaacctgg | tcttgactcgtct    c.-61

 .         .         .         .         .         .                g.12158
 gctgaacaaatcctctgacctcaggccggctgtgaacgtagttcctgagagatagcaaac       c.-1

          .         .         .         .         .         .       g.12218
 ATGCCCAACAGTGAGCCCGCATCTCTGCTGGAGCTGTTCAACAGCATCGCCACACAAGGG       c.60
 M  P  N  S  E  P  A  S  L  L  E  L  F  N  S  I  A  T  Q  G         p.20

          .         .         .          | 03        .         .    g.19443
 GAGCTCGTAAGGTCCCTCAAAGCGGGAAATGCGTCAAAG | GATGAAATTGATTCTGCAGTA    c.120
 E  L  V  R  S  L  K  A  G  N  A  S  K   | D  E  I  D  S  A  V      p.40

          .         .         .         .         .         .       g.19503
 AAGATGTTGGTGTCATTAAAAATGAGCTACAAAGCTGCCGCGGGGGAGGATTACAAGGCT       c.180
 K  M  L  V  S  L  K  M  S  Y  K  A  A  A  G  E  D  Y  K  A         p.60

          .         .         .         .         .         .       g.19563
 GACTGTCCTCCAGGGAACCCAGCACCTACCAGTAATCATGGCCCAGATGCCACAGAAGCT       c.240
 D  C  P  P  G  N  P  A  P  T  S  N  H  G  P  D  A  T  E  A         p.80

          .         .         .         .         .         .       g.19623
 GAAGAGGATTTTGTGGACCCATGGACAGTACAGACAAGCAGTGCAAAAGGCATAGACTAC       c.300
 E  E  D  F  V  D  P  W  T  V  Q  T  S  S  A  K  G  I  D  Y         p.100

          .    | 04    .         .         .         .         .    g.20728
 GATAAGCTCATTG | TTCGGTTTGGAAGTAGTAAAATTGACAAAGAGCTAATAAACCGAATA    c.360
 D  K  L  I  V |   R  F  G  S  S  K  I  D  K  E  L  I  N  R  I      p.120

          .         .         .         .         .         .       g.20788
 GAGAGAGCCACCGGCCAAAGACCACACCACTTCCTGCGCAGAGGCATCTTCTTCTCACAC       c.420
 E  R  A  T  G  Q  R  P  H  H  F  L  R  R  G  I  F  F  S  H         p.140

    | 05     .         .         .         .         .         .    g.26835
 AG | AGATATGAATCAGGTTCTTGATGCCTATGAAAATAAGAAGCCATTTTATCTGTACACG    c.480
 R  |  D  M  N  Q  V  L  D  A  Y  E  N  K  K  P  F  Y  L  Y  T      p.160

          .         .         .         .         .         .       g.26895
 GGCCGGGGCCCCTCTTCTGAAGCAATGCATGTAGGTCACCTCATTCCATTTATTTTCACA       c.540
 G  R  G  P  S  S  E  A  M  H  V  G  H  L  I  P  F  I  F  T         p.180

    | 06     .         .         .         .         .         .    g.27532
 AA | GTGGCTCCAGGATGTATTTAACGTGCCCTTGGTCATCCAGATGACGGATGACGAGAAG    c.600
 K  |  W  L  Q  D  V  F  N  V  P  L  V  I  Q  M  T  D  D  E  K      p.200

          .         .         .         .         .         .       g.27592
 TATCTGTGGAAGGACCTGACCCTGGACCAGGCCTATAGCTATGCTGTGGAGAATGCCAAG       c.660
 Y  L  W  K  D  L  T  L  D  Q  A  Y  S  Y  A  V  E  N  A  K         p.220

          .         .         .         .         .         .       g.27652
 GACATCATCGCCTGTGGCTTTGACATCAACAAGACTTTCATATTCTCTGACCTGGACTAC       c.720
 D  I  I  A  C  G  F  D  I  N  K  T  F  I  F  S  D  L  D  Y         p.240

       | 07  .         .         .         .         .         .    g.34552
 ATGGG | GATGAGCTCAGGTTTCTACAAAAATGTGGTGAAGATTCAAAAGCATGTTACCTTC    c.780
 M  G  |  M  S  S  G  F  Y  K  N  V  V  K  I  Q  K  H  V  T  F      p.260

          .         .         .         .       | 08 .         .    g.37970
 AACCAAGTGAAAGGCATTTTCGGCTTCACTGACAGCGACTGCATTG | GGAAGATCAGTTTT    c.840
 N  Q  V  K  G  I  F  G  F  T  D  S  D  C  I  G |   K  I  S  F      p.280

          .         .         .         .         .         .       g.38030
 CCTGCCATCCAGGCTGCTCCCTCCTTCAGCAACTCATTCCCACAGATCTTCCGAGACAGG       c.900
 P  A  I  Q  A  A  P  S  F  S  N  S  F  P  Q  I  F  R  D  R         p.300

          .         .         .          | 09        .         .    g.38793
 ACGGATATCCAGTGCCTTATCCCATGTGCCATTGACCAG | GATCCTTACTTTAGAATGACA    c.960
 T  D  I  Q  C  L  I  P  C  A  I  D  Q   | D  P  Y  F  R  M  T      p.320

          .         .         .         .         .         .       g.38853
 AGGGACGTCGCCCCCAGGATCGGCTATCCTAAACCAGCCCTGCTGCACTCCACCTTCTTC       c.1020
 R  D  V  A  P  R  I  G  Y  P  K  P  A  L  L  H  S  T  F  F         p.340

          .         .         .         .         .         .       g.38913
 CCAGCCCTGCAGGGCGCCCAGACCAAAATGAGTGCCAGCGACCCCAACTCCTCCATCTTC       c.1080
 P  A  L  Q  G  A  Q  T  K  M  S  A  S  D  P  N  S  S  I  F         p.360

          .         .         .    | 10    .         .         .    g.44168
 CTCACCGACACGGCCAAGCAGATCAAAACCAAG | GTCAATAAGCATGCGTTTTCTGGAGGG    c.1140
 L  T  D  T  A  K  Q  I  K  T  K   | V  N  K  H  A  F  S  G  G      p.380

          .         .         .         .         .         .       g.44228
 AGAGACACCATCGAGGAGCACAGGCAGTTTGGGGGCAACTGTGATGTGGACGTGTCTTTC       c.1200
 R  D  T  I  E  E  H  R  Q  F  G  G  N  C  D  V  D  V  S  F         p.400

          .         .         .         .         .     | 11   .    g.46313
 ATGTACCTGACCTTCTTCCTCGAGGACGACGACAAGCTCGAGCAGATCAGGAAG | GATTAC    c.1260
 M  Y  L  T  F  F  L  E  D  D  D  K  L  E  Q  I  R  K   | D  Y      p.420

          .         .         .         .         .         .       g.46373
 ACCAGCGGAGCCATGCTCACCGGTGAGCTCAAGAAGGCACTCATAGAGGTTCTGCAGCCC       c.1320
 T  S  G  A  M  L  T  G  E  L  K  K  A  L  I  E  V  L  Q  P         p.440

          .         .         .         .         .         .       g.46433
 TTGATCGCAGAGCACCAGGCCCGGCGCAAGGAGGTCACGGATGAGATAGTGAAAGAGTTC       c.1380
 L  I  A  E  H  Q  A  R  R  K  E  V  T  D  E  I  V  K  E  F         p.460

          .         .         .                                     g.46469
 ATGACTCCCCGGAAGCTGTCCTTCGACTTTCAGTAG                               c.1416
 M  T  P  R  K  L  S  F  D  F  Q  X                                 p.471

          .         .         .         .         .         .       g.46529
 cactcgttttacatatgcttataaaagaagtgatgtatcagtaatgtatcaataatccca       c.*60

          .         .         .         .         .         .       g.46589
 gcccagtcaaagcaccgccacctgtaggcttctgtctcatggtaattactgggcctggcc       c.*120

          .         .         .         .         .         .       g.46649
 tctgtaagcctgtgtatgttatcaatactgtttcttcctgtgagttccattatttctatc       c.*180

          .         .         .         .         .         .       g.46709
 tcttatgggcaaagcattgtgggtaattggtgctggctaacattgcatggtcggatagag       c.*240

          .         .         .         .         .         .       g.46769
 aagtccagctgtgagtctctccccaaagcagccccacagtggagcctttggctggaagtc       c.*300

          .         .         .         .         .         .       g.46829
 catgggccaccctgttcttgtccatggaggactccgagggttccaagtatactcttaaga       c.*360

          .         .         .         .         .         .       g.46889
 cccactctgtttaaaaatatatattctatgtatgcgtatatggaattgaaatgtcattat       c.*420

          .         .         .         .         .         .       g.46949
 tgtaacctagaaagtgctttgaaatattgatgtggggaggtttattgagcacaagatgta       c.*480

          .         .         .         .         .         .       g.47009
 tttcagcccatgccccctcccaaaaagaaattgataagtaaaagcttcgttatacatttg       c.*540

          .         .         .         .         .         .       g.47069
 actaagaaatcacccagctttaaagctgcttttaacaatgaagattgaacagagttcagc       c.*600

          .         .         .         .         .         .       g.47129
 aattttgattaaattaagacttgggggtgaaactttccagtttactgaactccagaccat       c.*660

          .         .         .         .         .         .       g.47189
 gcatgtagtccactccagaaatcatgctcgcttcccttggcacaccagtgttctcctgcc       c.*720

          .         .         .         .         .         .       g.47249
 aaatgaccctagaccctctgtcctgcagagtcagggtggcttttcccctgactgtgtccg       c.*780

          .         .         .         .         .         .       g.47309
 atgccaaggagtcctggcctccgcagatgcttcattttgacccttggctgcagtggaagt       c.*840

          .         .         .         .         .         .       g.47369
 cagcacagagcagtgccctggctgtgtccctggacgggtggacttagctagggagaaagt       c.*900

          .         .         .         .         .         .       g.47429
 cgaggcagcagccctcgaggccctcacagatgtctaggcaggcctcatttcatcacgcag       c.*960

          .         .         .         .         .         .       g.47489
 catgtgcaggcctggaagagcaaagccaaatctcagggaagtccttggttgatgtatctg       c.*1020

          .         .         .         .         .         .       g.47549
 ggtctcctctggagcactctgccctcctgtcacccagtagagtaaataaacttccttggc       c.*1080

                                                                    g.47556
 tcctgct                                                            c.*1087

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tryptophanyl-tRNA synthetase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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