WAS protein family, member 1 (WASF1) - coding DNA reference sequence

(used for variant description)

(last modified July 24, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_003931.2 in the WASF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering WASF1 transcript NM_003931.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    agcagtgttctcttcgtccccctcccccaaactgaggattgggcaataccacagaac       c.-781

 .         .         .         .         .         .                g.5117
 ctcaggaaaggggggaagagcgagcttcggccccactaatgggggagtgggcggaggctg       c.-721

 .         .         .         .         .         .                g.5177
 gatttcccacctcggctgcacctgggcactggaggctgaagaggaaagtgagaatctgaa       c.-661

 .         .         .         .         .         .                g.5237
 gttttgagacctctgactggccaggaatagctcctggggcggggggcaaggatgggacca       c.-601

 .         .         .         .         .         .                g.5297
 taggcggaaagagtctcgcggtcccccctgcttctggcgcgggtccctgcgcccggttgt       c.-541

 .         .         .         .         .         .                g.5357
 ggagcgtctcgcgcggggagggggcggggggaacggcagctcgcggtgttgttcactcgc       c.-481

 .         .         .         .         .         .                g.5417
 gcgtcgagcacacggtgggtccggcggcgggttggcgccccaggcggcgttccctgtggc       c.-421

 .         .         .         .         .         .                g.5477
 ctggcgcctgggccgctgccctgagcgggttccgccccagagcccgaccctcctgggggc       c.-361

 .         .         .         .         .         .                g.5537
 tctaggcggagtcccgcgagccgagggggaccggcgaccgctgccgaagcatgaagaagg       c.-301

 .         .         .         | 02         .         .             g.6293
 ggtaaggcgtgagcccccaagatttcacg | catgccccctagcttcggtactctgacacct    c.-241

 .         .         .         .         .         .                g.6353
 tctcttgcacttgcggatgatgaactggaataacgatgaaagaaagcacatccgatctca       c.-181

 .         .         .         .         .         .    | 03        g.24278
 acattcacgtcctgccctataaccgattaattaattgatccccagctagactag | tgttgg    c.-121

 .         .         .         .         .         .                g.24338
 agaaatcagcatgttaaaacaactgttgatgatagctgttggagtaaagttgcagtggaa       c.-61

 .         .         .         .  | 04      .         .             g.57403
 gctatggctgcaaaatcgttaaaatcttcaag | gtgaactggcacaaaggttaatctcaag    c.-1

          .         .         .         .         .         .       g.57463
 ATGCCGCTAGTGAAAAGAAACATCGATCCTAGGCACTTGTGCCACACAGCACTGCCTAGA       c.60
 M  P  L  V  K  R  N  I  D  P  R  H  L  C  H  T  A  L  P  R         p.20

          .         .         .         .         .         .       g.57523
 GGCATTAAGAATGAACTGGAATGTGTAACCAATATTTCCTTGGCAAATATAATTAGACAA       c.120
 G  I  K  N  E  L  E  C  V  T  N  I  S  L  A  N  I  I  R  Q         p.40

          .    | 05    .         .         .         .         .    g.71591
 CTAAGTAGCCTAA | GTAAATATGCTGAAGATATATTTGGAGAATTATTCAATGAAGCACAT    c.180
 L  S  S  L  S |   K  Y  A  E  D  I  F  G  E  L  F  N  E  A  H      p.60

          .         .         .         .         .         .       g.71651
 AGTTTTTCCTTCAGAGTCAACTCATTGCAAGAACGTGTGGACCGTTTATCTGTTAGTGTT       c.240
 S  F  S  F  R  V  N  S  L  Q  E  R  V  D  R  L  S  V  S  V         p.80

          .         .         | 06         .         .         .    g.76355
 ACACAGCTTGATCCAAAGGAAGAAGAAT | TGTCTTTGCAAGATATAACAATGAGGAAAGCT    c.300
 T  Q  L  D  P  K  E  E  E  L |   S  L  Q  D  I  T  M  R  K  A      p.100

          .         .         .         .         .         .       g.76415
 TTCCGAAGTTCTACAATTCAAGACCAGCAGCTTTTCGATCGCAAGACTTTGCCTATTCCA       c.360
 F  R  S  S  T  I  Q  D  Q  Q  L  F  D  R  K  T  L  P  I  P         p.120

          .         .         .         .         .         .       g.76475
 TTACAGGAGACGTACGATGTTTGTGAACAGCCTCCACCTCTCAATATACTCACTCCTTAT       c.420
 L  Q  E  T  Y  D  V  C  E  Q  P  P  P  L  N  I  L  T  P  Y         p.140

    | 07     .         .         .         .         .         .    g.77868
 AG | AGATGATGGTAAAGAAGGTCTGAAGTTTTATACCAATCCTTCGTATTTCTTTGATCTA    c.480
 R  |  D  D  G  K  E  G  L  K  F  Y  T  N  P  S  Y  F  F  D  L      p.160

          .         .         .         .         .         .       g.77928
 TGGAAAGAAAAAATGTTGCAAGATACAGAGGATAAGAGGAAGGAAAAGAGGAAGCAGAAG       c.540
 W  K  E  K  M  L  Q  D  T  E  D  K  R  K  E  K  R  K  Q  K         p.180

  | 08       .         .         .         .         .         .    g.79485
  | CAGAAAAATCTAGATCGTCCTCATGAACCAGAAAAAGTGCCAAGAGCACCTCATGACAGG    c.600
  | Q  K  N  L  D  R  P  H  E  P  E  K  V  P  R  A  P  H  D  R      p.200

          .         .         .         .         .         .       g.79545
 CGGCGAGAATGGCAGAAGCTGGCCCAAGGTCCAGAGCTGGCTGAAGATGATGCTAATCTC       c.660
 R  R  E  W  Q  K  L  A  Q  G  P  E  L  A  E  D  D  A  N  L         p.220

          .         .         .         .         .    | 09    .    g.81454
 TTACATAAGCATATTGAAGTTGCTAATGGCCCAGCCTCTCATTTTGAAACAAG | ACCTCAG    c.720
 L  H  K  H  I  E  V  A  N  G  P  A  S  H  F  E  T  R  |  P  Q      p.240

          .         .         .         .         .         .       g.81514
 ACATACGTGGATCATATGGATGGATCTTACTCACTTTCTGCCTTGCCATTTAGTCAGATG       c.780
 T  Y  V  D  H  M  D  G  S  Y  S  L  S  A  L  P  F  S  Q  M         p.260

          .         .         .         .         .         .       g.81574
 AGTGAGCTTCTGACTAGAGCTGAGGAAAGGGTATTAGTCAGACCACATGAACCACCTCCA       c.840
 S  E  L  L  T  R  A  E  E  R  V  L  V  R  P  H  E  P  P  P         p.280

          .         .         .         .         .    | 10    .    g.82795
 CCTCCACCAATGCATGGAGCAGGAGATGCAAAACCGATACCCACCTGTATCAG | TTCTGCT    c.900
 P  P  P  M  H  G  A  G  D  A  K  P  I  P  T  C  I  S  |  S  A      p.300

          .         .         .         .         .         .       g.82855
 ACAGGTTTGATAGAAAATCGCCCTCAGTCACCAGCTACAGGCAGAACACCTGTGTTTGTG       c.960
 T  G  L  I  E  N  R  P  Q  S  P  A  T  G  R  T  P  V  F  V         p.320

          .         .         .         .         .         .       g.82915
 AGCCCCACTCCCCCACCTCCTCCACCACCTCTTCCATCTGCCTTGTCAACTTCCTCATTA       c.1020
 S  P  T  P  P  P  P  P  P  P  L  P  S  A  L  S  T  S  S  L         p.340

          .         .         .         .         .         .       g.82975
 AGAGCTTCAATGACTTCAACTCCTCCCCCTCCAGTACCTCCCCCACCTCCACCTCCAGCC       c.1080
 R  A  S  M  T  S  T  P  P  P  P  V  P  P  P  P  P  P  P  A         p.360

          .         .         .         .         .         .       g.83035
 ACTGCTTTGCAAGCTCCAGCAGTACCACCACCTCCAGCTCCTCTTCAGATTGCCCCTGGA       c.1140
 T  A  L  Q  A  P  A  V  P  P  P  P  A  P  L  Q  I  A  P  G         p.380

          .         .         .         .         .         .       g.83095
 GTTCTTCACCCAGCTCCTCCTCCAATTGCACCTCCTCTAGTACAGCCCTCTCCACCAGTA       c.1200
 V  L  H  P  A  P  P  P  I  A  P  P  L  V  Q  P  S  P  P  V         p.400

          .         .         .         .         .         .       g.83155
 GCTAGAGCTGCCCCAGTATGTGAGACTGTACCAGTTCATCCACTCCCACAAGGTGAAGTT       c.1260
 A  R  A  A  P  V  C  E  T  V  P  V  H  P  L  P  Q  G  E  V         p.420

          .         .         .         .         .         .       g.83215
 CAGGGGCTGCCTCCACCCCCACCACCGCCTCCTCTGCCTCCACCTGGCATTCGACCATCA       c.1320
 Q  G  L  P  P  P  P  P  P  P  P  L  P  P  P  G  I  R  P  S         p.440

          .         .         .         .         .         .       g.83275
 TCACCTGTCACAGTTACAGCTCTTGCTCATCCTCCCTCTGGGCTACATCCAACTCCATCT       c.1380
 S  P  V  T  V  T  A  L  A  H  P  P  S  G  L  H  P  T  P  S         p.460

          .         .         .         .         .         .       g.83335
 ACTGCCCCAGGTCCCCATGTTCCATTAATGCCTCCATCTCCTCCATCACAAGTTATACCT       c.1440
 T  A  P  G  P  H  V  P  L  M  P  P  S  P  P  S  Q  V  I  P         p.480

          .         .         .         .         .         .       g.83395
 GCTTCTGAGCCAAAGCGCCATCCATCAACCCTACCTGTAATCAGTGATGCCAGGAGTGTG       c.1500
 A  S  E  P  K  R  H  P  S  T  L  P  V  I  S  D  A  R  S  V         p.500

          .         .   | 11     .         .         .         .    g.84363
 CTACTGGAAGCAATACGAAAAG | GTATTCAGCTACGCAAAGTAGAAGAGCAGCGTGAACAG    c.1560
 L  L  E  A  I  R  K  G |   I  Q  L  R  K  V  E  E  Q  R  E  Q      p.520

          .         .         .         .         .         .       g.84423
 GAAGCTAAGCATGAACGCATTGAAAACGATGTTGCCACCATCCTGTCTCGCCGTATTGCT       c.1620
 E  A  K  H  E  R  I  E  N  D  V  A  T  I  L  S  R  R  I  A         p.540

          .         .         .         .         .         .       g.84483
 GTTGAATATAGTGATTCGGAAGATGATTCAGAATTTGATGAAGTAGATTGGTTGGAGTAA       c.1680
 V  E  Y  S  D  S  E  D  D  S  E  F  D  E  V  D  W  L  E  X         p.559

          .         .         .         .         .         .       g.84543
 gaaaaatgcattgataaatattacaaaactgaatgcaaatgtcctttgtggtgcttgttc       c.*60

          .         .         .         .         .         .       g.84603
 cttgaaaatgtttggtcattctagtgttttgctttcttttccttataataaatgaccctt       c.*120

          .         .         .         .         .         .       g.84663
 ttcctccataacttttgatttctaaggaaaatattagcatacatttcaaactaaatgttt       c.*180

          .         .         .         .         .         .       g.84723
 tacagtggcttatcttttttttccccctgaaaagactaatttggtcaaataaaccactaa       c.*240

          .         .         .         .         .         .       g.84783
 gtattaagcatggacagctgttgttagagtagcagattcagttttttgatatatcttaat       c.*300

          .         .         .         .         .         .       g.84843
 tgtgtactttgtgaattttaatttaaagaaagcaactgaaattgaaatcttgagggcagc       c.*360

          .         .         .         .         .         .       g.84903
 tgtgtctactaatgagccttattccatttcctgatgttttaaaagaagaaacactgcctt       c.*420

          .         .         .         .         .         .       g.84963
 gattatacgaatacactcagaaagtacatttagcttgtagtgttgaattctcttaaagga       c.*480

          .         .         .         .         .         .       g.85023
 atgcttgaattttttcattattgttttattgtttttatatacttgccttatttgaatgtt       c.*540

          .         .         .         .         .         .       g.85083
 tagcagtatccccttcccacttatatattgtgtgatatgattttgcttgcctataggagt       c.*600

          .         .         .         .         .         .       g.85143
 taaaaacttttccatgtgaaatactctgacttaaacatacatgtaacttacataactgtt       c.*660

          .         .         .         .                           g.85186
 aagaataacagtctgatttaataaatggttcattttaaaagtt                        c.*703

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The WAS protein family, member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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