WW domain binding protein 4 (WBP4) - coding DNA reference sequence

(used for variant description)

(last modified December 8, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_007187.3 in the WBP4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000013.10, covering WBP4 transcript NM_007187.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5053
        tcggagggaggttcgggtgggcatcgggcggctggaagagctcgactcgtccc       c.-61

 .         .         .         .         .         .                g.5113
 gctgggaaagcgcgagtctgagtggaaccctggacgacttgcagagcggctggcgcagtc       c.-1

    | 02     .         .         .         .         .         .    g.6141
 AT | GGCGGACTACTGGAAGTCACAGCCAAAGAAATTCTGTGATTACTGCAAGTGCTGGATA    c.60
 M  |  A  D  Y  W  K  S  Q  P  K  K  F  C  D  Y  C  K  C  W  I      p.20

          .      | 03  .         .         .         .         .    g.8500
 GCAGACAATAGGCCT | AGTGTTGAATTTCATGAAAGAGGAAAGAATCATAAGGAAAATGTG    c.120
 A  D  N  R  P   | S  V  E  F  H  E  R  G  K  N  H  K  E  N  V      p.40

          .         | 04         .         .         .         .    g.8645
 GCAAAAAGGATCAGTGAG | ATTAAACAGAAAAGCCTGGATAAGGCAAAGGAAGAAGAAAAG    c.180
 A  K  R  I  S  E   | I  K  Q  K  S  L  D  K  A  K  E  E  E  K      p.60

          .         .         .         .         .         .       g.8705
 GCATCAAAGGAGTTTGCTGCAATGGAGGCAGCTGCCCTGAAAGCATACCAAGAGGATTTG       c.240
 A  S  K  E  F  A  A  M  E  A  A  A  L  K  A  Y  Q  E  D  L         p.80

          .         .   | 05     .         .         .         .    g.12038
 AAAAGACTTGGCTTAGAGTCAG | AAATTTTGGAGCCAAGCATAACACCAGTAACCAGCACT    c.300
 K  R  L  G  L  E  S  E |   I  L  E  P  S  I  T  P  V  T  S  T      p.100

          .         .         .         .         .         .       g.12098
 ATCCCACCTACCTCGACATCAAATCAACAGAAAGAAAAGAAAGAAAAGAAGAAAAGAAAA       c.360
 I  P  P  T  S  T  S  N  Q  Q  K  E  K  K  E  K  K  K  R  K         p.120

          .         .         .         .         .         .       g.12158
 AAAGATCCTTCAAAGGGCAGATGGGTAGAAGGCATAACCTCTGAGGGTTACCATTACTAT       c.420
 K  D  P  S  K  G  R  W  V  E  G  I  T  S  E  G  Y  H  Y  Y         p.140

          .          | 06        .         .         .         .    g.15007
 TATGATCTTATCTCAGGAG | CATCTCAGTGGGAGAAACCTGAAGGATTTCAAGGAGACTTA    c.480
 Y  D  L  I  S  G  A |   S  Q  W  E  K  P  E  G  F  Q  G  D  L      p.160

        | 07 .         .         .         .         .         .    g.16275
 AAAAAG | ACAGCAGTGAAGACCGTTTGGGTAGAAGGTTTAAGTGAAGATGGTTTTACCTAT    c.540
 K  K   | T  A  V  K  T  V  W  V  E  G  L  S  E  D  G  F  T  Y      p.180

          .         .   | 08     .         .         .         .    g.19521
 TACTATAATACAGAAACAGGAG | AATCCAGATGGGAGAAACCTGATGATTTCATTCCACAC    c.600
 Y  Y  N  T  E  T  G  E |   S  R  W  E  K  P  D  D  F  I  P  H      p.200

          .         .         .         .         .         .       g.19581
 ACTAGTGATCTGCCTTCTAGTAAGGTCAATGAAAATTCACTTGGCACCCTAGATGAATCC       c.660
 T  S  D  L  P  S  S  K  V  N  E  N  S  L  G  T  L  D  E  S         p.220

          .         .         .         .         .         .       g.19641
 AAATCATCAGATTCGCATAGTGATTCTGATGGGGAACAGGAAGCAGAAGAAGGAGGGGTC       c.720
 K  S  S  D  S  H  S  D  S  D  G  E  Q  E  A  E  E  G  G  V         p.240

          .         .         .       | 09 .         .         .    g.24109
 TCTACAGAGACAGAAAAGCCAAAAATAAAGTTTAAG | GAAAAAAATAAAAATAGTGATGGA    c.780
 S  T  E  T  E  K  P  K  I  K  F  K   | E  K  N  K  N  S  D  G      p.260

          .         .         .         .         .         .       g.24169
 GGAAGTGACCCAGAAACACAGAAAGAAAAAAGTATTCAGAAACAGAATTCATTAGGTTCA       c.840
 G  S  D  P  E  T  Q  K  E  K  S  I  Q  K  Q  N  S  L  G  S         p.280

          .         .         .         .         .         .       g.24229
 AATGAAGAAAAATCGAAAACTCTTAAGAAATCAAACCCATATGGAGAATGGCAAGAAATT       c.900
 N  E  E  K  S  K  T  L  K  K  S  N  P  Y  G  E  W  Q  E  I         p.300

          .         . | 10       .         .         .         .    g.26183
 AAACAAGAGGTTGAGTCTCA | TGAGGAGGTAGATTTGGAACTTCCAAGCACTGAAAATGAG    c.960
 K  Q  E  V  E  S  H  |  E  E  V  D  L  E  L  P  S  T  E  N  E      p.320

          .         .         .         .         .         .       g.26243
 TATGTATCAACTTCAGAAGCTGATGGTGGCGGAGAACCCAAAGTGGTATTTAAAGAAAAA       c.1020
 Y  V  S  T  S  E  A  D  G  G  G  E  P  K  V  V  F  K  E  K         p.340

          .         .         .         .         .         .       g.26303
 ACAGTCACTTCTCTTGGAGTTATGGCAGATGGAGTGGCCCCAGTCTTCAAAAAGAGAAGA       c.1080
 T  V  T  S  L  G  V  M  A  D  G  V  A  P  V  F  K  K  R  R         p.360

          .         .         .         .         .                 g.26354
 ACTGAAAATGGAAAATCTAGAAATTTAAGGCAACGAGGTGATGATCAATAG                c.1131
 T  E  N  G  K  S  R  N  L  R  Q  R  G  D  D  Q  X                  p.376

          .         .         .         .         .         .       g.26414
 ttgcaggagagctttttgtacatgcttttaggacagaatggagacttatacacccaaagt       c.*60

          .         .         .         .         .         .       g.26474
 ttatctgtgtttgtttgtaagtattatgatgctaaaaatttagatttattctaaatgtat       c.*120

          .         .         .         .         .         .       g.26534
 ttgatgtgaattaaaataaatattttttcatgtgaaatttattttggttcctaaaatgga       c.*180

          .         .         .         .         .         .       g.26594
 agcctaccacattgcattgtaatacagtgtattatgttcagtgtctaaaaactgctaatt       c.*240

          .         .         .         .         .         .       g.26654
 aagtcataatttaagatgctatgtatctgttatttaaaacatggagaaacagggccttta       c.*300

          .         .         .         .         .         .       g.26714
 ttccattcatattcataagagcatatttatcctgcattgaaaatgcattacttttgcaca       c.*360

          .         .         .         .         .         .       g.26774
 ttgatattaactgttgtccaacaaataagtatcggagtacgtgagaatattcccagccca       c.*420

          .         .         .         .         .         .       g.26834
 gtgatgatttggttctgaggctgatgtgagaaagctgatgtaaaaaatgtatgcatattg       c.*480

          .         .         .         .         .         .       g.26894
 gcttaccttactcaatttaaagtcaaaagccaacagccaggagcagctcaggtacttcag       c.*540

          .         .         .         .         .         .       g.26954
 atgtgcttaatatggagtgaaaactggaccagaggtggaaagatgtatttgccccagttc       c.*600

          .         .         .         .         .         .       g.27014
 acttcaaagcagcaaacgttgtttaagcattttagtttgaaccaggcattgtgttaggaa       c.*660

          .         .         .         .         .         .       g.27074
 tccagggataaagatgaatgaaatgtatttctgttcttcaggagttcacattctagcata       c.*720

          .         .         .         .         .         .       g.27134
 tgccttttttcccccagtcatgcactctttttagcagtcttatatgtactagaaaagatt       c.*780

          .         .         .         .         .         .       g.27194
 ttttaaagtttatttaaagctgtgtagatgaaggcttgatctaaaatagtataaggtctc       c.*840

          .         .         .         .         .         .       g.27254
 cagcttcagtaaaagtttttagtgtttacttaaattagtaatttctcactttctgtctgg       c.*900

          .         .         .         .         .         .       g.27314
 ttaaaatgtcttaaaaagtagaattttcttctttaatccgtttagtagttacctcccttt       c.*960

          .         .         .         .         .         .       g.27374
 tacttttcaaattcacaaaattacatttctcataaattgtatagtatttaacttataata       c.*1020

          .         .         .         .         .         .       g.27434
 gttaatatttgtctttttaagatgactgtacatgtaagaaaaaagcttattaaaaacttg       c.*1080

                                                                    g.27443
 atcaaagaa                                                          c.*1089

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The WW domain binding protein 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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