WD repeat containing planar cell polarity effector (WDPCP) - coding DNA reference sequence

(used for variant description)

(last modified November 26, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_015910.5 in the WDPCP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_028144.2, covering WDPCP transcript NM_015910.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5042
                   aaacggatggtttgggctcaggaggaaaggacctgcctgatg       c.-421

 .         .         .         .         .         .                g.5102
 gagcccggcaattggcgggagagatagcgtgtgtaactctagggaggggagaatcacccc       c.-361

 .         .         .         .         .         .                g.5162
 ttagcgacatcacccccacgcgcgtgactgagactgcatcctcccatgagggtaaacgtg       c.-301

 .         .         .         .         .         .                g.5222
 ggaggtaaagagaccttccgctgcgtaaagctggatcgacccggaaacaaaatcttttaa       c.-241

 .         .         .         .         .         .                g.5282
 aaaacgattgacactctggaggggcgggggaattgataagttgggacgaccggacagctt       c.-181

 .         .         .         .         .         .                g.5342
 ctcaggttgctaagcgacgaggcgggagcgcacgcacaccctggctgctttgtagcacct       c.-121

 .         .         .         .         .         .                g.5402
 gaggaaactgtggcggcggcggcggcgtcctggagacccaagagaccaagcgagcgtgtc       c.-61

 .         .         .         .         .         .                g.5462
 gctccctctcgggtccgaggacctagcctaggaaccttctgcccggggtagtgtctggtg       c.-1

          .         .         .         .         .         .       g.5522
 ATGAGGCGAGAGTTTTGCTGGGACGCCTACTCCAAAGCGGCCGGGAGTCGCGCTTCTTCC       c.60
 M  R  R  E  F  C  W  D  A  Y  S  K  A  A  G  S  R  A  S  S         p.20

          .      | 02  .         .         .         .         .    g.100838
 CCACTCCCGAGACAG | GATAGAGATTCCTTCTGCCATCAGATGTCTTTCTGCTTGACTGAA    c.120
 P  L  P  R  Q   | D  R  D  S  F  C  H  Q  M  S  F  C  L  T  E      p.40

          .         .         .         . | 03       .         .    g.106259
 CTGCACCTGTGGTCTTTGAAGAATACCTTACACATTGCGG | ATAGAGACATTGGGATCTAC    c.180
 L  H  L  W  S  L  K  N  T  L  H  I  A  D |   R  D  I  G  I  Y      p.60

          .         .         | 04         .         .         .    g.107179
 CAGTATTATGACAAGAAAGATCCACCAG | CGACAGAGCATGGTAACTTAGAAAAGAAGCAG    c.240
 Q  Y  Y  D  K  K  D  P  P  A |   T  E  H  G  N  L  E  K  K  Q      p.80

          .    | 05    .         .         .         .         .    g.108793
 AAGCTGGCAGAGT | CACGAGATTATCCTTGGACGCTCAAAAACAGACGCCCAGAAAAACTC    c.300
 K  L  A  E  S |   R  D  Y  P  W  T  L  K  N  R  R  P  E  K  L      p.100

          .         .     | 06   .         .         .         .    g.109106
 CGAGACTCGCTCAAAGAGTTGGAG | GAGCTGATGCAAAACAGTCGGTGTGTGCTGAGCAAA    c.360
 R  D  S  L  K  E  L  E   | E  L  M  Q  N  S  R  C  V  L  S  K      p.120

          .         .     | 07   .         .         .         .    g.153898
 TGGAAGAACAAATATGTCTGTCAG | CTCCTTTTTGGTTCAGGTGTGCTGGTGTCTCTAAGC    c.420
 W  K  N  K  Y  V  C  Q   | L  L  F  G  S  G  V  L  V  S  L  S      p.140

          .         .         .         .         .         .       g.153958
 CTTTCTGGGCCGCAGCTGGAGAAAGTGGTGATTGACAGAAGCCTGGTGGGGAAGCTCATC       c.480
 L  S  G  P  Q  L  E  K  V  V  I  D  R  S  L  V  G  K  L  I         p.160

          .          | 08        .         .         .         .    g.156220
 TCAGACACCATCAGTGATG | CTCTTCTCACAGACAGTTTTATCATCTTATCATTTTTGGCA    c.540
 S  D  T  I  S  D  A |   L  L  T  D  S  F  I  I  L  S  F  L  A      p.180

          .         .         .         .         .         .       g.156280
 CAAAACAAACTATGTTTTATTCAGTTTACCAAGAAGATGGAGTCTTCTGATGTAAACAAA       c.600
 Q  N  K  L  C  F  I  Q  F  T  K  K  M  E  S  S  D  V  N  K         p.200

          .         .         .    | 09    .         .         .    g.159824
 AGACTGGAAAAACTCTCAGCCTTGGATTATAAG | ATTTTCTATTATGAAATACCCGGCCCA    c.660
 R  L  E  K  L  S  A  L  D  Y  K   | I  F  Y  Y  E  I  P  G  P      p.220

          .         .         .         .         .         .       g.159884
 ATAAACAAGACAACAGAGCGACATCTAGCTATCAACTGTGTTCATGATAGAGTTGTTTGC       c.720
 I  N  K  T  T  E  R  H  L  A  I  N  C  V  H  D  R  V  V  C         p.240

          .         .         .         .         .         .       g.159944
 TGGTGGCCACTGGTCAACGATGATGCTTGGCCTTGGGCCCCCATTTCTTCTGAGAAGGAC       c.780
 W  W  P  L  V  N  D  D  A  W  P  W  A  P  I  S  S  E  K  D         p.260

          .         .         .         .      | 10  .         .    g.189090
 AGAGCCAATCTACTCCTCCTGGGTTATGCTCAAGGAAGACTAGAG | GTTCTGAGTTCTGTC    c.840
 R  A  N  L  L  L  L  G  Y  A  Q  G  R  L  E   | V  L  S  S  V      p.280

          .         .         .         .         .         .       g.189150
 CGCACAGAATGGGACCCACTGGATGTTCGCTTTGGCACCAAACAGCCTTATCAGGTGTTC       c.900
 R  T  E  W  D  P  L  D  V  R  F  G  T  K  Q  P  Y  Q  V  F         p.300

          .         .         .         .         .         .       g.189210
 ACAGTGGAGCACTCCGTAAGTGTAGACAAAGAGCCCATGGCTGACAGCTGCATCTATGAA       c.960
 T  V  E  H  S  V  S  V  D  K  E  P  M  A  D  S  C  I  Y  E         p.320

          .         .         .         .         .         .       g.189270
 TGCATTCGGAATAAAATCCAGTGTGTGTCAGTCACCAGAATACCACTAAAGTCAAAGGCC       c.1020
 C  I  R  N  K  I  Q  C  V  S  V  T  R  I  P  L  K  S  K  A         p.340

          .         .         .         .         .         .       g.189330
 ATCAGCTGCTGCAGGAATGTTACTGAAGACAAACTGATTCTGGGCTGTGAAGATTCTTCG       c.1080
 I  S  C  C  R  N  V  T  E  D  K  L  I  L  G  C  E  D  S  S         p.360

          .         .         .         .         .         .       g.189390
 CTAATTCTTTATGAAACTCACCGTAGAGTGACTCTCTTAGCACAGACTGAACTTTTGCCT       c.1140
 L  I  L  Y  E  T  H  R  R  V  T  L  L  A  Q  T  E  L  L  P         p.380

          .         .         .         .         .         .       g.189450
 TCATTAATAAGCTGCCACCCAAGTGGTGCCATTCTGCTAGTTGGCAGCAACCAAGGGGAG       c.1200
 S  L  I  S  C  H  P  S  G  A  I  L  L  V  G  S  N  Q  G  E         p.400

          .         .         .         .         .         .       g.189510
 TTGCAAATTTTTGATATGGCTCTATCCCCTATTAACATCCAACTGTTGGCTGAAGACCGC       c.1260
 L  Q  I  F  D  M  A  L  S  P  I  N  I  Q  L  L  A  E  D  R         p.420

          .         .         .         .         .         .       g.189570
 TTACCCAGGGAGACTCTGCAATTCAGTAAATTATTTGATGCCTCCAGCAGTCTTGTTCAA       c.1320
 L  P  R  E  T  L  Q  F  S  K  L  F  D  A  S  S  S  L  V  Q         p.440

          .         .         .         .         .         .       g.189630
 ATGCAATGGATAGCTCCTCAGGTTGTTTCTCAGAAGGGTGAAGGTAGTGATATCTATGAT       c.1380
 M  Q  W  I  A  P  Q  V  V  S  Q  K  G  E  G  S  D  I  Y  D         p.460

          .         .         .         .         .      | 11  .    g.211643
 CTCCTCTTCCTCAGGTTTGAAAGAGGACCTTTGGGTGTGCTGTTGTTTAAACTAG | GCGTC    c.1440
 L  L  F  L  R  F  E  R  G  P  L  G  V  L  L  F  K  L  G |   V      p.480

          .         .         .         .         .         .       g.211703
 TTCACTCGAGGACAGCTGGGCCTGATAGACATCATCTTCCAGTACATTCACTGTGATGAG       c.1500
 F  T  R  G  Q  L  G  L  I  D  I  I  F  Q  Y  I  H  C  D  E         p.500

          .         .         .         .         .         .       g.211763
 ATCTATGAGGCAATAAACATCCTGAGCAGCATGAACTGGGACACTCTGGGCCACCAGTGC       c.1560
 I  Y  E  A  I  N  I  L  S  S  M  N  W  D  T  L  G  H  Q  C         p.520

          .         .         .         .         .         .       g.211823
 TTTATCAGCATGAGCGCCATTGTAAACCATCTTCTTAGACAGAAGCTCACTCCAGAGAGA       c.1620
 F  I  S  M  S  A  I  V  N  H  L  L  R  Q  K  L  T  P  E  R         p.540

      | 12   .         .         .         .         .         .    g.215279
 GAAG | CACAGCTTGAGACAAGCCTTGGAACCTTCTATGCTCCAACAAGACCACTTCTGGAT    c.1680
 E  A |   Q  L  E  T  S  L  G  T  F  Y  A  P  T  R  P  L  L  D      p.560

          .         .         .         .         .         .       g.215339
 TCCACTATATTGGAATATAGAGATCAAATCAGCAAATATGCAAGGAGATTCTTCCATCAC       c.1740
 S  T  I  L  E  Y  R  D  Q  I  S  K  Y  A  R  R  F  F  H  H         p.580

          | 13         .         .         .         .         .    g.280473
 TTGCTCAG | GTACCAGAGGTTTGAAAAGGCATTTCTCCTAGCTGTTGACGTTGGTGCTCGT    c.1800
 L  L  R  |  Y  Q  R  F  E  K  A  F  L  L  A  V  D  V  G  A  R      p.600

          .   | 14     .         .         .         .         .    g.334371
 GACCTCTTTATG | GATATTCATTACCTTGCACTAGATAAAGGTGAATTGGCACTAGCTGAA    c.1860
 D  L  F  M   | D  I  H  Y  L  A  L  D  K  G  E  L  A  L  A  E      p.620

          .         .         .         .         .      | 15  .    g.418905
 GTGGCAAGAAAAAGAGCTAGTGACATTGATGCAGAATCAATAACCTCTGGGGTTG | AACTC    c.1920
 V  A  R  K  R  A  S  D  I  D  A  E  S  I  T  S  G  V  E |   L      p.640

          .         .         .         .         .         .       g.418965
 CTGGGACCCTTGGACAGAGGGGATATGCTAAATGAAGCATTTATTGGCCTGTCTTTAGCA       c.1980
 L  G  P  L  D  R  G  D  M  L  N  E  A  F  I  G  L  S  L  A         p.660

          .         .         .         .         .         .       g.419025
 CCTCAAGGAGAAGACTCATTTCCAGATAACCTCCCTCCCTCTTGCCCAACCCACAGACAT       c.2040
 P  Q  G  E  D  S  F  P  D  N  L  P  P  S  C  P  T  H  R  H         p.680

          .         .         .         | 16         .         .    g.440180
 ATTTTACAACAAAGAATACTGAATGGCTCTTCTAACAG | ACAAATAATTGACAGAAGGAAT    c.2100
 I  L  Q  Q  R  I  L  N  G  S  S  N  R  |  Q  I  I  D  R  R  N      p.700

          .         .         .         .         .         | 17    g.440789
 GAACTTGAAAAAGACATCTGTTCTGGATTTTTGATGACTAATACCTGTAATGCAGAAG | AC    c.2160
 E  L  E  K  D  I  C  S  G  F  L  M  T  N  T  C  N  A  E  D |       p.720

          .         .         . | 18       .         .         .    g.471706
 GGAGAACTGAGAGAAGACGGCAGAGAACAG | GAAATCAGAGATGGTGGTTCTCTCAAAATG    c.2220
 G  E  L  R  E  D  G  R  E  Q   | E  I  R  D  G  G  S  L  K  M      p.740

          .         .                                               g.471727
 ATTCACTTTGGTCTGGTGTAA                                              c.2241
 I  H  F  G  L  V  X                                                p.746

          .         .         .         .         .         .       g.471787
 acattaagaaaaaaagaaaactgccttcttcatatctaaacttttcatggcctgatacag       c.*60

          .         .         .         .         .         .       g.471847
 acttaaaatcccccgtgtggatttttaacaagagacagtatgaatcatataaattagtta       c.*120

          .         .         .         .         .         .       g.471907
 agagttttgagttgagtgtttgttttcaaaataaagttttattatttcaaaaacatgcag       c.*180

          .         .         .         .         .         .       g.471967
 cataacagcaaagtgatcgtaagtaaaagtcttcaacctacttattttcaataatgtaaa       c.*240

          .         .         .         .         .         .       g.472027
 attttgaaagtgtcttaaattgtatgttaattaggtgctacaaaaatagaatatttaaac       c.*300

          .         .         .         .         .         .       g.472087
 tttgttctcccaggtactttaaaaaaggggcagtagggggcaggcatagtgctcatgcct       c.*360

          .         .         .         .         .         .       g.472147
 gtagtcccagtgctttaggaggccaaggctgaaggatcacttgagcccaggagttcaaga       c.*420

          .         .         .         .         .         .       g.472207
 ctagcctgtgcaacatagtgaaacgctgtctctagaaaaaattttaaaaattagccaggc       c.*480

          .         .         .         .         .         .       g.472267
 atggtggtacatgcttgtgaagctgaggcagaagaattgcttgagcccaggagttcaagg       c.*540

          .         .         .         .         .         .       g.472327
 ctacagtgagctgtgatcgcgccactgcactctaacctgggcaacagagagtgaccctgt       c.*600

          .         .                                               g.472350
 ctccaaaaaaaaaaaaaaaaaaa                                            c.*623

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The WD repeat containing planar cell polarity effector protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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