WD repeat domain 11 (WDR11) - coding DNA reference sequence

(used for variant description)

(last modified March 1, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_018117.11 in the WDR11 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023290.1, covering WDR11 transcript NM_018117.11.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                       agcaca       c.-241

 .         .         .         .         .         .                g.5066
 accgcctaagcggcggaactctggagagtgcggaacctaggatcctaggaaactgaaggc       c.-181

 .         .         .         .         .         .                g.5126
 aacggaacctgggggcgatggaatccgggagcggtggaacccggagcctgtagaacttga       c.-121

 .         .         .         .         .         .                g.5186
 atctagaggaacctgacagcggcgccgagggggccacccggactctgtttggaacggaag       c.-61

 .         .         .         .         .         .                g.5246
 cacagtgtccgccgcttcctggttgcgggtcagcgcccaggtcctgggctggccgccggg       c.-1

          .         .         .         .         .         .       g.5306
 ATGTTGCCCTACACAGTGAACTTCAAGGTGTCGGCGCGCACCCTCACGGGGGCCCTCAAC       c.60
 M  L  P  Y  T  V  N  F  K  V  S  A  R  T  L  T  G  A  L  N         p.20

          .         .       | 02 .         .         .         .    g.6383
 GCCCACAACAAGGCGGCGGTGGACTG | GGGCTGGCAAGGTTTAATTGCTTATGGATGTCAT    c.120
 A  H  N  K  A  A  V  D  W  |  G  W  Q  G  L  I  A  Y  G  C  H      p.40

          .         .         .         .         .         .       g.6443
 TCACTTGTGGTAGTGATTGATTCCATTACTGCCCAAACTCTTCAAGTTTTAGAAAAGCAT       c.180
 S  L  V  V  V  I  D  S  I  T  A  Q  T  L  Q  V  L  E  K  H         p.60

          .         | 03         .         .         .         .    g.12510
 AAAGCTGATGTTGTAAAG | GTTAAATGGGCCAGGGAAAACTATCACCATAACATTGGCTCA    c.240
 K  A  D  V  V  K   | V  K  W  A  R  E  N  Y  H  H  N  I  G  S      p.80

          .         .         .         .         .         .       g.12570
 CCATATTGCTTACGGTTAGCTTCTGCTGATGTCAATGGGAAGATCATCGTCTGGGATGTA       c.300
 P  Y  C  L  R  L  A  S  A  D  V  N  G  K  I  I  V  W  D  V         p.100

          .         .         .         .         .   | 04     .    g.13942
 GCAGCAGGAGTAGCTCAGTGTGAGATCCAAGAGCATGCCAAGCCTATCCAGG | ATGTTCAG    c.360
 A  A  G  V  A  Q  C  E  I  Q  E  H  A  K  P  I  Q  D |   V  Q      p.120

          .         .         .         .         .         .       g.14002
 TGGTTGTGGAATCAAGATGCTTCCCGCGATTTACTGCTTGCTATCCACCCGCCAAATTAC       c.420
 W  L  W  N  Q  D  A  S  R  D  L  L  L  A  I  H  P  P  N  Y         p.140

          .         .         .         .         .         .       g.14062
 ATTGTGCTCTGGAATGCCGACACTGGCACCAAACTATGGAAGAAGAGCTATGCAGATAAC       c.480
 I  V  L  W  N  A  D  T  G  T  K  L  W  K  K  S  Y  A  D  N         p.160

          .         .         .         .       | 05 .         .    g.16574
 ATTCTTTCTTTTTCTTTTGACCCTTTTGATCCCTCACATTTAACTT | TGCTTACCAGCGAG    c.540
 I  L  S  F  S  F  D  P  F  D  P  S  H  L  T  L |   L  T  S  E      p.180

          .         .         .         .         .         .       g.16634
 GGTATTGTTTTCATCTCAGACTTCTCCCCATCCAAGCCTCCCTCAGGCCCTGGGAAAAAA       c.600
 G  I  V  F  I  S  D  F  S  P  S  K  P  P  S  G  P  G  K  K         p.200

          .         .         .         .         .         .       g.16694
 GTTTACATATCCAGCCCACACTCTAGCCCAGCTCATAACAAGCTGGCCACAGCCACAGGT       c.660
 V  Y  I  S  S  P  H  S  S  P  A  H  N  K  L  A  T  A  T  G         p.220

          .         .         .         .         .    | 06    .    g.18879
 GCCAAGAAAGCTCTAAATAAAGTAAAAATTTTAATCACTCAAGAGAAACCTAG | TGCTGAA    c.720
 A  K  K  A  L  N  K  V  K  I  L  I  T  Q  E  K  P  S  |  A  E      p.240

          .         .         .         .         .         .       g.18939
 TTCATAACTCTCAATGATTGCCTTCAGTTGGCATACCTGCCTTCAAAAAGGAATCACATG       c.780
 F  I  T  L  N  D  C  L  Q  L  A  Y  L  P  S  K  R  N  H  M         p.260

          .         .         .         .         .         .       g.18999
 TTGTTGCTCTATCCTCGAGAGATTTTAATCCTTGACCTTGAGGTGAATCAGACGGTGGGT       c.840
 L  L  L  Y  P  R  E  I  L  I  L  D  L  E  V  N  Q  T  V  G         p.280

          .         .         .          | 07        .         .    g.19476
 GTGATTGCAATAGAACGCACAGGAGTTCCATTTTTACAG | GTAATACCCTGCTTTCAGCGT    c.900
 V  I  A  I  E  R  T  G  V  P  F  L  Q   | V  I  P  C  F  Q  R      p.300

          .         .         .         .         .         .       g.19536
 GATGGTTTATTTTGTCTACATGAAAATGGTTGTATAACTTTACGTGTTCGAAGATCTTAT       c.960
 D  G  L  F  C  L  H  E  N  G  C  I  T  L  R  V  R  R  S  Y         p.320

          .         .         .     | 08   .         .         .    g.20420
 AATAACATTTTTACCACTTCAAATGAGGAACCAG | ATCCAGATCCAGTTCAGGAGCTTACC    c.1020
 N  N  I  F  T  T  S  N  E  E  P  D |   P  D  P  V  Q  E  L  T      p.340

          .         .         .         .         .         .       g.20480
 TATGATTTACGAAGCCAGTGTGATGCAATCAGGGTGACAAAAACCGTCCGTCCCTTCAGT       c.1080
 Y  D  L  R  S  Q  C  D  A  I  R  V  T  K  T  V  R  P  F  S         p.360

          .         .         .         .         .         .       g.20540
 ATGGTGTGCTGTCCTGTCAATGAGAATGCAGCCGCCCTCGTAGTGAGTGATGGCAGGGTC       c.1140
 M  V  C  C  P  V  N  E  N  A  A  A  L  V  V  S  D  G  R  V         p.380

          .         .         .         .         . | 09       .    g.20901
 ATGATATGGGAACTCAAGTCTGCAGTTTGTAATCGAAATTCACGGAACAG | TAGTTCTGGT    c.1200
 M  I  W  E  L  K  S  A  V  C  N  R  N  S  R  N  S  |  S  S  G      p.400

          .         .         .         .         .         .       g.20961
 GTGTCACCTTTATATTCACCAGTGTCTTTCTGTGGAATTCCTGTAGGAGTGCTACAGAAT       c.1260
 V  S  P  L  Y  S  P  V  S  F  C  G  I  P  V  G  V  L  Q  N         p.420

          .         .         .     | 10   .         .         .    g.25021
 AAACTCCCAGACCTTTCCTTAGATAACATGATTG | GGCAAAGTGCAATTGCTGGGGAAGAA    c.1320
 K  L  P  D  L  S  L  D  N  M  I  G |   Q  S  A  I  A  G  E  E      p.440

          .         .         .         .         .         .       g.25081
 CATCCCAGAGGTTCAATTCTGCGGGAAGTGCACCTCAAGTTCCTGCTGACGGGACTGCTT       c.1380
 H  P  R  G  S  I  L  R  E  V  H  L  K  F  L  L  T  G  L  L         p.460

          .         .         .         .         .         .       g.25141
 TCAGGACTGCCCGCACCACAGTTTGCTATTCGTATGTGTCCACCGTTGACCACAAAAAAC       c.1440
 S  G  L  P  A  P  Q  F  A  I  R  M  C  P  P  L  T  T  K  N         p.480

          .         .         .  | 11      .         .         .    g.27693
 ATCAAGATGTATCAGCCACTGCTGGCTGTTG | GTACAAGTAATGGTTCTGTCCTGGTGTAC    c.1500
 I  K  M  Y  Q  P  L  L  A  V  G |   T  S  N  G  S  V  L  V  Y      p.500

          .         .         .         .         .       | 12 .    g.32182
 CATCTCACCAGTGGTCTGCTACACAAAGAGTTAAGCATCCACTCATGTGAAGTCAA | GGGT    c.1560
 H  L  T  S  G  L  L  H  K  E  L  S  I  H  S  C  E  V  K  |  G      p.520

          .         .         .         .         .         .       g.32242
 ATTGAATGGACAAGTTTGACTAGTTTTCTTTCTTTTGCTACCTCAACACCAAACAATATG       c.1620
 I  E  W  T  S  L  T  S  F  L  S  F  A  T  S  T  P  N  N  M         p.540

          .         .         .         .    | 13    .         .    g.34668
 GGATTAGTGAGAAATGAACTTCAACTGGTTGATCTTCCAACAG | GTAGGAGCATTGCTTTT    c.1680
 G  L  V  R  N  E  L  Q  L  V  D  L  P  T  G |   R  S  I  A  F      p.560

          .         .         .         .         .          | 14    g.37606
 CGTGGTGAAAGAGGCAATGATGAATCTGCCATCGAAATGATTAAAGTATCTCATTTGAA | G    c.1740
 R  G  E  R  G  N  D  E  S  A  I  E  M  I  K  V  S  H  L  K  |      p.580

          .         .         .         .         .         .       g.37666
 CAGTATTTGGCAGTCGTATTCAGAGATAAACCCCTGGAGCTATGGGATGTTAGGACTTGT       c.1800
 Q  Y  L  A  V  V  F  R  D  K  P  L  E  L  W  D  V  R  T  C         p.600

          .         .         .         .         | 15         .    g.39651
 ACCCTTCTTAGAGAGATGTCCAAAAACTTCCCTACAATAACTGCTTTG | GAGTGGTCACCA    c.1860
 T  L  L  R  E  M  S  K  N  F  P  T  I  T  A  L   | E  W  S  P      p.620

          .         .         .         .         .         .       g.39711
 TCTCACAACTTGAAGAGCCTGAGAAAGAAGCAACTTGCAACTCGAGAGGCCATGGCCCGC       c.1920
 S  H  N  L  K  S  L  R  K  K  Q  L  A  T  R  E  A  M  A  R         p.640

          .         .         .         .         .    | 16    .    g.40521
 CAGACCGTAGTCTCAGACACAGAGCTGAGTATTGTTGAATCATCTGTGATCAG | CTTGCTG    c.1980
 Q  T  V  V  S  D  T  E  L  S  I  V  E  S  S  V  I  S  |  L  L      p.660

          .         .         .         .         .         .       g.40581
 CAGGAGGCAGAAAGTAAATCTGAACTTAGTCAGAACATCTCTGCCCGGGAACATTTTGTA       c.2040
 Q  E  A  E  S  K  S  E  L  S  Q  N  I  S  A  R  E  H  F  V         p.680

          .         .         .         .         .         .       g.40641
 TTTACCGATATTGATGGCCAAGTGTATCATCTCACTGTTGAAGGAAACTCAGTAAAAGAC       c.2100
 F  T  D  I  D  G  Q  V  Y  H  L  T  V  E  G  N  S  V  K  D         p.700

          .         .  | 17      .         .         .         .    g.42942
 AGTGCTCGGATTCCACCAGAT | GGAAGTATGGGTAGTATTACCTGCATCGCTTGGAAAGGT    c.2160
 S  A  R  I  P  P  D   | G  S  M  G  S  I  T  C  I  A  W  K  G      p.720

          .         .         .         .         .         .       g.43002
 GATACATTAGTGCTTGGAGATATGGATGGAAATTTAAATTTCTGGGACTTGAAAGGCAGA       c.2220
 D  T  L  V  L  G  D  M  D  G  N  L  N  F  W  D  L  K  G  R         p.740

          | 18         .         .         .         .         .    g.43772
 GTATCCAG | AGGAATACCCACACACCGAAGTTGGGTGAGGAAGATTCGTTTTGCTCCTGGT    c.2280
 V  S  R  |  G  I  P  T  H  R  S  W  V  R  K  I  R  F  A  P  G      p.760

          .         .         .         .         .         .       g.43832
 AAAGGAAATCAAAAATTAATAGCAATGTACAATGATGGAGCTGAAGTGTGGGATACTAAA       c.2340
 K  G  N  Q  K  L  I  A  M  Y  N  D  G  A  E  V  W  D  T  K         p.780

     | 19    .         .         .         .         .         .    g.44598
 GAG | GTTCAGATGGTGAGCAGTTTAAGAAGTGGCAGAAATGTGACCTTTCGTATATTGGAT    c.2400
 E   | V  Q  M  V  S  S  L  R  S  G  R  N  V  T  F  R  I  L  D      p.800

          .         .         .         .         .         .       g.44658
 GTGGACTGGTGTACGTCAGATAAAGTGATCTTGGCCTCAGATGATGGGTGCATCAGAGTC       c.2460
 V  D  W  C  T  S  D  K  V  I  L  A  S  D  D  G  C  I  R  V         p.820

          .         .         .         .         .      | 20  .    g.53859
 CTAGAGATGTCTATGAAGTCTGCGTGCTTTAGAATGGATGAACAAGAGTTAACCG | AGCCT    c.2520
 L  E  M  S  M  K  S  A  C  F  R  M  D  E  Q  E  L  T  E |   P      p.840

          .         .         .         .         .         .       g.53919
 GTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTA       c.2580
 V  W  C  P  Y  L  L  V  P  R  A  S  L  A  L  K  A  F  L  L         p.860

          .         .         .         .     | 21   .         .    g.54877
 CACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGT | TGACTATCCAGAAAAT    c.2640
 H  Q  P  W  N  G  Q  Y  S  L  D  I  S  H  V  |  D  Y  P  E  N      p.880

          .         .         .         .        | 22.         .    g.56095
 GAAGAAATAAAGAATCTCCTCCAAGAACAGTTGAATTCATTGTCTAA | TGACATAAAGAAA    c.2700
 E  E  I  K  N  L  L  Q  E  Q  L  N  S  L  S  N  |  D  I  K  K      p.900

          .         .         .         .         .    | 23    .    g.56887
 CTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAG | GCTCTAT    c.2760
 L  L  L  D  P  E  F  T  L  L  Q  R  C  L  L  V  S  R  |  L  Y      p.920

          .         .         .         .         .         .       g.56947
 GGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCC       c.2820
 G  D  E  S  E  L  H  F  W  T  V  A  A  H  Y  L  H  S  L  S         p.940

          .         .         .         .         .         .       g.57007
 CAGGAAAAGTCAGCCAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGC       c.2880
 Q  E  K  S  A  S  T  T  A  P  K  E  A  A  P  R  D  K  L  S         p.960

          .         .         .         .         .  | 24      .    g.57881
 AACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAG | AAATTTCAG    c.2940
 N  P  L  D  I  C  Y  D  V  L  C  E  N  A  Y  F  Q   | K  F  Q      p.980

          .         .         .         .         .         .       g.57941
 CTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGT       c.3000
 L  E  R  V  N  L  Q  E  V  K  R  S  T  Y  D  H  T  R  K  C         p.1000

          .         .        | 25.         .         .         .    g.58504
 ACAGACCAGCTACTGCTCTTGGGTCAA | ACAGACAGAGCTGTGCAGTTGCTGTTGGAAACA    c.3060
 T  D  Q  L  L  L  L  G  Q   | T  D  R  A  V  Q  L  L  L  E  T      p.1020

          .         .         .         .         .         .       g.58564
 AGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTC       c.3120
 S  A  D  N  Q  H  Y  Y  C  D  S  L  K  A  C  L  V  T  T  V         p.1040

          .         .         .         .         .         .       g.58624
 ACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAAT       c.3180
 T  S  S  G  P  S  Q  S  T  I  K  L  V  A  T  N  M  I  A  N         p.1060

          .    | 26    .         .         .         .         .    g.59191
 GGCAAATTGGCAG | AGGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGC    c.3240
 G  K  L  A  E |   G  V  Q  L  L  C  L  I  D  K  A  A  D  A  C      p.1080

          .         .         .         .         .  | 27      .    g.59710
 CGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAA | GTCCGTTTG    c.3300
 R  Y  L  Q  T  Y  G  E  W  N  R  A  A  W  L  A  K   | V  R  L      p.1100

          .         .         .         .         .         .       g.59770
 AATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAA       c.3360
 N  P  E  E  C  A  D  V  L  R  R  W  V  D  H  L  C  S  P  Q         p.1120

          .         .         .         .         .         .       g.59830
 GTCAATCAGAAATCAAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTG       c.3420
 V  N  Q  K  S  K  A  L  L  V  L  L  S  L  G  C  F  F  S  V         p.1140

          .        | 28.         .         .         .         .    g.60644
 GCAGAGACGCTTCACAG | CATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGC    c.3480
 A  E  T  L  H  S  |  M  R  Y  F  D  R  A  A  L  F  V  E  A  C      p.1160

          .         .         .        | 29.         .         .    g.62404
 CTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAG | AGAAACTCATCACTGCTATATAT    c.3540
 L  K  Y  G  A  F  E  V  T  E  D  T  E |   K  L  I  T  A  I  Y      p.1180

          .         .         .         .         .         .       g.62464
 GCAGATTATGCCCGGAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCT       c.3600
 A  D  Y  A  R  S  L  K  N  L  G  F  K  Q  G  A  V  L  F  A         p.1200

          .         .         .         .         .         .       g.62524
 TCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGAGTCCCCCAAGGAAGAA       c.3660
 S  K  A  G  A  A  G  K  D  L  L  N  E  L  E  S  P  K  E  E         p.1220

          .                                                         g.62539
 CCCATTGAAGAGTGA                                                    c.3675
 P  I  E  E  X                                                      p.1224

          .         .         .         .         .         .       g.62599
 cagcttaataaatgccagggaatctgacctggaaggcagatgggagggggctggtctggc       c.*60

          .         .         .         .         .         .       g.62659
 tgtggccaccgtcacagtccaggatgaagaggagtacagggtcctgtgagctgtttgacc       c.*120

          .         .         .         .         .         .       g.62719
 actgttctaagactatgtgtgcccaaaagcacataagcatctatgttgagagtaagtttg       c.*180

          .         .         .         .         .         .       g.62779
 tatcctgcgttggtctcagaaagaacgtgaatgcttaagattttgaaagtacataatatt       c.*240

          .         .         .         .         .         .       g.62839
 ttatactttgggagagagctttaagagtccctggaaatactttttaatttttttaactta       c.*300

          .         .         .         .         .         .       g.62899
 aaattcaagagactgaatcacttttctcattgattaaatgtaaagattattgagaaacct       c.*360

          .         .         .         .         .         .       g.62959
 atagtaaatgaaatttgtgagatgttttctcaaatatatgctgtgcctgtacttatatac       c.*420

          .         .         .         .         .         .       g.63019
 agtctttcaagagagatacaaacaaggcagaaacatttaaactagtattaaaggtagttt       c.*480

          .         .         .         .         .         .       g.63079
 accaaagcattttttgttttcttaccttgaaaacacagaaccgttaattccttggtttaa       c.*540

          .         .         .         .         .         .       g.63139
 gcagttgctaagttttgtaattttaggctcagaggaccataggaggttttaagatttatg       c.*600

          .         .         .         .         .         .       g.63199
 tttagtccgataggtgaggtctttgatattttgaattttaactccttttatgatacatca       c.*660

          .         .         .         .         .         .       g.63259
 cagtaacctcatttttgaagtctttctttgtactttaatgttctctctgttctaatagtt       c.*720

          .         .         .         .         .         .       g.63319
 gaagtatgagatgtaactattataaactgttgctgaaaacataaatgtctgtaacttaca       c.*780

          .         .         .                                     g.63352
 aacatgataaataaattaaaaattccatccagg                                  c.*813

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The WD repeat domain 11 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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