WD repeat domain 26 (WDR26) - coding DNA reference sequence

(used for variant description)

(last modified March 9, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_025160.6 in the WDR26 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_047198.1, covering WDR26 transcript NM_025160.6.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               cggagggagtagga       c.-181

 .         .         .         .         .         .                g.5074
 gagcccggggcttcggcaggcagagcaggcctctcccctccgtcctcgtcgtcctcgtcc       c.-121

 .         .         .         .         .         .                g.5134
 tcctcctcctcctcctcctccgtggtggtagtggtgggacttcccccggctgctgcccct       c.-61

 .         .         .         .         .         .                g.5194
 cccgccgccgctgctgtcccccaccgaagtagcggccacagcctggtcagcggcagcatc       c.-1

          .         .         .         .         .         .       g.5254
 ATGCAGGCCAATGGGGCAGGAGGAGGAGGAGGAGGTGGCGGCGGCGGCGGTGGAGGAGGA       c.60
 M  Q  A  N  G  A  G  G  G  G  G  G  G  G  G  G  G  G  G  G         p.20

          .         .         .         .         .         .       g.5314
 GGGGGCGGCGGGGGCCAGGGACAGACCCCGGAACTCGCCTGCTTGTCGGCCCAGAACGGG       c.120
 G  G  G  G  G  Q  G  Q  T  P  E  L  A  C  L  S  A  Q  N  G         p.40

          .         .         .         .         .         .       g.5374
 GAGTCGTCCCCCTCGTCGTCGTCGTCCGCGGGGGACCTGGCCCACGCCAATGGGCTCCTG       c.180
 E  S  S  P  S  S  S  S  S  A  G  D  L  A  H  A  N  G  L  L         p.60

          .         .         .         .         .         .       g.5434
 CCTTCCGCCCCCTCCGCCGCCAGCAACAATAGCAACAGCCTGAATGTCAATAACGGGGTT       c.240
 P  S  A  P  S  A  A  S  N  N  S  N  S  L  N  V  N  N  G  V         p.80

          .         .         .         .         .         .       g.5494
 CCCGGCGGGGCGGCCGCCGCATCCTCAGCCACCGTCGCAGCTGCCTCCGCCACCACCGCC       c.300
 P  G  G  A  A  A  A  S  S  A  T  V  A  A  A  S  A  T  T  A         p.100

          .         .         .         .         .         .       g.5554
 GCCTCCTCTTCCTTGGCCACCCCAGAACTGGGCAGCAGCCTCAAGAAGAAGAAGCGGCTC       c.360
 A  S  S  S  L  A  T  P  E  L  G  S  S  L  K  K  K  K  R  L         p.120

          .         .         .         .         .         .       g.5614
 TCCCAGTCAGATGAGGATGTCATTAGGCTAATAGGACAGCACTTGAATGGCTTAGGGCTC       c.420
 S  Q  S  D  E  D  V  I  R  L  I  G  Q  H  L  N  G  L  G  L         p.140

    | 02     .         .         .         .         .         .    g.7576
 AA | CCAGACTGTTGATCTCCTCATGCAAGAGTCAGGATGTCGTTTAGAACATCCTTCTGCT    c.480
 N  |  Q  T  V  D  L  L  M  Q  E  S  G  C  R  L  E  H  P  S  A      p.160

          .         .         .         .   | 03     .         .    g.7736
 ACCAAATTCCGAAATCATGTCATGGAAGGAGACTGGGATAAG | GCAGAAAATGACCTGAAT    c.540
 T  K  F  R  N  H  V  M  E  G  D  W  D  K   | A  E  N  D  L  N      p.180

          .         .         .         .         .         .       g.7796
 GAACTAAAGCCTTTAGTGCATTCTCCTCATGCTATTGTGGTAAGAGGCGCACTTGAAATC       c.600
 E  L  K  P  L  V  H  S  P  H  A  I  V  V  R  G  A  L  E  I         p.200

          .         .        | 04.         .         .         .    g.14678
 TCTCAAACGTTGTTGGGAATAATTGTG | AGGATGAAGTTTTTGCTGCTGCAGCAGAAGTAC    c.660
 S  Q  T  L  L  G  I  I  V   | R  M  K  F  L  L  L  Q  Q  K  Y      p.220

          .         .         .         .         .         .       g.14738
 CTAGAATACCTGGAGGATGGCAAGGTCCTGGAGGCACTTCAAGTTCTACGCTGTGAATTG       c.720
 L  E  Y  L  E  D  G  K  V  L  E  A  L  Q  V  L  R  C  E  L         p.240

          .         .         .         .     | 05   .         .    g.19700
 ACGCCGCTGAAATACAATACAGAGCGCATTCATGTTCTTAGTGG | GTATCTGATGTGTAGC    c.780
 T  P  L  K  Y  N  T  E  R  I  H  V  L  S  G  |  Y  L  M  C  S      p.260

          .         .         .         .         .         .       g.19760
 CATGCAGAAGACCTACGTGCAAAAGCAGAATGGGAAGGCAAAGGGACAGCTTCCCGATCT       c.840
 H  A  E  D  L  R  A  K  A  E  W  E  G  K  G  T  A  S  R  S         p.280

          .         .   | 06     .         .         .         .    g.20921
 AAACTATTGGATAAACTTCAGA | CCTATTTACCACCATCAGTGATGCTTCCCCCACGGCGT    c.900
 K  L  L  D  K  L  Q  T |   Y  L  P  P  S  V  M  L  P  P  R  R      p.300

          .         .         .         .         .         .       g.20981
 TTACAGACTCTCCTGCGGCAGGCGGTGGAACTACAAAGGGATCGGTGCCTATATCACAAT       c.960
 L  Q  T  L  L  R  Q  A  V  E  L  Q  R  D  R  C  L  Y  H  N         p.320

          .         .         .         .         .          | 07    g.27735
 ACCAAACTTGATAATAATCTAGATTCTGTGTCTCTGCTTATAGACCATGTTTGTAGTAG | G    c.1020
 T  K  L  D  N  N  L  D  S  V  S  L  L  I  D  H  V  C  S  R  |      p.340

          .         .         .         .         .         .       g.27795
 AGGCAGTTCCCATGTTATACGCAGCAGATACTTACGGAGCATTGTAATGAAGTGTGGTTC       c.1080
 R  Q  F  P  C  Y  T  Q  Q  I  L  T  E  H  C  N  E  V  W  F         p.360

          .         .         .         .         .         .       g.27855
 TGTAAATTCTCTAATGATGGCACTAAACTAGCAACAGGATCAAAAGATACAACAGTTATC       c.1140
 C  K  F  S  N  D  G  T  K  L  A  T  G  S  K  D  T  T  V  I         p.380

          .         | 08         .         .         .         .    g.34771
 ATATGGCAAGTTGATCCG | GATACACACCTGCTAAAACTGCTTAAAACATTAGAAGGACAT    c.1200
 I  W  Q  V  D  P   | D  T  H  L  L  K  L  L  K  T  L  E  G  H      p.400

          .         .         .         .         .         .       g.34831
 GCTTATGGCGTTTCTTATATTGCATGGAGTCCAGATGACAACTATCTTGTTGCTTGTGGC       c.1260
 A  Y  G  V  S  Y  I  A  W  S  P  D  D  N  Y  L  V  A  C  G         p.420

          .         .         .          | 09        .         .    g.38251
 CCAGATGACTGCTCTGAGCTTTGGCTTTGGAATGTACAA | ACAGGAGAACTAAGGACAAAA    c.1320
 P  D  D  C  S  E  L  W  L  W  N  V  Q   | T  G  E  L  R  T  K      p.440

          .         .         .         .         .         .       g.38311
 ATGAGCCAGTCTCATGAAGACAGTTTGACAAGTGTGGCTTGGAATCCAGATGGGAAGCGC       c.1380
 M  S  Q  S  H  E  D  S  L  T  S  V  A  W  N  P  D  G  K  R         p.460

          .         .         .          | 10        .         .    g.40286
 TTTGTGACTGGAGGTCAGCGTGGGCAGTTCTATCAGTGT | GACTTAGATGGTAATCTCCTT    c.1440
 F  V  T  G  G  Q  R  G  Q  F  Y  Q  C   | D  L  D  G  N  L  L      p.480

          .         .         .         .         .         .       g.40346
 GACTCCTGGGAAGGGGTAAGAGTGCAATGCCTTTGGTGCTTGAGTGATGGAAAGACTGTT       c.1500
 D  S  W  E  G  V  R  V  Q  C  L  W  C  L  S  D  G  K  T  V         p.500

          .         .         .         .         .         .       g.40406
 CTGGCATCAGATACACACCAGCGAATTCGGGGCTATAACTTCGAGGACCTTACAGATAGG       c.1560
 L  A  S  D  T  H  Q  R  I  R  G  Y  N  F  E  D  L  T  D  R         p.520

       | 11  .         .         .         .         .         .    g.40761
 AACAT | AGTACAAGAAGATCATCCTATTATGTCTTTTACTATTTCAAAAAATGGCCGATTA    c.1620
 N  I  |  V  Q  E  D  H  P  I  M  S  F  T  I  S  K  N  G  R  L      p.540

          .         .     | 12   .         .         .         .    g.41109
 GCTTTGTTAAATGTAGCAACTCAG | GGAGTTCATTTATGGGACTTGCAAGACAGAGTTTTA    c.1680
 A  L  L  N  V  A  T  Q   | G  V  H  L  W  D  L  Q  D  R  V  L      p.560

          .         .         .         .         .         .       g.41169
 GTAAGAAAGTATCAAGGTGTTACACAAGGGTTTTATACAATTCATTCATGTTTTGGAGGC       c.1740
 V  R  K  Y  Q  G  V  T  Q  G  F  Y  T  I  H  S  C  F  G  G         p.580

          .         .         .     | 13   .         .         .    g.45312
 CATAATGAAGACTTCATCGCTAGTGGCAGTGAAG | ATCACAAGGTTTACATCTGGCACAAA    c.1800
 H  N  E  D  F  I  A  S  G  S  E  D |   H  K  V  Y  I  W  H  K      p.600

          .         .         .         .         .         .       g.45372
 CGTAGTGAACTGCCAATTGCGGAGCTGACAGGGCACACACGTACAGTAAACTGTGTGAGC       c.1860
 R  S  E  L  P  I  A  E  L  T  G  H  T  R  T  V  N  C  V  S         p.620

          .         .         .         .         .         .       g.45432
 TGGAACCCACAGATTCCATCCATGATGGCCAGCGCCTCAGATGATGGCACTGTTAGAATA       c.1920
 W  N  P  Q  I  P  S  M  M  A  S  A  S  D  D  G  T  V  R  I         p.640

          .         .         .         . | 14       .         .    g.49459
 TGGGGACCAGCACCTTTTATAGACCACCAGAATATTGAAG | AGGAATGCAGTAGCATGGAT    c.1980
 W  G  P  A  P  F  I  D  H  Q  N  I  E  E |   E  C  S  S  M  D      p.660

                                                                    g.49465
 AGTTGA                                                             c.1986
 S  X                                                               p.661

          .         .         .         .         .         .       g.49525
 tggtgaatttggagcagacgacttctgtttaacttaaaattagtcgtattttaatggctt       c.*60

          .         .         .         .         .         .       g.49585
 gggatttggtgcaaacaaacatgattgatagctggacagacatgctcgtcatgaaaaaag       c.*120

          .         .         .         .         .         .       g.49645
 aaccatttctgaagcccgattggggccaaacatttacaccttgcttcatagtaaccagtt       c.*180

          .         .         .         .         .         .       g.49705
 gagatgaagcacgtcgttagaacgttgttggacaccatgttgaattattcccccatcggt       c.*240

          .         .         .         .         .         .       g.49765
 tgtgaagaactgtgctacattcaggcttacccattgaactcagtatatatatttttttcc       c.*300

          .         .         .         .         .         .       g.49825
 ttcctgtcttttgtctggcaggataccattcttgttgctcttctgtgtaatgaagtttaa       c.*360

          .         .         .         .         .         .       g.49885
 atgcttgtttggaaaactttatttaacagtttagaaggcttgatagaaagagtgcattag       c.*420

          .         .         .         .         .         .       g.49945
 tctgaagagtatacattggataggaaagaatttccttcttttgtttctccaaatctttcc       c.*480

          .         .         .         .         .         .       g.50005
 gccttatttagcttgagatctttgcagcttggttcatggattctagccttgcccgttgcg       c.*540

          .         .         .         .         .         .       g.50065
 cagtatatactgatccagatgataaaccagtgaactatgtcaaaagcactctcaatatta       c.*600

          .         .         .         .         .         .       g.50125
 catttgacaaaaagttttgtacttttcacatagcttgttgccccgtaaaagggttaacag       c.*660

          .         .         .         .         .         .       g.50185
 cacaattttttaaaaataaattaagaagtatttataggattaaagtgacttcatttgtat       c.*720

          .         .         .         .         .         .       g.50245
 acatttggaatctaaaccagcttaaaaacagtttcctcaatgacttagatacacagtata       c.*780

          .         .         .         .         .         .       g.50305
 actgatgctcttctggaataccacatgagacatggtcagaaacagtgcttggaaggacat       c.*840

          .         .         .         .         .         .       g.50365
 tacacaagaaattcagagtaatgctttgaagatttccccccttttgttttattcctgaag       c.*900

          .         .         .         .         .         .       g.50425
 gaacatcagtacccgatcttgaagaaattcaagattcaaaaagaattttaaatacaccaa       c.*960

          .         .         .         .         .         .       g.50485
 catgagacatcagtagtcagttggttttcagtaaagcttgttccaagttgttctcaactt       c.*1020

          .         .         .         .         .         .       g.50545
 aggaagtaattttggtgtgatctagcaaaagagtaggaatcagcgatacaaccactttgg       c.*1080

          .         .         .         .         .         .       g.50605
 aagtttatagtataattgaaattattagaagaattcagcaggttacagacatacttaaac       c.*1140

          .         .         .         .         .         .       g.50665
 tgggattaaaacctcatagtcatttttcttaattgcccttaatattttgacatataggga       c.*1200

          .         .         .         .         .         .       g.50725
 tacataaatttaaagaatattttttctcagttttttcagatattgccatactgaacctca       c.*1260

          .         .         .         .         .         .       g.50785
 ttctaaactggtgctgtggatagtctttccctctcccctcctgttttagtttaaggaaag       c.*1320

          .         .         .         .         .         .       g.50845
 gtttccttcatggaaaagcacttttaattttgagaatttcacatttaaaataagccaaaa       c.*1380

          .         .         .         .         .         .       g.50905
 gcctgatgttcacattgtgcttttaaactccgtaacagctgaatacaacataacatagtc       c.*1440

          .         .         .         .         .         .       g.50965
 tcccttgaaattccctccctttttcagtagaggataaatagggtgactccagctgttgga       c.*1500

          .         .         .         .         .         .       g.51025
 atgagaatggggatacccccaaaataagattctggtgaagaaaaagtcttgtactaagtt       c.*1560

          .         .         .         .         .         .       g.51085
 cccctttaggtgtagccaagtctataatataattatgatcatgaatagactccagaatcc       c.*1620

          .         .         .         .         .         .       g.51145
 acaaagagaagagggcttggatgtcaaaaattcttccattgtggggtaggtggtcgggga       c.*1680

          .         .         .         .         .         .       g.51205
 tgggagaaagggaaaagtcagggaaggggagaagaaagaaaaacacatttggccttaaaa       c.*1740

          .         .         .         .         .         .       g.51265
 tagcatgcattctcccagaagcccatagtaaagaaaatgacagatcgtggtcagcagact       c.*1800

          .         .         .         .         .         .       g.51325
 cttatcaaattggtatgtaaaagatttcttcaagctccattttgcagagaccaccactta       c.*1860

          .         .         .         .         .         .       g.51385
 gagaatcaaaaaattcctgttttgatacttctaagttaaaatatatgttacagtttatct       c.*1920

          .         .         .         .         .         .       g.51445
 ggtacttcatttttcttaactaaaattactttttactttaagcttgaataaaaatcttca       c.*1980

          .         .         .         .         .         .       g.51505
 ttggtaactgtatgtaattaagtggcaacttctctttacctcagtatagttaaaaaccat       c.*2040

          .         .         .         .         .         .       g.51565
 tcatattttaagtgattcatgtataccctgaagccgttaatacaccccagtctctatggt       c.*2100

          .         .         .         .         .         .       g.51625
 aacatcactaaatgtgggcatagaaactccacagctgtttacaaatttggttacagtgtg       c.*2160

          .         .         .         .         .         .       g.51685
 ctacggtgcatttgtaacactcagatttgtgcccattcaggggcaatttggcactcagat       c.*2220

          .         .         .         .         .         .       g.51745
 tctactctacttcacctaaccacccctagatctgagttttcagagtgcttctgaagtaca       c.*2280

          .         .         .         .         .         .       g.51805
 gtttaaaaacactttttaaaaagtggagtaaaagtgaggcacattttacaagaacataac       c.*2340

          .         .         .         .         .         .       g.51865
 tcctattaaaacggagtaacaactatgcaaaggtttctatagcagctaggtgagtttgtt       c.*2400

          .         .         .         .         .         .       g.51925
 ttccgggtctgtcttaactggcagcttcctgtacatactggtacttatttgctgtaaacg       c.*2460

          .         .         .         .         .         .       g.51985
 tctgtttcatacatttgccatgcagtgactgtgctcgaaaggtgaaatcaatggtaaaga       c.*2520

          .         .         .         .         .         .       g.52045
 agcctaggattttatggtatgagaaactgatcgcaggattttctgatccatagctattaa       c.*2580

          .         .         .         .         .         .       g.52105
 ttgaaaacttctgatagtgctgtaggctctatagtaggcttaagagtgagtcttatacta       c.*2640

          .         .         .         .         .         .       g.52165
 tgaagccagccacaagatactaacaaatgtataaattgaaaagtaccaatactttttgca       c.*2700

          .         .         .         .         .         .       g.52225
 catagatcaaaatagagtggagaatttgggctccaaaaatcaggttagtaggctcatttc       c.*2760

          .         .         .         .         .         .       g.52285
 catgtgcttaaaaatgtttttgttgttatgcattgattaagggctagagcaaatataaaa       c.*2820

          .         .         .         .         .         .       g.52345
 ttaaatgtctttttcctccaaataattggttattaatggtaaaatgttggacttggggat       c.*2880

          .         .         .         .         .         .       g.52405
 tactgagattagtatgtgggtagtaaagaattggagtgggagttagtggggagggatgac       c.*2940

          .         .         .         .         .         .       g.52465
 aaagcttcagctttggtttttgtatttttttagtcttcataacagctacatttctgttgc       c.*3000

          .         .         .         .         .         .       g.52525
 tcttattggccagataaatgtgttatattaaaccaggtaagtattttaaacagagaacat       c.*3060

          .         .         .         .         .         .       g.52585
 tttatttgcatatatccctacaaattggcccattttattgggtggggggataaaaaaggg       c.*3120

          .         .         .         .         .         .       g.52645
 attccctaactttaaataatcagaatatcctgcaattgaaaggagaaaaaaatccaattt       c.*3180

          .         .         .         .         .         .       g.52705
 tgtcagtattttcttagtctgaaaaaaacagcagtagtaatctggtgaatgttattatta       c.*3240

          .         .         .         .         .         .       g.52765
 ggagtgttctgcctctacagtggcatattccatgacattaatagaaaacccttctttccc       c.*3300

          .         .         .         .         .         .       g.52825
 acccctccccatcttgacattttcttttttaggatgttggttcctgcaaacaagaactga       c.*3360

          .         .         .         .         .         .       g.52885
 ccctatcacctctgcctcacagtgggtaaatatatcatacatctcttgaaagggaaaata       c.*3420

          .         .         .         .         .         .       g.52945
 tccatgtcagtttctttcacagtagaagaatggctgcttttgaatggggaggaaagaaga       c.*3480

          .         .         .         .         .         .       g.53005
 catttttcttaatatcctttttgtcccatctctaaaatgtataaatattttgatttggtt       c.*3540

          .         .         .         .         .         .       g.53065
 ttactttaatttctcattcataatttcgcaactgtccttttgggttgccctccaacacat       c.*3600

          .         .         .         .         .         .       g.53125
 tacttccatttcagaaaccatatctgatttaatataaactgctaacttaagaagaggtga       c.*3660

          .         .         .         .         .         .       g.53185
 atttgcatttacacttagacactttctaaaaacagggtgaacttaattgaaatttttcag       c.*3720

          .         .         .         .         .         .       g.53245
 tgttgttaagctattgttatagtagctgccctatagttacaaaaataaaaactataaaaa       c.*3780

          .         .         .         .         .         .       g.53305
 cccatcccctatctacttaatccagatagcctggatttaacaaaaccaatagtataaaaa       c.*3840

          .         .         .         .         .         .       g.53365
 tgtgtgtgtgtgttctgtgtgtgtgtgagagagagagtacttgattcattaaaaagtcct       c.*3900

          .         .         .         .         .         .       g.53425
 ggaaacagctgttctaggatcttgtcatttttactgaaagtctcgtgcacatgtgaagtg       c.*3960

          .         .         .         .         .         .       g.53485
 ccctctgagtttaaggtttggttaatactggtatatttttataagattgaaattgtgtcc       c.*4020

          .         .         .         .         .         .       g.53545
 ccatctttaacttaaacattttcattatcagggtcaatgtgctagaactgaattgtaaca       c.*4080

          .         .         .         .         .         .       g.53605
 tttttaggcacagatggaaaaaaatgttattggctccttgaaaatgtgtgtgtgtggcga       c.*4140

          .         .         .         .         .         .       g.53665
 ggggaatagatccacaaaagcatgtatgtacttacaaaccaagctgtagagatcaagaaa       c.*4200

          .         .         .         .         .         .       g.53725
 agaacttaagtgttgatctcaagatttctaaattgtcaagatttacatggcattgtggtg       c.*4260

          .         .         .         .         .         .       g.53785
 gaactagttaacacttagagcttttggtatgtaataactatttgctatggactgattaaa       c.*4320

          .         .         .         .         .         .       g.53845
 tgtttcaaaagattgtgttcttcaattttggtgggttttgatttttgtttttttaactgc       c.*4380

          .         .         .         .         .         .       g.53905
 ctctcagattatatttacttagtttaaatttctttgctttattcattaaagtataaaaac       c.*4440

          .         .         .         .         .         .       g.53965
 ttcaggtctctgatatttattttcacttgtttactaattatttacaaaacaccctttgtt       c.*4500

          .         .         .         .         .         .       g.54025
 gacttttattttataaatgtgtaatgtattaaacgtctttaaatttttgttcaactgaaa       c.*4560

          .         .         .         .         .         .       g.54085
 ctacattaactttgatttgctttactgggatttttttttaaagacactttttccatgtca       c.*4620

          .         .         .         .         .         .       g.54145
 gtgcgcagcacttaaccagtcgtttgtattccctttctttcaatccaataaacagaatga       c.*4680

          .                                                         g.54157
 atacctaaataa                                                       c.*4692

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The WD repeat domain 26 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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