WD repeat domain 60 (WDR60) - coding DNA reference sequence

(used for variant description)

(last modified January 22, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_018051.4 in the WDR60 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering WDR60 transcript NM_018051.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       ctgggcagtgcttctgggccctctgctgctcctgcttg       c.-121

 .         .         .         .         .         .                g.5098
 tcggttgctaggcgctgggacgcgcctcccgaagggtgcggggcacaggtggcctcttcg       c.-61

 .         .         .         .         .         .                g.5158
 gggtggaccgcgcctggccggggccgaggacaccgcggccgcccgggcctgcgggaagcg       c.-1

          .      | 02  .         .         .         .         .    g.18322
 ATGGAGCCCGGGAAG | AGAAGAACCAAAGATGATACCTGGAAAGCAGATGACCTCAGAAAA    c.60
 M  E  P  G  K   | R  R  T  K  D  D  T  W  K  A  D  D  L  R  K      p.20

           | 03        .         .         .         .         .    g.19615
 CATCTCTGG | GCCATACAGTCAGGTGGTTCCAAGGAAGAAAGAAAGCACAGAGAGAAGAAG    c.120
 H  L  W   | A  I  Q  S  G  G  S  K  E  E  R  K  H  R  E  K  K      p.40

          .         .         .         .         .         .       g.19675
 CTGCGTAAGGAGTCTGAGATGGACCTTCCTGAACATAAGGAGCCGAGGTGCAGGGATCCC       c.180
 L  R  K  E  S  E  M  D  L  P  E  H  K  E  P  R  C  R  D  P         p.60

          .         .         .         .         .         .       g.19735
 GACCAGGATGCCAGGAGCAGAGACAGGGTGGCCGAAGTCCACACCGCTAAGGAGAGTCCT       c.240
 D  Q  D  A  R  S  R  D  R  V  A  E  V  H  T  A  K  E  S  P         p.80

          .         .         .         .         .         .       g.19795
 CGTGGGGAGAGGGACAGAGACAGACAGAGGGAGAGGAGAAGAGACGCAAAAGACCGGGAG       c.300
 R  G  E  R  D  R  D  R  Q  R  E  R  R  R  D  A  K  D  R  E         p.100

          .         .         .         .         .         .       g.19855
 AAAGAAAAGCTGAAGGAGAAACATCGAGAGGCAGAAAAGTCTCACAGCAGAGGAAAGGAC       c.360
 K  E  K  L  K  E  K  H  R  E  A  E  K  S  H  S  R  G  K  D         p.120

          .         .         .         .         .         .       g.19915
 AGGGAAAAAGAAAAAGACAGAAGGGCCCGGAAGGAAGAGCTCCGGCAGACCGTGGCCCAC       c.420
 R  E  K  E  K  D  R  R  A  R  K  E  E  L  R  Q  T  V  A  H         p.140

          .         .         .         .         .         .       g.19975
 CACAACCTGCTGGGCCAGGAGACACGCGACCGGCAGCTCCTGGAGCGGGCGGAGAGGAAA       c.480
 H  N  L  L  G  Q  E  T  R  D  R  Q  L  L  E  R  A  E  R  K         p.160

          . | 04       .         .         .         .         .    g.25081
 GGCCGCTCAG | TAAGTAAAGTAAGAAGTGAAGAGAAAGATGAAGACTCTGAAAGAGGAGAT    c.540
 G  R  S  V |   S  K  V  R  S  E  E  K  D  E  D  S  E  R  G  D      p.180

          .         .         .    | 05    .         .         .    g.28133
 GAAGATAGAGAAAGAAGATACCGAGAAAGAAAG | CTGCAGTACGGAGACAGCAAGGACAAC    c.600
 E  D  R  E  R  R  Y  R  E  R  K   | L  Q  Y  G  D  S  K  D  N      p.200

          .         .         .         .         .         .       g.28193
 CCTCTCAAGTACTGGCTTTATAAAGAAGAAGGCGAGAGGAGACACAGGAAGCCCAGAGAG       c.660
 P  L  K  Y  W  L  Y  K  E  E  G  E  R  R  H  R  K  P  R  E         p.220

          .         .         .         .         .         .       g.28253
 CCAGATCGAGACAACAAACACCGAGAAAAAAGCAGCACAAGGGAAAAAAGAGAGAAATAT       c.720
 P  D  R  D  N  K  H  R  E  K  S  S  T  R  E  K  R  E  K  Y         p.240

          .         .         .         .         .         .       g.28313
 TCCAAAGAGAAAAGTAATTCATTCTCTGACAAAGGGGAAGAAAGACATAAAGAAAAGCGA       c.780
 S  K  E  K  S  N  S  F  S  D  K  G  E  E  R  H  K  E  K  R         p.260

          .         .         .         .         .         .       g.28373
 CACAAAGAAGGTTTTCATTTTGATGATGAGAGGCACCAAAGCAACGTGGATAGAAAAGAG       c.840
 H  K  E  G  F  H  F  D  D  E  R  H  Q  S  N  V  D  R  K  E         p.280

          .         .         .          | 06        .         .    g.33007
 AAATCGGCAAAAGATGAGCCCAGGAAAAGGGAATCCCAG | AATGGTGAACACAGAAATCGA    c.900
 K  S  A  K  D  E  P  R  K  R  E  S  Q   | N  G  E  H  R  N  R      p.300

          .         .         .      | 07  .         .         .    g.35468
 GGTGCAAGCTCAAAAAGAGATGGGACCAGCAGCCA | GCATGCTGAGAATTTAGTAAGGAAT    c.960
 G  A  S  S  K  R  D  G  T  S  S  Q  |  H  A  E  N  L  V  R  N      p.320

          .         .         . | 08       .         .         .    g.39717
 CATGGAAAAGATAAAGATTCAAGACGGAAG | CATGGCCACGAGGAAGGCTCTTCTGTGTGG    c.1020
 H  G  K  D  K  D  S  R  R  K   | H  G  H  E  E  G  S  S  V  W      p.340

          .         .         .          | 09        .         .    g.50182
 TGGAAGCTGGACCAGAGGCCGGGAGGCGAGGAAACCGTG | GAAATTGAAAAGGAAGAAACT    c.1080
 W  K  L  D  Q  R  P  G  G  E  E  T  V   | E  I  E  K  E  E  T      p.360

          .         .         .         .         .        | 10.    g.50801
 GATTTAGAAAATGCTAGAGCTGATGCATATACAGCCAGTTGTGAAGATGATTTTGAA | GAC    c.1140
 D  L  E  N  A  R  A  D  A  Y  T  A  S  C  E  D  D  F  E   | D      p.380

          .         .         .         .         .         .       g.50861
 TATGAAGATGACTTTGAGGTTTGTGATGGTGATGATGATGAAAGCAGTAATGAACCTGAG       c.1200
 Y  E  D  D  F  E  V  C  D  G  D  D  D  E  S  S  N  E  P  E         p.400

          .         .         .         .         .         .       g.50921
 TCAAGAGAAAAACTGGAAGAACTTCCTCTAGCTCAAAAAAAGGAAATACAAGAAATTCAA       c.1260
 S  R  E  K  L  E  E  L  P  L  A  Q  K  K  E  I  Q  E  I  Q         p.420

          .         .         .         .         .         .       g.50981
 AGAGCTATTAATGCAGAAAATGAAAGGATTGGCGAGTTATCTTTGAAACTGTTTCAGAAG       c.1320
 R  A  I  N  A  E  N  E  R  I  G  E  L  S  L  K  L  F  Q  K         p.440

          .         .         .        | 11.         .         .    g.54434
 CGAGGTAGAACAGAATTTGAAAAGGAGCCCAGGACAG | ATACAAACAGTTCCCCTTCCAGA    c.1380
 R  G  R  T  E  F  E  K  E  P  R  T  D |   T  N  S  S  P  S  R      p.460

          .         .         .         .         .         .       g.54494
 GCCTCTGTTTGTGGAATTTTTGTGGATTTTGCCTCAGCTTCACACCGTCAAAAGAGTCGG       c.1440
 A  S  V  C  G  I  F  V  D  F  A  S  A  S  H  R  Q  K  S  R         p.480

          .         . | 12       .         .         .         .    g.60012
 ACTCAGGCCCTTAAGCAAAA | GATGCGAAGTACAAAACTGCTTCGGCTCATTGACTTAGAT    c.1500
 T  Q  A  L  K  Q  K  |  M  R  S  T  K  L  L  R  L  I  D  L  D      p.500

          .         .         .         .         .         .       g.60072
 TTTTCATTTACTTTCTCTCTCTTGGATCTACCACCAGTAAATGAATATGACATGTATATC       c.1560
 F  S  F  T  F  S  L  L  D  L  P  P  V  N  E  Y  D  M  Y  I         p.520

          .         .         . | 13       .         .         .    g.61437
 AGAAACTTTGGGAAAAAAAATACCAAGCAG | GCATATGTTCAGTGTAACGAAGATAATGTT    c.1620
 R  N  F  G  K  K  N  T  K  Q   | A  Y  V  Q  C  N  E  D  N  V      p.540

          .         .         .         .         .         .       g.61497
 GAAAGAGACATTCAAACGGAGGAAATAGAGACCAGGGAAGTGTGGACCCAGCACCCGGGA       c.1680
 E  R  D  I  Q  T  E  E  I  E  T  R  E  V  W  T  Q  H  P  G         p.560

          .         .   | 14     .         .         .         .    g.62693
 GAAAGTACTGTTGTATCTGGAG | GCAGTGAACAAAGAGATACCTCTGATGCTGTAGTTATG    c.1740
 E  S  T  V  V  S  G  G |   S  E  Q  R  D  T  S  D  A  V  V  M      p.580

          .         .         .         .         .  | 15      .    g.67171
 CCAAAGATTGATACTCCAAGGTTATGTAGCTTTCTGCGGGCTGCTTGTCAG | GTGATGGCC    c.1800
 P  K  I  D  T  P  R  L  C  S  F  L  R  A  A  C  Q   | V  M  A      p.600

          .         .         .         .         .         .       g.67231
 GTTTTGCTGGAAGAGGATCGCTTGGCAGCTGAACCCAGCTGGAATCTTAGGGCTCAAGAC       c.1860
 V  L  L  E  E  D  R  L  A  A  E  P  S  W  N  L  R  A  Q  D         p.620

          .         .         .         .         .         .       g.67291
 AGGGCCCTGTATTTTAGTGACAGCTCATCTCAGCTGAACACCAGTCTACCATTCCTTCAA       c.1920
 R  A  L  Y  F  S  D  S  S  S  Q  L  N  T  S  L  P  F  L  Q         p.640

   | 16      .         .         .         .         .         .    g.70858
 A | ATCGAAAAGTATCCTCCTTGCACACCTCCCGAGTTCAGAGGCAGATGGTGGTCTCCGTT    c.1980
 N |   R  K  V  S  S  L  H  T  S  R  V  Q  R  Q  M  V  V  S  V      p.660

          .         .         .         .         .         .       g.70918
 CACGACTTACCCGAGAAGAGCTTTGTGCCCCTGCTGGACAGCAAATACGTCCTCTGTGTG       c.2040
 H  D  L  P  E  K  S  F  V  P  L  L  D  S  K  Y  V  L  C  V         p.680

          .         .         .         .         .     | 17   .    g.71999
 TGGGATATTTGGCAGCCTTCAGGGCCACAGAAAGTTCTGATATGTGAGTCCCAG | GTCACG    c.2100
 W  D  I  W  Q  P  S  G  P  Q  K  V  L  I  C  E  S  Q   | V  T      p.700

          .         .         .         .         .         .       g.72059
 TGTTGCTGCTTGAGCCCTTTGAAAGCATTTTTACTGTTTGCCGGAACAGCGCACGGCTCA       c.2160
 C  C  C  L  S  P  L  K  A  F  L  L  F  A  G  T  A  H  G  S         p.720

          .         .         .         .         .         .       g.72119
 GTTGTCGTCTGGGATTTGAGAGAAGACTCAAGGCTGCATTACTCTGTGACGCTGAGCGAT       c.2220
 V  V  V  W  D  L  R  E  D  S  R  L  H  Y  S  V  T  L  S  D         p.740

          .         .         .        | 18.         .         .    g.74632
 GGCTTCTGGACGTTCCGGACCGCCACGTTTTCCACCG | ATGGAATCCTTACCTCAGTAAAC    c.2280
 G  F  W  T  F  R  T  A  T  F  S  T  D |   G  I  L  T  S  V  N      p.760

          .         .         .         .         .         .       g.74692
 CACCGAAGCCCTCTTCAAGCAGTAGAACCTATCTCAACGTCCGTCCACAAAAAGCAGAGC       c.2340
 H  R  S  P  L  Q  A  V  E  P  I  S  T  S  V  H  K  K  Q  S         p.780

          .         .         .  | 19      .         .         .    g.74853
 TTTGTGCTTTCACCCTTTTCTACTCAAGAAG | AAATGTCAGGTTTGTCCTTCCACATCGCT    c.2400
 F  V  L  S  P  F  S  T  Q  E  E |   M  S  G  L  S  F  H  I  A      p.800

          .         .         .    | 20    .         .         .    g.75441
 TCCTTGGATGAGAGTGGGGTTCTCAATGTATGG | GTGGTTGTTGAATTACCAAAGGCAGAC    c.2460
 S  L  D  E  S  G  V  L  N  V  W   | V  V  V  E  L  P  K  A  D      p.820

          .         .      | 21  .         .         .         .    g.78912
 ATCGCAGGTTCAATAAGTGATTTAG | GTCTGATGCCTGGAGGGAGGGTCAAGCTGGTACAT    c.2520
 I  A  G  S  I  S  D  L  G |   L  M  P  G  G  R  V  K  L  V  H      p.840

          .         .       | 22 .         .         .         .    g.82585
 AGTGCTCTGATCCAGTTGGGTGACAG | TCTTTCCCATAAAGGTAATGAATTTTGGGGCACT    c.2580
 S  A  L  I  Q  L  G  D  S  |  L  S  H  K  G  N  E  F  W  G  T      p.860

          .         .         .         .         .         .       g.82645
 ACACAAACACTGAATGTTAAATTTCTGCCTTCAGATCCTAATCACTTTATTATTGGCACA       c.2640
 T  Q  T  L  N  V  K  F  L  P  S  D  P  N  H  F  I  I  G  T         p.880

        | 23 .         .         .         .         .         .    g.82894
 GACATG | GGTCTCATAAGCCATGGCACAAGACAAGATTTGAGAGTGGCTCCCAAACTATTC    c.2700
 D  M   | G  L  I  S  H  G  T  R  Q  D  L  R  V  A  P  K  L  F      p.900

          .         .         .         .         .         .       g.82954
 AAACCTCAGCAACATGGTATAAGACCAGTGAAAGTTAATGTCATTGATTTTTCACCATTT       c.2760
 K  P  Q  Q  H  G  I  R  P  V  K  V  N  V  I  D  F  S  P  F         p.920

          .         | 24         .         .         .         .    g.90389
 GGAGAACCAATATTTTTG | GCCGGCTGTTCGGACGGAAGCATCAGGCTGCACCAGCTGAGC    c.2820
 G  E  P  I  F  L   | A  G  C  S  D  G  S  I  R  L  H  Q  L  S      p.940

          .         .         .         .         .         .       g.90449
 TCCGCGTTTCCGCTCCTGCAGTGGGACAGCAGCACGGACAGCCATGCGGTCACCGGCCTG       c.2880
 S  A  F  P  L  L  Q  W  D  S  S  T  D  S  H  A  V  T  G  L         p.960

          .         .         .         .         .         .       g.90509
 CAGTGGTCCCCAACCAGGCCTGCCGTGTTCCTGGTGCAGGACGACACATCCAACATCTAC       c.2940
 Q  W  S  P  T  R  P  A  V  F  L  V  Q  D  D  T  S  N  I  Y         p.980

          .         .         .         .         .         .       g.90569
 ATCTGGGACCTCCTCCAGAGCGATCTGGGTCCTGTCGCCAAACAGCAGGTCTCCCCCAAC       c.3000
 I  W  D  L  L  Q  S  D  L  G  P  V  A  K  Q  Q  V  S  P  N         p.1000

    | 25     .         .         .         .         .         .    g.94061
 AG | GCTGGTGGCCATGGCTGCGGTGGGTGAGCCTGAGAAGGCTGGTGGCAGCTTCCTGGCC    c.3060
 R  |  L  V  A  M  A  A  V  G  E  P  E  K  A  G  G  S  F  L  A      p.1020

          .         .         .         .         .         .       g.94121
 CTGGTGCTGGCCAGGGCGTCTGGCTCCATCGACATCCAGCACCTGAAGAGGCGGTGGGCG       c.3120
 L  V  L  A  R  A  S  G  S  I  D  I  Q  H  L  K  R  R  W  A         p.1040

          .         .         .         .         .         .       g.94181
 GCCCCGGAGGTGGACGAGTGCAACAGGCTGCGTCTGCTTTTGCAGGAAGCCCTGTGGCCA       c.3180
 A  P  E  V  D  E  C  N  R  L  R  L  L  L  Q  E  A  L  W  P         p.1060

          .         .                                               g.94202
 GAGGGAAAACTGCACAAGTAG                                              c.3201
 E  G  K  L  H  K  X                                                p.1066

          .         .         .         .         .         .       g.94262
 cgggtgtggctgagaggaccgcgtttctgtaatgacccagatttaaaagacataaggtgg       c.*60

          .         .         .         .         .         .       g.94322
 ataattctacatttgtgtgcaagtatatttatgtatatagactatgtatattctgtatat       c.*120

          .         .         .         .         .         .       g.94382
 aatttattttacatgaatatgtctttggtattcccagtaaatagatgactacttttgagt       c.*180

          .         .         .         .         .         .       g.94442
 ggaaacaaagaacattctagcatttacaaaacttccaggggaatgtagagccacgtccag       c.*240

          .         .         .         .         .         .       g.94502
 ggtgctcttttctgagagtatttcgagttatttttagaacagtttaaatattgtcacatt       c.*300

          .         .         .         .         .         .       g.94562
 actgctagattttaaacagcctaccatgaaaatgtatcttaatgaactattttcttatgc       c.*360

          .         .         .         .         .                 g.94615
 ataaagtatgtgaacacatgtctaaattaaaaggaattactccaccgaaatga              c.*413

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The WD repeat domain 60 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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