WD repeat domain 66 (WDR66) - coding DNA reference sequence

(used for variant description)

(last modified February 13, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_144668.5 in the WDR66 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021364.1, covering WDR66 transcript NM_144668.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5039
                      gcggttgccatggggacggagcttgggtggcaaccagaa       c.-121

 .         .         .         .         .         .                g.5099
 ctagggagctggtggagaaggtggcggccgctggaaggaggcccgggaggtggctgaggg       c.-61

 .         .         .         .          | 02        .             g.7749
 gtccaggcggcgggacgactctggccttttgaagaccggg | aggaaactctacagagaaga    c.-1

          .         .         .         .         .         .       g.7809
 ATGTCAGATGCAGCAGAAGCTCCCCGAGAAGCAACAGGAGAAAATGGAGAAACAGAAATG       c.60
 M  S  D  A  A  E  A  P  R  E  A  T  G  E  N  G  E  T  E  M         p.20

          .         .         .         .         .         .       g.7869
 AAAGAAGAGGAGGAACCTAATCCAAATTATAAAGAAGTAGAAGATCCACAACAGGAATCA       c.120
 K  E  E  E  E  P  N  P  N  Y  K  E  V  E  D  P  Q  Q  E  S         p.40

          .         .         .         .         .         .       g.7929
 AAAGATGACACAATAGCATGGAGAGAGTCTCAGGAGGAGGAGAGGAAAACGGGCGAGGAG       c.180
 K  D  D  T  I  A  W  R  E  S  Q  E  E  E  R  K  T  G  E  E         p.60

          .         .         .         .         .         .       g.7989
 GAAGGGGAGGAGGAGGGGAAGGAGGACAAAAAGATTGTCATGGAAGAAACTGAGGAAAAG       c.240
 E  G  E  E  E  G  K  E  D  K  K  I  V  M  E  E  T  E  E  K         p.80

          .         .         .         .         .         .       g.8049
 GCTGGAGAAGTCCAAGAGAAGGAGGCTTCAGGAATACAGGAAGAAACCACAGTAGAGCCC       c.300
 A  G  E  V  Q  E  K  E  A  S  G  I  Q  E  E  T  T  V  E  P         p.100

          .         .         .         .         .         .       g.8109
 CAAGAAGTCACAGCGTCCATGATCCGTTTGGAGACACAGATTACTGATTCCCAGTCAATC       c.360
 Q  E  V  T  A  S  M  I  R  L  E  T  Q  I  T  D  S  Q  S  I         p.120

          .         | 03         .         .         .         .    g.10107
 ACATCAGGAATTTTCCCA | AAAACCCAAAGAGGTAGCAAGTCAAAGCTTTCCTTACAATTG    c.420
 T  S  G  I  F  P   | K  T  Q  R  G  S  K  S  K  L  S  L  Q  L      p.140

          .         .         .         .         .         .       g.10167
 GAGGATGCAGAAACAGATGAGCTTTTAAGAGACCTGAGCACACAAATTGAATTTCTTGAT       c.480
 E  D  A  E  T  D  E  L  L  R  D  L  S  T  Q  I  E  F  L  D         p.160

          .         .         .         .         .         .       g.10227
 TTGGATCAAATCAGTCCTGAGGAACAACAGATTAGTTCCCCTGAAAGGCAGCCCTCAGGA       c.540
 L  D  Q  I  S  P  E  E  Q  Q  I  S  S  P  E  R  Q  P  S  G         p.180

          .         .         .         .         .         .       g.10287
 GAGCTTGAGGAGAAAACCGACCGGATGCCCCAAGATGAACTGGGACAAGAAAGAAGGGAC       c.600
 E  L  E  E  K  T  D  R  M  P  Q  D  E  L  G  Q  E  R  R  D         p.200

          .         .         .         .         .         .       g.10347
 TTGGAGCCAGAAAACAGAGAGGAGGGACAAGAAAGGAGAGTATCCGACATCCAGTCCAAA       c.660
 L  E  P  E  N  R  E  E  G  Q  E  R  R  V  S  D  I  Q  S  K         p.220

          .         .         .         .         .         .       g.10407
 GCAGGGATCTCCCGGGAGTCACTGGTGTCCAGCACCACAGAGGACATTCTGTTTCAAAAG       c.720
 A  G  I  S  R  E  S  L  V  S  S  T  T  E  D  I  L  F  Q  K         p.240

          .         .        | 04.         .         .         .    g.18222
 GATAAAAGCACCCCGGTGTATCCCTTG | ACCATGACCTGGTCGTTTGGATGGAACAGTTCT    c.780
 D  K  S  T  P  V  Y  P  L   | T  M  T  W  S  F  G  W  N  S  S      p.260

          .         .         .         .         .         .       g.18282
 CTTCCTGTTTACTATATTCGAGAGGAAAGGCAGAGAGTTCTTCTGTATGTTTGTGCTCAC       c.840
 L  P  V  Y  Y  I  R  E  E  R  Q  R  V  L  L  Y  V  C  A  H         p.280

          .         .         .         .         | 05         .    g.20702
 ACTGCGATCATCTACAACGTGTTCAGGAACAATCAATACCACCTTCAG | GGCCACGCCAAT    c.900
 T  A  I  I  Y  N  V  F  R  N  N  Q  Y  H  L  Q   | G  H  A  N      p.300

          .         .         .         .         .         .       g.20762
 ATTATCTCCTGCCTCTGCGTCAGTGAAGACAGGCGGTGGATCGCCACAGCAGACAAAGGG       c.960
 I  I  S  C  L  C  V  S  E  D  R  R  W  I  A  T  A  D  K  G         p.320

          .         .         .         | 06         .         .    g.28999
 CCAGACTGCCTGGTGATTATATGGGACTCCTTCACAGG | TATTCCTGTGCACACAATATTT    c.1020
 P  D  C  L  V  I  I  W  D  S  F  T  G  |  I  P  V  H  T  I  F      p.340

          .         .         .         .         .         .       g.29059
 GACAGCTGCCCTGAAGGGAATGGCATCATGGCCATGGCCATGACCCACGACGCCAAGTAT       c.1080
 D  S  C  P  E  G  N  G  I  M  A  M  A  M  T  H  D  A  K  Y         p.360

          .         .         . | 07       .         .         .    g.29368
 CTGGCAACCATCTCAGATGCTGAAGTCCAG | AAGGTATGCATCTGGAAGTGGACTTTGGCA    c.1140
 L  A  T  I  S  D  A  E  V  Q   | K  V  C  I  W  K  W  T  L  A      p.380

          .         .         .         .         .  | 08      .    g.35436
 GTGGAAACGCCAGCATGCACTCTCGAACTCCCCACAGAGTACGGTGTTCAG | AACTACGTT    c.1200
 V  E  T  P  A  C  T  L  E  L  P  T  E  Y  G  V  Q   | N  Y  V      p.400

          .         .         .         .         .         .       g.35496
 ACTTTTAACCCAACAAATAATAAAGAATTGGTGAGCAATAGTAAAACACGGGCAATATAT       c.1260
 T  F  N  P  T  N  N  K  E  L  V  S  N  S  K  T  R  A  I  Y         p.420

           | 09        .         .         .         .         .    g.37974
 TATGCATGG | TATGAAGAGAGGGATACACTGGCTCACAGTGCCCCACTTTTAACTGAAAAA    c.1320
 Y  A  W   | Y  E  E  R  D  T  L  A  H  S  A  P  L  L  T  E  K      p.440

  | 10       .         .         .         .         .         .    g.40623
  | ACCTTCAACAAGCTTGTGGGAAAGTTTAGCCAGTCCATCTTTCACTTGAATTTAACACAA    c.1380
  | T  F  N  K  L  V  G  K  F  S  Q  S  I  F  H  L  N  L  T  Q      p.460

          .         .         .         .         .         .       g.40683
 ATACTCTCAGCCACAATGGAAGGGAAGCTGGTTGTCTGGGACATACACCGCCCACCCTCA       c.1440
 I  L  S  A  T  M  E  G  K  L  V  V  W  D  I  H  R  P  P  S         p.480

          .         .         .         .         .         .       g.40743
 TCTGCCTCCACCTTTTTGGGCTTTCCCTATATCAAGCCTTGTAAATTGGTTCATTTGCAG       c.1500
 S  A  S  T  F  L  G  F  P  Y  I  K  P  C  K  L  V  H  L  Q         p.500

          .         .         .      | 11  .         .         .    g.43542
 AAAGAGGGTATCACGGTACTTACCACAATTGATAG | CTACATTGTCACAGGTGACATTAAG    c.1560
 K  E  G  I  T  V  L  T  T  I  D  S  |  Y  I  V  T  G  D  I  K      p.520

          .         .         .         .         .         .       g.43602
 GGGAACATTAAGTTCTATGATCACACCCTGTCTATTGTTAACTGGTACAGTCACTTGAAA       c.1620
 G  N  I  K  F  Y  D  H  T  L  S  I  V  N  W  Y  S  H  L  K         p.540

          .         .         .         .         .         .       g.43662
 CTGGGCGCCATAAGAACTCTGTCCTTTTCAAAGACCCCAGCAACTCCTCCTACTGAAAAA       c.1680
 L  G  A  I  R  T  L  S  F  S  K  T  P  A  T  P  P  T  E  K         p.560

          .         .         .         .         . | 12       .    g.44725
 TCAAACTATCCTCCTGACTGCACTTTAAAAGGTGACCTTTTTGTCTTAAG | GAATTTTATC    c.1740
 S  N  Y  P  P  D  C  T  L  K  G  D  L  F  V  L  R  |  N  F  I      p.580

          .         .         .         .         .         .       g.44785
 ATTGGAACATCTGATGCCGCGGTGTACCACTTAACAACAGATGGGACCAAACTTGAGAAG       c.1800
 I  G  T  S  D  A  A  V  Y  H  L  T  T  D  G  T  K  L  E  K         p.600

          .         .         .         .         .         .       g.44845
 TTATTTGTAGAGCCCAAGGATGCCATTTGTGCCATCTCCTGCCACCCATATCAACCCCTC       c.1860
 L  F  V  E  P  K  D  A  I  C  A  I  S  C  H  P  Y  Q  P  L         p.620

          .         .         .         .         .         .       g.44905
 ATTGCCATCGGGAGCATCTGTGGGATGATCAAAGTGTGGAATTATGAAAACAAACAATAT       c.1920
 I  A  I  G  S  I  C  G  M  I  K  V  W  N  Y  E  N  K  Q  Y         p.640

          .         .         .         .         .         .       g.44965
 CTTTTCAGCAGGGTTTTTGAGAAGGGGCTTGGAGTCCAGAGTCTGACCTACAACCCCGAA       c.1980
 L  F  S  R  V  F  E  K  G  L  G  V  Q  S  L  T  Y  N  P  E         p.660

   | 13      .         .         .         .         .         .    g.45445
 G | GAGCCCTTCTTGGAGCTGGCTTTACAGAGGGGACAGTTTACATTCTTGATGCAATGTCT    c.2040
 G |   A  L  L  G  A  G  F  T  E  G  T  V  Y  I  L  D  A  M  S      p.680

          .         .         .         .         .         .       g.45505
 TTAGAAAATGAAAGCCCAGAGCCTTTCAAATATTCCAGAACCAGTGTGACTCATATAAGC       c.2100
 L  E  N  E  S  P  E  P  F  K  Y  S  R  T  S  V  T  H  I  S         p.700

          .         .         .    | 14    .         .         .    g.47055
 TTTTCCCATGACTCCCAGTATATGGCAACTGCT | GATAGAAGTTTTACTGTGGCTGTTTAC    c.2160
 F  S  H  D  S  Q  Y  M  A  T  A   | D  R  S  F  T  V  A  V  Y      p.720

          .         .         .         .         .         .       g.47115
 ATGCTGGTGGTCAGAAATGGACAGAGGGTCTGGGAGTACTTAGCAAGACTTCGCTCTCAT       c.2220
 M  L  V  V  R  N  G  Q  R  V  W  E  Y  L  A  R  L  R  S  H         p.740

          .         .         .         .         .         .       g.47175
 CGCAAAAGCATTCGAAGTCTCCTGTTTGGGGTTTACCTGGACAGCAATGAGCCTAGACTG       c.2280
 R  K  S  I  R  S  L  L  F  G  V  Y  L  D  S  N  E  P  R  L         p.760

          .         .        | 15.         .         .         .    g.48454
 CTGAGCCTTGGGACAGACAGGCTCTTG | ATAGAGTATGATCTTCTCAGGAGCTACAAAGAC    c.2340
 L  S  L  G  T  D  R  L  L   | I  E  Y  D  L  L  R  S  Y  K  D      p.780

          .         .         .         .         .         .       g.48514
 CACCTGGAAGTCCTGGACATTCACCACACCGACCAGGGCTGCTATCCCACCTGCATGGTC       c.2400
 H  L  E  V  L  D  I  H  H  T  D  Q  G  C  Y  P  T  C  M  V         p.800

          .         .         .         .         .         .       g.48574
 TGGTACCCACCACTCACCAGGGAACTCTTCCTGCTTATTTGCAACAGTGGCTACAAAGTG       c.2460
 W  Y  P  P  L  T  R  E  L  F  L  L  I  C  N  S  G  Y  K  V         p.820

          .         .         .   | 16     .         .         .    g.53426
 AAGCTTTTTAATGCTACTACCAAAATGTGCAG | AAAGACGCTTCTGGGGCCAGCTTATGGT    c.2520
 K  L  F  N  A  T  T  K  M  C  R  |  K  T  L  L  G  P  A  Y  G      p.840

          .         .         .         .         .         .       g.53486
 TCCCCTATTGAGCAGACACAAGTCCTCCCAGTGAGAAGCATGGCGGAGCTACAGAAACGC       c.2580
 S  P  I  E  Q  T  Q  V  L  P  V  R  S  M  A  E  L  Q  K  R         p.860

          .         .        | 17.         .         .         .    g.54482
 TACTTGGTGTTTATTAACAGAGACAAG | GTGGGACTTCAGATCTTACCAGTTGACGGCAAT    c.2640
 Y  L  V  F  I  N  R  D  K   | V  G  L  Q  I  L  P  V  D  G  N      p.880

          .         .         .         .         .         .       g.54542
 CCACATAAGACATCTGCTATTGTTTGCCACCCGAACGGGGTGGCCGGCATGGCCGTTTCC       c.2700
 P  H  K  T  S  A  I  V  C  H  P  N  G  V  A  G  M  A  V  S         p.900

          .         .         .         .         .         .       g.54602
 TATGATGGCTGCTACGCCTTCACTGCGGGAGGGCACGATCGCTCGGTGGTGCAGTGGAAA       c.2760
 Y  D  G  C  Y  A  F  T  A  G  G  H  D  R  S  V  V  Q  W  K         p.920

          .  | 18      .         .         .         .         .    g.61736
 ATCACCTTAAG | TGTCCTGGAGGCAGCGGTTTCTCTTGGGGGTGAAGACTTGACCCCATTC    c.2820
 I  T  L  S  |  V  L  E  A  A  V  S  L  G  G  E  D  L  T  P  F      p.940

          .         .         .         .   | 19     .         .    g.62003
 TATGGTCTGCTGTCTGGTGGCCGGGAAGGAAAATTCTACAGG | GAGCTAGAAGACTACTTC    c.2880
 Y  G  L  L  S  G  G  R  E  G  K  F  Y  R   | E  L  E  D  Y  F      p.960

          .         .         .         .         .         .       g.62063
 TACTATTCTCAGCTCCGCAGTCAAGGCATCGACACAATGGAGACCAGAAAGGTGTCAGAA       c.2940
 Y  Y  S  Q  L  R  S  Q  G  I  D  T  M  E  T  R  K  V  S  E         p.980

          .         .         .         .         .         .       g.62123
 CACATTTGCCTGTCAGAGCTTCCTTTTGTCATGAGAGCAATTGGCTTTTACCCATCTGAA       c.3000
 H  I  C  L  S  E  L  P  F  V  M  R  A  I  G  F  Y  P  S  E         p.1000

        | 20 .         .         .         .         .         .    g.86213
 GAGAAG | ATTGATGATATATTTAACGAAATCAAATTTGGTGAATATGTGGACACTGGAAAG    c.3060
 E  K   | I  D  D  I  F  N  E  I  K  F  G  E  Y  V  D  T  G  K      p.1020

          .         .         .         .         .         .       g.86273
 CTAATCGACAAGATCAACTTACCAGATTTCCTAAAAGTGTACCTTAACCACAAGCCACCT       c.3120
 L  I  D  K  I  N  L  P  D  F  L  K  V  Y  L  N  H  K  P  P         p.1040

          .         .         .         .         .         .       g.86333
 TTTGGTAACACCATGAGTGGCATCCACAAGAGCTTTGAGGTGCTCGGTTATACCAACTCC       c.3180
 F  G  N  T  M  S  G  I  H  K  S  F  E  V  L  G  Y  T  N  S         p.1060

          .         .         .         .         .      | 21  .    g.87945
 AAAGGGAAAAAGGCCATTCGAAGAGAGGACTTCCTGAGACTGCTCGTTACTAAAG | GTGAG    c.3240
 K  G  K  K  A  I  R  R  E  D  F  L  R  L  L  V  T  K  G |   E      p.1080

          .         .         .         .         .         .       g.88005
 CATATGACGGAGGAGGAGATGTTGGATTGCTTTGCTTCACTGTTTGGCCTGAATCCCGAG       c.3300
 H  M  T  E  E  E  M  L  D  C  F  A  S  L  F  G  L  N  P  E         p.1100

          .         .         .        | 22.         .         .    g.90118
 GGATGGAAATCCGAGCCTGCAACCTGCTCCGTCAAAG | GTTCAGAAATTTGCCTTGAAGAA    c.3360
 G  W  K  S  E  P  A  T  C  S  V  K  G |   S  E  I  C  L  E  E      p.1120

          .         .         .         .         .         .       g.90178
 GAACTTCCAGACGAAATCACTGCAGAAATATTCGCGACTGAAATTCTTGGCTTAACCATT       c.3420
 E  L  P  D  E  I  T  A  E  I  F  A  T  E  I  L  G  L  T  I         p.1140

          .         .         .                                     g.90208
 TCAGAAGATTCCGGCCAGGATGGTCAGTGA                                     c.3450
 S  E  D  S  G  Q  D  G  Q  X                                       p.1149

          .         .         .         .         .         .       g.90268
 agttaccaggaatgtttaaagcacaaaggactttgggtgtgtgtgcatgcacatgtgtgt       c.*60

          .         .         .         .         .         .       g.90328
 gttttccatgaggcactgctttttatgcatttccctcccccctctcatctttagaacatt       c.*120

          .         .         .         .                           g.90371
 tagacattaaagcaagtttctggtgagcaatggaattcacaaa                        c.*163

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The WD repeat domain 66 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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