WNT1 inducible signaling pathway protein 3 (WISP3) - coding DNA reference sequence

(used for variant description)

(last modified July 31, 2019)

This file was created to facilitate the description of sequence variants on transcript NM_003880.3 in the WISP3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011748.1, covering WISP3 transcript NM_003880.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
           .         .         .         .         .                g.5050
           cctgagtcccgggaggaaagtgctcgcccattcctgacctgtgacacgct       c.-61

 .         .         .         .       | 02 .         .             g.5283
 cactgcgaaggcaggttattagaagagtcccatgaaa | ggtggctccacggtcccagcgac    c.-1

          .         .         .         .         | 03         .    g.11928
 ATGCAGGGGCTCCTCTTCTCCACTCTTCTGCTTGCTGGCCTGGCACAG | TTCTGCTGCAGG    c.60
 M  Q  G  L  L  F  S  T  L  L  L  A  G  L  A  Q   | F  C  C  R      p.20

          .         .         .         .         .         .       g.11988
 GTACAGGGCACTGGACCATTAGATACAACACCTGAAGGAAGGCCTGGAGAAGTGTCAGAT       c.120
 V  Q  G  T  G  P  L  D  T  T  P  E  G  R  P  G  E  V  S  D         p.40

          .         .         .         .         .         .       g.12048
 GCACCTCAGCGTAAACAGTTTTGTCACTGGCCCTGCAAATGCCCTCAGCAGAAGCCCCGT       c.180
 A  P  Q  R  K  Q  F  C  H  W  P  C  K  C  P  Q  Q  K  P  R         p.60

          .         .         .         .         .         .       g.12108
 TGCCCTCCTGGAGTGAGCCTGGTGAGAGATGGCTGTGGATGCTGTAAAATCTGTGCCAAG       c.240
 C  P  P  G  V  S  L  V  R  D  G  C  G  C  C  K  I  C  A  K         p.80

          .         .         .         .         .         .       g.12168
 CAACCAGGGGAAATCTGCAATGAAGCTGACCTCTGTGACCCACACAAAGGGCTGTATTGT       c.300
 Q  P  G  E  I  C  N  E  A  D  L  C  D  P  H  K  G  L  Y  C         p.100

          .         .         .         .       | 04 .         .    g.15694
 GACTACTCAGTAGACAGGCCTAGGTACGAGACTGGAGTGTGTGCAT | ACCTTGTAGCTGTT    c.360
 D  Y  S  V  D  R  P  R  Y  E  T  G  V  C  A  Y |   L  V  A  V      p.120

          .         .         .         .         .         .       g.15754
 GGGTGCGAGTTCAACCAGGTACATTATCATAATGGCCAAGTGTTTCAGCCCAACCCCTTG       c.420
 G  C  E  F  N  Q  V  H  Y  H  N  G  Q  V  F  Q  P  N  P  L         p.140

          .         .         .         .         .         .       g.15814
 TTCAGCTGCCTCTGTGTGAGTGGGGCCATTGGATGCACACCTCTGTTCATACCAAAGCTG       c.480
 F  S  C  L  C  V  S  G  A  I  G  C  T  P  L  F  I  P  K  L         p.160

          .         .         .         .         .         .       g.15874
 GCTGGCAGTCACTGCTCTGGAGCTAAAGGTGGAAAGAAGTCTGATCAGTCAAACTGTAGC       c.540
 A  G  S  H  C  S  G  A  K  G  G  K  K  S  D  Q  S  N  C  S         p.180

          .         .         .         .          | 05        .    g.19141
 CTGGAACCATTACTACAGCAGCTTTCAACAAGCTACAAAACAATGCCAG | CTTATAGAAAT    c.600
 L  E  P  L  L  Q  Q  L  S  T  S  Y  K  T  M  P  A |   Y  R  N      p.200

          .         .         .         .         .         .       g.19201
 CTCCCACTTATTTGGAAAAAAAAATGTCTTGTGCAAGCAACAAAATGGACTCCCTGCTCC       c.660
 L  P  L  I  W  K  K  K  C  L  V  Q  A  T  K  W  T  P  C  S         p.220

          .         .         .         .         .         .       g.19261
 AGAACATGTGGGATGGGAATATCTAACAGGGTGACCAATGAAAACAGCAACTGTGAAATG       c.720
 R  T  C  G  M  G  I  S  N  R  V  T  N  E  N  S  N  C  E  M         p.240

          .         .         .         .         .         .       g.19321
 AGAAAAGAGAAAAGACTGTGTTACATTCAGCCTTGCGACAGCAATATATTAAAGACAATA       c.780
 R  K  E  K  R  L  C  Y  I  Q  P  C  D  S  N  I  L  K  T  I         p.260

     | 06    .         .         .         .         .         .    g.20321
 AAG | ATTCCCAAAGGAAAAACATGCCAACCTACTTTCCAACTCTCCAAAGCTGAAAAATTT    c.840
 K   | I  P  K  G  K  T  C  Q  P  T  F  Q  L  S  K  A  E  K  F      p.280

          .         .         .         .         .         .       g.20381
 GTCTTTTCTGGATGCTCAAGTACTCAGAGTTACAAACCCACTTTTTGTGGAATATGCTTG       c.900
 V  F  S  G  C  S  S  T  Q  S  Y  K  P  T  F  C  G  I  C  L         p.300

          .         .         .         .         .         .       g.20441
 GATAAGAGATGCTGTATCCCTAATAAGTCTAAAATGATTACTATTCAATTTGATTGCCCA       c.960
 D  K  R  C  C  I  P  N  K  S  K  M  I  T  I  Q  F  D  C  P         p.320

          .         .         .         .         .         .       g.20501
 AATGAGGGGTCATTTAAATGGAAGATGCTGTGGATTACATCTTGTGTGTGTCAGAGAAAC       c.1020
 N  E  G  S  F  K  W  K  M  L  W  I  T  S  C  V  C  Q  R  N         p.340

          .         .         .         .                           g.20546
 TGCAGAGAACCTGGAGATATATTTTCTGAGCTCAAGATTCTGTAA                      c.1065
 C  R  E  P  G  D  I  F  S  E  L  K  I  L  X                        p.354

          .         .         .         .         .         .       g.20606
 aaccaagcaaatgggggaaaagttagtcaatcctgtcatataataaaaaaattagtgagt       c.*60

                                                                    g.20612
 ataaaa                                                             c.*66

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The WNT1 inducible signaling pathway protein 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.