wingless-type MMTV integration site family, member 1 (WNT1) - coding DNA reference sequence

(used for variant description)

(last modified May 12, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_005430.3 in the WNT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering WNT1 transcript NM_005430.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           gcggtgccgcccgccgtg       c.-181

 .         .         .         .         .         .                g.5078
 gccgcctcagcccaccagccgggaccgcgagccatgctgtccgccgcccgcccccagggt       c.-121

 .         .         .         .         .         .                g.5138
 tgttaaagccagactgcgaactctcgccactgccgccaccgccgcgtcccgtcccaccgt       c.-61

 .         .         .         .         .         .                g.5198
 cgcgggcaacaaccaaagtcgccgcaactgcagcacagagcgggcaaagccaggcaggcc       c.-1

          .         .         .         .         .         .       g.5258
 ATGGGGCTCTGGGCGCTGTTGCCTGGCTGGGTTTCTGCTACGCTGCTGCTGGCGCTGGCC       c.60
 M  G  L  W  A  L  L  P  G  W  V  S  A  T  L  L  L  A  L  A         p.20

          .         .         .         .     | 02   .         .    g.6031
 GCTCTGCCCGCAGCCCTGGCTGCCAACAGCAGTGGCCGATGGTG | GGGTATTGTGAACGTA    c.120
 A  L  P  A  A  L  A  A  N  S  S  G  R  W  W  |  G  I  V  N  V      p.40

          .         .         .         .         .         .       g.6091
 GCCTCCTCCACGAACCTGCTTACAGACTCCAAGAGTCTGCAACTGGTACTCGAGCCCAGT       c.180
 A  S  S  T  N  L  L  T  D  S  K  S  L  Q  L  V  L  E  P  S         p.60

          .         .         .         .         .         .       g.6151
 CTGCAGCTGTTGAGCCGCAAACAGCGGCGTCTGATACGCCAAAATCCGGGGATCCTGCAC       c.240
 L  Q  L  L  S  R  K  Q  R  R  L  I  R  Q  N  P  G  I  L  H         p.80

          .         .         .         .         .         .       g.6211
 AGCGTGAGTGGGGGGCTGCAGAGTGCCGTGCGCGAGTGCAAGTGGCAGTTCCGGAATCGC       c.300
 S  V  S  G  G  L  Q  S  A  V  R  E  C  K  W  Q  F  R  N  R         p.100

          .         .         .         .         .         | 03    g.6973
 CGCTGGAACTGTCCCACTGCTCCAGGGCCCCACCTCTTCGGCAAGATCGTCAACCGAG | GC    c.360
 R  W  N  C  P  T  A  P  G  P  H  L  F  G  K  I  V  N  R  G |       p.120

          .         .         .         .         .         .       g.7033
 TGTCGAGAAACGGCGTTTATCTTCGCTATCACCTCCGCCGGGGTCACCCATTCGGTGGCG       c.420
 C  R  E  T  A  F  I  F  A  I  T  S  A  G  V  T  H  S  V  A         p.140

          .         .         .         .         .         .       g.7093
 CGCTCCTGCTCAGAAGGTTCCATCGAATCCTGCACGTGTGACTACCGGCGGCGCGGCCCC       c.480
 R  S  C  S  E  G  S  I  E  S  C  T  C  D  Y  R  R  R  G  P         p.160

          .         .         .         .         .         .       g.7153
 GGGGGCCCCGACTGGCACTGGGGGGGCTGCAGCGACAACATTGACTTCGGCCGCCTCTTC       c.540
 G  G  P  D  W  H  W  G  G  C  S  D  N  I  D  F  G  R  L  F         p.180

          .         .         .         .         .         .       g.7213
 GGCCGGGAGTTCGTGGACTCCGGGGAGAAGGGGCGGGACCTGCGCTTCCTCATGAACCTT       c.600
 G  R  E  F  V  D  S  G  E  K  G  R  D  L  R  F  L  M  N  L         p.200

          .         .     | 04   .         .         .         .    g.7735
 CACAACAACGAGGCAGGCCGTACG | ACCGTATTCTCCGAGATGCGCCAGGAGTGCAAGTGC    c.660
 H  N  N  E  A  G  R  T   | T  V  F  S  E  M  R  Q  E  C  K  C      p.220

          .         .         .         .         .         .       g.7795
 CACGGGATGTCCGGCTCATGCACGGTGCGCACGTGCTGGATGCGGCTGCCCACGCTGCGC       c.720
 H  G  M  S  G  S  C  T  V  R  T  C  W  M  R  L  P  T  L  R         p.240

          .         .         .         .         .         .       g.7855
 GCCGTGGGCGATGTGCTGCGCGACCGCTTCGACGGCGCCTCGCGCGTCCTGTACGGCAAC       c.780
 A  V  G  D  V  L  R  D  R  F  D  G  A  S  R  V  L  Y  G  N         p.260

          .         .         .         .         .         .       g.7915
 CGCGGCAGCAACCGCGCTTCGCGGGCGGAGCTGCTGCGCCTGGAGCCGGAAGACCCGGCC       c.840
 R  G  S  N  R  A  S  R  A  E  L  L  R  L  E  P  E  D  P  A         p.280

          .         .         .         .         .         .       g.7975
 CACAAACCGCCCTCCCCCCACGACCTCGTCTACTTCGAGAAATCGCCCAACTTCTGCACG       c.900
 H  K  P  P  S  P  H  D  L  V  Y  F  E  K  S  P  N  F  C  T         p.300

          .         .         .         .         .         .       g.8035
 TACAGCGGACGCCTGGGCACAGCAGGCACGGCAGGGCGCGCCTGTAACAGCTCGTCGCCC       c.960
 Y  S  G  R  L  G  T  A  G  T  A  G  R  A  C  N  S  S  S  P         p.320

          .         .         .         .         .         .       g.8095
 GCGCTGGACGGCTGCGAGCTGCTCTGCTGCGGCAGGGGCCACCGCACGCGCACGCAGCGC       c.1020
 A  L  D  G  C  E  L  L  C  C  G  R  G  H  R  T  R  T  Q  R         p.340

          .         .         .         .         .         .       g.8155
 GTCACCGAGCGCTGCAACTGCACCTTCCACTGGTGCTGCCACGTCAGCTGCCGCAACTGC       c.1080
 V  T  E  R  C  N  C  T  F  H  W  C  C  H  V  S  C  R  N  C         p.360

          .         .         .                                     g.8188
 ACGCACACGCGCGTACTGCACGAGTGTCTGTGA                                  c.1113
 T  H  T  R  V  L  H  E  C  L  X                                    p.370

          .         .         .         .         .         .       g.8248
 ggcgctgcgcggactcgcccccaggaacgctctcctcgagccctcccccaaacagactcg       c.*60

          .         .         .         .         .         .       g.8308
 ctagcactcaagacccggttattcgcccacccgagtacctccagtcacactccccgcggt       c.*120

          .         .         .         .         .         .       g.8368
 tcatacgcatcccatctctcccacttcctcctacctggggactcctcaaaccacttgcct       c.*180

          .         .         .         .         .         .       g.8428
 ggggcggcatgaaccctcttgccatcctgatggacctgccccggacctacctccctccct       c.*240

          .         .         .         .         .         .       g.8488
 ctccgcgggagaccccttgttgcactgccccctgcttggccaggaggtgagagaaggatg       c.*300

          .         .         .         .         .         .       g.8548
 ggtcccctccgccatggggtcggctcctgatggtgtcattctgcctgctccatcgcgcca       c.*360

          .         .         .         .         .         .       g.8608
 gcgacctctctgcctctcttcttcccctttgtcctgcgttttctccgggtcctcctaagt       c.*420

          .         .         .         .         .         .       g.8668
 cccttcctattctcctgccatgggtgcagaccctgaacccacacctgggcatcagggcct       c.*480

          .         .         .         .         .         .       g.8728
 ttctcctccccacctgtagctgaagcaggaggttacagggcaaaagggcagctgtgatga       c.*540

          .         .         .         .         .         .       g.8788
 tgtggaaatgaggttgggggaaccagcagaaatgcccccattctcccagtctctgtcgtg       c.*600

          .         .         .         .         .         .       g.8848
 gagccattgaacagctgtgagccatgcctccctgggccacctcctaccccttcctgtcct       c.*660

          .         .         .         .         .         .       g.8908
 gcctcctcatcagtgtgtaaataatttgcactgaaacgtggatacagagccacgagtttg       c.*720

          .         .         .         .         .         .       g.8968
 gatgttgtaaataaaactatttattgtgctgggtcccagcctggtttgcaaagaccacct       c.*780

          .         .         .         .         .         .       g.9028
 ccaacccaacccaatccctctccactcttctctcctttctccctgcagccttttctggtc       c.*840

          .         .         .         .         .         .       g.9088
 cctcttctctcctcagtttctcaaagatgcgtttgcctcctggaatcagtatttccttcc       c.*900

          .         .         .         .         .         .       g.9148
 actgtagctattagcggctcctcgcccccaccagtgtagcatcttcctctgcagaataaa       c.*960

          .                                                         g.9161
 atctctattttta                                                      c.*973

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Wingless-type MMTV integration site family, member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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