wingless-type MMTV integration site family, member 5A (WNT5A) - coding DNA reference sequence

(used for variant description)

(last modified November 11, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_003392.4 in the WNT5A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031992.1, covering WNT5A transcript NM_003392.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    actaactcgcggctgcaggatcagcgtctggaagcagacgtttcggctacagaccca       c.-601

 .         .         .         .         .         .                g.5117
 gagaggaggagctggagatcaggaggcgtgagccgccaagagtttgcagaatctgtggtg       c.-541

 .         .         .         .         .         .                g.5177
 tgaatgaactgggggcacctgggcgcacagatcgccccccttcccccgccccgggccaca       c.-481

 .         .         .         .         .         .                g.5237
 gttgagtagtggtacatttttttcaccctcttgtgaagaatttctttttattattatttg       c.-421

 .         .         .         .         .         .                g.5297
 tcgtaaggtcttttgcacaatcacgcccacatttggggttggaaagccctaattaccgcc       c.-361

 .         .         .         .         .         .                g.5357
 gtcgctgatggacgttggaaacggagcgcctctccgtggaacagttgcctgcgcgccctc       c.-301

 .         .         .         .         .         .                g.5417
 gccggaccggcggctccctagttgcgccccgaccaggccctgcccttgctgccggctcgc       c.-241

 .         .         .         .         .         .                g.5477
 gcgcgtccgcgccccctccattcctgggcgcatcccagctctgccccaactcgggagtcc       c.-181

 .         .         .         .         .         .                g.5537
 aggcccgggcgccagtgcccgcttcagctccggttcactgcgcccgccggacgcgcgccg       c.-121

 .         .         .         .         .         .                g.5597
 gaggactccgcagccctgctcctgaccgtccccccaggcttaacccggtcgctccgctcg       c.-61

 .         .         .         .         .         .                g.5657
 gattcctcggctgcgctcgctcgggtggcgacttcctccccgcgccccctccccctcgcc       c.-1

        | 02 .         .         .         .         .         .    g.11778
 ATGAAG | AAGTCCATTGGAATATTAAGCCCAGGAGTTGCTTTGGGGATGGCTGGAAGTGCA    c.60
 M  K   | K  S  I  G  I  L  S  P  G  V  A  L  G  M  A  G  S  A      p.20

          .         .         .         .         .         .       g.11838
 ATGTCTTCCAAGTTCTTCCTAGTGGCTTTGGCCATATTTTTCTCCTTCGCCCAGGTTGTA       c.120
 M  S  S  K  F  F  L  V  A  L  A  I  F  F  S  F  A  Q  V  V         p.40

          .         . | 03       .         .         .         .    g.13118
 ATTGAAGCCAATTCTTGGTG | GTCGCTAGGTATGAATAACCCTGTTCAGATGTCAGAAGTA    c.180
 I  E  A  N  S  W  W  |  S  L  G  M  N  N  P  V  Q  M  S  E  V      p.60

          .         .         .         .         .         .       g.13178
 TATATTATAGGAGCACAGCCTCTCTGCAGCCAACTGGCAGGACTTTCTCAAGGACAGAAG       c.240
 Y  I  I  G  A  Q  P  L  C  S  Q  L  A  G  L  S  Q  G  Q  K         p.80

          .         .         .         .         .         .       g.13238
 AAACTGTGCCACTTGTATCAGGACCACATGCAGTACATCGGAGAAGGCGCGAAGACAGGC       c.300
 K  L  C  H  L  Y  Q  D  H  M  Q  Y  I  G  E  G  A  K  T  G         p.100

          .         .         .         .         .         .       g.13298
 ATCAAAGAATGCCAGTATCAATTCCGACATCGAAGGTGGAACTGCAGCACTGTGGATAAC       c.360
 I  K  E  C  Q  Y  Q  F  R  H  R  R  W  N  C  S  T  V  D  N         p.120

          .         .         .  | 04      .         .         .    g.18042
 ACCTCTGTTTTTGGCAGGGTGATGCAGATAG | GCAGCCGCGAGACGGCCTTCACATACGCG    c.420
 T  S  V  F  G  R  V  M  Q  I  G |   S  R  E  T  A  F  T  Y  A      p.140

          .         .         .         .         .         .       g.18102
 GTGAGCGCAGCAGGGGTGGTGAACGCCATGAGCCGGGCGTGCCGCGAGGGCGAGCTGTCC       c.480
 V  S  A  A  G  V  V  N  A  M  S  R  A  C  R  E  G  E  L  S         p.160

          .         .         .         .         .         .       g.18162
 ACCTGCGGCTGCAGCCGCGCCGCGCGCCCCAAGGACCTGCCGCGGGACTGGCTCTGGGGC       c.540
 T  C  G  C  S  R  A  A  R  P  K  D  L  P  R  D  W  L  W  G         p.180

          .         .         .         .         .         .       g.18222
 GGCTGCGGCGACAACATCGACTATGGCTACCGCTTTGCCAAGGAGTTCGTGGACGCCCGC       c.600
 G  C  G  D  N  I  D  Y  G  Y  R  F  A  K  E  F  V  D  A  R         p.200

          .         .         .         .         .         .       g.18282
 GAGCGGGAGCGCATCCACGCCAAGGGCTCCTACGAGAGTGCTCGCATCCTCATGAACCTG       c.660
 E  R  E  R  I  H  A  K  G  S  Y  E  S  A  R  I  L  M  N  L         p.220

          .         .     | 05   .         .         .         .    g.22128
 CACAACAACGAGGCCGGCCGCAGG | ACGGTGTACAACCTGGCTGATGTGGCCTGCAAGTGC    c.720
 H  N  N  E  A  G  R  R   | T  V  Y  N  L  A  D  V  A  C  K  C      p.240

          .         .         .         .         .         .       g.22188
 CATGGGGTGTCCGGCTCATGTAGCCTGAAGACATGCTGGCTGCAGCTGGCAGACTTCCGC       c.780
 H  G  V  S  G  S  C  S  L  K  T  C  W  L  Q  L  A  D  F  R         p.260

          .         .         .         .         .         .       g.22248
 AAGGTGGGTGATGCCCTGAAGGAGAAGTACGACAGCGCGGCGGCCATGCGGCTCAACAGC       c.840
 K  V  G  D  A  L  K  E  K  Y  D  S  A  A  A  M  R  L  N  S         p.280

          .         .         .         .         .         .       g.22308
 CGGGGCAAGTTGGTACAGGTCAACAGCCGCTTCAACTCGCCCACCACACAAGACCTGGTC       c.900
 R  G  K  L  V  Q  V  N  S  R  F  N  S  P  T  T  Q  D  L  V         p.300

          .         .         .         .         .         .       g.22368
 TACATCGACCCCAGCCCTGACTACTGCGTGCGCAATGAGAGCACCGGCTCGCTGGGCACG       c.960
 Y  I  D  P  S  P  D  Y  C  V  R  N  E  S  T  G  S  L  G  T         p.320

          .         .         .         .         .         .       g.22428
 CAGGGCCGCCTGTGCAACAAGACGTCGGAGGGCATGGATGGCTGCGAGCTCATGTGCTGC       c.1020
 Q  G  R  L  C  N  K  T  S  E  G  M  D  G  C  E  L  M  C  C         p.340

          .         .         .         .         .         .       g.22488
 GGCCGTGGCTACGACCAGTTCAAGACCGTGCAGACGGAGCGCTGCCACTGCAAGTTCCAC       c.1080
 G  R  G  Y  D  Q  F  K  T  V  Q  T  E  R  C  H  C  K  F  H         p.360

          .         .         .         .         .         .       g.22548
 TGGTGCTGCTACGTCAAGTGCAAGAAGTGCACGGAGATCGTGGACCAGTTTGTGTGCAAG       c.1140
 W  C  C  Y  V  K  C  K  K  C  T  E  I  V  D  Q  F  V  C  K         p.380

                                                                    g.22551
 TAG                                                                c.1143
 X                                                                  p.380

          .         .         .         .         .         .       g.22611
 tgggtgccacccagcactcagccccgctcccaggacccgcttatttatagaaagtacagt       c.*60

          .         .         .         .         .         .       g.22671
 gattctggtttttggtttttagaaatattttttatttttccccaagaattgcaaccggaa       c.*120

          .         .         .         .         .         .       g.22731
 ccattttttttcctgttaccatctaagaactctgtggtttattattaatattataattat       c.*180

          .         .         .         .         .         .       g.22791
 tatttggcaataatgggggtgggaaccaagaaaaatatttattttgtggatctttgaaaa       c.*240

          .         .         .         .         .         .       g.22851
 ggtaatacaagacttcttttgatagtatagaatgaaggggaaataacacataccctaact       c.*300

          .         .         .         .         .         .       g.22911
 tagctgtgtggacatggtacacatccagaaggtaaagaaatacattttctttttctcaaa       c.*360

          .         .         .         .         .         .       g.22971
 tatgccatcatatgggatgggtaggttccagttgaaagagggtggtagaaatctattcac       c.*420

          .         .         .         .         .         .       g.23031
 aattcagcttctatgaccaaaatgagttgtaaattctctggtgcaagataaaaggtcttg       c.*480

          .         .         .         .         .         .       g.23091
 ggaaaacaaaacaaaacaaaacaaacctcccttccccagcagggctgctagcttgctttc       c.*540

          .         .         .         .         .         .       g.23151
 tgcattttcaaaatgataatttacaatggaaggacaagaatgtcatattctcaaggaaaa       c.*600

          .         .         .         .         .         .       g.23211
 aaggtatatcacatgtctcattctcctcaaatattccatttgcagacagaccgtcatatt       c.*660

          .         .         .         .         .         .       g.23271
 ctaatagctcatgaaatttgggcagcagggaggaaagtccccagaaattaaaaaatttaa       c.*720

          .         .         .         .         .         .       g.23331
 aactcttatgtcaagatgttgatttgaagctgttataagaattaggattccagattgtaa       c.*780

          .         .         .         .         .         .       g.23391
 aaagatccccaaatgattctggacactagatttttttgtttggggaggttggcttgaaca       c.*840

          .         .         .         .         .         .       g.23451
 taaatgaaaatatcctgttattttcttagggatacttggttagtaaattataatagtaaa       c.*900

          .         .         .         .         .         .       g.23511
 aataatacatgaatcccattcacaggttctcagcccaagcaacaaggtaattgcgtgcca       c.*960

          .         .         .         .         .         .       g.23571
 ttcagcactgcaccagagcagacaacctatttgaggaaaaacagtgaaatccaccttcct       c.*1020

          .         .         .         .         .         .       g.23631
 cttcacactgagccctctctgattcctccgtgttgtgatgtgatgctggccacgtttcca       c.*1080

          .         .         .         .         .         .       g.23691
 aacggcagctccactgggtcccctttggttgtaggacaggaaatgaaacattaggagctc       c.*1140

          .         .         .         .         .         .       g.23751
 tgcttggaaaacagttcactacttagggatttttgtttcctaaaacttttattttgagga       c.*1200

          .         .         .         .         .         .       g.23811
 gcagtagttttctatgttttaatgacagaacttggctaatggaattcacagaggtgttgc       c.*1260

          .         .         .         .         .         .       g.23871
 agcgtatcactgttatgatcctgtgtttagattatccactcatgcttctcctattgtact       c.*1320

          .         .         .         .         .         .       g.23931
 gcaggtgtaccttaaaactgttcccagtgtacttgaacagttgcatttataaggggggaa       c.*1380

          .         .         .         .         .         .       g.23991
 atgtggtttaatggtgcctgatatctcaaagtcttttgtacataacatatatatatatat       c.*1440

          .         .         .         .         .         .       g.24051
 acatatatataaatataaatataaatatatctcattgcagccagtgatttagatttacag       c.*1500

          .         .         .         .         .         .       g.24111
 tttactctggggttatttctctgtctagagcattgttgtccttcactgcagtccagttgg       c.*1560

          .         .         .         .         .         .       g.24171
 gattattccaaaagttttttgagtcttgagcttgggctgtggccctgctgtgatcatacc       c.*1620

          .         .         .         .         .         .       g.24231
 ttgagcacgacgaagcaaccttgtttctgaggaagcttgagttctgactcactgaaatgc       c.*1680

          .         .         .         .         .         .       g.24291
 gtgttgggttgaagatatcttttttcttttctgcctcacccctttgtctccaacctccat       c.*1740

          .         .         .         .         .         .       g.24351
 ttctgttcactttgtggagagggcattacttgttcgttatagacatggacgttaagagat       c.*1800

          .         .         .         .         .         .       g.24411
 attcaaaactcagaagcatcagcaatgtttctcttttcttagttcattctgcagaatgga       c.*1860

          .         .         .         .         .         .       g.24471
 aacccatgcctattagaaatgacagtacttattaattgagtccctaaggaatattcagcc       c.*1920

          .         .         .         .         .         .       g.24531
 cactacatagatagcttttttttttttttttttaataaggacacctctttccaaacagtg       c.*1980

          .         .         .         .         .         .       g.24591
 ccatcaaatatgttcttatctcagacttacgttgttttaaaagtttggaaagatacacat       c.*2040

          .         .         .         .         .         .       g.24651
 ctttcataccccccttaggcaggttggctttcatatcacctcagccaactgtggctctta       c.*2100

          .         .         .         .         .         .       g.24711
 atttattgcataatgatattcacatcccctcagttgcagtgaattgtgagcaaaagatct       c.*2160

          .         .         .         .         .         .       g.24771
 tgaaagcaaaaagcactaattagtttaaaatgtcacttttttggtttttattatacaaaa       c.*2220

          .         .         .         .         .         .       g.24831
 accatgaagtactttttttatttgctaaatcagattgttcctttttagtgactcatgttt       c.*2280

          .         .         .         .         .         .       g.24891
 atgaagagagttgagtttaacaatcctagcttttaaaagaaactatttaatgtaaaatat       c.*2340

          .         .         .         .         .         .       g.24951
 tctacatgtcattcagatattatgtatatcttctagcctttattctgtacttttaatgta       c.*2400

          .         .         .         .         .         .       g.25011
 catatttctgtcttgcgtgatttgtatatttcactggtttaaaaaacaaacatcgaaagg       c.*2460

          .         .         .         .         .         .       g.25071
 cttatgccaaatggaagatagaatataaaataaaacgttacttgtatattggtaagtggt       c.*2520

          .         .         .         .         .         .       g.25131
 ttcaattgtccttcagataattcatgtggagatttttggagaaaccatgacggatagttt       c.*2580

          .         .         .         .         .         .       g.25191
 aggatgactacatgtcaaagtaataaaagagtggtgaattttaccaaaaccaagctattt       c.*2640

          .         .         .         .         .         .       g.25251
 ggaagcttcaaaaggtttctatatgtaatggaacaaaaggggaattctcttttcctatat       c.*2700

          .         .         .         .         .         .       g.25311
 atgttccttacaaaaaaaaaaaaaaaagaaatcaagcagatggcttaaagctggttatag       c.*2760

          .         .         .         .         .         .       g.25371
 gattgctcacattcttttagcattatgcatgtaacttaattgttttagagcgtgttgctg       c.*2820

          .         .         .         .         .         .       g.25431
 ttgtaacatcccagagaagaatgaaaaggcacatgcttttatccgtgaccagatttttag       c.*2880

          .         .         .         .         .         .       g.25491
 tccaaaaaaatgtatttttttgtgtgtttaccactgcaactattgcacctctctatttga       c.*2940

          .         .         .         .         .         .       g.25551
 atttactgtggaccatgtgtggtgtctctatgccctttgaaagcagtttttataaaaaga       c.*3000

          .         .         .         .         .         .       g.25611
 aagcccgggtctgcagagaatgaaaactggttggaaactaaaggttcattgtgttaagtg       c.*3060

          .         .         .         .         .         .       g.25671
 caattaatacaagttattgtgcttttcaaaaatgtacacggaaatctggacagtgctcca       c.*3120

          .         .         .         .         .         .       g.25731
 cagattgatacattagcctttgctttttctctttccggataaccttgtaacatattgaaa       c.*3180

          .         .         .         .         .         .       g.25791
 ccttttaaggatgccaagaatgcattattccacaaaaaaacagcagaccaacatatagag       c.*3240

          .         .         .         .         .         .       g.25851
 tgtttaaaatagcatttctgggcaaattcaaactcttgtggttctaggactcacatctgt       c.*3300

          .         .         .         .         .         .       g.25911
 ttcagtttttcctcagttgtatattgaccagtgttctttattgcaaaaacatatacccga       c.*3360

          .         .         .         .         .         .       g.25971
 tttagcagtgtcagcgtattttttcttctcatcctggagcgtattcaagatcttcccaat       c.*3420

          .         .         .         .         .         .       g.26031
 acaagaaaattaataaaaaatttatatataggcagcagcaaaagagccatgttcaaaata       c.*3480

          .         .         .         .         .         .       g.26091
 gtcattatgggctcaaatagaaagaagacttttaagttttaatccagtttatctgttgag       c.*3540

          .         .         .         .         .         .       g.26151
 ttctgtgagctactgacctcctgagactggcactgtgtaagttttagttgcctaccctag       c.*3600

          .         .         .         .         .         .       g.26211
 ctcttttctcgtacaattttgccaataccaagtttcaatttgtttttacaaaacattatt       c.*3660

          .         .         .         .         .         .       g.26271
 caagccactagaattatcaaatatgacgctatagcagagtaaatactctgaataagagac       c.*3720

          .         .         .         .         .         .       g.26331
 cggtactagctaactccaagagatcgttagcagcatcagtccacaaacacttagtggccc       c.*3780

          .         .         .         .         .         .       g.26391
 acaatatatagagagatagaaaaggtagttataacttgaagcatgtatttaatgcaaata       c.*3840

          .         .         .         .         .         .       g.26451
 ggcacgaaggcacaggtctaaaatactacattgtcactgtaagctatacttttaaaatat       c.*3900

          .         .         .         .         .         .       g.26511
 ttattttttttaaagtattttctagtcttttctctctctgtggaatggtgaaagagagat       c.*3960

          .         .         .         .         .         .       g.26571
 gccgtgttttgaaagtaagatgatgaaatgaatttttaattcaagaaacattcagaaaca       c.*4020

          .         .         .         .         .         .       g.26631
 taggaattaaaacttagagaaatgatctaatttccctgttcacacaaactttacacttta       c.*4080

          .         .         .         .         .         .       g.26691
 atctgatgattggatattttattttagtgaaacatcatcttgttagctaactttaaaaaa       c.*4140

          .         .         .         .         .         .       g.26751
 tggatgtagaatgattaaaggttggtatgatttttttttaatgtatcagtttgaacctag       c.*4200

          .         .         .         .         .         .       g.26811
 aatattgaattaaaatgctgtctcagtattttaaaagcaaaaaaggaatggaggaaaatt       c.*4260

          .         .         .         .         .         .       g.26871
 gcatcttagaccatttttatatgcagtgtacaatttgctgggctagaaatgagataaaga       c.*4320

          .         .         .         .         .                 g.26928
 ttatttatttttgttcatatcttgtacttttctattaaaatcattttatgaaatcca          c.*4377

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Wingless-type MMTV integration site family, member 5A protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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