Wilms tumor 1 (WT1) - coding DNA reference sequence

(used for variant description)

(last modified May 29, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_024426.4 in the WT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009272.1, covering WT1 transcript NM_024426.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   agctggggta       c.-181

 .         .         .         .         .         .                g.5070
 aggagttcaaggcagcgcccacacccgggggctctccgcaacccgaccgcctgtccgctc       c.-121

 .         .         .         .         .         .                g.5130
 ccccacttcccgccctccctcccacctactcattcacccacccacccacccagagccggg       c.-61

 .         .         .         .         .         .                g.5190
 acggcagcccaggcgcccgggccccgccgtctcctcgccgcgatcctggacttcctcttg       c.-1

          .         .         .         .         .         .       g.5250
 CTGCAGGACCCGGCTTCCACGTGTGTCCCGGAGCCGGCGTCTCAGCACACGCTCCGCTCC       c.60
 L  Q  D  P  A  S  T  C  V  P  E  P  A  S  Q  H  T  L  R  S         p.20

          .         .         .         .         .         .       g.5310
 GGGCCTGGGTGCCTACAGCAGCCAGAGCAGCAGGGAGTCCGGGACCCGGGCGGCATCTGG       c.120
 G  P  G  C  L  Q  Q  P  E  Q  Q  G  V  R  D  P  G  G  I  W         p.40

          .         .         .         .         .         .       g.5370
 GCCAAGTTAGGCGCCGCCGAGGCCAGCGCTGAACGTCTCCAGGGCCGGAGGAGCCGCGGG       c.180
 A  K  L  G  A  A  E  A  S  A  E  R  L  Q  G  R  R  S  R  G         p.60

          .         .         .         .         .         .       g.5430
 GCGTCCGGGTCTGAGCCGCAGCAAATGGGCTCCGACGTGCGGGACCTGAACGCGCTGCTG       c.240
 A  S  G  S  E  P  Q  Q  M  G  S  D  V  R  D  L  N  A  L  L         p.80

          .         .         .         .         .         .       g.5490
 CCCGCCGTCCCCTCCCTGGGTGGCGGCGGCGGCTGTGCCCTGCCTGTGAGCGGCGCGGCG       c.300
 P  A  V  P  S  L  G  G  G  G  G  C  A  L  P  V  S  G  A  A         p.100

          .         .         .         .         .         .       g.5550
 CAGTGGGCGCCGGTGCTGGACTTTGCGCCCCCGGGCGCTTCGGCTTACGGGTCGTTGGGC       c.360
 Q  W  A  P  V  L  D  F  A  P  P  G  A  S  A  Y  G  S  L  G         p.120

          .         .         .         .         .         .       g.5610
 GGCCCCGCGCCGCCACCGGCTCCGCCGCCACCCCCGCCGCCGCCGCCTCACTCCTTCATC       c.420
 G  P  A  P  P  P  A  P  P  P  P  P  P  P  P  P  H  S  F  I         p.140

          .         .         .         .         .         .       g.5670
 AAACAGGAGCCGAGCTGGGGCGGCGCGGAGCCGCACGAGGAGCAGTGCCTGAGCGCCTTC       c.480
 K  Q  E  P  S  W  G  G  A  E  P  H  E  E  Q  C  L  S  A  F         p.160

          .         .         .         .         .         .       g.5730
 ACTGTCCACTTTTCCGGCCAGTTCACTGGCACAGCCGGAGCCTGTCGCTACGGGCCCTTC       c.540
 T  V  H  F  S  G  Q  F  T  G  T  A  G  A  C  R  Y  G  P  F         p.180

          .         .         .         .         .         .       g.5790
 GGTCCTCCTCCGCCCAGCCAGGCGTCATCCGGCCAGGCCAGGATGTTTCCTAACGCGCCC       c.600
 G  P  P  P  P  S  Q  A  S  S  G  Q  A  R  M  F  P  N  A  P         p.200

          .         .         .         .       | 02 .         .    g.11930
 TACCTGCCCAGCTGCCTCGAGAGCCAGCCCGCTATTCGCAATCAGG | GTTACAGCACGGTC    c.660
 Y  L  P  S  C  L  E  S  Q  P  A  I  R  N  Q  G |   Y  S  T  V      p.220

          .         .         .         .         .         .       g.11990
 ACCTTCGACGGGACGCCCAGCTACGGTCACACGCCCTCGCACCATGCGGCGCAGTTCCCC       c.720
 T  F  D  G  T  P  S  Y  G  H  T  P  S  H  H  A  A  Q  F  P         p.240

          .         .         .         .          | 03        .    g.12488
 AACCACTCATTCAAGCATGAGGATCCCATGGGCCAGCAGGGCTCGCTGG | GTGAGCAGCAG    c.780
 N  H  S  F  K  H  E  D  P  M  G  Q  Q  G  S  L  G |   E  Q  Q      p.260

          .         .         .         .         .         .       g.12548
 TACTCGGTGCCGCCCCCGGTCTATGGCTGCCACACCCCCACCGACAGCTGCACCGGCAGC       c.840
 Y  S  V  P  P  P  V  Y  G  C  H  T  P  T  D  S  C  T  G  S         p.280

          .         .         .   | 04     .         .         .    g.22909
 CAGGCTTTGCTGCTGAGGACGCCCTACAGCAG | TGACAATTTATACCAAATGACATCCCAG    c.900
 Q  A  L  L  L  R  T  P  Y  S  S  |  D  N  L  Y  Q  M  T  S  Q      p.300

          .         .         .         .         . | 05       .    g.24005
 CTTGAATGCATGACCTGGAATCAGATGAACTTAGGAGCCACCTTAAAGGG | AGTTGCTGCT    c.960
 L  E  C  M  T  W  N  Q  M  N  L  G  A  T  L  K  G  |  V  A  A      p.320

          .         .         .         .  | 06      .         .    g.40510
 GGGAGCTCCAGCTCAGTGAAATGGACAGAAGGGCAGAGCAA | CCACAGCACAGGGTACGAG    c.1020
 G  S  S  S  S  V  K  W  T  E  G  Q  S  N  |  H  S  T  G  Y  E      p.340

          .         .         .         .         .         .       g.40570
 AGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATACACACGCACGGT       c.1080
 S  D  N  H  T  T  P  I  L  C  G  A  Q  Y  R  I  H  T  H  G         p.360

          .         | 07         .         .         .         .    g.44170
 GTCTTCAGAGGCATTCAG | GATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGG    c.1140
 V  F  R  G  I  Q   | D  V  R  R  V  P  G  V  A  P  T  L  V  R      p.380

          .         .         .         .         .         .       g.44230
 TCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAG       c.1200
 S  A  S  E  T  S  E  K  R  P  F  M  C  A  Y  P  G  C  N  K         p.400

          .         .         .         .          | 08        .    g.47791
 AGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTG | GTGAGAAACCA    c.1260
 R  Y  F  K  L  S  H  L  Q  M  H  S  R  K  H  T  G |   E  K  P      p.420

          .         .         .         .         .         .       g.47851
 TACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGA       c.1320
 Y  Q  C  D  F  K  D  C  E  R  R  F  S  R  S  D  Q  L  K  R         p.440

          .          | 09        .         .         .         .    g.48512
 CACCAAAGGAGACATACAG | GTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTC    c.1380
 H  Q  R  R  H  T  G |   V  K  P  F  Q  C  K  T  C  Q  R  K  F      p.460

          .         .         .         .         .   | 10     .    g.51364
 TCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTAAAACAA | GTGAAAAG    c.1440
 S  R  S  D  H  L  K  T  H  T  R  T  H  T  G  K  T  S |   E  K      p.480

          .         .         .         .         .         .       g.51424
 CCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTC       c.1500
 P  F  S  C  R  W  P  S  C  Q  K  K  F  A  R  S  D  E  L  V         p.500

          .         .         .         .         .                 g.51478
 CGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGA             c.1554
 R  H  H  N  M  H  Q  R  N  M  T  K  L  Q  L  A  L  X               p.517

          .         .         .         .         .         .       g.51538
 ggggtctccctcggggaccgttcagtgtcccaggcagcacagtgtgtgaactgctttcaa       c.*60

          .         .         .         .         .         .       g.51598
 gtctgactctccactcctcctcactaaaaaggaaacttcagttgatcttcttcatccaac       c.*120

          .         .         .         .         .         .       g.51658
 ttccaagacaagataccggtgcttctggaaactaccaggtgtgcctggaagagttggtct       c.*180

          .         .         .         .         .         .       g.51718
 ctgccctgcctacttttagttgactcacaggccctggagaagcagctaacaatgtctggt       c.*240

          .         .         .         .         .         .       g.51778
 tagttaaaagcccattgccatttggtgtggattttctactgtaagaagagccatagctga       c.*300

          .         .         .         .         .         .       g.51838
 tcatgtccccctgacccttcccttctttttttatgctcgttttcgctggggatggaatta       c.*360

          .         .         .         .         .         .       g.51898
 ttgtaccattttctatcatggaatatttataggccagggcatgtgtatgtgtctgctaat       c.*420

          .         .         .         .         .         .       g.51958
 gtaaactttgtcatggtttccatttactaacagcaacagcaagaaataaatcagagagca       c.*480

          .         .         .         .         .         .       g.52018
 aggcatcgggggtgaatcttgtctaacattcccgaggtcagccaggctgctaacctggaa       c.*540

          .         .         .         .         .         .       g.52078
 agcaggatgtagttctgccaggcaacttttaaagctcatgcatttcaagcagctgaagaa       c.*600

          .         .         .         .         .         .       g.52138
 aaaatcagaactaaccagtacctctgtatagaaatctaaaagaattttaccattcagtta       c.*660

          .         .         .         .         .         .       g.52198
 attcaatgtgaacactggcacactgctcttaagaaactatgaagatctgagatttttttg       c.*720

          .         .         .         .         .         .       g.52258
 tgtatgtttttgactcttttgagtggtaatcatatgtgtctttatagatgtacatacctc       c.*780

          .         .         .         .         .         .       g.52318
 cttgcacaaatggaggggaattcattttcatcactgggagtgtccttagtgtataaaaac       c.*840

          .         .         .         .         .         .       g.52378
 catgctggtatatggcttcaagttgtaaaaatgaaagtgactttaaaagaaaatagggga       c.*900

          .         .         .         .         .         .       g.52438
 tggtccaggatctccactgataagactgtttttaagtaacttaaggacctttgggtctac       c.*960

          .         .         .         .         .         .       g.52498
 aagtatatgtgaaaaaaatgagacttactgggtgaggaaatccattgtttaaagatggtc       c.*1020

          .         .         .         .         .         .       g.52558
 gtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgttgtgttgtgttttgttttttaaggga       c.*1080

          .         .         .         .         .         .       g.52618
 gggaatttattatttaccgttgcttgaaattactgtgtaaatatatgtctgataatgatt       c.*1140

          .         .         .         .         .         .       g.52678
 tgctctttgacaactaaaattaggactgtataagtactagatgcatcactgggtgttgat       c.*1200

          .         .         .         .         .         .       g.52738
 cttacaagatattgatgataacacttaaaattgtaacctgcatttttcactttgctctca       c.*1260

          .         .                                               g.52761
 attaaagtctattcaaaaggaaa                                            c.*1283

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Wilms tumor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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